{"id":847,"date":"2025-05-29T08:33:56","date_gmt":"2025-05-29T08:33:56","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-l-isoleucine\/"},"modified":"2026-09-28T20:54:17","modified_gmt":"2026-09-28T13:54:17","slug":"nguyen-lieu-l-isoleucine","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-l-isoleucine\/","title":{"rendered":"L-Isoleucine: acid amin m\u1ea1ch nh\u00e1nh (BCAA) \u2013 c\u1ea5u t\u1ea1o, t\u00ednh ch\u1ea5t, s\u1ea3n xu\u1ea5t"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">L-Isoleucine: acid amin m\u1ea1ch nh\u00e1nh (BCAA) \u2013 c\u1ea5u t\u1ea1o, t\u00ednh ch\u1ea5t, s\u1ea3n xu\u1ea5t<\/h1>\n<p><strong>L-Isoleucine<\/strong> (isoleucin) l\u00e0 m\u1ed9t trong 9 <strong>acid amin thi\u1ebft y\u1ebfu<\/strong>: c\u01a1 th\u1ec3 ng\u01b0\u1eddi kh\u00f4ng t\u1ef1 t\u1ed5ng h\u1ee3p \u0111\u01b0\u1ee3c, ph\u1ea3i nh\u1eadn t\u1eeb th\u1ee9c \u0103n. Isoleucin c\u00f9ng v\u1edbi leucin v\u00e0 valin t\u1ea1o th\u00e0nh nh\u00f3m <strong>acid amin m\u1ea1ch nh\u00e1nh<\/strong> (BCAA \u2013 branched-chain amino acids).<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>L-Isoleucine, isoleucin, acid (2S,3S)-2-amino-3-methylpentanoic; k\u00fd hi\u1ec7u Ile, I<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c, kh\u1ed1i l\u01b0\u1ee3ng mol<\/td>\n<td>C<sub>6<\/sub>H<sub>13<\/sub>NO<sub>2<\/sub> \u2013 131,17 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>73-32-5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u1ea5u t\u1ea1o v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Isoleucin l\u00e0 \u0111\u1ed3ng ph\u00e2n c\u1ea5u t\u1ea1o c\u1ee7a <a href=\"\/en\/leucin\/\">leucin<\/a>: c\u00f9ng c\u00f4ng th\u1ee9c ph\u00e2n t\u1eed, kh\u00e1c v\u1ecb tr\u00ed nh\u00e1nh methyl. Kh\u00e1c v\u1edbi ph\u1ea7n l\u1edbn acid amin, isoleucin c\u00f3 <strong>hai carbon b\u1ea5t \u0111\u1ed1i<\/strong>, n\u00ean c\u00f3 b\u1ed1n \u0111\u1ed3ng ph\u00e2n l\u1eadp th\u1ec3; d\u1ea1ng t\u1ef1 nhi\u00ean l\u00e0 (2S,3S).<\/li>\n<li>B\u1ed9t k\u1ebft tinh m\u00e0u tr\u1eafng, v\u1ecb h\u01a1i \u0111\u1eafng, tan v\u1eeba ph\u1ea3i trong n\u01b0\u1edbc, \u00edt tan trong ethanol.<\/li>\n<li>M\u1ea1ch b\u00ean l\u00e0 nh\u00f3m hydrocarbon kh\u00f4ng ph\u00e2n c\u1ef1c. Trong protein, isoleucin th\u01b0\u1eddng n\u1eb1m \u1edf v\u00f9ng k\u1ef5 n\u01b0\u1edbc b\u00ean trong.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>L-Isoleucine \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng <strong>l\u00ean men vi sinh v\u1eadt<\/strong> (<em>Corynebacterium glutamicum<\/em> or <em>Escherichia coli<\/em> \u0111\u01b0\u1ee3c c\u1ea3i bi\u1ebfn), ti\u1ebfp theo l\u00e0 t\u00e1ch, tinh ch\u1ebf v\u00e0 k\u1ebft tinh. T\u00e1ch \u0111\u01b0\u1ee3c \u0111\u00fang \u0111\u1ed3ng ph\u00e2n (2S,3S) kh\u1ecfi \u0111\u1ed3ng ph\u00e2n allo-isoleucin l\u00e0 m\u1ed9t ch\u1ec9 ti\u00eau ch\u1ea5t l\u01b0\u1ee3ng.<\/p>\n<h2>Applications<\/h2>\n<ul>\n<li>Th\u1ef1c ph\u1ea9m b\u1ed5 sung d\u1ea1ng BCAA, th\u01b0\u1eddng ph\u1ed1i h\u1ee3p leucin : isoleucin : valin theo t\u1ef7 l\u1ec7 kh\u1ed1i l\u01b0\u1ee3ng 2 : 1 : 1.<\/li>\n<li>Dinh d\u01b0\u1ee1ng l\u00e2m s\u00e0ng; th\u1ee9c \u0103n ch\u0103n nu\u00f4i.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li><strong>Hoa K\u1ef3<\/strong>: 21 CFR 172.320 cho ph\u00e9p d\u00f9ng l\u00e0m ph\u1ee5 gia c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng protein, t\u1ed1i \u0111a 6,6% kh\u1ed1i l\u01b0\u1ee3ng protein to\u00e0n ph\u1ea7n.