{"id":965,"date":"2025-05-29T09:34:02","date_gmt":"2025-05-29T09:34:02","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-chiet-xuat-la-cay-o-liu-olea-vita\/"},"modified":"2026-09-30T15:27:19","modified_gmt":"2026-09-30T08:27:19","slug":"nguyen-lieu-chiet-xuat-la-cay-o-liu-olea-vita","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-chiet-xuat-la-cay-o-liu-olea-vita\/","title":{"rendered":"Chi\u1ebft xu\u1ea5t l\u00e1 \u00f4 liu (Olea europaea): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Chi\u1ebft xu\u1ea5t l\u00e1 \u00f4 liu (Olea europaea): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng<\/h1>\n<p><strong>Chi\u1ebft xu\u1ea5t l\u00e1 \u00f4 liu<\/strong> l\u00e0 cao chi\u1ebft t\u1eeb l\u00e1 c\u00e2y \u00f4 liu (<em>Olea europaea<\/em>), ti\u00eau chu\u1ea9n h\u00f3a theo <strong>oleuropein<\/strong>, secoiridoid v\u1ecb \u0111\u1eafng \u0111\u1eb7c tr\u01b0ng c\u1ee7a c\u00e2y \u00f4 liu. L\u00e1 \u00f4 liu l\u00e0 ph\u1ee5 ph\u1ea9m l\u1edbn c\u1ee7a ng\u00e0nh tr\u1ed3ng \u00f4 liu v\u00f9ng \u0110\u1ecba Trung H\u1ea3i.<\/p>\n<figure class=\"wp-block-image size-large cpc1-anh-cay\"><img decoding=\"async\" src=\"https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-la-o-liu-cay-2.jpg\" alt=\"C\u00e2y \u00f4 liu \u2013 Olea europaea, ngu\u1ed3n nguy\u00ean li\u1ec7u chi\u1ebft xu\u1ea5t\"\/><figcaption>\u00d4 liu (<em>Olea europaea<\/em>). \u1ea2nh: Forest and Kim Starr, <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Starr-180919-0941-Olea_europaea_subsp_europaea-green_fruit-Skyline_Zipline_Crater_Rd-Maui_(45766421342).jpg\" rel=\"nofollow noopener\" target=\"_blank\">Wikimedia Commons<\/a>, gi\u1ea5y ph\u00e9p <a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/us\/deed.en\" rel=\"nofollow noopener\" target=\"_blank\">CC BY 3.0 US<\/a>.<\/figcaption><\/figure>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>L\u00e1 \u00f4 liu, olive leaf; Oleae folium<\/td>\n<\/tr>\n<tr>\n<td>Lo\u00e0i<\/td>\n<td><em>Olea europaea L.<\/em>, h\u1ecd \u00d4 liu (Oleaceae)<\/td>\n<\/tr>\n<tr>\n<td>B\u1ed9 ph\u1eadn d\u00f9ng<\/td>\n<td>L\u00e1<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ho\u1ea1t ch\u1ea5t ch\u00ednh<\/td>\n<td>Secoiridoid oleuropein (ch\u00ednh), hydroxytyrosol, flavonoid (luteolin-7-glucosid, verbascosid)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u00e2y v\u00e0 d\u01b0\u1ee3c li\u1ec7u<\/h2>\n<p>\u00d4 liu l\u00e0 c\u00e2y g\u1ed7 th\u01b0\u1eddng xanh, l\u00e1 h\u1eb9p d\u00e0i, m\u1eb7t d\u01b0\u1edbi m\u00e0u b\u1ea1c. L\u00e1 \u0111\u01b0\u1ee3c thu t\u1eeb vi\u1ec7c t\u1ec9a c\u00e0nh \u1edf c\u00e1c v\u01b0\u1eddn \u00f4 liu. Xem th\u00eam <a href=\"https:\/\/cpc1.vn\/en\/nguyen-lieu-chiet-xuat-tu-qua-oliu-dang-kho-olive-dry-extract-20-hydroxytyrosol\/\">hydroxytyrosol t\u1eeb qu\u1ea3 \u00f4 liu<\/a> v\u00e0 <a href=\"\/en\/dau-o-liu\/\">d\u1ea7u \u00f4 liu<\/a>.<\/p>\n<h2>Th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc<\/h2>\n<ul>\n<li><strong>Oleuropein<\/strong>: secoiridoid glycosid, th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a l\u00e1.<\/li>\n<li><strong>Hydroxytyrosol<\/strong> (sinh ra khi oleuropein b\u1ecb th\u1ee7y ph\u00e2n), tyrosol.<\/li>\n<li>Flavonoid: luteolin-7-glucosid, apigenin glycosid; verbascosid.