{"id":736,"date":"2025-05-29T07:38:34","date_gmt":"2025-05-29T07:38:34","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-chiet-xuat-ho-tieu-piperine\/"},"modified":"2026-09-28T22:34:26","modified_gmt":"2026-09-28T15:34:26","slug":"nguyen-lieu-chiet-xuat-ho-tieu-piperine","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-chiet-xuat-ho-tieu-piperine\/","title":{"rendered":"Piperine (chi\u1ebft xu\u1ea5t h\u1ed3 ti\u00eau): c\u1ea5u t\u1ea1o, v\u1ecb cay, s\u1ea3n xu\u1ea5t v\u00e0 \u1ee9ng d\u1ee5ng"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Piperine (chi\u1ebft xu\u1ea5t h\u1ed3 ti\u00eau): c\u1ea5u t\u1ea1o, v\u1ecb cay, s\u1ea3n xu\u1ea5t v\u00e0 \u1ee9ng d\u1ee5ng<\/h1>\n<p><strong>Piperine<\/strong> l\u00e0 <strong>alkaloid<\/strong> ch\u00ednh t\u1ea1o <strong>v\u1ecb cay<\/strong> c\u1ee7a h\u1ea1t ti\u00eau \u0111en (<em>Piper nigrum<\/em>) v\u00e0 ti\u00eau d\u00e0i (<em>Piper longum<\/em>). Chi\u1ebft xu\u1ea5t h\u1ed3 ti\u00eau ti\u00eau chu\u1ea9n h\u00f3a theo piperine (th\u01b0\u1eddng 95% tr\u1edf l\u00ean) l\u00e0 nguy\u00ean li\u1ec7u ph\u1ed5 bi\u1ebfn trong th\u1ef1c ph\u1ea9m b\u1ed5 sung.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>Piperine, (E,E)-1-piperoylpiperidin<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c, kh\u1ed1i l\u01b0\u1ee3ng mol<\/td>\n<td>C<sub>17<\/sub>H<sub>19<\/sub>NO<sub>3<\/sub> \u2013 285,34 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>94-62-2<\/td>\n<\/tr>\n<tr>\n<td>Ngu\u1ed3n<\/td>\n<td>Qu\u1ea3 (h\u1ea1t) ti\u00eau \u0111en, <em>Piper nigrum<\/em> L., h\u1ecd H\u1ed3 ti\u00eau (Piperaceae)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u1ea5u t\u1ea1o v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Ph\u00e2n t\u1eed g\u1ed3m v\u00f2ng piperidin n\u1ed1i qua li\u00ean k\u1ebft amid v\u1edbi acid piperic (c\u00f3 nh\u00f3m methylenedioxyphenyl v\u00e0 hai li\u00ean k\u1ebft \u0111\u00f4i li\u00ean h\u1ee3p).<\/li>\n<li>Hai li\u00ean k\u1ebft \u0111\u00f4i \u0111\u1ec1u \u1edf d\u1ea1ng <strong>trans<\/strong> (E,E). D\u01b0\u1edbi \u00e1nh s\u00e1ng, piperine \u0111\u1ed3ng ph\u00e2n h\u00f3a th\u00e0nh c\u00e1c d\u1ea1ng cis (chavicin, isopiperine\u2026) \u00edt cay h\u01a1n. \u0110\u00e2y l\u00e0 m\u1ed9t l\u00fd do h\u1ea1t ti\u00eau xay \u0111\u1ec3 l\u00e2u ngo\u00e0i s\u00e1ng b\u1ecb gi\u1ea3m v\u1ecb cay.<\/li>\n<li>Tinh th\u1ec3 m\u00e0u v\u00e0ng nh\u1ea1t, g\u1ea7n nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc, tan trong ethanol, cloroform. V\u1ecb cay do piperine k\u00edch ho\u1ea1t th\u1ee5 th\u1ec3 nhi\u1ec7t TRPV1 v\u00e0 TRPA1.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>H\u1ea1t ti\u00eau (th\u01b0\u1eddng l\u00e0 ti\u00eau \u0111en) \u0111\u01b0\u1ee3c nghi\u1ec1n, chi\u1ebft b\u1eb1ng dung m\u00f4i (ethanol, ho\u1eb7c CO<sub>2<\/sub> si\u00eau t\u1edbi h\u1ea1n cho oleoresin h\u1ea1t ti\u00eau), r\u1ed3i k\u1ebft tinh l\u1ea1i \u0111\u1ec3 thu piperine tinh khi\u1ebft. Vi\u1ec7t Nam l\u00e0 qu\u1ed1c gia s\u1ea3n xu\u1ea5t v\u00e0 xu\u1ea5t kh\u1ea9u h\u1ea1t ti\u00eau l\u1edbn nh\u1ea5t th\u1ebf gi\u1edbi.<\/p>\n<h2>Applications<\/h2>\n<ul>\n<li>Th\u1ef1c ph\u1ea9m b\u1ed5 sung; piperine \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u nhi\u1ec1u v\u1ec1 kh\u1ea3 n\u0103ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u1ea5p thu v\u00e0 chuy\u1ec3n h\u00f3a m\u1ed9t s\u1ed1 ch\u1ea5t kh\u00e1c, n\u00ean th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n trong c\u00f4ng th\u1ee9c ph\u1ed1i h\u1ee3p (v\u00ed d\u1ee5 v\u1edbi <a href=\"https:\/\/cpc1.vn\/en\/nguyen-lieu-chiet-xuat-cu-nghe-nano-curcumin-5\/\">curcumin<\/a>).<\/li>\n<li>Ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng v\u1ecb cay trong th\u1ef1c ph\u1ea9m (d\u1ea1ng oleoresin h\u1ea1t ti\u00eau).