{"id":841,"date":"2025-05-29T08:30:56","date_gmt":"2025-05-29T08:30:56","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-chiet-xuat-tu-hat-nho-grape-seed-extract-95\/"},"modified":"2026-09-30T15:23:47","modified_gmt":"2026-09-30T08:23:47","slug":"nguyen-lieu-chiet-xuat-tu-hat-nho-grape-seed-extract-95","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-chiet-xuat-tu-hat-nho-grape-seed-extract-95\/","title":{"rendered":"Chi\u1ebft xu\u1ea5t h\u1ea1t nho (Vitis vinifera): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Chi\u1ebft xu\u1ea5t h\u1ea1t nho (Vitis vinifera): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng<\/h1>\n<p><strong>Chi\u1ebft xu\u1ea5t h\u1ea1t nho<\/strong> l\u00e0 cao chi\u1ebft t\u1eeb h\u1ea1t nho (<em>Vitis vinifera<\/em>), th\u01b0\u1eddng t\u1eadn d\u1ee5ng t\u1eeb b\u00e3 \u00e9p r\u01b0\u1ee3u vang, ti\u00eau chu\u1ea9n h\u00f3a theo <strong>proanthocyanidin<\/strong> (OPC). OPC l\u00e0 c\u00e1c chu\u1ed7i ng\u1eafn (oligomer) g\u1ed3m c\u00e1c \u0111\u01a1n v\u1ecb catechin v\u00e0 epicatechin.<\/p>\n<figure class=\"wp-block-image size-large cpc1-anh-cay\"><img decoding=\"async\" src=\"https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitis-vinifera-cay-nguyen-lieu.jpg\" alt=\"C\u00e2y nho \u0111\u1ecf \u2013 Vitis vinifera, ngu\u1ed3n nguy\u00ean li\u1ec7u chi\u1ebft xu\u1ea5t\"\/><figcaption>Nho \u0111\u1ecf (<em>Vitis vinifera<\/em>). \u1ea2nh: Unknown authorUnknown author, <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Plant_de_grenache_blanc.jpg\" rel=\"nofollow noopener\" target=\"_blank\">Wikimedia Commons<\/a>, gi\u1ea5y ph\u00e9p <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\" rel=\"nofollow noopener\" target=\"_blank\">CC0<\/a>.<\/figcaption><\/figure>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>Chi\u1ebft xu\u1ea5t h\u1ea1t nho, grape seed extract, OPC (oligomeric proanthocyanidins)<\/td>\n<\/tr>\n<tr>\n<td>Lo\u00e0i<\/td>\n<td><em>Vitis vinifera L.<\/em>, h\u1ecd Nho (Vitaceae)<\/td>\n<\/tr>\n<tr>\n<td>B\u1ed9 ph\u1eadn d\u00f9ng<\/td>\n<td>H\u1ea1t<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ho\u1ea1t ch\u1ea5t ch\u00ednh<\/td>\n<td>Proanthocyanidin (OPC \u2013 oligomer c\u1ee7a catechin, epicatechin), catechin, epicatechin, acid gallic<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u00e2y v\u00e0 d\u01b0\u1ee3c li\u1ec7u<\/h2>\n<p>H\u1ea1t nho chi\u1ebfm m\u1ed9t ph\u1ea7n nh\u1ecf kh\u1ed1i l\u01b0\u1ee3ng qu\u1ea3 nh\u01b0ng r\u1ea5t gi\u00e0u polyphenol. Sau khi \u00e9p n\u01b0\u1edbc nho l\u00e0m r\u01b0\u1ee3u, b\u00e3 (v\u1ecf, h\u1ea1t) \u0111\u01b0\u1ee3c t\u00e1ch h\u1ea1t \u0111\u1ec3 chi\u1ebft xu\u1ea5t v\u00e0 \u00e9p d\u1ea7u h\u1ea1t nho.