{"id":729,"date":"2025-05-29T07:34:45","date_gmt":"2025-05-29T07:34:45","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-chiet-xuat-tu-mam-dau-nanh-soy-isoflavones\/"},"modified":"2026-09-28T22:26:28","modified_gmt":"2026-09-28T15:26:28","slug":"nguyen-lieu-chiet-xuat-tu-mam-dau-nanh-soy-isoflavones","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-chiet-xuat-tu-mam-dau-nanh-soy-isoflavones\/","title":{"rendered":"Isoflavone \u0111\u1eadu n\u00e0nh: th\u00e0nh ph\u1ea7n, d\u1ea1ng glycosid v\u00e0 aglycon, chi\u1ebft xu\u1ea5t"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Isoflavone \u0111\u1eadu n\u00e0nh: th\u00e0nh ph\u1ea7n, d\u1ea1ng glycosid v\u00e0 aglycon, chi\u1ebft xu\u1ea5t<\/h1>\n<p><strong>Isoflavone \u0111\u1eadu n\u00e0nh<\/strong> l\u00e0 nh\u00f3m h\u1ee3p ch\u1ea5t phenol c\u00f3 trong h\u1ea1t \u0111\u1eadu n\u00e0nh (<em>Glycine max<\/em>), g\u1ed3m <strong>genistein<\/strong>, <strong>daidzein<\/strong>, <strong>glycitein<\/strong> v\u00e0 c\u00e1c d\u1ea1ng g\u1eafn \u0111\u01b0\u1eddng c\u1ee7a ch\u00fang. Isoflavon c\u00f3 c\u1ea5u tr\u00fac gi\u1ed1ng estrogen n\u00ean \u0111\u01b0\u1ee3c x\u1ebfp v\u00e0o nh\u00f3m <strong>phytoestrogen<\/strong>. Nguy\u00ean li\u1ec7u th\u01b0\u01a1ng m\u1ea1i th\u01b0\u1eddng chi\u1ebft t\u1eeb <strong>m\u1ea7m \u0111\u1eadu n\u00e0nh<\/strong> (tr\u1ee5 ph\u00f4i), ph\u1ea7n gi\u00e0u isoflavon nh\u1ea5t.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>Isoflavone \u0111\u1eadu n\u00e0nh, soy isoflavones, chi\u1ebft xu\u1ea5t m\u1ea7m \u0111\u1eadu n\u00e0nh<\/td>\n<\/tr>\n<tr>\n<td>Lo\u00e0i<\/td>\n<td><em>Glycine max (L.) Merr.<\/em>, h\u1ecd \u0110\u1eadu (Fabaceae)<\/td>\n<\/tr>\n<tr>\n<td>B\u1ed9 ph\u1eadn d\u00f9ng<\/td>\n<td>H\u1ea1t, \u0111\u1eb7c bi\u1ec7t m\u1ea7m h\u1ea1t (tr\u1ee5 ph\u00f4i)<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ho\u1ea1t ch\u1ea5t ch\u00ednh<\/td>\n<td>Isoflavon: genistein, daidzein, glycitein (d\u1ea1ng glycosid genistin, daidzin, glycitin v\u00e0 d\u1ea1ng malonyl, acetyl)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u00e2y v\u00e0 d\u01b0\u1ee3c li\u1ec7u<\/h2>\n<p>H\u1ea1t \u0111\u1eadu n\u00e0nh ch\u1ee9a isoflavon ch\u1ee7 y\u1ebfu \u1edf d\u1ea1ng glycosid. M\u1ea7m h\u1ea1t (hypocotyl) tuy ch\u1ec9 chi\u1ebfm m\u1ed9t ph\u1ea7n nh\u1ecf kh\u1ed1i l\u01b0\u1ee3ng h\u1ea1t nh\u01b0ng c\u00f3 n\u1ed3ng \u0111\u1ed9 isoflavon cao h\u01a1n nhi\u1ec1u so v\u1edbi l\u00e1 m\u1ea7m, v\u00e0 gi\u00e0u daidzein, glycitein h\u01a1n. Th\u1ef1c ph\u1ea9m l\u00ean men (t\u01b0\u01a1ng, miso, tempeh) c\u00f3 t\u1ef7 l\u1ec7 d\u1ea1ng aglycon cao h\u01a1n do vi sinh v\u1eadt c\u1eaft \u0111\u01b0\u1eddng.<\/p>\n<h2>Th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc<\/h2>\n<ul>\n<li><strong>D\u1ea1ng glycosid<\/strong>: genistin, daidzin, glycitin; v\u00e0 c\u00e1c d\u1ea1ng malonyl-, acetyl-glycosid.