{"id":815,"date":"2025-05-29T08:17:18","date_gmt":"2025-05-29T08:17:18","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-l-phenylalanine\/"},"modified":"2026-09-28T20:54:37","modified_gmt":"2026-09-28T13:54:37","slug":"nguyen-lieu-l-phenylalanine","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-l-phenylalanine\/","title":{"rendered":"L-Phenylalanine: c\u1ea5u t\u1ea1o, t\u00ednh ch\u1ea5t, s\u1ea3n xu\u1ea5t v\u00e0 l\u01b0u \u00fd PKU"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">L-Phenylalanine: c\u1ea5u t\u1ea1o, t\u00ednh ch\u1ea5t, s\u1ea3n xu\u1ea5t v\u00e0 l\u01b0u \u00fd PKU<\/h1>\n<p><strong>L-Phenylalanine<\/strong> (phenylalanin) l\u00e0 acid amin thi\u1ebft y\u1ebfu c\u00f3 m\u1ea1ch b\u00ean l\u00e0 <strong>nh\u00f3m benzyl<\/strong> (v\u00f2ng th\u01a1m). Trong c\u01a1 th\u1ec3, phenylalanin \u0111\u01b0\u1ee3c chuy\u1ec3n th\u00e0nh tyrosin. Ngo\u00e0i dinh d\u01b0\u1ee1ng, L-phenylalanine l\u00e0 m\u1ed9t trong hai nguy\u00ean li\u1ec7u \u0111\u1ec3 t\u1ed5ng h\u1ee3p ch\u1ea5t t\u1ea1o ng\u1ecdt <a href=\"\/en\/aspartam\/\">aspartam<\/a>.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>L-Phenylalanine, phenylalanin, acid (S)-2-amino-3-phenylpropanoic; k\u00fd hi\u1ec7u Phe, F<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c, kh\u1ed1i l\u01b0\u1ee3ng mol<\/td>\n<td>C<sub>9<\/sub>H<sub>11<\/sub>NO<sub>2<\/sub> \u2013 165,19 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>63-91-2<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u1ea5u t\u1ea1o v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>V\u00f2ng th\u01a1m kh\u00f4ng ph\u00e2n c\u1ef1c l\u00e0m phenylalanin l\u00e0 acid amin k\u1ef5 n\u01b0\u1edbc; ph\u00e2n t\u1eed h\u1ea5p th\u1ee5 tia t\u1eed ngo\u1ea1i, tuy y\u1ebfu h\u01a1n tyrosin v\u00e0 tryptophan.<\/li>\n<li>B\u1ed9t k\u1ebft tinh ho\u1eb7c v\u1ea3y m\u00e0u tr\u1eafng, v\u1ecb h\u01a1i \u0111\u1eafng, tan v\u1eeba ph\u1ea3i trong n\u01b0\u1edbc.<\/li>\n<li>D\u1ea1ng D-phenylalanine v\u00e0 h\u1ed7n h\u1ee3p DL c\u0169ng c\u00f3 tr\u00ean th\u1ecb tr\u01b0\u1eddng, nh\u01b0ng ch\u1ec9 d\u1ea1ng L tham gia c\u1ea5u t\u1ea1o protein.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>L-Phenylalanine \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t ch\u1ee7 y\u1ebfu b\u1eb1ng <strong>l\u00ean men<\/strong> (<em>Escherichia coli<\/em> \u0111\u01b0\u1ee3c c\u1ea3i bi\u1ebfn) ho\u1eb7c b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p enzym t\u1eeb ti\u1ec1n ch\u1ea5t. Nhu c\u1ea7u t\u0103ng m\u1ea1nh t\u1eeb khi aspartam \u0111\u01b0\u1ee3c th\u01b0\u01a1ng m\u1ea1i h\u00f3a, v\u00ec m\u1ed7i ph\u00e2n t\u1eed aspartam ch\u1ee9a m\u1ed9t g\u1ed1c L-phenylalanin.<\/p>\n<h2>L\u01b0u \u00fd: phenylketon ni\u1ec7u (PKU)<\/h2>\n<p>Ng\u01b0\u1eddi m\u1eafc b\u1ec7nh di truy\u1ec1n <strong>phenylketon ni\u1ec7u<\/strong> kh\u00f4ng chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c phenylalanin v\u00e0 ph\u1ea3i ki\u1ec3m so\u00e1t ch\u1eb7t l\u01b0\u1ee3ng \u0103n v\u00e0o. V\u00ec v\u1eady nhi\u1ec1u qu\u1ed1c gia b\u1eaft bu\u1ed9c ghi c\u1ea3nh b\u00e1o &#8220;c\u00f3 ch\u1ee9a ngu\u1ed3n phenylalanin&#8221; tr\u00ean nh\u00e3n th\u1ef1c ph\u1ea9m ch\u1ee9a aspartam. Nh\u00e0 s\u1ea3n xu\u1ea5t d\u00f9ng L-phenylalanine l\u00e0m th\u00e0nh ph\u1ea7n c\u0169ng c\u1ea7n l\u01b0u \u00fd th\u00f4ng tin n\u00e0y khi ghi nh\u00e3n.<\/p>\n<h2>Applications<\/h2>\n<ul>\n<li>Nguy\u00ean li\u1ec7u t\u1ed5ng h\u1ee3p aspartam.<\/li>\n<li>Th\u1ef1c ph\u1ea9m b\u1ed5 sung; dinh d\u01b0\u1ee1ng l\u00e2m s\u00e0ng.