<\/li>\n<\/ul>\n<h2>Chi\u1ebft xu\u1ea5t v\u00e0 ti\u00eau chu\u1ea9n h\u00f3a<\/h2>\n<p>L\u00e1 kh\u00f4 \u0111\u01b0\u1ee3c chi\u1ebft b\u1eb1ng ethanol \u2013 n\u01b0\u1edbc ho\u1eb7c n\u01b0\u1edbc, c\u00f4 \u0111\u1eb7c v\u00e0 s\u1ea5y; nguy\u00ean li\u1ec7u ti\u00eau chu\u1ea9n h\u00f3a theo oleuropein (v\u00ed d\u1ee5 20%, 40%) ho\u1eb7c hydroxytyrosol. D\u1ea1ng chi\u1ebft l\u1ecfng d\u00f9ng cho m\u1ef9 ph\u1ea9m.<\/p>\n<h2>Ch\u1ec9 ti\u00eau ch\u1ea5t l\u01b0\u1ee3ng n\u00ean xem<\/h2>\n<ul>\n<li>Oleuropein, hydroxytyrosol (HPLC).<\/li>\n<li>Kim lo\u1ea1i n\u1eb7ng, vi sinh v\u1eadt, d\u01b0 l\u01b0\u1ee3ng thu\u1ed1c b\u1ea3o v\u1ec7 th\u1ef1c v\u1eadt; \u0111\u1ed9c t\u1ed1 vi n\u1ea5m v\u1edbi d\u01b0\u1ee3c li\u1ec7u d\u1ec5 m\u1ed1c.<\/li>\n<\/ul>\n<h2>Applications<\/h2>\n<ul>\n<li>Thu\u1ed1c d\u01b0\u1ee3c li\u1ec7u (EU c\u00f3 chuy\u00ean lu\u1eadn Oleae folium).<\/li>\n<li>Th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe, tr\u00e0 th\u1ea3o m\u1ed9c; m\u1ef9 ph\u1ea9m.<\/li>\n<li>C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n<h2>An to\u00e0n v\u00e0 l\u01b0u \u00fd<\/h2>\n<ul>\n<li>C\u00f3 th\u1ec3 c\u1ed9ng h\u01b0\u1edfng v\u1edbi thu\u1ed1c tim m\u1ea1ch, huy\u1ebft \u00e1p v\u00e0 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft; ng\u01b0\u1eddi \u0111ang d\u00f9ng thu\u1ed1c n\u00ean h\u1ecfi \u00fd ki\u1ebfn chuy\u00ean gia y t\u1ebf.<\/li>\n<li>Ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u an to\u00e0n cho ph\u1ee5 n\u1eef mang thai, cho con b\u00fa v\u00e0 tr\u1ebb em; ng\u01b0\u1eddi \u0111ang d\u00f9ng thu\u1ed1c n\u00ean h\u1ecfi \u00fd ki\u1ebfn chuy\u00ean gia y t\u1ebf.<\/li>\n<\/ul>\n<p><!--my-pham--><\/p>\n<h2>In Cosmetics<\/h2>\n<p>Ngo\u00e0i d\u01b0\u1ee3c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m, nguy\u00ean li\u1ec7u t\u1eeb lo\u00e0i n\u00e0y c\u00f2n \u0111\u01b0\u1ee3c d\u00f9ng trong m\u1ef9 ph\u1ea9m d\u01b0\u1edbi c\u00e1c t\u00ean INCI sau (ch\u1ee9c n\u0103ng theo c\u01a1 s\u1edf d\u1eef li\u1ec7u CosIng c\u1ee7a \u1ee6y ban ch\u00e2u \u00c2u):<\/p>\n<table>\n<thead>\n<tr>\n<th>T\u00ean INCI<\/th>\n<th>D\u1ea1ng nguy\u00ean li\u1ec7u<\/th>\n<th>Ch\u1ee9c n\u0103ng (CosIng)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Olea Europaea (Olive) Fruit Extract<\/td>\n<td>chi\u1ebft xu\u1ea5t b\u1eb1ng dung m\u00f4i (th\u01b0\u1eddng l\u00e0 n\u01b0\u1edbc, glycol ho\u1eb7c ethanol), sau \u0111\u00f3 pha lo\u00e3ng trong dung m\u00f4i mang<\/td>\n<td>l\u00e0m s\u00e1ng, d\u01b0\u1ee1ng da<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Theo CosIng, c\u00e1c t\u00ean INCI tr\u00ean kh\u00f4ng thu\u1ed9c ph\u1ee5 l\u1ee5c ch\u1ea5t c\u1ea5m (Annex II) hay h\u1ea1n ch\u1ebf (Annex III) c\u1ee7a EU t\u1ea1i th\u1eddi \u0111i\u1ec3m vi\u1ebft b\u00e0i; ph\u1ee5 l\u1ee5c c\u1ee7a Hi\u1ec7p \u0111\u1ecbnh m\u1ef9 ph\u1ea9m ASEAN \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadt theo danh m\u1ee5c n\u00e0y. T\u1ea1i Vi\u1ec7t Nam, m\u1ef9 ph\u1ea9m qu\u1ea3n l\u00fd theo Th\u00f4ng t\u01b0 06\/2011\/TT-BYT; t\u00ednh n\u0103ng c\u00f4ng b\u1ed1 ph\u1ea3i theo H\u01b0\u1edbng d\u1eabn c\u00f4ng b\u1ed1 t\u00ednh n\u0103ng m\u1ef9 ph\u1ea9m ASEAN, kh\u00f4ng \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 c\u00f4ng d\u1ee5ng nh\u01b0 thu\u1ed1c.<\/p>\n<p><!