<\/li>\n<li><strong>D\u1ea1ng aglycon<\/strong>: genistein, daidzein, glycitein.<\/li>\n<li>Saponin \u0111\u1eadu n\u00e0nh, protein.<\/li>\n<\/ul>\n<h2>Chi\u1ebft xu\u1ea5t v\u00e0 ti\u00eau chu\u1ea9n h\u00f3a<\/h2>\n<p>M\u1ea7m \u0111\u1eadu n\u00e0nh ho\u1eb7c h\u1ea1t \u0111\u01b0\u1ee3c chi\u1ebft b\u1eb1ng ethanol \u2013 n\u01b0\u1edbc, tinh ch\u1ebf qua nh\u1ef1a h\u1ea5p ph\u1ee5 v\u00e0 s\u1ea5y; nguy\u00ean li\u1ec7u ti\u00eau chu\u1ea9n h\u00f3a theo <strong>t\u1ed5ng isoflavon<\/strong> (v\u00ed d\u1ee5 10%, 40%, 80%). C\u1ea7n l\u01b0u \u00fd c\u00e1ch t\u00ednh: &#8220;t\u1ed5ng isoflavon&#8221; t\u00ednh theo kh\u1ed1i l\u01b0\u1ee3ng glycosid cho con s\u1ed1 cao h\u01a1n t\u00ednh quy \u0111\u1ed5i v\u1ec1 aglycon (kho\u1ea3ng 60% kh\u1ed1i l\u01b0\u1ee3ng glycosid). C\u00f3 lo\u1ea1i \u0111\u01b0\u1ee3c th\u1ee7y ph\u00e2n b\u1eb1ng enzym, l\u00ean men \u0111\u1ec3 t\u0103ng t\u1ef7 l\u1ec7 aglycon.<\/p>\n<h2>Ch\u1ec9 ti\u00eau ch\u1ea5t l\u01b0\u1ee3ng n\u00ean xem<\/h2>\n<ul>\n<li>Isoflavon t\u1eebng d\u1ea1ng (HPLC), c\u00e1ch quy \u0111\u1ed5i (glycosid hay aglycon).<\/li>\n<li>Ngu\u1ed3n \u0111\u1eadu n\u00e0nh (bi\u1ebfn \u0111\u1ed5i gen hay kh\u00f4ng \u2013 m\u1ed9t s\u1ed1 th\u1ecb tr\u01b0\u1eddng y\u00eau c\u1ea7u ghi nh\u00e3n).<\/li>\n<li>Kim lo\u1ea1i n\u1eb7ng, vi sinh v\u1eadt, d\u01b0 l\u01b0\u1ee3ng thu\u1ed1c b\u1ea3o v\u1ec7 th\u1ef1c v\u1eadt; \u0111\u1ed9c t\u1ed1 vi n\u1ea5m v\u1edbi d\u01b0\u1ee3c li\u1ec7u d\u1ec5 m\u1ed1c.<\/li>\n<\/ul>\n<h2>Applications<\/h2>\n<ul>\n<li>Th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe; th\u1ef1c ph\u1ea9m t\u1eeb \u0111\u1eadu n\u00e0nh.<\/li>\n<li>M\u1ef9 ph\u1ea9m.<\/li>\n<li>C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n<h2>An to\u00e0n v\u00e0 l\u01b0u \u00fd<\/h2>\n<ul>\n<li><strong>\u0110\u1eadu n\u00e0nh l\u00e0 ch\u1ea5t g\u00e2y d\u1ecb \u1ee9ng<\/strong> ph\u1ea3i ghi nh\u00e3n theo quy \u0111\u1ecbnh.<\/li>\n<li>Do ho\u1ea1t t\u00ednh gi\u1ed1ng estrogen, ng\u01b0\u1eddi c\u00f3 b\u1ec7nh l\u00fd ph\u1ee5 thu\u1ed9c hormon, ph\u1ee5 n\u1eef mang thai, cho con b\u00fa, tr\u1ebb em c\u1ea7n h\u1ecfi \u00fd ki\u1ebfn chuy\u00ean gia y t\u1ebf tr\u01b0\u1edbc khi d\u00f9ng s\u1ea3n ph\u1ea9m h\u00e0m l\u01b0\u1ee3ng cao; c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi thu\u1ed1c n\u1ed9i ti\u1ebft, thu\u1ed1c tuy\u1ebfn gi\u00e1p.