{"id":778,"date":"2025-05-29T07:59:52","date_gmt":"2025-05-29T07:59:52","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-chiet-xuat-tu-cay-ke-sua-silymarin-dongtai\/"},"modified":"2026-09-28T20:46:12","modified_gmt":"2026-09-28T13:46:12","slug":"nguyen-lieu-chiet-xuat-tu-cay-ke-sua-silymarin-dongtai","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-chiet-xuat-tu-cay-ke-sua-silymarin-dongtai\/","title":{"rendered":"Chi\u1ebft xu\u1ea5t k\u1ebf s\u1eefa (Silybum marianum): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Chi\u1ebft xu\u1ea5t k\u1ebf s\u1eefa (Silybum marianum): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng<\/h1>\n<p><strong>Chi\u1ebft xu\u1ea5t k\u1ebf s\u1eefa<\/strong> l\u00e0 cao chi\u1ebft t\u1eeb qu\u1ea3 c\u00e2y k\u1ebf s\u1eefa (<em>Silybum marianum<\/em>), ti\u00eau chu\u1ea9n h\u00f3a theo <strong>silymarin<\/strong>, h\u1ed7n h\u1ee3p c\u00e1c flavonolignan \u0111\u1eb7c tr\u01b0ng c\u1ee7a lo\u00e0i n\u00e0y. T\u00ean &#8220;k\u1ebf s\u1eefa&#8221; xu\u1ea5t ph\u00e1t t\u1eeb nh\u1eefng v\u1ec7t tr\u1eafng nh\u01b0 s\u1eefa tr\u00ean l\u00e1 c\u00e2y.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>K\u1ebf s\u1eefa, c\u00fac gai, milk thistle; Silybi mariani fructus; silymarin<\/td>\n<\/tr>\n<tr>\n<td>Lo\u00e0i<\/td>\n<td><em>Silybum marianum (L.) Gaertn.<\/em>, h\u1ecd C\u00fac (Asteraceae)<\/td>\n<\/tr>\n<tr>\n<td>B\u1ed9 ph\u1eadn d\u00f9ng<\/td>\n<td>Qu\u1ea3 (th\u01b0\u1eddng g\u1ecdi l\u00e0 h\u1ea1t)<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ho\u1ea1t ch\u1ea5t ch\u00ednh<\/td>\n<td>Silymarin: h\u1ed7n h\u1ee3p flavonolignan (silybin A v\u00e0 B, isosilybin, silychristin, silydianin) v\u00e0 taxifolin<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u00e2y v\u00e0 d\u01b0\u1ee3c li\u1ec7u<\/h2>\n<p>K\u1ebf s\u1eefa l\u00e0 c\u00e2y th\u1ea3o m\u1ed9t \u0111\u1ebfn hai n\u0103m, g\u1ed1c v\u00f9ng \u0110\u1ecba Trung H\u1ea3i, l\u00e1 c\u00f3 gai v\u00e0 v\u1ec7t tr\u1eafng, hoa m\u00e0u t\u00edm. Ph\u1ea7n d\u00f9ng l\u00e0 qu\u1ea3 b\u1ebf nh\u1ecf, v\u1ecf c\u1ee9ng, th\u01b0\u1eddng \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 &#8220;h\u1ea1t&#8221;. C\u00e2y hi\u1ec7n \u0111\u01b0\u1ee3c tr\u1ed3ng nhi\u1ec1u \u1edf ch\u00e2u \u00c2u, Trung Qu\u1ed1c, Argentina.<\/p>\n<h2>Th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc<\/h2>\n<ul>\n<li><strong>Silymarin<\/strong> (th\u01b0\u1eddng v\u00e0i ph\u1ea7n tr\u0103m trong qu\u1ea3): silybin A v\u00e0 B (th\u00e0nh ph\u1ea7n ch\u00ednh), isosilybin A v\u00e0 B, silychristin, silydianin; k\u00e8m flavonoid taxifolin.<\/li>\n<li>D\u1ea7u b\u00e9o (qu\u1ea3 ch\u1ee9a l\u01b0\u1ee3ng d\u1ea7u \u0111\u00e1ng k\u1ec3; th\u01b0\u1eddng \u0111\u01b0\u1ee3c lo\u1ea1i tr\u01b0\u1edbc khi chi\u1ebft silymarin), protein.<\/li>\n<\/ul>\n<h2>Chi\u1ebft xu\u1ea5t v\u00e0 ti\u00eau chu\u1ea9n h\u00f3a<\/h2>\n<p>Qu\u1ea3 \u0111\u01b0\u1ee3c \u00e9p ho\u1eb7c chi\u1ebft \u0111\u1ec3 lo\u1ea1i d\u1ea7u, sau \u0111\u00f3 chi\u1ebft silymarin b\u1eb1ng ethanol, aceton ho\u1eb7c ethyl acetat, c\u00f4 \u0111\u1eb7c v\u00e0 s\u1ea5y. Nguy\u00ean li\u1ec7u th\u01b0\u01a1ng m\u1ea1i ghi h\u00e0m l\u01b0\u1ee3ng silymarin, v\u00ed d\u1ee5 60%, 70% ho\u1eb7c 80%. C\u1ea7n l\u01b0u \u00fd <strong>con s\u1ed1 ph\u1ee5 thu\u1ed9c ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ecbnh l\u01b0\u1ee3ng<\/strong>: ph\u01b0\u01a1ng ph\u00e1p \u0111o quang UV th\u01b0\u1eddng cho k\u1ebft qu\u1ea3 cao h\u01a1n HPLC v\u00ec t\u00ednh c\u1ea3 c\u00e1c ch\u1ea5t h\u1ea5p th\u1ee5 t\u01b0\u01a1ng t\u1ef1. Khi so s\u00e1nh hai nguy\u00ean li\u1ec7u, ph\u1ea3i so tr\u00ean c\u00f9ng ph\u01b0\u01a1ng ph\u00e1p. Silymarin g\u1ea7n nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc.<\/p>\n<h2>Ch\u1ec9 ti\u00eau ch\u1ea5t l\u01b0\u1ee3ng n\u00ean xem<\/h2>\n<ul>\n<li>Silymarin \u0111\u1ecbnh l\u01b0\u1ee3ng b\u1eb1ng HPLC (k\u00e8m t\u1ef7 l\u1ec7 c\u00e1c th\u00e0nh ph\u1ea7n silybin, isosilybin, silychristin, silydianin).<\/li>\n<li>Dung m\u00f4i t\u1ed3n d\u01b0; kim lo\u1ea1i n\u1eb7ng; \u0111\u1ed9c t\u1ed1 vi n\u1ea5m (aflatoxin) v\u00e0 thu\u1ed1c b\u1ea3o v\u1ec7 th\u1ef1c v\u1eadt v\u00ec nguy\u00ean li\u1ec7u l\u00e0 h\u1ea1t.