{"id":868,"date":"2025-05-29T08:44:11","date_gmt":"2025-05-29T08:44:11","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-chiet-xuat-bo-gai-purple-butterbur-extract\/"},"modified":"2026-09-30T15:25:21","modified_gmt":"2026-09-30T08:25:21","slug":"nguyen-lieu-chiet-xuat-bo-gai-purple-butterbur-extract","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-chiet-xuat-bo-gai-purple-butterbur-extract\/","title":{"rendered":"Chi\u1ebft xu\u1ea5t b\u01a1 gai (Petasites hybridus): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Chi\u1ebft xu\u1ea5t b\u01a1 gai (Petasites hybridus): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng<\/h1>\n<p><strong>Chi\u1ebft xu\u1ea5t b\u01a1 gai<\/strong> (butterbur) l\u00e0 cao chi\u1ebft t\u1eeb th\u00e2n r\u1ec5 ho\u1eb7c l\u00e1 c\u00e2y <em>Petasites hybridus<\/em>, c\u00e2y th\u1ea3o l\u00e1 r\u1ea5t to m\u1ecdc ven su\u1ed1i \u1edf ch\u00e2u \u00c2u. \u0110i\u1ec3m quan tr\u1ecdng nh\u1ea5t v\u1ec1 ch\u1ea5t l\u01b0\u1ee3ng l\u00e0 c\u00e2y t\u1ef1 nhi\u00ean ch\u1ee9a <strong>alkaloid pyrrolizidin (PA)<\/strong> g\u00e2y \u0111\u1ed9c gan, n\u00ean ch\u1ec9 chi\u1ebft xu\u1ea5t <strong>\u0111\u00e3 lo\u1ea1i PA<\/strong> (PA-free) m\u1edbi \u0111\u01b0\u1ee3c xem x\u00e9t d\u00f9ng.<\/p>\n<figure class=\"wp-block-image size-large cpc1-anh-cay\"><img decoding=\"async\" src=\"https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/petasites-hybridus-cay-nguyen-lieu.jpg\" alt=\"C\u00e2y b\u01a1 gai \u2013 Petasites hybridus, ngu\u1ed3n nguy\u00ean li\u1ec7u chi\u1ebft xu\u1ea5t\"\/><figcaption>B\u01a1 gai (<em>Petasites hybridus<\/em>). \u1ea2nh: AnRo0002, <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:20170327Petasites_hybridus08.jpg\" rel=\"nofollow noopener\" target=\"_blank\">Wikimedia Commons<\/a>, gi\u1ea5y ph\u00e9p <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\" rel=\"nofollow noopener\" target=\"_blank\">CC0<\/a>.<\/figcaption><\/figure>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>B\u01a1 gai, c\u00fac ma t\u00edm, butterbur, purple butterbur<\/td>\n<\/tr>\n<tr>\n<td>Lo\u00e0i<\/td>\n<td><em>Petasites hybridus (L.) G.Gaertn., B.Mey. &#038; Scherb.<\/em>, h\u1ecd C\u00fac (Asteraceae)<\/td>\n<\/tr>\n<tr>\n<td>B\u1ed9 ph\u1eadn d\u00f9ng<\/td>\n<td>Th\u00e2n r\u1ec5, r\u1ec5; l\u00e1<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ho\u1ea1t ch\u1ea5t ch\u00ednh<\/td>\n<td>Sesquiterpen ester (petasin, isopetasin); alkaloid pyrrolizidin (PA) \u2013 t\u1ea1p ch\u1ea5t \u0111\u1ed9c c\u1ea7n lo\u1ea1i b\u1ecf<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u00e2y v\u00e0 d\u01b0\u1ee3c li\u1ec7u<\/h2>\n<p>B\u01a1 gai l\u00e0 c\u00e2y th\u1ea3o s\u1ed1ng l\u00e2u n\u0103m, hoa m\u00e0u h\u1ed3ng t\u00edm n\u1edf tr\u01b0\u1edbc khi ra l\u00e1, l\u00e1 h\u00ecnh tim r\u1ea5t l\u1edbn (c\u00f3 th\u1ec3 r\u1ed9ng t\u1edbi 60 cm). T\u00ean ti\u1ebfng Anh &#8220;butterbur&#8221; xu\u1ea5t ph\u00e1t t\u1eeb vi\u1ec7c l\u00e1 x\u01b0a \u0111\u01b0\u1ee3c d\u00f9ng g\u00f3i b\u01a1.