{"id":857,"date":"2025-05-29T08:38:46","date_gmt":"2025-05-29T08:38:46","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-chiet-xuat-hat-de-ngua-horse-chestnut-extract\/"},"modified":"2026-09-30T15:24:40","modified_gmt":"2026-09-30T08:24:40","slug":"nguyen-lieu-chiet-xuat-hat-de-ngua-horse-chestnut-extract","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-chiet-xuat-hat-de-ngua-horse-chestnut-extract\/","title":{"rendered":"Chi\u1ebft xu\u1ea5t h\u1ea1t d\u1ebb ng\u1ef1a (Aesculus hippocastanum): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Chi\u1ebft xu\u1ea5t h\u1ea1t d\u1ebb ng\u1ef1a (Aesculus hippocastanum): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng<\/h1>\n<p><strong>Chi\u1ebft xu\u1ea5t h\u1ea1t d\u1ebb ng\u1ef1a<\/strong> l\u00e0 cao chi\u1ebft t\u1eeb h\u1ea1t c\u00e2y d\u1ebb ng\u1ef1a (<em>Aesculus hippocastanum<\/em>), ti\u00eau chu\u1ea9n h\u00f3a theo <strong>escin<\/strong> (aescin), h\u1ed7n h\u1ee3p saponin \u0111\u1eb7c tr\u01b0ng. H\u1ea1t d\u1ebb ng\u1ef1a <strong>kh\u00f4ng \u0103n \u0111\u01b0\u1ee3c<\/strong> v\u00e0 kh\u00e1c ho\u00e0n to\u00e0n v\u1edbi h\u1ea1t d\u1ebb \u0103n (<em>Castanea<\/em>).<\/p>\n<figure class=\"wp-block-image size-large cpc1-anh-cay\"><img decoding=\"async\" src=\"https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aesculus-hippocastanum-cay-nguyen-lieu.jpg\" alt=\"C\u00e2y d\u1ebb ng\u1ef1a \u2013 Aesculus hippocastanum, ngu\u1ed3n nguy\u00ean li\u1ec7u chi\u1ebft xu\u1ea5t\"\/><figcaption>D\u1ebb ng\u1ef1a (<em>Aesculus hippocastanum<\/em>). \u1ea2nh: Jan Kops, <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Aesculus_hippocastanum_%E2%80%94_Flora_Batava_%E2%80%94_Volume_v12.jpg\" rel=\"nofollow noopener\" target=\"_blank\">Wikimedia Commons<\/a>, gi\u1ea5y ph\u00e9p <a href=\"https:\/\/creativecommons.org\/publicdomain\/mark\/1.0\/\" rel=\"nofollow noopener\" target=\"_blank\">Public domain<\/a>.<\/figcaption><\/figure>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>D\u1ebb ng\u1ef1a, horse chestnut; Hippocastani semen<\/td>\n<\/tr>\n<tr>\n<td>Lo\u00e0i<\/td>\n<td><em>Aesculus hippocastanum L.<\/em>, h\u1ecd B\u1ed3 h\u00f2n (Sapindaceae)<\/td>\n<\/tr>\n<tr>\n<td>B\u1ed9 ph\u1eadn d\u00f9ng<\/td>\n<td>H\u1ea1t<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ho\u1ea1t ch\u1ea5t ch\u00ednh<\/td>\n<td>Escin (aescin) \u2013 h\u1ed7n h\u1ee3p saponin triterpen; flavonoid, coumarin (esculin \u1edf v\u1ecf c\u00e2y)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u00e2y v\u00e0 d\u01b0\u1ee3c li\u1ec7u<\/h2>\n<p>D\u1ebb ng\u1ef1a l\u00e0 c\u00e2y g\u1ed7 l\u1edbn g\u1ed1c v\u00f9ng Balkan, \u0111\u01b0\u1ee3c tr\u1ed3ng l\u00e0m c\u00e2y c\u1ea3nh, c\u00e2y b\u00f3ng m\u00e1t \u1edf ch\u00e2u \u00c2u. Qu\u1ea3 c\u00f3 v\u1ecf gai, b\u00ean trong l\u00e0 h\u1ea1t l\u1edbn m\u00e0u n\u00e2u b\u00f3ng.<\/p>\n<h2>Th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc<\/h2>\n<ul>\n<li><strong>Escin<\/strong> (aescin): h\u1ed7n h\u1ee3p h\u01a1n 30 saponin triterpen; \u03b2-escin l\u00e0 d\u1ea1ng \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u nhi\u1ec1u nh\u1ea5t.<\/li>\n<li>Flavonoid, tinh b\u1ed9t, protein, d\u1ea7u b\u00e9o trong h\u1ea1t; v\u1ecf c\u00e2y v\u00e0 v\u1ecf h\u1ea1t c\u00f3 coumarin (esculin, esculetin).<\/li>\n<\/ul>\n<h2>Chi\u1ebft xu\u1ea5t v\u00e0 ti\u00eau chu\u1ea9n h\u00f3a<\/h2>\n<p>H\u1ea1t \u0111\u01b0\u1ee3c nghi\u1ec1n, chi\u1ebft b\u1eb1ng ethanol \u2013 n\u01b0\u1edbc, c\u00f4 \u0111\u1eb7c v\u00e0 tinh ch\u1ebf, ti\u00eau chu\u1ea9n h\u00f3a theo <strong>triterpen glycosid t\u00ednh theo escin<\/strong> (v\u00ed d\u1ee5 16\u201320% trong cao chi\u1ebft, ho\u1eb7c escin tinh khi\u1ebft h\u01a1n cho d\u01b0\u1ee3c ph\u1ea9m). Escin c\u00f2n \u0111\u01b0\u1ee3c tinh ch\u1ebf th\u00e0nh ho\u1ea1t ch\u1ea5t d\u00f9ng trong thu\u1ed1c v\u00e0 m\u1ef9 ph\u1ea9m.