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Khi d\u00f9ng l\u00e0m th\u00e0nh ph\u1ea7n c\u1ee7a th\u1ef1c ph\u1ea9m ho\u1eb7c th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe, s\u1ea3n ph\u1ea9m tu\u00e2n theo Lu\u1eadt An to\u00e0n th\u1ef1c ph\u1ea9m, Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP v\u00e0 c\u00e1c v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n m\u1edbi nh\u1ea5t tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Isoflavone \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Isoflavone\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Isoflavone<\/a><\/li>\n<li>Wikipedia \u2013 Genistein \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Genistein\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Genistein<\/a><\/li>\n<li>Wikipedia \u2013 Daidzein \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Daidzein\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Daidzein<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Isoflavone \u0111\u1eadu n\u00e0nh: th\u00e0nh ph\u1ea7n, d\u1ea1ng glycosid v\u00e0 aglycon, chi\u1ebft xu\u1ea5t Isoflavone \u0111\u1eadu n\u00e0nh l\u00e0 nh\u00f3m h\u1ee3p ch\u1ea5t phenol c\u00f3 trong h\u1ea1t \u0111\u1eadu n\u00e0nh (Glycine max), g\u1ed3m genistein, daidzein, glycitein v\u00e0 c\u00e1c d\u1ea1ng g\u1eafn \u0111\u01b0\u1eddng c\u1ee7a ch\u00fang. Isoflavon c\u00f3 c\u1ea5u tr\u00fac gi\u1ed1ng estrogen n\u00ean \u0111\u01b0\u1ee3c x\u1ebfp v\u00e0o nh\u00f3m phytoestrogen. Nguy\u00ean li\u1ec7u th\u01b0\u01a1ng m\u1ea1i th\u01b0\u1eddng chi\u1ebft [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3476,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-729","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isoflavone-dau-nanh.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isoflavone-dau-nanh-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isoflavone-dau-nanh-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isoflavone-dau-nanh-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isoflavone-dau-nanh-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isoflavone-dau-nanh.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isoflavone-dau-nanh.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/isoflavone-dau-nanh-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Isoflavone \u0111\u1eadu n\u00e0nh: th\u00e0nh ph\u1ea7n, d\u1ea1ng glycosid v\u00e0 aglycon, chi\u1ebft xu\u1ea5t Isoflavone \u0111\u1eadu n\u00e0nh l\u00e0 nh\u00f3m h\u1ee3p ch\u1ea5t phenol c\u00f3 trong h\u1ea1t \u0111\u1eadu n\u00e0nh (Glycine max), g\u1ed3m genistein, daidzein, glycitein v\u00e0 c\u00e1c d\u1ea1ng g\u1eafn \u0111\u01b0\u1eddng c\u1ee7a ch\u00fang. Isoflavon c\u00f3 c\u1ea5u tr\u00fac gi\u1ed1ng estrogen n\u00ean \u0111\u01b0\u1ee3c x\u1ebfp v\u00e0o nh\u00f3m phytoestrogen. Nguy\u00ean li\u1ec7u th\u01b0\u01a1ng m\u1ea1i th\u01b0\u1eddng chi\u1ebft&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=729"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/729\/revisions"}],"predecessor-version":[{"id":1360,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/729\/revisions\/1360"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3476"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}