{"id":721,"date":"2025-05-29T07:31:37","date_gmt":"2025-05-29T07:31:37","guid":{"rendered":"http:\/\/http:\/\/chempharco.com\/2025\/05\/29\/nguyen-lieu-chiet-xuat-cu-nghe-nano-curcumin-5\/"},"modified":"2026-09-30T15:19:19","modified_gmt":"2026-09-30T08:19:19","slug":"nguyen-lieu-chiet-xuat-cu-nghe-nano-curcumin-5","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nguyen-lieu-chiet-xuat-cu-nghe-nano-curcumin-5\/","title":{"rendered":"Curcumin (chi\u1ebft xu\u1ea5t ngh\u1ec7, INS 100): c\u1ea5u t\u1ea1o, t\u00ednh ch\u1ea5t v\u00e0 c\u00e1c d\u1ea1ng nguy\u00ean li\u1ec7u"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Curcumin (chi\u1ebft xu\u1ea5t ngh\u1ec7, INS 100): c\u1ea5u t\u1ea1o, t\u00ednh ch\u1ea5t v\u00e0 c\u00e1c d\u1ea1ng nguy\u00ean li\u1ec7u<\/h1>\n<p><strong>Curcumin<\/strong> l\u00e0 s\u1eafc t\u1ed1 v\u00e0ng ch\u00ednh c\u1ee7a <strong>c\u1ee7 ngh\u1ec7<\/strong> (<em>Curcuma longa<\/em>, h\u1ecd G\u1eebng \u2013 Zingiberaceae). Trong th\u1ef1c ph\u1ea9m, curcumin l\u00e0 ph\u1ea9m m\u00e0u m\u00e3 <strong>INS 100(i)<\/strong>; b\u1ed9t ngh\u1ec7 v\u00e0 oleoresin ngh\u1ec7 l\u00e0 INS 100(ii). &#8220;Chi\u1ebft xu\u1ea5t ngh\u1ec7&#8221; tr\u00ean th\u1ecb tr\u01b0\u1eddng th\u01b0\u1eddng l\u00e0 h\u1ed7n h\u1ee3p <strong>curcuminoid<\/strong> ti\u00eau chu\u1ea9n h\u00f3a, v\u00ed d\u1ee5 95%.<\/p>\n<figure class=\"wp-block-image size-large cpc1-anh-cay\"><img decoding=\"async\" src=\"https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/curcuma-longa-cay-nguyen-lieu.jpg\" alt=\"C\u00e2y ngh\u1ec7 \u2013 Curcuma longa, ngu\u1ed3n nguy\u00ean li\u1ec7u chi\u1ebft xu\u1ea5t\"\/><figcaption>Ngh\u1ec7 (<em>Curcuma longa<\/em>). \u1ea2nh: Govind Bhalerao, <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Close-up_of_freshly_harvested_Vasmat_turmeric_fingers.jpg\" rel=\"nofollow noopener\" target=\"_blank\">Wikimedia Commons<\/a>, gi\u1ea5y ph\u00e9p <a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/\" rel=\"nofollow noopener\" target=\"_blank\">CC0<\/a>.<\/figcaption><\/figure>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean g\u1ecdi<\/td>\n<td>Curcumin, diferuloylmethan; E100<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c, kh\u1ed1i l\u01b0\u1ee3ng mol<\/td>\n<td>C<sub>21<\/sub>H<sub>20<\/sub>O<sub>6<\/sub> \u2013 368,39 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>458-37-7<\/td>\n<\/tr>\n<tr>\n<td>Ngu\u1ed3n<\/td>\n<td>Th\u00e2n r\u1ec5 (c\u1ee7) ngh\u1ec7 v\u00e0ng, <em>Curcuma longa<\/em> L.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u1ea5u t\u1ea1o v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>&#8220;Curcuminoid&#8221; g\u1ed3m ba ch\u1ea5t: <strong>curcumin<\/strong> (chi\u1ebfm ph\u1ea7n l\u1edbn), <strong>demethoxycurcumin<\/strong> v\u00e0 <strong>bisdemethoxycurcumin<\/strong>. C\u1ee7 ngh\u1ec7 kh\u00f4 th\u01b0\u1eddng ch\u1ee9a v\u00e0i ph\u1ea7n tr\u0103m curcuminoid.<\/li>\n<li>Ph\u00e2n t\u1eed c\u00f3 hai v\u00f2ng phenol n\u1ed1i qua m\u1ea1ch \u03b2-diceton, t\u1ed3n t\u1ea1i ch\u1ee7 y\u1ebfu \u1edf d\u1ea1ng keto-enol.