{"id":757,"date":"2025-05-29T07:48:13","date_gmt":"2025-05-29T07:48:13","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-menaquinone-7-vitamin-k2\/"},"modified":"2026-09-28T20:55:51","modified_gmt":"2026-09-28T13:55:51","slug":"nguyen-lieu-menaquinone-7-vitamin-k2","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-menaquinone-7-vitamin-k2\/","title":{"rendered":"Menaquinone-7 (MK-7, vitamin K2): c\u1ea5u t\u1ea1o, ngu\u1ed3n g\u1ed1c v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Menaquinone-7 (MK-7, vitamin K2): c\u1ea5u t\u1ea1o, ngu\u1ed3n g\u1ed1c v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng<\/h1>\n<p><strong>Menaquinone-7<\/strong> (MK-7) l\u00e0 m\u1ed9t d\u1ea1ng c\u1ee7a <strong>vitamin K2<\/strong>. Vitamin K g\u1ed3m hai nh\u00f3m ch\u00ednh: K1 (phylloquinon, c\u00f3 trong rau xanh) v\u00e0 K2 (c\u00e1c menaquinon, do vi khu\u1ea9n t\u1ea1o ra). C\u00e1c menaquinon \u0111\u01b0\u1ee3c k\u00fd hi\u1ec7u MK-n, v\u1edbi n l\u00e0 s\u1ed1 \u0111\u01a1n v\u1ecb isopren trong chu\u1ed7i b\u00ean; MK-7 c\u00f3 b\u1ea3y \u0111\u01a1n v\u1ecb. Trong c\u01a1 th\u1ec3, vitamin K l\u00e0 \u0111\u1ed3ng y\u1ebfu t\u1ed1 c\u1ee7a enzym carboxyl h\u00f3a m\u1ed9t s\u1ed1 protein li\u00ean quan \u0111\u1ebfn \u0111\u00f4ng m\u00e1u v\u00e0 chuy\u1ec3n h\u00f3a x\u01b0\u01a1ng.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>Menaquinone-7, MK-7, vitamin K2-7<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c, kh\u1ed1i l\u01b0\u1ee3ng mol<\/td>\n<td>C<sub>46<\/sub>H<sub>64<\/sub>O<sub>2<\/sub> \u2013 649,02 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>2124-57-4 (all-trans)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u1ea5u t\u1ea1o v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Nh\u00e2n <strong>2-methyl-1,4-naphthoquinon<\/strong> (menadion) g\u1eafn chu\u1ed7i b\u00ean g\u1ed3m 7 \u0111\u01a1n v\u1ecb isopren. Chu\u1ed7i d\u00e0i l\u00e0m MK-7 r\u1ea5t tan trong d\u1ea7u v\u00e0 l\u01b0u l\u1ea1i trong m\u00e1u l\u00e2u h\u01a1n MK-4 hay vitamin K1.<\/li>\n<li>M\u1ed7i li\u00ean k\u1ebft \u0111\u00f4i trong chu\u1ed7i c\u00f3 th\u1ec3 \u1edf d\u1ea1ng <strong>trans<\/strong> or <strong>cis<\/strong>. D\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc l\u00e0 <strong>all-trans<\/strong>. T\u1ef7 l\u1ec7 \u0111\u1ed3ng ph\u00e2n cis l\u00e0 ch\u1ec9 ti\u00eau ch\u1ea5t l\u01b0\u1ee3ng quan tr\u1ecdng, \u0111\u1eb7c bi\u1ec7t v\u1edbi MK-7 t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc.<\/li>\n<li>Ch\u1ea5t r\u1eafn m\u00e0u v\u00e0ng, kh\u00f4ng tan trong n\u01b0\u1edbc. Nh\u1ea1y v\u1edbi \u00e1nh s\u00e1ng v\u00e0 ki\u1ec1m.<\/li>\n<\/ul>\n<h2>Ngu\u1ed3n g\u1ed1c v\u00e0 s\u1ea3n xu\u1ea5t<\/h2>\n<ul>\n<li><strong>L\u00ean men<\/strong>: <em>Bacillus subtilis<\/em> var. <em>natto<\/em>, vi khu\u1ea9n l\u00e0m m\u00f3n \u0111\u1eadu n\u00e0nh l\u00ean men natto c\u1ee7a Nh\u1eadt B\u1ea3n, l\u00e0 ngu\u1ed3n MK-7 phong ph\u00fa nh\u1ea5t trong th\u1ef1c ph\u1ea9m. MK-7 th\u01b0\u01a1ng m\u1ea1i th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng l\u00ean men ch\u1ee7ng n\u00e0y, r\u1ed3i chi\u1ebft v\u00e0 tinh ch\u1ebf.<\/li>\n<li><strong>T\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc<\/strong>: cho MK-7 tinh khi\u1ebft cao; c\u1ea7n ki\u1ec3m so\u00e1t \u0111\u1ed3ng ph\u00e2n cis.<\/li>\n<\/ul>\n<h2>D\u1ea1ng nguy\u00ean li\u1ec7u<\/h2>\n<p>V\u00ec l\u01b0\u1ee3ng d\u00f9ng t\u00ednh b\u1eb1ng microgam, MK-7 th\u01b0\u1eddng \u1edf d\u1ea1ng pha lo\u00e3ng: <strong>d\u1ea7u<\/strong> (h\u00f2a trong d\u1ea7u th\u1ef1c v\u1eadt ho\u1eb7c MCT) ho\u1eb7c <strong>b\u1ed9t vi nang<\/strong>. H\u00e0m l\u01b0\u1ee3ng ghi theo \u00b5g\/g ho\u1eb7c % tr\u00ean COA.