{"id":888,"date":"2025-05-29T08:54:15","date_gmt":"2025-05-29T08:54:15","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-beta-arbutin\/"},"modified":"2026-09-28T20:38:58","modified_gmt":"2026-09-28T13:38:58","slug":"nguyen-lieu-beta-arbutin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-beta-arbutin\/","title":{"rendered":"Arbutin (alpha-arbutin, beta-arbutin): c\u1ea5u t\u1ea1o, kh\u00e1c bi\u1ec7t v\u00e0 gi\u1edbi h\u1ea1n"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Arbutin (alpha-arbutin, beta-arbutin): c\u1ea5u t\u1ea1o, kh\u00e1c bi\u1ec7t v\u00e0 gi\u1edbi h\u1ea1n<\/h1>\n<p><strong>Arbutin<\/strong> l\u00e0 m\u1ed9t <strong>glycosid<\/strong>: ph\u00e2n t\u1eed hydroquinon g\u1eafn v\u1edbi m\u1ed9t ph\u00e2n t\u1eed glucose. C\u00f3 hai d\u1ea1ng th\u01b0\u01a1ng m\u1ea1i, kh\u00e1c nhau \u1edf ki\u1ec3u li\u00ean k\u1ebft gi\u1eefa glucose v\u00e0 hydroquinon: <strong>beta-arbutin<\/strong> (d\u1ea1ng t\u1ef1 nhi\u00ean, th\u01b0\u1eddng g\u1ecdi t\u1eaft l\u00e0 &#8220;arbutin&#8221;) v\u00e0 <strong>alpha-arbutin<\/strong>. C\u1ea3 hai \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t l\u00e0m s\u00e1ng da trong m\u1ef9 ph\u1ea9m.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>Arbutin (\u03b2-arbutin), hydroquinon \u03b2-D-glucopyranosid; alpha-arbutin (hydroquinon \u03b1-D-glucopyranosid)<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c, kh\u1ed1i l\u01b0\u1ee3ng mol<\/td>\n<td>C<sub>12<\/sub>H<sub>16<\/sub>O<sub>7<\/sub> \u2013 272,25 g\/mol (c\u1ea3 hai d\u1ea1ng)<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>497-76-7 (\u03b2-arbutin); 84380-01-8 (\u03b1-arbutin)<\/td>\n<\/tr>\n<tr>\n<td>T\u00ean INCI<\/td>\n<td>Arbutin; Alpha-Arbutin<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Ngu\u1ed3n g\u1ed1c v\u00e0 s\u1ea3n xu\u1ea5t<\/h2>\n<ul>\n<li><strong>Beta-arbutin<\/strong> c\u00f3 t\u1ef1 nhi\u00ean trong l\u00e1 c\u00e2y bearberry (<em>Arctostaphylos uva-ursi<\/em>), l\u00e1 l\u00ea, l\u00e1 vi\u1ec7t qu\u1ea5t. D\u1ea1ng th\u01b0\u01a1ng m\u1ea1i \u0111\u01b0\u1ee3c chi\u1ebft t\u1eeb th\u1ef1c v\u1eadt ho\u1eb7c t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc.<\/li>\n<li><strong>Alpha-arbutin<\/strong> h\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3 trong t\u1ef1 nhi\u00ean; \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng <strong>enzym<\/strong>: enzym chuy\u1ec3n glucose t\u1eeb \u0111\u01b0\u1eddng (sucrose, tinh b\u1ed9t) sang hydroquinon theo li\u00ean k\u1ebft alpha.<\/li>\n<\/ul>\n<h2>T\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t k\u1ebft tinh m\u00e0u tr\u1eafng, tan t\u1ed1t trong n\u01b0\u1edbc.<\/li>\n<li>Arbutin \u1ee9c ch\u1ebf enzym tyrosinase (t\u1ea1o melanin). Alpha-arbutin \u0111\u01b0\u1ee3c ghi nh\u1eadn c\u00f3 ho\u1ea1t t\u00ednh \u1ee9c ch\u1ebf m\u1ea1nh h\u01a1n beta-arbutin trong m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u in vitro.<\/li>\n<li>Arbutin c\u00f3 th\u1ec3 b\u1ecb th\u1ee7y ph\u00e2n (nhi\u1ec7t, pH acid ho\u1eb7c ki\u1ec1m m\u1ea1nh, vi sinh v\u1eadt) gi\u1ea3i ph\u00f3ng <strong>hydroquinon<\/strong>, ch\u1ea5t b\u1ecb c\u1ea5m trong m\u1ef9 ph\u1ea9m b\u00f4i da t\u1ea1i EU. V\u00ec v\u1eady c\u00f4ng th\u1ee9c c\u1ea7n pH ph\u00f9 h\u1ee3p (th\u01b0\u1eddng kho\u1ea3ng 4\u20136), tr\u00e1nh nhi\u1ec7t \u0111\u1ed9 cao, v\u00e0 ki\u1ec3m so\u00e1t hydroquinon t\u1ef1 do trong nguy\u00ean li\u1ec7u.<\/li>\n<\/ul>\n<h2>Gi\u1edbi h\u1ea1n t\u1ea1i EU<\/h2>\n<p>Quy \u0111\u1ecbnh (EU) 2024\/996 \u0111\u01b0a arbutin v\u00e0o Ph\u1ee5 l\u1ee5c III:<\/p>\n<ul>\n<li><strong>Alpha-arbutin<\/strong>: t\u1ed1i \u0111a 2% trong kem m\u1eb7t, 0,5% trong s\u1eefa d\u01b0\u1ee1ng th\u1ec3.<\/li>\n<li><strong>Arbutin (beta)<\/strong>: t\u1ed1i \u0111a 7% trong kem m\u1eb7t.<\/li>\n<li>H\u00e0m l\u01b0\u1ee3ng hydroquinon trong th\u00e0nh ph\u1ea9m ch\u1ec9 \u1edf m\u1ee9c v\u1ebft kh\u00f4ng tr\u00e1nh \u0111\u01b0\u1ee3c.