<\/li>\n<\/ul>\n<h2>Note<\/h2>\n<p>V\u00ec c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn enzym chuy\u1ec3n h\u00f3a thu\u1ed1c \u1edf gan v\u00e0 ru\u1ed9t, s\u1ea3n ph\u1ea9m ch\u1ee9a piperine h\u00e0m l\u01b0\u1ee3ng cao c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi m\u1ed9t s\u1ed1 thu\u1ed1c. Ng\u01b0\u1eddi \u0111ang d\u00f9ng thu\u1ed1c n\u00ean h\u1ecfi \u00fd ki\u1ebfn chuy\u00ean gia y t\u1ebf.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Khi d\u00f9ng l\u00e0m th\u00e0nh ph\u1ea7n c\u1ee7a th\u1ef1c ph\u1ea9m ho\u1eb7c th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe, s\u1ea3n ph\u1ea9m tu\u00e2n theo Lu\u1eadt An to\u00e0n th\u1ef1c ph\u1ea9m, Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP v\u00e0 c\u00e1c v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n m\u1edbi nh\u1ea5t tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Piperine \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Piperine\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Piperine<\/a><\/li>\n<li>Wikipedia \u2013 Black pepper \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Black_pepper\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Black_pepper<\/a><\/li>\n<li>Wikidata \u2013 \u0111\u1ecbnh danh h\u00f3a h\u1ecdc (CAS, c\u00f4ng th\u1ee9c) \u2014 <a href=\"https:\/\/www.wikidata.org\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.wikidata.org\/<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Piperine (chi\u1ebft xu\u1ea5t h\u1ed3 ti\u00eau): c\u1ea5u t\u1ea1o, v\u1ecb cay, s\u1ea3n xu\u1ea5t v\u00e0 \u1ee9ng d\u1ee5ng Piperine l\u00e0 alkaloid ch\u00ednh t\u1ea1o v\u1ecb cay c\u1ee7a h\u1ea1t ti\u00eau \u0111en (Piper nigrum) v\u00e0 ti\u00eau d\u00e0i (Piper longum). Chi\u1ebft xu\u1ea5t h\u1ed3 ti\u00eau ti\u00eau chu\u1ea9n h\u00f3a theo piperine (th\u01b0\u1eddng 95% tr\u1edf l\u00ean) l\u00e0 nguy\u00ean li\u1ec7u ph\u1ed5 bi\u1ebfn trong th\u1ef1c ph\u1ea9m b\u1ed5 sung. [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2946,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-736","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/piperine.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/piperine-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/piperine-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/piperine-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/piperine-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/piperine.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/piperine.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/piperine-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":1,"uagb_excerpt":"Piperine (chi\u1ebft xu\u1ea5t h\u1ed3 ti\u00eau): c\u1ea5u t\u1ea1o, v\u1ecb cay, s\u1ea3n xu\u1ea5t v\u00e0 \u1ee9ng d\u1ee5ng Piperine l\u00e0 alkaloid ch\u00ednh t\u1ea1o v\u1ecb cay c\u1ee7a h\u1ea1t ti\u00eau \u0111en (Piper nigrum) v\u00e0 ti\u00eau d\u00e0i (Piper longum). Chi\u1ebft xu\u1ea5t h\u1ed3 ti\u00eau ti\u00eau chu\u1ea9n h\u00f3a theo piperine (th\u01b0\u1eddng 95% tr\u1edf l\u00ean) l\u00e0 nguy\u00ean li\u1ec7u ph\u1ed5 bi\u1ebfn trong th\u1ef1c ph\u1ea9m b\u1ed5 sung.&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/736","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=736"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/736\/revisions"}],"predecessor-version":[{"id":3079,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/736\/revisions\/3079"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2946"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=736"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=736"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}