{"id":733,"date":"2025-05-29T07:37:02","date_gmt":"2025-05-29T07:37:02","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-dl-methionine\/"},"modified":"2026-09-28T22:32:34","modified_gmt":"2026-09-28T15:32:34","slug":"nguyen-lieu-dl-methionine","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-dl-methionine\/","title":{"rendered":"DL-Methionine: c\u1ea5u t\u1ea1o, t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc v\u00e0 \u1ee9ng d\u1ee5ng"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">DL-Methionine: c\u1ea5u t\u1ea1o, t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc v\u00e0 \u1ee9ng d\u1ee5ng<\/h1>\n<p><strong>Methionine<\/strong> (methionin) l\u00e0 acid amin thi\u1ebft y\u1ebfu c\u00f3 nguy\u00ean t\u1eed <strong>l\u01b0u hu\u1ef3nh<\/strong> trong m\u1ea1ch b\u00ean (nh\u00f3m thioether \u2013S\u2013CH<sub>3<\/sub>). <strong>DL-Methionine<\/strong> l\u00e0 h\u1ed7n h\u1ee3p racemic, g\u1ed3m hai \u0111\u1ed3ng ph\u00e2n L v\u00e0 D v\u1edbi t\u1ec9 l\u1ec7 b\u1eb1ng nhau. \u0110\u00e2y l\u00e0 acid amin \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc v\u1edbi s\u1ea3n l\u01b0\u1ee3ng l\u1edbn nh\u1ea5t.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>DL-Methionine, methionin, acid 2-amino-4-(methylthio)butanoic; k\u00fd hi\u1ec7u Met, M<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c, kh\u1ed1i l\u01b0\u1ee3ng mol<\/td>\n<td>C<sub>5<\/sub>H<sub>11<\/sub>NO<sub>2<\/sub>S \u2013 149,21 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>59-51-8 (DL); 63-68-3 (L-methionine)<\/td>\n<\/tr>\n<tr>\n<td>H\u00e0m l\u01b0\u1ee3ng l\u01b0u hu\u1ef3nh (t\u00ednh theo c\u00f4ng th\u1ee9c)<\/td>\n<td>kho\u1ea3ng 21,5%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u1ea5u t\u1ea1o v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Methionin l\u00e0 acid amin m\u1edf \u0111\u1ea7u cho qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p h\u1ea7u h\u1ebft protein: m\u00e3 kh\u1edfi \u0111\u1ea7u AUG tr\u00ean mRNA m\u00e3 h\u00f3a methionin.<\/li>\n<li>Tinh th\u1ec3 d\u1ea1ng v\u1ea3y ho\u1eb7c b\u1ed9t m\u00e0u tr\u1eafng, c\u00f3 m\u00f9i l\u01b0u hu\u1ef3nh \u0111\u1eb7c tr\u01b0ng, tan v\u1eeba ph\u1ea3i trong n\u01b0\u1edbc.<\/li>\n<li>Nh\u00f3m thioether d\u1ec5 b\u1ecb oxy h\u00f3a th\u00e0nh methionin sulfoxid, n\u00ean c\u1ea7n tr\u00e1nh ch\u1ea5t oxy h\u00f3a khi b\u1ea3o qu\u1ea3n v\u00e0 ch\u1ebf bi\u1ebfn.<\/li>\n<li><strong>V\u00ec sao d\u00f9ng \u0111\u01b0\u1ee3c d\u1ea1ng DL?<\/strong> Nhi\u1ec1u lo\u00e0i \u0111\u1ed9ng v\u1eadt (v\u00e0 \u1edf m\u1ee9c \u0111\u1ed9 nh\u1ea5t \u0111\u1ecbnh c\u1ea3 ng\u01b0\u1eddi) chuy\u1ec3n \u0111\u01b0\u1ee3c D-methionin th\u00e0nh L-methionin, n\u00ean d\u1ea1ng DL r\u1ebb h\u01a1n v\u1eabn c\u00f3 gi\u00e1 tr\u1ecb dinh d\u01b0\u1ee1ng. \u0110\u00e2y l\u00e0 tr\u01b0\u1eddng h\u1ee3p ngo\u1ea1i l\u1ec7; v\u1edbi ph\u1ea7n l\u1edbn acid amin kh\u00e1c, ch\u1ec9 d\u1ea1ng L c\u00f3 gi\u00e1 tr\u1ecb.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>DL-Methionine \u0111\u01b0\u1ee3c <strong>t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc<\/strong> t\u1eeb acrolein, methyl mercaptan v\u00e0 hydro cyanid, qua trung gian hydantoin, r\u1ed3i th\u1ee7y ph\u00e2n v\u00e0 k\u1ebft tinh. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y t\u1ea1o s\u1ea3n ph\u1ea9m racemic. L-Methionine tinh khi\u1ebft (d\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m, dinh d\u01b0\u1ee1ng l\u00e2m s\u00e0ng) \u0111\u01b0\u1ee3c thu b\u1eb1ng c\u00e1ch t\u00e1ch \u0111\u1ed3ng ph\u00e2n b\u1eb1ng enzym ho\u1eb7c b\u1eb1ng l\u00ean men.<\/p>\n<h2>Applications<\/h2>\n<ul>\n<li><strong>Animal Feed<\/strong>: \u1ee9ng d\u1ee5ng l\u1edbn nh\u1ea5t. Methionin th\u01b0\u1eddng l\u00e0 acid amin gi\u1edbi h\u1ea1n th\u1ee9 nh\u1ea5t trong kh\u1ea9u ph\u1ea7n gia c\u1ea7m.<\/li>\n<li>Th\u1ef1c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m b\u1ed5 sung (theo quy \u0111\u1ecbnh t\u1eebng n\u01b0\u1edbc); dinh d\u01b0\u1ee1ng l\u00e2m s\u00e0ng (th\u01b0\u1eddng d\u00f9ng d\u1ea1ng L).