<\/p>\n<h2>Th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc<\/h2>\n<ul>\n<li><strong>Proanthocyanidin<\/strong>: dimer, trimer (procyanidin B1, B2\u2026) v\u00e0 oligomer, polymer c\u1ee7a catechin, epicatechin; m\u1ed9t ph\u1ea7n g\u1eafn g\u1ed1c gallat.<\/li>\n<li>Catechin, epicatechin \u0111\u01a1n ph\u00e2n, acid gallic.<\/li>\n<\/ul>\n<h2>Chi\u1ebft xu\u1ea5t v\u00e0 ti\u00eau chu\u1ea9n h\u00f3a<\/h2>\n<p>H\u1ea1t \u0111\u01b0\u1ee3c nghi\u1ec1n, chi\u1ebft b\u1eb1ng n\u01b0\u1edbc n\u00f3ng ho\u1eb7c ethanol \u2013 n\u01b0\u1edbc, tinh ch\u1ebf b\u1eb1ng nh\u1ef1a h\u1ea5p ph\u1ee5, si\u00eau l\u1ecdc v\u00e0 s\u1ea5y phun; nguy\u00ean li\u1ec7u ti\u00eau chu\u1ea9n h\u00f3a theo proanthocyanidin (v\u00ed d\u1ee5 95%). Con s\u1ed1 <strong>ph\u1ee5 thu\u1ed9c m\u1ea1nh v\u00e0o ph\u01b0\u01a1ng ph\u00e1p<\/strong>: ph\u01b0\u01a1ng ph\u00e1p \u0111o quang UV th\u01b0\u1eddng cho k\u1ebft qu\u1ea3 r\u1ea5t cao, c\u00f2n ph\u01b0\u01a1ng ph\u00e1p \u0111\u1eb7c hi\u1ec7u h\u01a1n (acid-butanol, DMAC, HPLC) cho s\u1ed1 th\u1ea5p h\u01a1n nhi\u1ec1u. Khi so s\u00e1nh nguy\u00ean li\u1ec7u, ph\u1ea3i ghi r\u00f5 ph\u01b0\u01a1ng ph\u00e1p.<\/p>\n<h2>Ch\u1ec9 ti\u00eau ch\u1ea5t l\u01b0\u1ee3ng n\u00ean xem<\/h2>\n<ul>\n<li>Proanthocyanidin (ghi r\u00f5 ph\u01b0\u01a1ng ph\u00e1p), ph\u1ed5 HPLC c\u00e1c procyanidin \u0111\u1ec3 x\u00e1c nh\u1eadn ngu\u1ed3n h\u1ea1t nho.<\/li>\n<li>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o chi\u1ebft xu\u1ea5t h\u1ea1t nho b\u1ecb <strong>pha tr\u1ed9n<\/strong> v\u1edbi proanthocyanidin r\u1ebb h\u01a1n t\u1eeb v\u1ecf l\u1ea1c (\u0111\u1eadu ph\u1ed9ng) \u2013 nguy c\u01a1 d\u1ecb \u1ee9ng l\u1ea1c; ph\u1ed5 procyanidin lo\u1ea1i A (\u0111\u1eb7c tr\u01b0ng v\u1ecf l\u1ea1c) gi\u00fap ph\u00e1t hi\u1ec7n.<\/li>\n<li>Kim lo\u1ea1i n\u1eb7ng, vi sinh v\u1eadt, d\u01b0 l\u01b0\u1ee3ng thu\u1ed1c b\u1ea3o v\u1ec7 th\u1ef1c v\u1eadt; \u0111\u1ed9c t\u1ed1 vi n\u1ea5m v\u1edbi d\u01b0\u1ee3c li\u1ec7u d\u1ec5 m\u1ed1c.<\/li>\n<\/ul>\n<h2>Applications<\/h2>\n<ul>\n<li>Th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe.<\/li>\n<li>M\u1ef9 ph\u1ea9m (ch\u1ea5t ch\u1ed1ng oxy h\u00f3a).<\/li>\n<li>Ch\u1ea5t ch\u1ed1ng oxy h\u00f3a t\u1ef1 nhi\u00ean trong th\u1ef1c ph\u1ea9m theo quy \u0111\u1ecbnh t\u1eebng n\u01b0\u1edbc.<\/li>\n<li>C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n<h2>An to\u00e0n v\u00e0 l\u01b0u \u00fd<\/h2>\n<ul>\n<li>Th\u1eadn tr\u1ecdng khi d\u00f9ng c\u00f9ng thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng.<\/li>\n<li>Ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u an to\u00e0n cho ph\u1ee5 n\u1eef mang thai, cho con b\u00fa v\u00e0 tr\u1ebb em; ng\u01b0\u1eddi \u0111ang d\u00f9ng thu\u1ed1c n\u00ean h\u1ecfi \u00fd ki\u1ebfn chuy\u00ean gia y t\u1ebf.