{"id":887,"date":"2025-05-29T08:53:57","date_gmt":"2025-05-29T08:53:57","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-climbazole\/"},"modified":"2026-09-29T11:49:02","modified_gmt":"2026-09-29T04:49:02","slug":"nguyen-lieu-climbazole","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-climbazole\/","title":{"rendered":"Climbazole: ho\u1ea1t ch\u1ea5t ch\u1ed1ng g\u00e0u nh\u00f3m azol \u2013 c\u1ea5u t\u1ea1o, gi\u1edbi h\u1ea1n s\u1eed d\u1ee5ng"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Climbazole: ho\u1ea1t ch\u1ea5t ch\u1ed1ng g\u00e0u nh\u00f3m azol \u2013 c\u1ea5u t\u1ea1o, gi\u1edbi h\u1ea1n s\u1eed d\u1ee5ng<\/h1>\n<p><strong>Climbazole<\/strong> l\u00e0 ho\u1ea1t ch\u1ea5t kh\u00e1ng n\u1ea5m thu\u1ed9c nh\u00f3m <strong>imidazol<\/strong> (azol), d\u00f9ng ch\u1ee7 y\u1ebfu trong <strong>d\u1ea7u g\u1ed9i ch\u1ed1ng g\u00e0u<\/strong>. G\u00e0u li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n qu\u00e1 m\u1ee9c c\u1ee7a n\u1ea5m men <em>Malassezia<\/em> tr\u00ean da \u0111\u1ea7u; climbazole \u1ee9c ch\u1ebf lo\u1ea1i n\u1ea5m n\u00e0y.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>Climbazole, 1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-on<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c, kh\u1ed1i l\u01b0\u1ee3ng mol<\/td>\n<td>C<sub>15<\/sub>H<sub>17<\/sub>ClN<sub>2<\/sub>O<sub>2<\/sub> \u2013 292,77 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>38083-17-9<\/td>\n<\/tr>\n<tr>\n<td>T\u00ean INCI<\/td>\n<td>Climbazole<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u1ea5u t\u1ea1o v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Ph\u00e2n t\u1eed c\u00f3 v\u00f2ng imidazol, v\u00f2ng 4-chlorophenoxy v\u00e0 nh\u00f3m tert-butyl ceton. Gi\u1ed1ng c\u00e1c thu\u1ed1c kh\u00e1ng n\u1ea5m azol, climbazole \u1ee9c ch\u1ebf enzym t\u1ed5ng h\u1ee3p ergosterol, th\u00e0nh ph\u1ea7n m\u00e0ng t\u1ebf b\u00e0o n\u1ea5m.<\/li>\n<li>B\u1ed9t k\u1ebft tinh m\u00e0u tr\u1eafng. <strong>R\u1ea5t \u00edt tan trong n\u01b0\u1edbc<\/strong>, tan trong ethanol, glycol v\u00e0 dung d\u1ecbch ch\u1ea5t di\u1ec7n ho\u1ea1t. Trong d\u1ea7u g\u1ed9i, climbazole th\u01b0\u1eddng \u0111\u01b0\u1ee3c h\u00f2a tan tr\u01b0\u1edbc trong dung m\u00f4i ho\u1eb7c ch\u1ea5t di\u1ec7n ho\u1ea1t \u1edf giai \u0111o\u1ea1n \u1ea5m.<\/li>\n<\/ul>\n<h2>Gi\u1edbi h\u1ea1n s\u1eed d\u1ee5ng t\u1ea1i EU<\/h2>\n<ul>\n<li>L\u00e0m <strong>ch\u1ea5t b\u1ea3o qu\u1ea3n<\/strong> (Ph\u1ee5 l\u1ee5c V, Quy \u0111\u1ecbnh (EC) 1223\/2009): t\u1ed1i \u0111a <strong>0,5%<\/strong>.<\/li>\n<li>L\u00e0m <strong>ch\u1ea5t ch\u1ed1ng g\u00e0u<\/strong>: n\u1ed3ng \u0111\u1ed9 \u0111\u01b0\u1ee3c \u1ee6y ban khoa h\u1ecdc v\u1ec1 an to\u00e0n ng\u01b0\u1eddi ti\u00eau d\u00f9ng (SCCS) \u0111\u00e1nh gi\u00e1 l\u00e0 an to\u00e0n t\u1edbi <strong>2% trong d\u1ea7u g\u1ed9i<\/strong> (s\u1ea3n ph\u1ea9m x\u1ea3 s\u1ea1ch).<\/li>\n<\/ul>\n<h2>Applications<\/h2>\n<ul>\n<li>D\u1ea7u g\u1ed9i, d\u1ea7u x\u1ea3 ch\u1ed1ng g\u00e0u, th\u01b0\u1eddng ph\u1ed1i h\u1ee3p v\u1edbi piroctone olamine ho\u1eb7c k\u1ebdm pyrithion.<\/li>\n<li>X\u00e0 ph\u00f2ng, s\u1eefa t\u1eafm kh\u1eed m\u00f9i.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>M\u1ef9 ph\u1ea9m t\u1ea1i Vi\u1ec7t Nam \u0111\u01b0\u1ee3c qu\u1ea3n l\u00fd theo Th\u00f4ng t\u01b0 06\/2011\/TT-BYT v\u00e0 Hi\u1ec7p \u0111\u1ecbnh h\u00f2a h\u1ee3p trong qu\u1ea3n l\u00fd m\u1ef9 ph\u1ea9m ASEAN. Danh m\u1ee5c ch\u1ea5t c\u1ea5m, ch\u1ea5t h\u1ea1n ch\u1ebf v\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n c\u1ee7a ASEAN ph\u1ea7n l\u1edbn t\u01b0\u01a1ng \u0111\u1ed3ng v\u1edbi EU v\u00e0 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadt \u0111\u1ecbnh k\u1ef3. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu ph\u1ee5 l\u1ee5c ASEAN hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Climbazole \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Climbazole\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Climbazole<\/a><\/li>\n<li>ECHA \u2013 Climbazole, th\u00f4ng tin ch\u1ea5t \u2014 <a href=\"https:\/\/echa.europa.eu\/substance-information\/-\/substanceinfo\/100.048.870\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/echa.europa.eu\/substance-information\/-\/substanceinfo\/100.048.870<\/a><\/li>\n<li>SCCS \u2013 Addendum to the scientific Opinions on Climbazole (P64) \u2014 <a href=\"https:\/\/op.europa.eu\/en\/publication-detail\/-\/publication\/f1a0a971-38cd-11e9-8d04-01aa75ed71a1\/language-en\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/op.europa.eu\/en\/publication-detail\/-\/publication\/f1a0a971-38cd-11e9-8d04-01aa75ed71a1\/language-en<\/a><\/li>\n<li>Wikidata \u2013 \u0111\u1ecbnh danh h\u00f3a h\u1ecdc (CAS, c\u00f4ng th\u1ee9c) \u2014 <a href=\"https:\/\/www.wikidata.org\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.wikidata.org\/<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Climbazole: ho\u1ea1t ch\u1ea5t ch\u1ed1ng g\u00e0u nh\u00f3m azol \u2013 c\u1ea5u t\u1ea1o, gi\u1edbi h\u1ea1n s\u1eed d\u1ee5ng Climbazole l\u00e0 ho\u1ea1t ch\u1ea5t kh\u00e1ng n\u1ea5m thu\u1ed9c nh\u00f3m imidazol (azol), d\u00f9ng ch\u1ee7 y\u1ebfu trong d\u1ea7u g\u1ed9i ch\u1ed1ng g\u00e0u. G\u00e0u li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n qu\u00e1 m\u1ee9c c\u1ee7a n\u1ea5m men Malassezia tr\u00ean da \u0111\u1ea7u; climbazole \u1ee9c ch\u1ebf lo\u1ea1i n\u1ea5m n\u00e0y. Th\u00f4ng [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2899,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-887","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/climbazole.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/climbazole-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/climbazole-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/climbazole-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/climbazole-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/climbazole.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/climbazole.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/climbazole-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":1,"uagb_excerpt":"Climbazole: ho\u1ea1t ch\u1ea5t ch\u1ed1ng g\u00e0u nh\u00f3m azol \u2013 c\u1ea5u t\u1ea1o, gi\u1edbi h\u1ea1n s\u1eed d\u1ee5ng Climbazole l\u00e0 ho\u1ea1t ch\u1ea5t kh\u00e1ng n\u1ea5m thu\u1ed9c nh\u00f3m imidazol (azol), d\u00f9ng ch\u1ee7 y\u1ebfu trong d\u1ea7u g\u1ed9i ch\u1ed1ng g\u00e0u. G\u00e0u li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n qu\u00e1 m\u1ee9c c\u1ee7a n\u1ea5m men Malassezia tr\u00ean da \u0111\u1ea7u; climbazole \u1ee9c ch\u1ebf lo\u1ea1i n\u1ea5m n\u00e0y. Th\u00f4ng&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=887"}],"version-history":[{"count":3,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/887\/revisions"}],"predecessor-version":[{"id":3698,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/887\/revisions\/3698"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2899"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}