<\/p>\n<h2>Ch\u1ec9 ti\u00eau ch\u1ea5t l\u01b0\u1ee3ng n\u00ean xem<\/h2>\n<ul>\n<li>Escin (HPLC ho\u1eb7c ph\u01b0\u01a1ng ph\u00e1p d\u01b0\u1ee3c \u0111i\u1ec3n).<\/li>\n<li>Kim lo\u1ea1i n\u1eb7ng, dung m\u00f4i t\u1ed3n d\u01b0, vi sinh.<\/li>\n<\/ul>\n<h2>Applications<\/h2>\n<ul>\n<li>Thu\u1ed1c d\u01b0\u1ee3c li\u1ec7u (EU c\u00f3 chuy\u00ean lu\u1eadn Hippocastani semen).<\/li>\n<li>Th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe.<\/li>\n<li>M\u1ef9 ph\u1ea9m (gel, kem cho v\u00f9ng m\u1eaft, ch\u00e2n).<\/li>\n<li>C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n<h2>An to\u00e0n v\u00e0 l\u01b0u \u00fd<\/h2>\n<ul>\n<li>H\u1ea1t, v\u1ecf, l\u00e1 t\u01b0\u01a1i <strong>c\u00f3 \u0111\u1ed9c<\/strong> n\u1ebfu \u0103n tr\u1ef1c ti\u1ebfp; ch\u1ec9 d\u00f9ng chi\u1ebft xu\u1ea5t \u0111\u00e3 qua ch\u1ebf bi\u1ebfn, ti\u00eau chu\u1ea9n h\u00f3a.<\/li>\n<li>C\u00f3 th\u1ec3 g\u00e2y k\u00edch \u1ee9ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a; th\u1eadn tr\u1ecdng khi d\u00f9ng c\u00f9ng thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng.<\/li>\n<\/ul>\n<p><!--my-pham--><\/p>\n<h2>In Cosmetics<\/h2>\n<p>Ngo\u00e0i d\u01b0\u1ee3c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m, nguy\u00ean li\u1ec7u t\u1eeb lo\u00e0i n\u00e0y c\u00f2n \u0111\u01b0\u1ee3c d\u00f9ng trong m\u1ef9 ph\u1ea9m d\u01b0\u1edbi c\u00e1c t\u00ean INCI sau (ch\u1ee9c n\u0103ng theo c\u01a1 s\u1edf d\u1eef li\u1ec7u CosIng c\u1ee7a \u1ee6y ban ch\u00e2u \u00c2u):<\/p>\n<table>\n<thead>\n<tr>\n<th>T\u00ean INCI<\/th>\n<th>D\u1ea1ng nguy\u00ean li\u1ec7u<\/th>\n<th>Ch\u1ee9c n\u0103ng (CosIng)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Aesculus Hippocastanum (Horse Chestnut) Extract<\/td>\n<td>chi\u1ebft xu\u1ea5t b\u1eb1ng dung m\u00f4i (th\u01b0\u1eddng l\u00e0 n\u01b0\u1edbc, glycol ho\u1eb7c ethanol), sau \u0111\u00f3 pha lo\u00e3ng trong dung m\u00f4i mang<\/td>\n<td>ch\u1ed1ng oxy h\u00f3a (b\u1ea3o v\u1ec7 c\u00f4ng th\u1ee9c), l\u00e0m se da, l\u00e0m m\u1ec1m da, d\u01b0\u1ee1ng da, b\u1ea3o v\u1ec7 da<\/td>\n<\/tr>\n<tr>\n<td>Aesculus Hippocastanum (Horse Chestnut) Seed Extract<\/td>\n<td>chi\u1ebft xu\u1ea5t b\u1eb1ng dung m\u00f4i (th\u01b0\u1eddng l\u00e0 n\u01b0\u1edbc, glycol ho\u1eb7c ethanol), sau \u0111\u00f3 pha lo\u00e3ng trong dung m\u00f4i mang<\/td>\n<td>d\u01b0\u1ee1ng da<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Theo CosIng, c\u00e1c t\u00ean INCI tr\u00ean kh\u00f4ng thu\u1ed9c ph\u1ee5 l\u1ee5c ch\u1ea5t c\u1ea5m (Annex II) hay h\u1ea1n ch\u1ebf (Annex III) c\u1ee7a EU t\u1ea1i th\u1eddi \u0111i\u1ec3m vi\u1ebft b\u00e0i; ph\u1ee5 l\u1ee5c c\u1ee7a Hi\u1ec7p \u0111\u1ecbnh m\u1ef9 ph\u1ea9m ASEAN \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadt theo danh m\u1ee5c n\u00e0y. T\u1ea1i Vi\u1ec7t Nam, m\u1ef9 ph\u1ea9m qu\u1ea3n l\u00fd theo Th\u00f4ng t\u01b0 06\/2011\/TT-BYT; t\u00ednh n\u0103ng c\u00f4ng b\u1ed1 ph\u1ea3i theo H\u01b0\u1edbng d\u1eabn c\u00f4ng b\u1ed1 t\u00ednh n\u0103ng m\u1ef9 ph\u1ea9m ASEAN, kh\u00f4ng \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 c\u00f4ng d\u1ee5ng nh\u01b0 thu\u1ed1c.<\/p>\n<p><!--\/my-pham--><\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Chi\u1ebft xu\u1ea5t d\u01b0\u1ee3c li\u1ec7u \u0111\u01b0\u1ee3c d\u00f9ng c\u1ea3 trong thu\u1ed1c d\u01b0\u1ee3c li\u1ec7u v\u00e0 trong th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe; s\u1ea3n ph\u1ea9m thu\u1ed9c lo\u1ea1i n\u00e0o th\u00ec theo quy \u0111\u1ecbnh c\u1ee7a lo\u1ea1i \u0111\u00f3 (Lu\u1eadt D\u01b0\u1ee3c ho\u1eb7c Lu\u1eadt An to\u00e0n th\u1ef1c ph\u1ea9m, Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP). Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>EMA \u2013 Hippocastani semen (chuy\u00ean lu\u1eadn d\u01b0\u1ee3c li\u1ec7u EU) \u2014 <a href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/herbal\/hippocastani-semen\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.ema.europa.eu\/en\/medicines\/herbal\/hippocastani-semen<\/a><\/li>\n<li>Wikipedia \u2013 Aesculus hippocastanum \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Aesculus_hippocastanum\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Aesculus_hippocastanum<\/a><\/li>\n<li>Wikipedia \u2013 Aescin \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Aescin\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Aescin<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Chi\u1ebft xu\u1ea5t h\u1ea1t d\u1ebb ng\u1ef1a (Aesculus hippocastanum): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng Chi\u1ebft xu\u1ea5t h\u1ea1t d\u1ebb ng\u1ef1a l\u00e0 cao chi\u1ebft t\u1eeb h\u1ea1t c\u00e2y d\u1ebb ng\u1ef1a (Aesculus hippocastanum), ti\u00eau chu\u1ea9n h\u00f3a theo escin (aescin), h\u1ed7n h\u1ee3p saponin \u0111\u1eb7c tr\u01b0ng. H\u1ea1t d\u1ebb ng\u1ef1a kh\u00f4ng \u0103n \u0111\u01b0\u1ee3c v\u00e0 kh\u00e1c ho\u00e0n to\u00e0n v\u1edbi h\u1ea1t d\u1ebb \u0103n (Castanea). [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2018,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-857","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aesculus-hippocastanum-cay-nguyen-lieu.jpg",1200,900,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aesculus-hippocastanum-cay-nguyen-lieu-150x150.jpg",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aesculus-hippocastanum-cay-nguyen-lieu-300x225.jpg",300,225,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aesculus-hippocastanum-cay-nguyen-lieu-768x576.jpg",768,576,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aesculus-hippocastanum-cay-nguyen-lieu-1024x768.jpg",1024,768,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aesculus-hippocastanum-cay-nguyen-lieu.jpg",1200,900,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aesculus-hippocastanum-cay-nguyen-lieu.jpg",1200,900,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/aesculus-hippocastanum-cay-nguyen-lieu-16x12.jpg",16,12,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Chi\u1ebft xu\u1ea5t h\u1ea1t d\u1ebb ng\u1ef1a (Aesculus hippocastanum): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng Chi\u1ebft xu\u1ea5t h\u1ea1t d\u1ebb ng\u1ef1a l\u00e0 cao chi\u1ebft t\u1eeb h\u1ea1t c\u00e2y d\u1ebb ng\u1ef1a (Aesculus hippocastanum), ti\u00eau chu\u1ea9n h\u00f3a theo escin (aescin), h\u1ed7n h\u1ee3p saponin \u0111\u1eb7c tr\u01b0ng. H\u1ea1t d\u1ebb ng\u1ef1a kh\u00f4ng \u0103n \u0111\u01b0\u1ee3c v\u00e0 kh\u00e1c ho\u00e0n to\u00e0n v\u1edbi h\u1ea1t d\u1ebb \u0103n (Castanea).&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/857","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=857"}],"version-history":[{"count":5,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/857\/revisions"}],"predecessor-version":[{"id":5066,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/857\/revisions\/5066"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2018"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=857"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=857"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}