<\/li>\n<\/ul>\n<p><!--my-pham--><\/p>\n<h2>In Cosmetics<\/h2>\n<p>Ngo\u00e0i d\u01b0\u1ee3c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m, nguy\u00ean li\u1ec7u t\u1eeb lo\u00e0i n\u00e0y c\u00f2n \u0111\u01b0\u1ee3c d\u00f9ng trong m\u1ef9 ph\u1ea9m d\u01b0\u1edbi c\u00e1c t\u00ean INCI sau (ch\u1ee9c n\u0103ng theo c\u01a1 s\u1edf d\u1eef li\u1ec7u CosIng c\u1ee7a \u1ee6y ban ch\u00e2u \u00c2u):<\/p>\n<table>\n<thead>\n<tr>\n<th>T\u00ean INCI<\/th>\n<th>D\u1ea1ng nguy\u00ean li\u1ec7u<\/th>\n<th>Ch\u1ee9c n\u0103ng (CosIng)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vitis Vinifera (Grape) Fruit Extract<\/td>\n<td>chi\u1ebft xu\u1ea5t b\u1eb1ng dung m\u00f4i (th\u01b0\u1eddng l\u00e0 n\u01b0\u1edbc, glycol ho\u1eb7c ethanol), sau \u0111\u00f3 pha lo\u00e3ng trong dung m\u00f4i mang<\/td>\n<td>d\u01b0\u1ee1ng da<\/td>\n<\/tr>\n<tr>\n<td>Vitis Vinifera (Grape) Skin Extract<\/td>\n<td>chi\u1ebft xu\u1ea5t b\u1eb1ng dung m\u00f4i (th\u01b0\u1eddng l\u00e0 n\u01b0\u1edbc, glycol ho\u1eb7c ethanol), sau \u0111\u00f3 pha lo\u00e3ng trong dung m\u00f4i mang<\/td>\n<td>ch\u1ed1ng oxy h\u00f3a (b\u1ea3o v\u1ec7 c\u00f4ng th\u1ee9c)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Theo CosIng, c\u00e1c t\u00ean INCI tr\u00ean kh\u00f4ng thu\u1ed9c ph\u1ee5 l\u1ee5c ch\u1ea5t c\u1ea5m (Annex II) hay h\u1ea1n ch\u1ebf (Annex III) c\u1ee7a EU t\u1ea1i th\u1eddi \u0111i\u1ec3m vi\u1ebft b\u00e0i; ph\u1ee5 l\u1ee5c c\u1ee7a Hi\u1ec7p \u0111\u1ecbnh m\u1ef9 ph\u1ea9m ASEAN \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadt theo danh m\u1ee5c n\u00e0y. T\u1ea1i Vi\u1ec7t Nam, m\u1ef9 ph\u1ea9m qu\u1ea3n l\u00fd theo Th\u00f4ng t\u01b0 06\/2011\/TT-BYT; t\u00ednh n\u0103ng c\u00f4ng b\u1ed1 ph\u1ea3i theo H\u01b0\u1edbng d\u1eabn c\u00f4ng b\u1ed1 t\u00ednh n\u0103ng m\u1ef9 ph\u1ea9m ASEAN, kh\u00f4ng \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 c\u00f4ng d\u1ee5ng nh\u01b0 thu\u1ed1c.<\/p>\n<p><!--\/my-pham--><\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Chi\u1ebft xu\u1ea5t d\u01b0\u1ee3c li\u1ec7u \u0111\u01b0\u1ee3c d\u00f9ng c\u1ea3 trong thu\u1ed1c d\u01b0\u1ee3c li\u1ec7u v\u00e0 trong th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe; s\u1ea3n ph\u1ea9m thu\u1ed9c lo\u1ea1i n\u00e0o th\u00ec theo quy \u0111\u1ecbnh c\u1ee7a lo\u1ea1i \u0111\u00f3 (Lu\u1eadt D\u01b0\u1ee3c ho\u1eb7c Lu\u1eadt An to\u00e0n th\u1ef1c ph\u1ea9m, Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP). Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Grape seed extract \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Grape_seed_extract\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Grape_seed_extract<\/a><\/li>\n<li>Wikipedia \u2013 Proanthocyanidin \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Proanthocyanidin\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Proanthocyanidin<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Chi\u1ebft xu\u1ea5t h\u1ea1t nho (Vitis vinifera): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng Chi\u1ebft xu\u1ea5t h\u1ea1t nho l\u00e0 cao chi\u1ebft t\u1eeb h\u1ea1t nho (Vitis vinifera), th\u01b0\u1eddng t\u1eadn d\u1ee5ng t\u1eeb b\u00e3 \u00e9p r\u01b0\u1ee3u vang, ti\u00eau chu\u1ea9n h\u00f3a theo proanthocyanidin (OPC). OPC l\u00e0 c\u00e1c chu\u1ed7i ng\u1eafn (oligomer) g\u1ed3m c\u00e1c \u0111\u01a1n v\u1ecb catechin v\u00e0 epicatechin. Nho \u0111\u1ecf (Vitis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2016,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-841","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitis-vinifera-cay-nguyen-lieu.jpg",1200,900,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitis-vinifera-cay-nguyen-lieu-150x150.jpg",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitis-vinifera-cay-nguyen-lieu-300x225.jpg",300,225,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitis-vinifera-cay-nguyen-lieu-768x576.jpg",768,576,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitis-vinifera-cay-nguyen-lieu-1024x768.jpg",1024,768,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitis-vinifera-cay-nguyen-lieu.jpg",1200,900,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitis-vinifera-cay-nguyen-lieu.jpg",1200,900,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitis-vinifera-cay-nguyen-lieu-16x12.jpg",16,12,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":1,"uagb_excerpt":"Chi\u1ebft xu\u1ea5t h\u1ea1t nho (Vitis vinifera): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng Chi\u1ebft xu\u1ea5t h\u1ea1t nho l\u00e0 cao chi\u1ebft t\u1eeb h\u1ea1t nho (Vitis vinifera), th\u01b0\u1eddng t\u1eadn d\u1ee5ng t\u1eeb b\u00e3 \u00e9p r\u01b0\u1ee3u vang, ti\u00eau chu\u1ea9n h\u00f3a theo proanthocyanidin (OPC). OPC l\u00e0 c\u00e1c chu\u1ed7i ng\u1eafn (oligomer) g\u1ed3m c\u00e1c \u0111\u01a1n v\u1ecb catechin v\u00e0 epicatechin. Nho \u0111\u1ecf (Vitis&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=841"}],"version-history":[{"count":5,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/841\/revisions"}],"predecessor-version":[{"id":5055,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/841\/revisions\/5055"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2016"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=841"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=841"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}