<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li><strong>Hoa K\u1ef3<\/strong>: 21 CFR 172.320 cho ph\u00e9p c\u1ea3 L- v\u00e0 DL-methionine l\u00e0m ph\u1ee5 gia c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng protein, t\u1ed1i \u0111a 3,1% kh\u1ed1i l\u01b0\u1ee3ng protein to\u00e0n ph\u1ea7n.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Khi d\u00f9ng l\u00e0m th\u00e0nh ph\u1ea7n c\u1ee7a th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe ho\u1eb7c th\u1ef1c ph\u1ea9m dinh d\u01b0\u1ee1ng, s\u1ea3n ph\u1ea9m tu\u00e2n theo Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP v\u00e0 c\u00e1c v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n m\u1edbi nh\u1ea5t tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ch\u1ea5t li\u00ean quan<\/h2>\n<ul>\n<li><a href=\"https:\/\/cpc1.vn\/en\/nguyen-lieu-l-cystine\/\">L-Cystine<\/a> (acid amin ch\u1ee9a l\u01b0u hu\u1ef3nh); S-adenosylmethionin.<\/li>\n<\/ul>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Methionine \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Methionine\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Methionine<\/a><\/li>\n<li>Wikidata \u2013 DL-methionine (CAS 59-51-8), L-methionine (CAS 63-68-3) \u2014 <a href=\"https:\/\/www.wikidata.org\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.wikidata.org\/<\/a><\/li>\n<li>U.S. FDA \u2013 21 CFR 172.320 Amino acids \u2014 <a href=\"https:\/\/www.law.cornell.edu\/cfr\/text\/21\/172.320\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.law.cornell.edu\/cfr\/text\/21\/172.320<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>DL-Methionine: c\u1ea5u t\u1ea1o, t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc v\u00e0 \u1ee9ng d\u1ee5ng Methionine (methionin) l\u00e0 acid amin thi\u1ebft y\u1ebfu c\u00f3 nguy\u00ean t\u1eed l\u01b0u hu\u1ef3nh trong m\u1ea1ch b\u00ean (nh\u00f3m thioether \u2013S\u2013CH3). DL-Methionine l\u00e0 h\u1ed7n h\u1ee3p racemic, g\u1ed3m hai \u0111\u1ed3ng ph\u00e2n L v\u00e0 D v\u1edbi t\u1ec9 l\u1ec7 b\u1eb1ng nhau. \u0110\u00e2y l\u00e0 acid amin \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng t\u1ed5ng h\u1ee3p [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2910,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-733","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dl-methionine.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dl-methionine-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dl-methionine-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dl-methionine-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dl-methionine-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dl-methionine.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dl-methionine.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dl-methionine-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"DL-Methionine: c\u1ea5u t\u1ea1o, t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc v\u00e0 \u1ee9ng d\u1ee5ng Methionine (methionin) l\u00e0 acid amin thi\u1ebft y\u1ebfu c\u00f3 nguy\u00ean t\u1eed l\u01b0u hu\u1ef3nh trong m\u1ea1ch b\u00ean (nh\u00f3m thioether \u2013S\u2013CH3). DL-Methionine l\u00e0 h\u1ed7n h\u1ee3p racemic, g\u1ed3m hai \u0111\u1ed3ng ph\u00e2n L v\u00e0 D v\u1edbi t\u1ec9 l\u1ec7 b\u1eb1ng nhau. \u0110\u00e2y l\u00e0 acid amin \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng t\u1ed5ng h\u1ee3p&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/733","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=733"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/733\/revisions"}],"predecessor-version":[{"id":3043,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/733\/revisions\/3043"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2910"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=733"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=733"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=733"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}