<\/p>\n<h2>Applications<\/h2>\n<p>Th\u1ef1c ph\u1ea9m b\u1ed5 sung, th\u01b0\u1eddng ph\u1ed1i h\u1ee3p v\u1edbi vitamin D3 v\u00e0 calci; th\u1ef1c ph\u1ea9m t\u0103ng c\u01b0\u1eddng. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/p>\n<h2>Note<\/h2>\n<p>Vitamin K \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng nh\u00f3m kh\u00e1ng vitamin K (nh\u01b0 warfarin). Ng\u01b0\u1eddi \u0111ang d\u00f9ng lo\u1ea1i thu\u1ed1c n\u00e0y c\u1ea7n tham kh\u1ea3o \u00fd ki\u1ebfn chuy\u00ean gia y t\u1ebf tr\u01b0\u1edbc khi d\u00f9ng s\u1ea3n ph\u1ea9m ch\u1ee9a vitamin K.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Khi d\u00f9ng l\u00e0m th\u00e0nh ph\u1ea7n c\u1ee7a th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe ho\u1eb7c th\u1ef1c ph\u1ea9m t\u0103ng c\u01b0\u1eddng vi ch\u1ea5t, s\u1ea3n ph\u1ea9m tu\u00e2n theo Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP v\u00e0 c\u00e1c v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf, k\u1ec3 c\u1ea3 quy \u0111\u1ecbnh v\u1ec1 h\u00e0m l\u01b0\u1ee3ng vitamin so v\u1edbi nhu c\u1ea7u khuy\u1ebfn ngh\u1ecb. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n m\u1edbi nh\u1ea5t tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Vitamin K2 \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Vitamin_K2\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Vitamin_K2<\/a><\/li>\n<li>Wikidata \u2013 trans-menaquinone 7 (CAS 2124-57-4) \u2014 <a href=\"https:\/\/www.wikidata.org\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.wikidata.org\/<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Menaquinone-7 (MK-7, vitamin K2): c\u1ea5u t\u1ea1o, ngu\u1ed3n g\u1ed1c v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng Menaquinone-7 (MK-7) l\u00e0 m\u1ed9t d\u1ea1ng c\u1ee7a vitamin K2. Vitamin K g\u1ed3m hai nh\u00f3m ch\u00ednh: K1 (phylloquinon, c\u00f3 trong rau xanh) v\u00e0 K2 (c\u00e1c menaquinon, do vi khu\u1ea9n t\u1ea1o ra). C\u00e1c menaquinon \u0111\u01b0\u1ee3c k\u00fd hi\u1ec7u MK-n, v\u1edbi n l\u00e0 s\u1ed1 \u0111\u01a1n v\u1ecb isopren trong chu\u1ed7i [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2938,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-757","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/menaquinone-7.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/menaquinone-7-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/menaquinone-7-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/menaquinone-7-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/menaquinone-7-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/menaquinone-7.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/menaquinone-7.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/menaquinone-7-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":2,"uagb_excerpt":"Menaquinone-7 (MK-7, vitamin K2): c\u1ea5u t\u1ea1o, ngu\u1ed3n g\u1ed1c v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng Menaquinone-7 (MK-7) l\u00e0 m\u1ed9t d\u1ea1ng c\u1ee7a vitamin K2. Vitamin K g\u1ed3m hai nh\u00f3m ch\u00ednh: K1 (phylloquinon, c\u00f3 trong rau xanh) v\u00e0 K2 (c\u00e1c menaquinon, do vi khu\u1ea9n t\u1ea1o ra). C\u00e1c menaquinon \u0111\u01b0\u1ee3c k\u00fd hi\u1ec7u MK-n, v\u1edbi n l\u00e0 s\u1ed1 \u0111\u01a1n v\u1ecb isopren trong chu\u1ed7i&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=757"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/757\/revisions"}],"predecessor-version":[{"id":3071,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/757\/revisions\/3071"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2938"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=757"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=757"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}