{"id":994,"date":"2025-05-29T09:47:25","date_gmt":"2025-05-29T09:47:25","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-kojic-acid\/"},"modified":"2026-09-28T22:33:31","modified_gmt":"2026-09-28T15:33:31","slug":"nguyen-lieu-kojic-acid","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-kojic-acid\/","title":{"rendered":"Kojic acid (acid kojic): ngu\u1ed3n g\u1ed1c, t\u00ednh ch\u1ea5t v\u00e0 gi\u1edbi h\u1ea1n trong m\u1ef9 ph\u1ea9m"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Kojic acid (acid kojic): ngu\u1ed3n g\u1ed1c, t\u00ednh ch\u1ea5t v\u00e0 gi\u1edbi h\u1ea1n trong m\u1ef9 ph\u1ea9m<\/h1>\n<p><strong>Kojic acid<\/strong> (acid kojic) l\u00e0 ch\u1ea5t do m\u1ed9t s\u1ed1 lo\u00e0i n\u1ea5m t\u1ea1o ra, n\u1ed5i b\u1eadt l\u00e0 <em>Aspergillus oryzae<\/em>, lo\u1ea1i n\u1ea5m m\u1ed1c d\u00f9ng l\u00e0m <strong>koji<\/strong> \u0111\u1ec3 l\u00ean men r\u01b0\u1ee3u sake, t\u01b0\u01a1ng miso v\u00e0 n\u01b0\u1edbc t\u01b0\u01a1ng c\u1ee7a Nh\u1eadt B\u1ea3n. T\u00ean g\u1ecdi b\u1eaft ngu\u1ed3n t\u1eeb \u0111\u00f3; ch\u1ea5t \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp l\u1ea7n \u0111\u1ea7u n\u0103m 1907. Trong m\u1ef9 ph\u1ea9m, kojic acid \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m <strong>ch\u1ea5t l\u00e0m s\u00e1ng da<\/strong>.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>Kojic acid, 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-on<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c, kh\u1ed1i l\u01b0\u1ee3ng mol<\/td>\n<td>C<sub>6<\/sub>H<sub>6<\/sub>O<sub>4<\/sub> \u2013 142,11 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>501-30-4<\/td>\n<\/tr>\n<tr>\n<td>T\u00ean INCI<\/td>\n<td>Kojic Acid<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u1ea5u t\u1ea1o v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Ph\u00e2n t\u1eed l\u00e0 v\u00f2ng \u03b3-pyron mang nh\u00f3m hydroxyl v\u00e0 hydroxymethyl. Nh\u00f3m enol c\u1ea1nh nh\u00f3m carbonyl t\u1ea1o ph\u1ee9c m\u1ea1nh v\u1edbi ion kim lo\u1ea1i, \u0111\u1eb7c bi\u1ec7t <strong>\u0111\u1ed3ng<\/strong>. Tyrosinase, enzym then ch\u1ed1t t\u1ea1o s\u1eafc t\u1ed1 melanin, c\u00f3 trung t\u00e2m ho\u1ea1t \u0111\u1ed9ng ch\u1ee9a \u0111\u1ed3ng; \u0111\u00e2y l\u00e0 c\u01a1 s\u1edf cho kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf tyrosinase c\u1ee7a kojic acid.<\/li>\n<li>Tinh th\u1ec3 h\u00ecnh kim m\u00e0u tr\u1eafng \u0111\u1ebfn v\u00e0ng nh\u1ea1t, tan trong n\u01b0\u1edbc v\u00e0 ethanol.<\/li>\n<li><strong>K\u00e9m b\u1ec1n<\/strong>: d\u1ec5 b\u1ecb oxy h\u00f3a v\u00e0 chuy\u1ec3n m\u00e0u v\u00e0ng n\u00e2u khi ti\u1ebfp x\u00fac \u00e1nh s\u00e1ng, nhi\u1ec7t, kh\u00f4ng kh\u00ed v\u00e0 ion s\u1eaft. C\u00f4ng th\u1ee9c th\u01b0\u1eddng c\u1ea7n ch\u1ea5t ch\u1ed1ng oxy h\u00f3a, ch\u1ea5t t\u1ea1o ph\u1ee9c, pH h\u01a1i acid v\u00e0 bao b\u00ec c\u1ea3n quang. D\u1ea1ng ester <a href=\"https:\/\/cpc1.vn\/en\/nguyen-lieu-kojic-acid-dipalmitate\/\">kojic dipalmitate<\/a> \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ec3 kh\u1eafc ph\u1ee5c \u0111i\u1ec3m y\u1ebfu n\u00e0y.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Kojic acid \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng <strong>l\u00ean men hi\u1ebfu kh\u00ed<\/strong> n\u1ea5m <em>Aspergillus<\/em> tr\u00ean m\u00f4i tr\u01b0\u1eddng \u0111\u01b0\u1eddng (glucose), sau \u0111\u00f3 t\u00e1ch t\u1eeb d\u1ecbch l\u00ean men, tinh ch\u1ebf v\u00e0 k\u1ebft tinh.<\/p>\n<h2>Gi\u1edbi h\u1ea1n trong m\u1ef9 ph\u1ea9m<\/h2>\n<p>T\u1ea1i EU, Quy \u0111\u1ecbnh (EU) 2024\/996 \u0111\u01b0a kojic acid v\u00e0o Ph\u1ee5 l\u1ee5c III: ch\u1ec9 \u0111\u01b0\u1ee3c d\u00f9ng trong <strong>s\u1ea3n ph\u1ea9m cho m\u1eb7t v\u00e0 tay<\/strong>, n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a <strong>1%<\/strong>. S\u1ea3n ph\u1ea9m kh\u00f4ng \u0111\u00e1p \u1ee9ng kh\u00f4ng \u0111\u01b0\u1ee3c \u0111\u01b0a ra th\u1ecb tr\u01b0\u1eddng EU t\u1eeb 01\/02\/2025, v\u00e0 kh\u00f4ng \u0111\u01b0\u1ee3c b\u00e1n t\u1eeb 01\/11\/2025.