<\/li>\n<li>B\u1ed9t m\u00e0u v\u00e0ng cam. <strong>G\u1ea7n nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc<\/strong> \u1edf pH acid v\u00e0 trung t\u00ednh, tan trong ethanol, aceton, d\u1ea7u (\u00edt).<\/li>\n<li><strong>\u0110\u1ed5i m\u00e0u theo pH<\/strong>: v\u00e0ng trong m\u00f4i tr\u01b0\u1eddng acid, chuy\u1ec3n \u0111\u1ecf n\u00e2u trong m\u00f4i tr\u01b0\u1eddng ki\u1ec1m. Trong m\u00f4i tr\u01b0\u1eddng ki\u1ec1m, curcumin c\u0169ng k\u00e9m b\u1ec1n, b\u1ecb ph\u00e2n h\u1ee7y nhanh.<\/li>\n<li><strong>Nh\u1ea1y \u00e1nh s\u00e1ng<\/strong>: b\u1ecb phai m\u00e0u khi ph\u01a1i s\u00e1ng.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t v\u00e0 c\u00e1c d\u1ea1ng nguy\u00ean li\u1ec7u<\/h2>\n<ul>\n<li><strong>Curcumin 95%<\/strong>: ngh\u1ec7 kh\u00f4 \u0111\u01b0\u1ee3c chi\u1ebft b\u1eb1ng dung m\u00f4i (ethanol, aceton, ethyl acetat) th\u00e0nh oleoresin, r\u1ed3i k\u1ebft tinh curcuminoid.<\/li>\n<li><strong>D\u1ea1ng ph\u00e2n t\u00e1n trong n\u01b0\u1edbc<\/strong> (&#8220;nano curcumin&#8221;, d\u1ea1ng h\u00f2a tan): curcuminoid \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf th\u00e0nh h\u1ea1t nano, micelle, liposome, ph\u1ee9c v\u1edbi cyclodextrin ho\u1eb7c phospholipid, \u0111\u1ec3 ph\u00e2n t\u00e1n trong n\u01b0\u1edbc v\u00e0 d\u00f9ng cho \u0111\u1ed3 u\u1ed1ng, d\u1ea1ng l\u1ecfng. H\u00e0m l\u01b0\u1ee3ng curcumin trong c\u00e1c d\u1ea1ng n\u00e0y th\u01b0\u1eddng th\u1ea5p (v\u00ed d\u1ee5 5\u201325%), v\u00ec ph\u1ea7n c\u00f2n l\u1ea1i l\u00e0 ch\u1ea5t mang v\u00e0 ch\u1ea5t nh\u0169 h\u00f3a.<\/li>\n<li><strong>Liquid turmeric extract<\/strong> (glycerin, propylen glycol) cho m\u1ef9 ph\u1ea9m.<\/li>\n<\/ul>\n<h2>Applications<\/h2>\n<ul>\n<li>Ph\u1ea9m m\u00e0u v\u00e0ng: m\u00f9 t\u1ea1t, c\u00e0 ri, s\u1ea3n ph\u1ea9m s\u1eefa, b\u00e1nh k\u1eb9o, \u0111\u1ed3 u\u1ed1ng.<\/li>\n<li>Th\u1ef1c ph\u1ea9m b\u1ed5 sung; m\u1ef9 ph\u1ea9m.<\/li>\n<\/ul>\n<h2>An to\u00e0n v\u00e0 ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li><strong>JECFA<\/strong> \u0111\u1eb7t l\u01b0\u1ee3ng \u0103n v\u00e0o h\u1eb1ng ng\u00e0y ch\u1ea5p nh\u1eadn \u0111\u01b0\u1ee3c (ADI) cho curcumin l\u00e0 0\u20133 mg\/kg th\u1ec3 tr\u1ecdng.<\/li>\n<li><strong>Vi\u1ec7t Nam<\/strong>: curcumin (INS 100(i)) v\u00e0 ngh\u1ec7 (INS 100(ii)) c\u00f3 trong danh m\u1ee5c ph\u1ee5 gia ph\u1ea9m m\u00e0u \u0111\u01b0\u1ee3c ph\u00e9p theo Th\u00f4ng t\u01b0 24\/2019\/TT-BYT.<\/li>\n<\/ul>\n<p><!--my-pham--><\/p>\n<h2>In Cosmetics<\/h2>\n<p>Ngo\u00e0i d\u01b0\u1ee3c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m, nguy\u00ean li\u1ec7u t\u1eeb lo\u00e0i n\u00e0y c\u00f2n \u0111\u01b0\u1ee3c d\u00f9ng trong m\u1ef9 ph\u1ea9m d\u01b0\u1edbi c\u00e1c t\u00ean INCI sau (ch\u1ee9c n\u0103ng theo c\u01a1 s\u1edf d\u1eef li\u1ec7u CosIng c\u1ee7a \u1ee6y ban ch\u00e2u \u00c2u):<\/p>\n<table>\n<thead>\n<tr>\n<th>T\u00ean INCI<\/th>\n<th>D\u1ea1ng nguy\u00ean li\u1ec7u<\/th>\n<th>Ch\u1ee9c n\u0103ng (CosIng)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Curcuma Longa (Turmeric) Root Extract<\/td>\n<td>chi\u1ebft xu\u1ea5t b\u1eb1ng dung m\u00f4i (th\u01b0\u1eddng l\u00e0 n\u01b0\u1edbc, glycol ho\u1eb7c ethanol), sau \u0111\u00f3 pha lo\u00e3ng trong dung m\u00f4i mang<\/td>\n<td>t\u1ea1o