<\/li>\n<\/ul>\n<p>\u00c1p d\u1ee5ng v\u1edbi s\u1ea3n ph\u1ea9m m\u1edbi t\u1eeb 01\/02\/2025, m\u1ecdi s\u1ea3n ph\u1ea9m t\u1eeb 01\/11\/2025.<\/p>\n<h2>Applications<\/h2>\n<p>Kem, serum, m\u1eb7t n\u1ea1 l\u00e0m s\u00e1ng da.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>M\u1ef9 ph\u1ea9m t\u1ea1i Vi\u1ec7t Nam \u0111\u01b0\u1ee3c qu\u1ea3n l\u00fd theo Th\u00f4ng t\u01b0 06\/2011\/TT-BYT v\u00e0 Hi\u1ec7p \u0111\u1ecbnh h\u00f2a h\u1ee3p trong qu\u1ea3n l\u00fd m\u1ef9 ph\u1ea9m ASEAN. Danh m\u1ee5c ch\u1ea5t c\u1ea5m, ch\u1ea5t h\u1ea1n ch\u1ebf v\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n c\u1ee7a ASEAN ph\u1ea7n l\u1edbn t\u01b0\u01a1ng \u0111\u1ed3ng v\u1edbi EU v\u00e0 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadt \u0111\u1ecbnh k\u1ef3. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu ph\u1ee5 l\u1ee5c ASEAN hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Arbutin \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Arbutin\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Arbutin<\/a><\/li>\n<li>Wikidata \u2013 arbutin (CAS 497-76-7), alpha-arbutin (CAS 84380-01-8) \u2014 <a href=\"https:\/\/www.wikidata.org\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.wikidata.org\/<\/a><\/li>\n<li>Quy \u0111\u1ecbnh (EU) 2024\/996 s\u1eeda \u0111\u1ed5i Ph\u1ee5 l\u1ee5c Quy \u0111\u1ecbnh m\u1ef9 ph\u1ea9m (EC) 1223\/2009 \u2013 t\u00f3m t\u1eaft c\u1ee7a UL Solutions \u2014 <a href=\"https:\/\/www.ul.com\/news\/eu-updates-annexes-ii-iii-v-and-vi-cosmetics-regulation\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.ul.com\/news\/eu-updates-annexes-ii-iii-v-and-vi-cosmetics-regulation<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Arbutin (alpha-arbutin, beta-arbutin): c\u1ea5u t\u1ea1o, kh\u00e1c bi\u1ec7t v\u00e0 gi\u1edbi h\u1ea1n Arbutin l\u00e0 m\u1ed9t glycosid: ph\u00e2n t\u1eed hydroquinon g\u1eafn v\u1edbi m\u1ed9t ph\u00e2n t\u1eed glucose. C\u00f3 hai d\u1ea1ng th\u01b0\u01a1ng m\u1ea1i, kh\u00e1c nhau \u1edf ki\u1ec3u li\u00ean k\u1ebft gi\u1eefa glucose v\u00e0 hydroquinon: beta-arbutin (d\u1ea1ng t\u1ef1 nhi\u00ean, th\u01b0\u1eddng g\u1ecdi t\u1eaft l\u00e0 &#8220;arbutin&#8221;) v\u00e0 alpha-arbutin. C\u1ea3 hai \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2841,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-888","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/arbutin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/arbutin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/arbutin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/arbutin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/arbutin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/arbutin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/arbutin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/arbutin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Arbutin (alpha-arbutin, beta-arbutin): c\u1ea5u t\u1ea1o, kh\u00e1c bi\u1ec7t v\u00e0 gi\u1edbi h\u1ea1n Arbutin l\u00e0 m\u1ed9t glycosid: ph\u00e2n t\u1eed hydroquinon g\u1eafn v\u1edbi m\u1ed9t ph\u00e2n t\u1eed glucose. C\u00f3 hai d\u1ea1ng th\u01b0\u01a1ng m\u1ea1i, kh\u00e1c nhau \u1edf ki\u1ec3u li\u00ean k\u1ebft gi\u1eefa glucose v\u00e0 hydroquinon: beta-arbutin (d\u1ea1ng t\u1ef1 nhi\u00ean, th\u01b0\u1eddng g\u1ecdi t\u1eaft l\u00e0 &#8220;arbutin&#8221;) v\u00e0 alpha-arbutin. C\u1ea3 hai \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=888"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/888\/revisions"}],"predecessor-version":[{"id":2972,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/888\/revisions\/2972"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2841"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=888"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}