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li><strong>Hoa K\u1ef3<\/strong>: 21 CFR 172.320 cho ph\u00e9p d\u00f9ng l\u00e0m ph\u1ee5 gia c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng protein, t\u1ed1i \u0111a 5,8% kh\u1ed1i l\u01b0\u1ee3ng protein to\u00e0n ph\u1ea7n.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Khi d\u00f9ng l\u00e0m th\u00e0nh ph\u1ea7n c\u1ee7a th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe ho\u1eb7c th\u1ef1c ph\u1ea9m dinh d\u01b0\u1ee1ng, s\u1ea3n ph\u1ea9m tu\u00e2n theo Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP v\u00e0 c\u00e1c v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n m\u1edbi nh\u1ea5t tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Phenylalanine \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Phenylalanine\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Phenylalanine<\/a><\/li>\n<li>Wikidata \u2013 L-phenylalanine (CAS 63-91-2) \u2014 <a href=\"https:\/\/www.wikidata.org\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.wikidata.org\/<\/a><\/li>\n<li>U.S. FDA \u2013 21 CFR 172.320 Amino acids \u2014 <a href=\"https:\/\/www.law.cornell.edu\/cfr\/text\/21\/172.320\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.law.cornell.edu\/cfr\/text\/21\/172.320<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>L-Phenylalanine: c\u1ea5u t\u1ea1o, t\u00ednh ch\u1ea5t, s\u1ea3n xu\u1ea5t v\u00e0 l\u01b0u \u00fd PKU L-Phenylalanine (phenylalanin) l\u00e0 acid amin thi\u1ebft y\u1ebfu c\u00f3 m\u1ea1ch b\u00ean l\u00e0 nh\u00f3m benzyl (v\u00f2ng th\u01a1m). Trong c\u01a1 th\u1ec3, phenylalanin \u0111\u01b0\u1ee3c chuy\u1ec3n th\u00e0nh tyrosin. Ngo\u00e0i dinh d\u01b0\u1ee1ng, L-phenylalanine l\u00e0 m\u1ed9t trong hai nguy\u00ean li\u1ec7u \u0111\u1ec3 t\u1ed5ng h\u1ee3p ch\u1ea5t t\u1ea1o ng\u1ecdt aspartam. Th\u00f4ng tin nhanh T\u00ean [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2930,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-815","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-phenylalanine.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-phenylalanine-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-phenylalanine-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-phenylalanine-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-phenylalanine-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-phenylalanine.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-phenylalanine.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/l-phenylalanine-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":1,"uagb_excerpt":"L-Phenylalanine: c\u1ea5u t\u1ea1o, t\u00ednh ch\u1ea5t, s\u1ea3n xu\u1ea5t v\u00e0 l\u01b0u \u00fd PKU L-Phenylalanine (phenylalanin) l\u00e0 acid amin thi\u1ebft y\u1ebfu c\u00f3 m\u1ea1ch b\u00ean l\u00e0 nh\u00f3m benzyl (v\u00f2ng th\u01a1m). Trong c\u01a1 th\u1ec3, phenylalanin \u0111\u01b0\u1ee3c chuy\u1ec3n th\u00e0nh tyrosin. Ngo\u00e0i dinh d\u01b0\u1ee1ng, L-phenylalanine l\u00e0 m\u1ed9t trong hai nguy\u00ean li\u1ec7u \u0111\u1ec3 t\u1ed5ng h\u1ee3p ch\u1ea5t t\u1ea1o ng\u1ecdt aspartam. Th\u00f4ng tin nhanh T\u00ean&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/815","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=815"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/815\/revisions"}],"predecessor-version":[{"id":3063,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/815\/revisions\/3063"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2930"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=815"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=815"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}