{"id":787,"date":"2025-05-29T08:03:28","date_gmt":"2025-05-29T08:03:28","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-caffeine-anhydrous-dang-bot\/"},"modified":"2026-09-28T20:40:42","modified_gmt":"2026-09-28T13:40:42","slug":"nguyen-lieu-caffeine-anhydrous-dang-bot","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-caffeine-anhydrous-dang-bot\/","title":{"rendered":"Caffeine (cafein khan): c\u1ea5u t\u1ea1o, s\u1ea3n xu\u1ea5t, \u1ee9ng d\u1ee5ng v\u00e0 gi\u1edbi h\u1ea1n"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Caffeine (cafein khan): c\u1ea5u t\u1ea1o, s\u1ea3n xu\u1ea5t, \u1ee9ng d\u1ee5ng v\u00e0 gi\u1edbi h\u1ea1n<\/h1>\n<p><strong>Caffeine<\/strong> (cafein) l\u00e0 <strong>alkaloid nh\u00f3m methylxanthin<\/strong> c\u00f3 t\u1ef1 nhi\u00ean trong h\u1ea1t c\u00e0 ph\u00ea, l\u00e1 tr\u00e0, h\u1ea1t ca cao, qu\u1ea3 cola, l\u00e1 guaran\u00e1, l\u00e1 mate. \u0110\u00e2y l\u00e0 ch\u1ea5t k\u00edch th\u00edch th\u1ea7n kinh trung \u01b0\u01a1ng \u0111\u01b0\u1ee3c ti\u00eau th\u1ee5 ph\u1ed5 bi\u1ebfn nh\u1ea5t th\u1ebf gi\u1edbi. Nguy\u00ean li\u1ec7u th\u01b0\u01a1ng m\u1ea1i th\u01b0\u1eddng l\u00e0 <strong>cafein khan<\/strong> (caffeine anhydrous), d\u1ea1ng b\u1ed9t ho\u1eb7c d\u1ea1ng h\u1ea1t.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>Caffeine, cafein, 1,3,7-trimethylxanthin, guaranin, thein<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c, kh\u1ed1i l\u01b0\u1ee3ng mol<\/td>\n<td>C<sub>8<\/sub>H<sub>10<\/sub>N<sub>4<\/sub>O<sub>2<\/sub> \u2013 194,19 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>58-08-2<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>T\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t ho\u1eb7c tinh th\u1ec3 h\u00ecnh kim m\u00e0u tr\u1eafng, kh\u00f4ng m\u00f9i, <strong>v\u1ecb \u0111\u1eafng<\/strong> r\u00f5 r\u1ec7t.<\/li>\n<li>Tan v\u1eeba ph\u1ea3i trong n\u01b0\u1edbc \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng, tan t\u1ed1t trong n\u01b0\u1edbc n\u00f3ng. Cafein <strong>th\u0103ng hoa<\/strong> khi \u0111un n\u00f3ng.<\/li>\n<li>D\u1ea1ng khan c\u00f3 th\u1ec3 h\u00fat \u1ea9m th\u00e0nh d\u1ea1ng monohydrat. <strong>D\u1ea1ng h\u1ea1t<\/strong> (granular) ch\u1ea3y t\u1ed1t v\u00e0 \u00edt b\u1ee5i h\u01a1n d\u1ea1ng b\u1ed9t m\u1ecbn, thu\u1eadn l\u1ee3i cho d\u1eadp vi\u00ean v\u00e0 pha tr\u1ed9n.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<ul>\n<li><strong>Thu h\u1ed3i t\u1eeb qu\u00e1 tr\u00ecnh kh\u1eed cafein<\/strong> c\u00e0 ph\u00ea, tr\u00e0 (chi\u1ebft b\u1eb1ng CO<sub>2<\/sub> si\u00eau t\u1edbi h\u1ea1n, n\u01b0\u1edbc ho\u1eb7c dung m\u00f4i), sau \u0111\u00f3 tinh ch\u1ebf. Cafein lo\u1ea1i n\u00e0y \u0111\u00f4i khi \u0111\u01b0\u1ee3c ghi l\u00e0 &#8220;t\u1ef1 nhi\u00ean&#8221;.