<\/p>\n<h2>Applications<\/h2>\n<ul>\n<li>M\u1ef9 ph\u1ea9m l\u00e0m s\u00e1ng da (kem, serum, x\u00e0 ph\u00f2ng) trong gi\u1edbi h\u1ea1n cho ph\u00e9p.<\/li>\n<li>T\u1ea1i m\u1ed9t s\u1ed1 n\u01b0\u1edbc ch\u00e2u \u00c1, kojic acid t\u1eebng \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t ch\u1ed1ng h\u00f3a n\u00e2u trong th\u1ef1c ph\u1ea9m; vi\u1ec7c d\u00f9ng trong th\u1ef1c ph\u1ea9m ph\u1ee5 thu\u1ed9c quy \u0111\u1ecbnh t\u1eebng n\u01b0\u1edbc.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>M\u1ef9 ph\u1ea9m t\u1ea1i Vi\u1ec7t Nam \u0111\u01b0\u1ee3c qu\u1ea3n l\u00fd theo Th\u00f4ng t\u01b0 06\/2011\/TT-BYT v\u00e0 Hi\u1ec7p \u0111\u1ecbnh h\u00f2a h\u1ee3p trong qu\u1ea3n l\u00fd m\u1ef9 ph\u1ea9m ASEAN. Danh m\u1ee5c ch\u1ea5t c\u1ea5m, ch\u1ea5t h\u1ea1n ch\u1ebf v\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n c\u1ee7a ASEAN ph\u1ea7n l\u1edbn t\u01b0\u01a1ng \u0111\u1ed3ng v\u1edbi EU v\u00e0 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadt \u0111\u1ecbnh k\u1ef3. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu ph\u1ee5 l\u1ee5c ASEAN hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Kojic acid \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Kojic_acid\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Kojic_acid<\/a><\/li>\n<li>Wikidata \u2013 \u0111\u1ecbnh danh h\u00f3a h\u1ecdc (CAS, c\u00f4ng th\u1ee9c) \u2014 <a href=\"https:\/\/www.wikidata.org\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.wikidata.org\/<\/a><\/li>\n<li>Euverify \u2013 The New Kojic Acid Limit in EU and UK Cosmetics Law \u2014 <a href=\"https:\/\/euverify.com\/resource\/kojic-acid-limit-in-eu-and-uk-cosmetics-law\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/euverify.com\/resource\/kojic-acid-limit-in-eu-and-uk-cosmetics-law\/<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Kojic acid (acid kojic): ngu\u1ed3n g\u1ed1c, t\u00ednh ch\u1ea5t v\u00e0 gi\u1edbi h\u1ea1n trong m\u1ef9 ph\u1ea9m Kojic acid (acid kojic) l\u00e0 ch\u1ea5t do m\u1ed9t s\u1ed1 lo\u00e0i n\u1ea5m t\u1ea1o ra, n\u1ed5i b\u1eadt l\u00e0 Aspergillus oryzae, lo\u1ea1i n\u1ea5m m\u1ed1c d\u00f9ng l\u00e0m koji \u0111\u1ec3 l\u00ean men r\u01b0\u1ee3u sake, t\u01b0\u01a1ng miso v\u00e0 n\u01b0\u1edbc t\u01b0\u01a1ng c\u1ee7a Nh\u1eadt B\u1ea3n. T\u00ean g\u1ecdi b\u1eaft ngu\u1ed3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2923,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-994","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kojic-acid.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kojic-acid-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kojic-acid-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kojic-acid-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kojic-acid-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kojic-acid.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kojic-acid.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kojic-acid-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Kojic acid (acid kojic): ngu\u1ed3n g\u1ed1c, t\u00ednh ch\u1ea5t v\u00e0 gi\u1edbi h\u1ea1n trong m\u1ef9 ph\u1ea9m Kojic acid (acid kojic) l\u00e0 ch\u1ea5t do m\u1ed9t s\u1ed1 lo\u00e0i n\u1ea5m t\u1ea1o ra, n\u1ed5i b\u1eadt l\u00e0 Aspergillus oryzae, lo\u1ea1i n\u1ea5m m\u1ed1c d\u00f9ng l\u00e0m koji \u0111\u1ec3 l\u00ean men r\u01b0\u1ee3u sake, t\u01b0\u01a1ng miso v\u00e0 n\u01b0\u1edbc t\u01b0\u01a1ng c\u1ee7a Nh\u1eadt B\u1ea3n. T\u00ean g\u1ecdi b\u1eaft ngu\u1ed3n&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=994"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/994\/revisions"}],"predecessor-version":[{"id":3056,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/994\/revisions\/3056"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2923"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}