--\/my-pham--><\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Khi d\u00f9ng l\u00e0m th\u00e0nh ph\u1ea7n c\u1ee7a th\u1ef1c ph\u1ea9m ho\u1eb7c th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe, s\u1ea3n ph\u1ea9m tu\u00e2n theo Lu\u1eadt An to\u00e0n th\u1ef1c ph\u1ea9m, Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP v\u00e0 c\u00e1c v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n m\u1edbi nh\u1ea5t tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>EMA \u2013 Oleae folium (chuy\u00ean lu\u1eadn d\u01b0\u1ee3c li\u1ec7u EU) \u2014 <a href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/herbal\/oleae-folium\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.ema.europa.eu\/en\/medicines\/herbal\/oleae-folium<\/a><\/li>\n<li>Wikipedia \u2013 Oleuropein \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Oleuropein\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Oleuropein<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Chi\u1ebft xu\u1ea5t l\u00e1 \u00f4 liu (Olea europaea): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng Chi\u1ebft xu\u1ea5t l\u00e1 \u00f4 liu l\u00e0 cao chi\u1ebft t\u1eeb l\u00e1 c\u00e2y \u00f4 liu (Olea europaea), ti\u00eau chu\u1ea9n h\u00f3a theo oleuropein, secoiridoid v\u1ecb \u0111\u1eafng \u0111\u1eb7c tr\u01b0ng c\u1ee7a c\u00e2y \u00f4 liu. L\u00e1 \u00f4 liu l\u00e0 ph\u1ee5 ph\u1ea9m l\u1edbn c\u1ee7a ng\u00e0nh tr\u1ed3ng \u00f4 liu [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4743,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-965","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-la-o-liu-cay-2.jpg",1280,960,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-la-o-liu-cay-2-150x150.jpg",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-la-o-liu-cay-2-300x225.jpg",300,225,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-la-o-liu-cay-2-768x576.jpg",768,576,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-la-o-liu-cay-2-1024x768.jpg",1024,768,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-la-o-liu-cay-2.jpg",1280,960,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-la-o-liu-cay-2.jpg",1280,960,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-la-o-liu-cay-2-16x12.jpg",16,12,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":1,"uagb_excerpt":"Chi\u1ebft xu\u1ea5t l\u00e1 \u00f4 liu (Olea europaea): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng Chi\u1ebft xu\u1ea5t l\u00e1 \u00f4 liu l\u00e0 cao chi\u1ebft t\u1eeb l\u00e1 c\u00e2y \u00f4 liu (Olea europaea), ti\u00eau chu\u1ea9n h\u00f3a theo oleuropein, secoiridoid v\u1ecb \u0111\u1eafng \u0111\u1eb7c tr\u01b0ng c\u1ee7a c\u00e2y \u00f4 liu. L\u00e1 \u00f4 liu l\u00e0 ph\u1ee5 ph\u1ea9m l\u1edbn c\u1ee7a ng\u00e0nh tr\u1ed3ng \u00f4 liu&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/965","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=965"}],"version-history":[{"count":6,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/965\/revisions"}],"predecessor-version":[{"id":5098,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/965\/revisions\/5098"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/4743"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=965"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=965"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=965"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}