{"id":907,"date":"2025-05-29T09:03:56","date_gmt":"2025-05-29T09:03:56","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-vitamin-d3-powder\/"},"modified":"2026-09-28T21:00:21","modified_gmt":"2026-09-28T14:00:21","slug":"nguyen-lieu-vitamin-d3-powder","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-vitamin-d3-powder\/","title":{"rendered":"Cholecalciferol (vitamin D3): c\u1ea5u t\u1ea1o, s\u1ea3n xu\u1ea5t v\u00e0 c\u00e1c d\u1ea1ng nguy\u00ean li\u1ec7u"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Cholecalciferol (vitamin D3): c\u1ea5u t\u1ea1o, s\u1ea3n xu\u1ea5t v\u00e0 c\u00e1c d\u1ea1ng nguy\u00ean li\u1ec7u<\/h1>\n<p><strong>Cholecalciferol<\/strong> (<strong>vitamin D3<\/strong>) l\u00e0 vitamin tan trong d\u1ea7u, \u0111\u01b0\u1ee3c da ng\u01b0\u1eddi t\u1ef1 t\u1ea1o ra khi ti\u1ebfp x\u00fac v\u1edbi tia UVB c\u1ee7a \u00e1nh n\u1eafng. Trong c\u01a1 th\u1ec3, cholecalciferol \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a \u1edf gan r\u1ed3i \u1edf th\u1eadn th\u00e0nh d\u1ea1ng ho\u1ea1t \u0111\u1ed9ng, tham gia \u0111i\u1ec1u h\u00f2a h\u1ea5p thu calci v\u00e0 phosphat.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>Cholecalciferol, colecalciferol, vitamin D3<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c, kh\u1ed1i l\u01b0\u1ee3ng mol<\/td>\n<td>C<sub>27<\/sub>H<sub>44<\/sub>O \u2013 384,65 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>67-97-0<\/td>\n<\/tr>\n<tr>\n<td>Quy \u0111\u1ed5i \u0111\u01a1n v\u1ecb<\/td>\n<td>1 \u00b5g cholecalciferol = 40 IU; 1 IU = 0,025 \u00b5g<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u1ea5u t\u1ea1o v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Vitamin D3 l\u00e0 m\u1ed9t <strong>secosteroid<\/strong>: khung steroid b\u1ecb m\u1edf m\u1ed9t v\u00f2ng (v\u00f2ng B) do t\u00e1c d\u1ee5ng c\u1ee7a tia UV l\u00ean ti\u1ec1n ch\u1ea5t 7-dehydrocholesterol.<\/li>\n<li>D\u1ea1ng tinh khi\u1ebft l\u00e0 tinh th\u1ec3 m\u00e0u tr\u1eafng, kh\u00f4ng tan trong n\u01b0\u1edbc, tan trong d\u1ea7u v\u00e0 dung m\u00f4i h\u1eefu c\u01a1.<\/li>\n<li><strong>K\u00e9m b\u1ec1n<\/strong> v\u1edbi \u00e1nh s\u00e1ng, oxy, nhi\u1ec7t v\u00e0 acid. V\u00ec v\u1eady nguy\u00ean li\u1ec7u th\u01b0\u01a1ng m\u1ea1i th\u01b0\u1eddng c\u00f3 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a v\u00e0 \u0111\u01b0\u1ee3c bao vi nang.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Ngu\u1ed3n c\u00f4ng nghi\u1ec7p ch\u1ee7 y\u1ebfu l\u00e0 <strong>lanolin<\/strong> (m\u1ee1 l\u00f4ng c\u1eebu): t\u00e1ch cholesterol, chuy\u1ec3n th\u00e0nh 7-dehydrocholesterol, r\u1ed3i chi\u1ebfu tia UV \u0111\u1ec3 m\u1edf v\u00f2ng, sau \u0111\u00f3 tinh ch\u1ebf. Ngu\u1ed3n thu\u1ea7n chay l\u00e0 vitamin D3 t\u1eeb <strong>\u0111\u1ecba y<\/strong> (lichen). Vitamin D2 (ergocalciferol) l\u00e0 d\u1ea1ng kh\u00e1c, t\u1ea1o ra t\u1eeb ergosterol c\u1ee7a n\u1ea5m men ho\u1eb7c n\u1ea5m.<\/p>\n<h2>D\u1ea1ng nguy\u00ean li\u1ec7u<\/h2>\n<p>V\u00ec l\u01b0\u1ee3ng d\u00f9ng t\u00ednh b\u1eb1ng microgam, vitamin D3 h\u1ea7u nh\u01b0 kh\u00f4ng d\u00f9ng \u1edf d\u1ea1ng tinh khi\u1ebft m\u00e0 \u1edf d\u1ea1ng pha lo\u00e3ng:<\/p>\n<ul>\n<li><strong>D\u1ea1ng d\u1ea7u<\/strong>: h\u00f2a tan trong d\u1ea7u th\u1ef1c v\u1eadt ho\u1eb7c triglycerid m\u1ea1ch trung b\u00ecnh, d\u00f9ng cho vi\u00ean nang m\u1ec1m, d\u1ea1ng gi\u1ecdt.<\/li>\n<li><strong>D\u1ea1ng b\u1ed9t<\/strong> (v\u00ed d\u1ee5 100.000 IU\/g): vi nang trong g\u00f4m arabic, tinh b\u1ed9t bi\u1ebfn t\u00ednh ho\u1eb7c gelatin, c\u00f3 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a. Lo\u1ea1i &#8220;tan trong n\u01b0\u1edbc&#8221; (CWS \u2013 cold water soluble) d\u00f9ng cho \u0111\u1ed3 u\u1ed1ng, lo\u1ea1i d\u1eadp vi\u00ean ch\u1ecbu \u0111\u01b0\u1ee3c l\u1ef1c n\u00e9n.<\/li>\n<\/ul>\n<p>Khi t\u00ednh c\u00f4ng th\u1ee9c ph\u1ea3i d\u00f9ng <strong>h\u00e0m l\u01b0\u1ee3ng ghi tr\u00ean COA<\/strong> c\u1ee7a t\u1eebng l\u00f4 (IU\/g). N\u00ean t\u00ednh d\u01b0 m\u1ed9t ph\u1ea7n \u0111\u1ec3 b\u00f9 hao h\u1ee5t trong h\u1ea1n d\u00f9ng, theo d\u1eef li\u1ec7u \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u1ee7a ch\u00ednh s\u1ea3n ph\u1ea9m.