{"id":816,"date":"2025-05-29T08:18:30","date_gmt":"2025-05-29T08:18:30","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-l-tryptophan\/"},"modified":"2026-09-28T20:55:04","modified_gmt":"2026-09-28T13:55:04","slug":"nguyen-lieu-l-tryptophan","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-l-tryptophan\/","title":{"rendered":"L-Tryptophan: c\u1ea5u t\u1ea1o, s\u1ea3n xu\u1ea5t v\u00e0 b\u00e0i h\u1ecdc v\u1ec1 \u0111\u1ed9 tinh khi\u1ebft"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">L-Tryptophan: c\u1ea5u t\u1ea1o, s\u1ea3n xu\u1ea5t v\u00e0 b\u00e0i h\u1ecdc v\u1ec1 \u0111\u1ed9 tinh khi\u1ebft<\/h1>\n<p><strong>L-Tryptophan<\/strong> l\u00e0 acid amin thi\u1ebft y\u1ebfu c\u00f3 m\u1ea1ch b\u00ean l\u00e0 <strong>v\u00f2ng indol<\/strong>, l\u1edbn nh\u1ea5t trong 20 acid amin c\u1ea5u t\u1ea1o protein. Trong c\u01a1 th\u1ec3, tryptophan l\u00e0 ti\u1ec1n ch\u1ea5t sinh t\u1ed5ng h\u1ee3p c\u1ee7a serotonin, melatonin v\u00e0 niacin (vitamin B3).<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>L-Tryptophan, acid (S)-2-amino-3-(1H-indol-3-yl)propanoic; k\u00fd hi\u1ec7u Trp, W<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c, kh\u1ed1i l\u01b0\u1ee3ng mol<\/td>\n<td>C<sub>11<\/sub>H<sub>12<\/sub>N<sub>2<\/sub>O<sub>2<\/sub> \u2013 204,23 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>73-22-3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u1ea5u t\u1ea1o v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>V\u00f2ng indol h\u1ea5p th\u1ee5 m\u1ea1nh tia t\u1eed ngo\u1ea1i \u1edf kho\u1ea3ng 280 nm. \u0110\u00e2y l\u00e0 c\u01a1 s\u1edf c\u1ee7a ph\u00e9p \u0111o n\u1ed3ng \u0111\u1ed9 protein b\u1eb1ng quang ph\u1ed5 UV.<\/li>\n<li>B\u1ed9t k\u1ebft tinh m\u00e0u tr\u1eafng \u0111\u1ebfn h\u01a1i v\u00e0ng, v\u1ecb h\u01a1i \u0111\u1eafng, \u00edt tan trong n\u01b0\u1edbc.<\/li>\n<li>Nh\u1ea1y v\u1edbi \u00e1nh s\u00e1ng v\u00e0 ch\u1ea5t oxy h\u00f3a: v\u00f2ng indol d\u1ec5 b\u1ecb oxy h\u00f3a t\u1ea1o s\u1ea3n ph\u1ea9m c\u00f3 m\u00e0u. Trong th\u1ee7y ph\u00e2n protein b\u1eb1ng acid, tryptophan b\u1ecb ph\u00e1 h\u1ee7y ph\u1ea7n l\u1edbn, n\u00ean ph\u1ea3i \u0111\u1ecbnh l\u01b0\u1ee3ng b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p ri\u00eang.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>L-Tryptophan \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng <strong>l\u00ean men<\/strong> vi sinh v\u1eadt \u0111\u01b0\u1ee3c c\u1ea3i bi\u1ebfn ho\u1eb7c b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p enzym t\u1eeb indol v\u00e0 serin. Tryptophan l\u00e0 acid amin c\u00f3 s\u1ea3n l\u01b0\u1ee3ng nh\u1ecf v\u00e0 gi\u00e1 th\u00e0nh cao h\u01a1n so v\u1edbi lysin, threonin.<\/p>\n<h2>B\u00e0i h\u1ecdc v\u1ec1 \u0111\u1ed9 tinh khi\u1ebft: s\u1ef1 c\u1ed1 n\u0103m 1989<\/h2>\n<p>N\u0103m 1989, h\u01a1n m\u1ed9t ngh\u00ecn ng\u01b0\u1eddi t\u1ea1i M\u1ef9 m\u1eafc <strong>h\u1ed9i ch\u1ee9ng t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan \u2013 \u0111au c\u01a1<\/strong> (EMS) sau khi d\u00f9ng th\u1ef1c ph\u1ea9m b\u1ed5 sung L-tryptophan. \u0110i\u1ec1u tra truy v\u1ec1 c\u00e1c l\u00f4 nguy\u00ean li\u1ec7u c\u1ee7a m\u1ed9t nh\u00e0 s\u1ea3n xu\u1ea5t t\u1ea1i Nh\u1eadt B\u1ea3n \u0111\u00e3 thay \u0111\u1ed5i quy tr\u00ecnh l\u00ean men v\u00e0 tinh ch\u1ebf. C\u00e1c l\u00f4 n\u00e0y ch\u1ee9a l\u01b0\u1ee3ng v\u1ebft m\u1ed9t s\u1ed1 t\u1ea1p ch\u1ea5t m\u1edbi. Sau s\u1ef1 c\u1ed1, nhi\u1ec1u n\u01b0\u1edbc h\u1ea1n ch\u1ebf L-tryptophan trong th\u1ef1c ph\u1ea9m b\u1ed5 sung m\u1ed9t th\u1eddi gian d\u00e0i, v\u00e0 ti\u00eau chu\u1ea9n hi\u1ec7n nay gi\u1edbi h\u1ea1n ch\u1eb7t c\u00e1c t\u1ea1p ch\u1ea5t li\u00ean quan. \u0110\u00e2y l\u00e0 v\u00ed d\u1ee5 kinh \u0111i\u1ec3n cho th\u1ea5y <strong>h\u1ed3 s\u01a1 t\u1ea1p ch\u1ea5t<\/strong> (kh\u00f4ng ch\u1ec9 h\u00e0m l\u01b0\u1ee3ng) quan tr\u1ecdng th\u1ebf n\u00e0o v\u1edbi nguy\u00ean li\u1ec7u d\u00f9ng cho ng\u01b0\u1eddi.<\/p>\n<h2>Applications<\/h2>\n<ul>\n<li>Dinh d\u01b0\u1ee1ng l\u00e2m s\u00e0ng; th\u1ef1c ph\u1ea9m b\u1ed5 sung (theo quy \u0111\u1ecbnh t\u1eebng n\u01b0\u1edbc).