<\/p>\n<h2>Th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc<\/h2>\n<ul>\n<li><strong>Sesquiterpen ester<\/strong>: petasin, isopetasin, neopetasin (ch\u1ea5t \u0111\u00e1nh d\u1ea5u ho\u1ea1t t\u00ednh).<\/li>\n<li><strong>Alkaloid pyrrolizidin<\/strong>: senecionin, integerrimin \u2013 \u0111\u1ed9c v\u1edbi gan, c\u00f3 trong c\u1ea3 r\u1ec5 v\u00e0 l\u00e1.<\/li>\n<\/ul>\n<h2>Chi\u1ebft xu\u1ea5t v\u00e0 ti\u00eau chu\u1ea9n h\u00f3a<\/h2>\n<p>Th\u00e2n r\u1ec5 ho\u1eb7c l\u00e1 \u0111\u01b0\u1ee3c chi\u1ebft b\u1eb1ng CO<sub>2<\/sub> si\u00eau t\u1edbi h\u1ea1n ho\u1eb7c dung m\u00f4i, sau \u0111\u00f3 qua c\u00e1c b\u01b0\u1edbc <strong>lo\u1ea1i PA<\/strong>; chi\u1ebft xu\u1ea5t ti\u00eau chu\u1ea9n h\u00f3a theo petasin (v\u00ed d\u1ee5 15%) v\u00e0 ph\u1ea3i c\u00f3 k\u1ebft qu\u1ea3 PA d\u01b0\u1edbi ng\u01b0\u1ee1ng ph\u00e1t hi\u1ec7n.<\/p>\n<h2>Ch\u1ec9 ti\u00eau ch\u1ea5t l\u01b0\u1ee3ng n\u00ean xem<\/h2>\n<ul>\n<li>Petasin, isopetasin (HPLC).<\/li>\n<li><strong>Alkaloid pyrrolizidin<\/strong>: b\u1eaft bu\u1ed9c ki\u1ec3m, gi\u1edbi h\u1ea1n kh\u00f4ng ph\u00e1t hi\u1ec7n (th\u01b0\u1eddng d\u01b0\u1edbi 0,08 ppm theo c\u00e1c chi\u1ebft xu\u1ea5t th\u01b0\u01a1ng m\u1ea1i lo\u1ea1i PA).<\/li>\n<li>Kim lo\u1ea1i n\u1eb7ng, vi sinh v\u1eadt, d\u01b0 l\u01b0\u1ee3ng thu\u1ed1c b\u1ea3o v\u1ec7 th\u1ef1c v\u1eadt; \u0111\u1ed9c t\u1ed1 vi n\u1ea5m v\u1edbi d\u01b0\u1ee3c li\u1ec7u d\u1ec5 m\u1ed1c.<\/li>\n<\/ul>\n<h2>Applications<\/h2>\n<ul>\n<li>Thu\u1ed1c d\u01b0\u1ee3c li\u1ec7u \u1edf m\u1ed9t s\u1ed1 n\u01b0\u1edbc ch\u00e2u \u00c2u (t\u00f9y th\u1eddi k\u1ef3), th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe \u1edf m\u1ed9t s\u1ed1 th\u1ecb tr\u01b0\u1eddng.<\/li>\n<li>C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n<h2>An to\u00e0n v\u00e0 l\u01b0u \u00fd<\/h2>\n<ul>\n<li>\u0110\u00e3 c\u00f3 c\u00e1c b\u00e1o c\u00e1o <strong>t\u1ed5n th\u01b0\u01a1ng gan<\/strong> li\u00ean quan \u0111\u1ebfn ch\u1ebf ph\u1ea9m b\u01a1 gai, k\u1ec3 c\u1ea3 lo\u1ea1i \u0111\u01b0\u1ee3c ghi l\u00e0 \u0111\u00e3 lo\u1ea1i PA; m\u1ed9t s\u1ed1 c\u01a1 quan qu\u1ea3n l\u00fd ch\u00e2u \u00c2u \u0111\u00e3 r\u00fat ho\u1eb7c h\u1ea1n ch\u1ebf s\u1ea3n ph\u1ea9m. Ng\u01b0\u1eddi c\u00f3 b\u1ec7nh gan kh\u00f4ng n\u00ean d\u00f9ng.<\/li>\n<li>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng c\u00e2y h\u1ecd C\u00fac c\u00f3 th\u1ec3 d\u1ecb \u1ee9ng.<\/li>\n<li>Ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u an to\u00e0n cho ph\u1ee5 n\u1eef mang thai, cho con b\u00fa v\u00e0 tr\u1ebb em; ng\u01b0\u1eddi \u0111ang d\u00f9ng thu\u1ed1c n\u00ean h\u1ecfi \u00fd ki\u1ebfn chuy\u00ean gia y t\u1ebf.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Chi\u1ebft xu\u1ea5t d\u01b0\u1ee3c li\u1ec7u \u0111\u01b0\u1ee3c d\u00f9ng c\u1ea3 trong thu\u1ed1c d\u01b0\u1ee3c li\u1ec7u v\u00e0 trong th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe; s\u1ea3n ph\u1ea9m thu\u1ed9c lo\u1ea1i n\u00e0o th\u00ec theo quy \u0111\u1ecbnh c\u1ee7a lo\u1ea1i \u0111\u00f3 (Lu\u1eadt D\u01b0\u1ee3c ho\u1eb7c Lu\u1eadt An to\u00e0n th\u1ef1c ph\u1ea9m, Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP). Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Petasites hybridus \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Petasites_hybridus\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Petasites_hybridus<\/a><\/li>\n<li>Wikipedia \u2013 Pyrrolizidine alkaloid \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrrolizidine_alkaloid\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Pyrrolizidine_alkaloid<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Chi\u1ebft xu\u1ea5t b\u01a1 gai (Petasites hybridus): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng Chi\u1ebft xu\u1ea5t b\u01a1 gai (butterbur) l\u00e0 cao chi\u1ebft t\u1eeb th\u00e2n r\u1ec5 ho\u1eb7c l\u00e1 c\u00e2y Petasites hybridus, c\u00e2y th\u1ea3o l\u00e1 r\u1ea5t to m\u1ecdc ven su\u1ed1i \u1edf ch\u00e2u \u00c2u. \u0110i\u1ec3m quan tr\u1ecdng nh\u1ea5t v\u1ec1 ch\u1ea5t l\u01b0\u1ee3ng l\u00e0 c\u00e2y t\u1ef1 nhi\u00ean ch\u1ee9a alkaloid pyrrolizidin (PA) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2012,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-868","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/petasites-hybridus-cay-nguyen-lieu.jpg",1200,900,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/petasites-hybridus-cay-nguyen-lieu-150x150.jpg",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/petasites-hybridus-cay-nguyen-lieu-300x225.jpg",300,225,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/petasites-hybridus-cay-nguyen-lieu-768x576.jpg",768,576,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/petasites-hybridus-cay-nguyen-lieu-1024x768.jpg",1024,768,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/petasites-hybridus-cay-nguyen-lieu.jpg",1200,900,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/petasites-hybridus-cay-nguyen-lieu.jpg",1200,900,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/petasites-hybridus-cay-nguyen-lieu-16x12.jpg",16,12,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Chi\u1ebft xu\u1ea5t b\u01a1 gai (Petasites hybridus): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng Chi\u1ebft xu\u1ea5t b\u01a1 gai (butterbur) l\u00e0 cao chi\u1ebft t\u1eeb th\u00e2n r\u1ec5 ho\u1eb7c l\u00e1 c\u00e2y Petasites hybridus, c\u00e2y th\u1ea3o l\u00e1 r\u1ea5t to m\u1ecdc ven su\u1ed1i \u1edf ch\u00e2u \u00c2u. \u0110i\u1ec3m quan tr\u1ecdng nh\u1ea5t v\u1ec1 ch\u1ea5t l\u01b0\u1ee3ng l\u00e0 c\u00e2y t\u1ef1 nhi\u00ean ch\u1ee9a alkaloid pyrrolizidin (PA)&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/868","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=868"}],"version-history":[{"count":3,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/868\/revisions"}],"predecessor-version":[{"id":5074,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/868\/revisions\/5074"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2012"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=868"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=868"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=868"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}