<\/li>\n<li><strong>T\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc<\/strong> t\u1eeb dimethylur\u00ea v\u00e0 c\u00e1c ti\u1ec1n ch\u1ea5t kh\u00e1c. Ph\u1ea7n l\u1edbn cafein tr\u00ean th\u1ecb tr\u01b0\u1eddng l\u00e0 cafein t\u1ed5ng h\u1ee3p.<\/li>\n<\/ul>\n<p>V\u1ec1 h\u00f3a h\u1ecdc, hai ngu\u1ed3n cho c\u00f9ng m\u1ed9t ph\u00e2n t\u1eed. C\u00f3 th\u1ec3 ph\u00e2n bi\u1ec7t b\u1eb1ng ph\u00e2n t\u00edch \u0111\u1ed3ng v\u1ecb carbon (<sup>14<\/sup>C, <sup>13<\/sup>C) khi c\u1ea7n x\u00e1c minh ngu\u1ed3n g\u1ed1c.<\/p>\n<h2>Applications<\/h2>\n<ul>\n<li>\u0110\u1ed3 u\u1ed1ng: n\u01b0\u1edbc ng\u1ecdt c\u00f3 ga lo\u1ea1i cola, \u0111\u1ed3 u\u1ed1ng n\u0103ng l\u01b0\u1ee3ng.<\/li>\n<li>Th\u1ef1c ph\u1ea9m b\u1ed5 sung, s\u1ea3n ph\u1ea9m th\u1ec3 thao.<\/li>\n<li>M\u1ef9 ph\u1ea9m: kem v\u00f9ng m\u1eaft, s\u1ea3n ph\u1ea9m ch\u0103m s\u00f3c da, d\u1ea7u g\u1ed9i.<\/li>\n<li>D\u01b0\u1ee3c ph\u1ea9m ph\u1ed1i h\u1ee3p; c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n<h2>An to\u00e0n v\u00e0 quy \u0111\u1ecbnh<\/h2>\n<ul>\n<li><strong>EFSA (2015)<\/strong>: v\u1edbi ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh kh\u1ecfe m\u1ea1nh, l\u01b0\u1ee3ng cafein \u0111\u1ebfn 400 mg\/ng\u00e0y (v\u00e0 li\u1ec1u \u0111\u01a1n \u0111\u1ebfn 200 mg) kh\u00f4ng g\u00e2y lo ng\u1ea1i v\u1ec1 an to\u00e0n; ph\u1ee5 n\u1eef mang thai v\u00e0 cho con b\u00fa n\u00ean gi\u1edbi h\u1ea1n \u1edf 200 mg\/ng\u00e0y.<\/li>\n<li><strong>Hoa K\u1ef3<\/strong>: 21 CFR 182.1180 x\u1ebfp cafein l\u00e0 ch\u1ea5t GRAS khi d\u00f9ng trong \u0111\u1ed3 u\u1ed1ng lo\u1ea1i cola, t\u1ed1i \u0111a 0,02% (200 ppm).<\/li>\n<li>Cafein d\u1ea1ng b\u1ed9t tinh khi\u1ebft r\u1ea5t nguy hi\u1ec3m n\u1ebfu d\u00f9ng sai: m\u1ed9t th\u00eca nh\u1ecf \u0111\u00e3 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng h\u00e0ng ch\u1ee5c c\u1ed1c c\u00e0 ph\u00ea. Nguy\u00ean li\u1ec7u ph\u1ea3i \u0111\u01b0\u1ee3c c\u00e2n chia b\u1eb1ng thi\u1ebft b\u1ecb ch\u00ednh x\u00e1c, b\u1ea3o qu\u1ea3n tr\u00e1nh xa ng\u01b0\u1eddi kh\u00f4ng c\u00f3 chuy\u00ean m\u00f4n.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Khi d\u00f9ng l\u00e0m th\u00e0nh ph\u1ea7n c\u1ee7a th\u1ef1c ph\u1ea9m ho\u1eb7c th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe, s\u1ea3n ph\u1ea9m tu\u00e2n theo Lu\u1eadt An to\u00e0n th\u1ef1c ph\u1ea9m, Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP v\u00e0 c\u00e1c v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n m\u1edbi nh\u1ea5t tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Caffeine \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Caffeine\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Caffeine<\/a><\/li>\n<li>Wikidata \u2013 \u0111\u1ecbnh danh h\u00f3a h\u1ecdc (CAS, c\u00f4ng th\u1ee9c) \u2014 <a href=\"https:\/\/www.wikidata.org\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.wikidata.org\/<\/a><\/li>\n<li>U.S. FDA \u2013 21 CFR 182.1180 Caffeine \u2014 <a href=\"https:\/\/www.law.cornell.edu\/cfr\/text\/21\/182.1180\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.law.cornell.edu\/cfr\/text\/21\/182.1180<\/a><\/li>\n<li>EFSA NDA Panel (2015). Scientific Opinion on the safety of caffeine. EFSA Journal 13(5):4102 \u2014 <a href=\"https:\/\/www.efsa.europa.eu\/en\/efsajournal\/pub\/4102\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.efsa.europa.eu\/en\/efsajournal\/pub\/4102<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Caffeine (cafein khan): c\u1ea5u t\u1ea1o, s\u1ea3n xu\u1ea5t, \u1ee9ng d\u1ee5ng v\u00e0 gi\u1edbi h\u1ea1n Caffeine (cafein) l\u00e0 alkaloid nh\u00f3m methylxanthin c\u00f3 t\u1ef1 nhi\u00ean trong h\u1ea1t c\u00e0 ph\u00ea, l\u00e1 tr\u00e0, h\u1ea1t ca cao, qu\u1ea3 cola, l\u00e1 guaran\u00e1, l\u00e1 mate. \u0110\u00e2y l\u00e0 ch\u1ea5t k\u00edch th\u00edch th\u1ea7n kinh trung \u01b0\u01a1ng \u0111\u01b0\u1ee3c ti\u00eau th\u1ee5 ph\u1ed5 bi\u1ebfn nh\u1ea5t th\u1ebf gi\u1edbi. Nguy\u00ean li\u1ec7u [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2851,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-787","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/caffeine.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/caffeine-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/caffeine-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/caffeine-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/caffeine-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/caffeine.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/caffeine.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/caffeine-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Caffeine (cafein khan): c\u1ea5u t\u1ea1o, s\u1ea3n xu\u1ea5t, \u1ee9ng d\u1ee5ng v\u00e0 gi\u1edbi h\u1ea1n Caffeine (cafein) l\u00e0 alkaloid nh\u00f3m methylxanthin c\u00f3 t\u1ef1 nhi\u00ean trong h\u1ea1t c\u00e0 ph\u00ea, l\u00e1 tr\u00e0, h\u1ea1t ca cao, qu\u1ea3 cola, l\u00e1 guaran\u00e1, l\u00e1 mate. \u0110\u00e2y l\u00e0 ch\u1ea5t k\u00edch th\u00edch th\u1ea7n kinh trung \u01b0\u01a1ng \u0111\u01b0\u1ee3c ti\u00eau th\u1ee5 ph\u1ed5 bi\u1ebfn nh\u1ea5t th\u1ebf gi\u1edbi. Nguy\u00ean li\u1ec7u&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/787","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=787"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/787\/revisions"}],"predecessor-version":[{"id":2982,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/787\/revisions\/2982"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2851"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=787"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=787"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=787"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}