<\/li>\n<li>Th\u1ee9c \u0103n ch\u0103n nu\u00f4i.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li><strong>Hoa K\u1ef3<\/strong>: 21 CFR 172.320 cho ph\u00e9p d\u00f9ng l\u00e0m ph\u1ee5 gia c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng protein, t\u1ed1i \u0111a 1,6% kh\u1ed1i l\u01b0\u1ee3ng protein to\u00e0n ph\u1ea7n.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Khi d\u00f9ng l\u00e0m th\u00e0nh ph\u1ea7n c\u1ee7a th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe ho\u1eb7c th\u1ef1c ph\u1ea9m dinh d\u01b0\u1ee1ng, s\u1ea3n ph\u1ea9m tu\u00e2n theo Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP v\u00e0 c\u00e1c v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n m\u1edbi nh\u1ea5t tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>B\u1ea3o qu\u1ea3n<\/h2>\n<p>Tr\u00e1nh \u00e1nh s\u00e1ng, \u0111\u1ec3 n\u01a1i kh\u00f4 m\u00e1t trong bao b\u00ec k\u00edn.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Tryptophan \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Tryptophan\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Tryptophan<\/a><\/li>\n<li>Wikipedia \u2013 Eosinophilia\u2013myalgia syndrome \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Eosinophilia%E2%80%93myalgia_syndrome\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Eosinophilia%E2%80%93myalgia_syndrome<\/a><\/li>\n<li>Wikidata \u2013 L-tryptophan (CAS 73-22-3) \u2014 <a href=\"https:\/\/www.wikidata.org\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.wikidata.org\/<\/a><\/li>\n<li>U.S. FDA \u2013 21 CFR 172.320 Amino acids \u2014 <a href=\"https:\/\/www.law.cornell.edu\/cfr\/text\/21\/172.320\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.law.cornell.edu\/cfr\/text\/21\/172.320<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>L-Tryptophan: c\u1ea5u t\u1ea1o, s\u1ea3n xu\u1ea5t v\u00e0 b\u00e0i h\u1ecdc v\u1ec1 \u0111\u1ed9 tinh khi\u1ebft L-Tryptophan l\u00e0 acid amin thi\u1ebft y\u1ebfu c\u00f3 m\u1ea1ch b\u00ean l\u00e0 v\u00f2ng indol, l\u1edbn nh\u1ea5t trong 20 acid amin c\u1ea5u t\u1ea1o protein. Trong c\u01a1 th\u1ec3, tryptophan l\u00e0 ti\u1ec1n ch\u1ea5t sinh t\u1ed5ng h\u1ee3p c\u1ee7a serotonin, melatonin v\u00e0 niacin (vitamin B3). Th\u00f4ng tin nhanh T\u00ean g\u1ecdi [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2933,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-816","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-tryptophan.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-tryptophan-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-tryptophan-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-tryptophan-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-tryptophan-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-tryptophan.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-tryptophan.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-tryptophan-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"L-Tryptophan: c\u1ea5u t\u1ea1o, s\u1ea3n xu\u1ea5t v\u00e0 b\u00e0i h\u1ecdc v\u1ec1 \u0111\u1ed9 tinh khi\u1ebft L-Tryptophan l\u00e0 acid amin thi\u1ebft y\u1ebfu c\u00f3 m\u1ea1ch b\u00ean l\u00e0 v\u00f2ng indol, l\u1edbn nh\u1ea5t trong 20 acid amin c\u1ea5u t\u1ea1o protein. Trong c\u01a1 th\u1ec3, tryptophan l\u00e0 ti\u1ec1n ch\u1ea5t sinh t\u1ed5ng h\u1ee3p c\u1ee7a serotonin, melatonin v\u00e0 niacin (vitamin B3). Th\u00f4ng tin nhanh T\u00ean g\u1ecdi&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/816","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=816"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/816\/revisions"}],"predecessor-version":[{"id":3066,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/816\/revisions\/3066"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2933"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=816"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=816"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}