<\/li>\n<\/ul>\n<h2>Applications<\/h2>\n<ul>\n<li>Thu\u1ed1c d\u01b0\u1ee3c li\u1ec7u v\u00e0 th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe; silybin tinh khi\u1ebft c\u00f2n \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf th\u00e0nh ph\u1ee9c phospholipid \u0111\u1ec3 c\u1ea3i thi\u1ec7n \u0111\u1ed9 tan.<\/li>\n<li>C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n<h2>An to\u00e0n v\u00e0 l\u01b0u \u00fd<\/h2>\n<ul>\n<li>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi c\u00e2y h\u1ecd C\u00fac (Asteraceae) c\u00f3 th\u1ec3 d\u1ecb \u1ee9ng v\u1edbi k\u1ebf s\u1eefa.<\/li>\n<li>Nguy\u00ean li\u1ec7u d\u1ea1ng h\u1ea1t c\u1ea7n ki\u1ec3m so\u00e1t aflatoxin.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Chi\u1ebft xu\u1ea5t d\u01b0\u1ee3c li\u1ec7u \u0111\u01b0\u1ee3c d\u00f9ng c\u1ea3 trong thu\u1ed1c d\u01b0\u1ee3c li\u1ec7u v\u00e0 trong th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe; s\u1ea3n ph\u1ea9m thu\u1ed9c lo\u1ea1i n\u00e0o th\u00ec theo quy \u0111\u1ecbnh c\u1ee7a lo\u1ea1i \u0111\u00f3 (Lu\u1eadt D\u01b0\u1ee3c ho\u1eb7c Lu\u1eadt An to\u00e0n th\u1ef1c ph\u1ea9m, Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP). Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>EMA \u2013 Silybi mariani fructus (chuy\u00ean lu\u1eadn d\u01b0\u1ee3c li\u1ec7u EU) \u2014 <a href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/herbal\/silybi-mariani-fructus\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.ema.europa.eu\/en\/medicines\/herbal\/silybi-mariani-fructus<\/a><\/li>\n<li>Wikipedia \u2013 Silybum marianum \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Silybum_marianum\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Silybum_marianum<\/a><\/li>\n<li>Wikipedia \u2013 Silymarin \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Silymarin\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Silymarin<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Chi\u1ebft xu\u1ea5t k\u1ebf s\u1eefa (Silybum marianum): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng Chi\u1ebft xu\u1ea5t k\u1ebf s\u1eefa l\u00e0 cao chi\u1ebft t\u1eeb qu\u1ea3 c\u00e2y k\u1ebf s\u1eefa (Silybum marianum), ti\u00eau chu\u1ea9n h\u00f3a theo silymarin, h\u1ed7n h\u1ee3p c\u00e1c flavonolignan \u0111\u1eb7c tr\u01b0ng c\u1ee7a lo\u00e0i n\u00e0y. T\u00ean &#8220;k\u1ebf s\u1eefa&#8221; xu\u1ea5t ph\u00e1t t\u1eeb nh\u1eefng v\u1ec7t tr\u1eafng nh\u01b0 s\u1eefa tr\u00ean l\u00e1 c\u00e2y. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2884,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-778","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-ke-sua.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-ke-sua-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-ke-sua-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-ke-sua-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-ke-sua-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-ke-sua.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-ke-sua.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/chiet-xuat-ke-sua-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Chi\u1ebft xu\u1ea5t k\u1ebf s\u1eefa (Silybum marianum): th\u00e0nh ph\u1ea7n, chi\u1ebft xu\u1ea5t v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng Chi\u1ebft xu\u1ea5t k\u1ebf s\u1eefa l\u00e0 cao chi\u1ebft t\u1eeb qu\u1ea3 c\u00e2y k\u1ebf s\u1eefa (Silybum marianum), ti\u00eau chu\u1ea9n h\u00f3a theo silymarin, h\u1ed7n h\u1ee3p c\u00e1c flavonolignan \u0111\u1eb7c tr\u01b0ng c\u1ee7a lo\u00e0i n\u00e0y. T\u00ean &#8220;k\u1ebf s\u1eefa&#8221; xu\u1ea5t ph\u00e1t t\u1eeb nh\u1eefng v\u1ec7t tr\u1eafng nh\u01b0 s\u1eefa tr\u00ean l\u00e1 c\u00e2y.&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=778"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/778\/revisions"}],"predecessor-version":[{"id":3016,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/778\/revisions\/3016"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2884"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=778"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=778"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}