h\u01b0\u01a1ng<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Theo CosIng, c\u00e1c t\u00ean INCI tr\u00ean kh\u00f4ng thu\u1ed9c ph\u1ee5 l\u1ee5c ch\u1ea5t c\u1ea5m (Annex II) hay h\u1ea1n ch\u1ebf (Annex III) c\u1ee7a EU t\u1ea1i th\u1eddi \u0111i\u1ec3m vi\u1ebft b\u00e0i; ph\u1ee5 l\u1ee5c c\u1ee7a Hi\u1ec7p \u0111\u1ecbnh m\u1ef9 ph\u1ea9m ASEAN \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadt theo danh m\u1ee5c n\u00e0y. T\u1ea1i Vi\u1ec7t Nam, m\u1ef9 ph\u1ea9m qu\u1ea3n l\u00fd theo Th\u00f4ng t\u01b0 06\/2011\/TT-BYT; t\u00ednh n\u0103ng c\u00f4ng b\u1ed1 ph\u1ea3i theo H\u01b0\u1edbng d\u1eabn c\u00f4ng b\u1ed1 t\u00ednh n\u0103ng m\u1ef9 ph\u1ea9m ASEAN, kh\u00f4ng \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 c\u00f4ng d\u1ee5ng nh\u01b0 thu\u1ed1c.<\/p>\n<p><!--\/my-pham--><\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd t\u1ea1i Vi\u1ec7t Nam<\/h2>\n<p>Khi d\u00f9ng l\u00e0m th\u00e0nh ph\u1ea7n c\u1ee7a th\u1ef1c ph\u1ea9m ho\u1eb7c th\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe, s\u1ea3n ph\u1ea9m tu\u00e2n theo Lu\u1eadt An to\u00e0n th\u1ef1c ph\u1ea9m, Ngh\u1ecb \u0111\u1ecbnh 15\/2018\/N\u0110-CP v\u00e0 c\u00e1c v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh c\u1ee7a B\u1ed9 Y t\u1ebf. Doanh nghi\u1ec7p c\u1ea7n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n m\u1edbi nh\u1ea5t tr\u01b0\u1edbc khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c.<\/p>\n<h2>Ch\u1ea5t li\u00ean quan<\/h2>\n<ul>\n<li><a href=\"https:\/\/cpc1.vn\/en\/nguyen-lieu-chiet-xuat-ho-tieu-piperine\/\">Piperine<\/a>; b\u1ed9t ngh\u1ec7, oleoresin ngh\u1ec7; ngh\u1ec7 \u0111en (<em>Curcuma zedoaria<\/em>, lo\u00e0i kh\u00e1c).<\/li>\n<\/ul>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<ul>\n<li>Wikipedia \u2013 Curcumin \u2014 <a href=\"https:\/\/en.wikipedia.org\/wiki\/Curcumin\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/en.wikipedia.org\/wiki\/Curcumin<\/a><\/li>\n<li>Wikidata \u2013 \u0111\u1ecbnh danh h\u00f3a h\u1ecdc (CAS, c\u00f4ng th\u1ee9c, m\u00e3 E) \u2014 <a href=\"https:\/\/www.wikidata.org\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.wikidata.org\/<\/a><\/li>\n<li>JECFA (FAO\/WHO) \u2013 c\u01a1 s\u1edf d\u1eef li\u1ec7u \u0111\u00e1nh gi\u00e1 ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u2014 <a href=\"https:\/\/apps.who.int\/food-additives-contaminants-jecfa-database\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/apps.who.int\/food-additives-contaminants-jecfa-database\/<\/a><\/li>\n<li>B\u1ed9 Y t\u1ebf \u2013 Th\u00f4ng t\u01b0 24\/2019\/TT-BYT v\u1ec1 qu\u1ea3n l\u00fd v\u00e0 s\u1eed d\u1ee5ng ph\u1ee5 gia th\u1ef1c ph\u1ea9m, Ph\u1ee5 l\u1ee5c 1 \u2014 <a href=\"https:\/\/vfa.gov.vn\/van-ban\/thong-tu-so-242019tt-byt-quy-dinh-ve-quan-ly-va-su-dung-phu-gia-thuc-pham.html\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/vfa.gov.vn\/van-ban\/thong-tu-so-242019tt-byt-quy-dinh-ve-quan-ly-va-su-dung-phu-gia-thuc-pham.html<\/a><\/li>\n<\/ul>\n<p><em>B\u00e0i vi\u1ebft cung c\u1ea5p th\u00f4ng tin ki\u1ebfn th\u1ee9c chung v\u1ec1 ch\u1ea5t\/nguy\u00ean li\u1ec7u, t\u1ed5ng h\u1ee3p v\u00e0 di\u1ec5n gi\u1ea3i t\u1eeb c\u00e1c ngu\u1ed3n c\u00f4ng khai n\u00eau tr\u00ean. N\u1ed9i dung n\u00e0y kh\u00f4ng thay th\u1ebf \u00fd ki\u1ebfn c\u1ee7a c\u01a1 quan qu\u1ea3n l\u00fd hay chuy\u00ean gia y t\u1ebf. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. Quy \u0111\u1ecbnh ph\u00e1p l\u00fd c\u00f3 th\u1ec3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu v\u0103n b\u1ea3n hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Curcumin (chi\u1ebft xu\u1ea5t ngh\u1ec7, INS 100): c\u1ea5u t\u1ea1o, t\u00ednh ch\u1ea5t v\u00e0 c\u00e1c d\u1ea1ng nguy\u00ean li\u1ec7u Curcumin l\u00e0 s\u1eafc t\u1ed1 v\u00e0ng ch\u00ednh c\u1ee7a c\u1ee7 ngh\u1ec7 (Curcuma longa, h\u1ecd G\u1eebng \u2013 Zingiberaceae). Trong th\u1ef1c ph\u1ea9m, curcumin l\u00e0 ph\u1ea9m m\u00e0u m\u00e3 INS 100(i); b\u1ed9t ngh\u1ec7 v\u00e0 oleoresin ngh\u1ec7 l\u00e0 INS 100(ii). &#8220;Chi\u1ebft xu\u1ea5t ngh\u1ec7&#8221; tr\u00ean th\u1ecb tr\u01b0\u1eddng th\u01b0\u1eddng [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1976,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-721","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kien-thuc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/curcuma-longa-cay-nguyen-lieu.jpg",1200,900,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/curcuma-longa-cay-nguyen-lieu-150x150.jpg",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/curcuma-longa-cay-nguyen-lieu-300x225.jpg",300,225,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/curcuma-longa-cay-nguyen-lieu-768x576.jpg",768,576,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/curcuma-longa-cay-nguyen-lieu-1024x768.jpg",1024,768,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/curcuma-longa-cay-nguyen-lieu.jpg",1200,900,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/curcuma-longa-cay-nguyen-lieu.jpg",1200,900,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/curcuma-longa-cay-nguyen-lieu-16x12.jpg",16,12,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":1,"uagb_excerpt":"Curcumin (chi\u1ebft xu\u1ea5t ngh\u1ec7, INS 100): c\u1ea5u t\u1ea1o, t\u00ednh ch\u1ea5t v\u00e0 c\u00e1c d\u1ea1ng nguy\u00ean li\u1ec7u Curcumin l\u00e0 s\u1eafc t\u1ed1 v\u00e0ng ch\u00ednh c\u1ee7a c\u1ee7 ngh\u1ec7 (Curcuma longa, h\u1ecd G\u1eebng \u2013 Zingiberaceae). Trong th\u1ef1c ph\u1ea9m, curcumin l\u00e0 ph\u1ea9m m\u00e0u m\u00e3 INS 100(i); b\u1ed9t ngh\u1ec7 v\u00e0 oleoresin ngh\u1ec7 l\u00e0 INS 100(ii). &#8220;Chi\u1ebft xu\u1ea5t ngh\u1ec7&#8221; tr\u00ean th\u1ecb tr\u01b0\u1eddng th\u01b0\u1eddng&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/721","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=721"}],"version-history":[{"count":5,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/721\/revisions"}],"predecessor-version":[{"id":5000,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/721\/revisions\/5000"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/1976"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=721"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=721"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=721"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}