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Khi d\u00f9ng l\u00e0m th\u00e0nh ph\u1ea7n c\u1ee7a th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe ho\u1eb7c th\u1ef1c ph\u1ea9m dinh d\u01b0\u1ee1ng, s\u1ea3n ph\u1ea9m tu\u00e2n theo Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP v\u00e0 c\u00e1c v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n m\u1edbi nh\u1ea5t tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ch\u1ea5t li\u00ean quan<\/h2>\n<ul>\n<li><a href=\"\/en\/leucin\/\">Leucin<\/a>, L-valin (c\u00e1c BCAA kh\u00e1c).<\/li>\n<\/ul>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Isoleucine \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Isoleucine\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Isoleucine<\/a><\/li>\n<li>Wikidata \u2013 L-isoleucine (CAS 73-32-5) \u2014 <a href=\"https:\/\/www.wikidata.org\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.wikidata.org\/<\/a><\/li>\n<li>U.S. FDA \u2013 21 CFR 172.320 Amino acids \u2014 <a href=\"https:\/\/www.law.cornell.edu\/cfr\/text\/21\/172.320\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.law.cornell.edu\/cfr\/text\/21\/172.320<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>L-Isoleucine: acid amin m\u1ea1ch nh\u00e1nh (BCAA) \u2013 c\u1ea5u t\u1ea1o, t\u00ednh ch\u1ea5t, s\u1ea3n xu\u1ea5t L-Isoleucine (isoleucin) l\u00e0 m\u1ed9t trong 9 acid amin thi\u1ebft y\u1ebfu: c\u01a1 th\u1ec3 ng\u01b0\u1eddi kh\u00f4ng t\u1ef1 t\u1ed5ng h\u1ee3p \u0111\u01b0\u1ee3c, ph\u1ea3i nh\u1eadn t\u1eeb th\u1ee9c \u0103n. Isoleucin c\u00f9ng v\u1edbi leucin v\u00e0 valin t\u1ea1o th\u00e0nh nh\u00f3m acid amin m\u1ea1ch nh\u00e1nh (BCAA \u2013 branched-chain amino acids). Th\u00f4ng [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2928,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-847","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-isoleucine.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-isoleucine-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-isoleucine-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-isoleucine-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-isoleucine-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-isoleucine.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-isoleucine.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-isoleucine-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":1,"uagb_excerpt":"L-Isoleucine: acid amin m\u1ea1ch nh\u00e1nh (BCAA) \u2013 c\u1ea5u t\u1ea1o, t\u00ednh ch\u1ea5t, s\u1ea3n xu\u1ea5t L-Isoleucine (isoleucin) l\u00e0 m\u1ed9t trong 9 acid amin thi\u1ebft y\u1ebfu: c\u01a1 th\u1ec3 ng\u01b0\u1eddi kh\u00f4ng t\u1ef1 t\u1ed5ng h\u1ee3p \u0111\u01b0\u1ee3c, ph\u1ea3i nh\u1eadn t\u1eeb th\u1ee9c \u0103n. Isoleucin c\u00f9ng v\u1edbi leucin v\u00e0 valin t\u1ea1o th\u00e0nh nh\u00f3m acid amin m\u1ea1ch nh\u00e1nh (BCAA \u2013 branched-chain amino acids). Th\u00f4ng&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=847"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/847\/revisions"}],"predecessor-version":[{"id":3061,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/847\/revisions\/3061"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2928"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}