<\/p>\n<h2>Applications<\/h2>\n<ul>\n<li>Th\u1ef1c ph\u1ea9m b\u1ed5 sung; s\u1eefa, d\u1ea7u \u0103n v\u00e0 th\u1ef1c ph\u1ea9m t\u0103ng c\u01b0\u1eddng vi ch\u1ea5t; s\u1eefa c\u00f4ng th\u1ee9c.<\/li>\n<li>Th\u1ee9c \u0103n ch\u0103n nu\u00f4i.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Khi d\u00f9ng l\u00e0m th\u00e0nh ph\u1ea7n c\u1ee7a th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe ho\u1eb7c th\u1ef1c ph\u1ea9m t\u0103ng c\u01b0\u1eddng vi ch\u1ea5t, s\u1ea3n ph\u1ea9m tu\u00e2n theo Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP v\u00e0 c\u00e1c v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf, k\u1ec3 c\u1ea3 quy \u0111\u1ecbnh v\u1ec1 h\u00e0m l\u01b0\u1ee3ng vitamin so v\u1edbi nhu c\u1ea7u khuy\u1ebfn ngh\u1ecb. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n m\u1edbi nh\u1ea5t tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>B\u1ea3o qu\u1ea3n<\/h2>\n<p>Tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t v\u00e0 kh\u00f4ng kh\u00ed; bao b\u00ec k\u00edn, n\u01a1i m\u00e1t. D\u00f9ng h\u1ebft s\u1edbm sau khi m\u1edf bao.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Cholecalciferol \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Cholecalciferol\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Cholecalciferol<\/a><\/li>\n<li>Wikidata \u2013 \u0111\u1ecbnh danh h\u00f3a h\u1ecdc (CAS, c\u00f4ng th\u1ee9c) \u2014 <a href=\"https:\/\/www.wikidata.org\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.wikidata.org\/<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Cholecalciferol (vitamin D3): c\u1ea5u t\u1ea1o, s\u1ea3n xu\u1ea5t v\u00e0 c\u00e1c d\u1ea1ng nguy\u00ean li\u1ec7u Cholecalciferol (vitamin D3) l\u00e0 vitamin tan trong d\u1ea7u, \u0111\u01b0\u1ee3c da ng\u01b0\u1eddi t\u1ef1 t\u1ea1o ra khi ti\u1ebfp x\u00fac v\u1edbi tia UVB c\u1ee7a \u00e1nh n\u1eafng. Trong c\u01a1 th\u1ec3, cholecalciferol \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a \u1edf gan r\u1ed3i \u1edf th\u1eadn th\u00e0nh d\u1ea1ng ho\u1ea1t \u0111\u1ed9ng, tham gia \u0111i\u1ec1u h\u00f2a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2967,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-907","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-d3.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-d3-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-d3-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-d3-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-d3-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-d3.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-d3.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-d3-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Cholecalciferol (vitamin D3): c\u1ea5u t\u1ea1o, s\u1ea3n xu\u1ea5t v\u00e0 c\u00e1c d\u1ea1ng nguy\u00ean li\u1ec7u Cholecalciferol (vitamin D3) l\u00e0 vitamin tan trong d\u1ea7u, \u0111\u01b0\u1ee3c da ng\u01b0\u1eddi t\u1ef1 t\u1ea1o ra khi ti\u1ebfp x\u00fac v\u1edbi tia UVB c\u1ee7a \u00e1nh n\u1eafng. Trong c\u01a1 th\u1ec3, cholecalciferol \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a \u1edf gan r\u1ed3i \u1edf th\u1eadn th\u00e0nh d\u1ea1ng ho\u1ea1t \u0111\u1ed9ng, tham gia \u0111i\u1ec1u h\u00f2a&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/907","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=907"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/907\/revisions"}],"predecessor-version":[{"id":3100,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/907\/revisions\/3100"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2967"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=907"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=907"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=907"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}