{"id":3688,"date":"2026-09-29T09:38:52","date_gmt":"2026-09-29T02:38:52","guid":{"rendered":"https:\/\/cpc1.vn\/vitamin-e-tpgs\/"},"modified":"2026-09-29T12:16:46","modified_gmt":"2026-09-29T05:16:46","slug":"vitamin-e-tpgs","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/vitamin-e-tpgs\/","title":{"rendered":"Vitamin E TPGS (tocofersolan) \u2013 ch\u1ea5t tr\u1ee3 tan, nh\u0169 h\u00f3a, d\u1eabn thu\u1ed1c n\u1ec1n lipid"},"content":{"rendered":"

Vitamin E TPGS (tocofersolan) \u2013 ch\u1ea5t tr\u1ee3 tan, nh\u0169 h\u00f3a, d\u1eabn thu\u1ed1c n\u1ec1n lipid<\/h1>\n

Vitamin E TPGS<\/strong> (D-\u03b1-tocopheryl polyethylen glycol 1000 succinat, tocofersolan) l\u00e0 d\u1eabn ch\u1ea5t ester h\u00f3a c\u1ee7a vitamin E: acid succinic n\u1ed1i \u03b1-tocopherol v\u1edbi PEG 1000. Kh\u00e1c v\u1edbi tocopherol, TPGS l\u01b0\u1ee1ng th\u00e2n v\u00e0 th\u00e2n n\u01b0\u1edbc, tan \u0111\u01b0\u1ee3c trong n\u01b0\u1edbc. Trong b\u00e0o ch\u1ebf, TPGS ch\u1ee7 y\u1ebfu l\u00e0 ch\u1ea5t tr\u1ee3 tan<\/strong> v\u00e0 ch\u1ea5t nh\u0169 h\u00f3a<\/strong> (di\u1ec7n ho\u1ea1t kh\u00f4ng ion), \u0111\u1eb7c bi\u1ec7t l\u00e0m t\u00e1 d\u01b0\u1ee3c mang cho h\u1ec7 cung c\u1ea5p thu\u1ed1c n\u1ec1n lipid<\/strong>; ngo\u00e0i ra l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a, t\u1ea1o h\u1ed7n d\u1ecbch, n\u1ec1n thu\u1ed1c m\u1ee1 v\u00e0 t\u00e1 d\u01b0\u1ee3c d\u00ednh.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nTPGS, tocofersolan, tocopherol polyethylen glycol succinat, vitamin E PEG 1000 succinat, VEGS; t\u00ean th\u01b0\u01a1ng m\u1ea1i Kolliphor TPGS, speziol TPGS Pharma<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n9002-96-4; 30999-06-5<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC33<\/sub>O5<\/sub>H54<\/sub>(CH2<\/sub>CH2<\/sub>O)20\u201322<\/sub> \u2013 kho\u1ea3ng 1513<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ch\u1ed1ng oxy h\u00f3a, nh\u0169 h\u00f3a, di\u1ec7n ho\u1ea1t kh\u00f4ng ion, n\u1ec1n thu\u1ed1c m\u1ee1, t\u0103ng tan, t\u1ea1o h\u1ed7n d\u1ecbch, t\u00e1 d\u01b0\u1ee3c d\u00ednh vi\u00ean n\u00e9n\/vi\u00ean nang<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nUSP-NF (h\u00e0m l\u01b0\u1ee3ng \u03b1-tocopherol \u2265 25,0%; n\u0103ng su\u1ea5t quay c\u1ef1c \u2265 +24\u00b0)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t tr\u1ee3 tan, nh\u0169 h\u00f3a trong nang, vi\u00ean n\u00e9n, \u0111\u00f9n n\u00f3ng ch\u1ea3y, vi nh\u0169 t\u01b0\u01a1ng, ch\u1ebf ph\u1ea9m b\u00f4i v\u00e0 thu\u1ed1c ti\u00eam.<\/li>\n
  • \u1ee8ng d\u1ee5ng quan tr\u1ecdng: t\u00e1 d\u01b0\u1ee3c mang cho c\u00f4ng th\u1ee9c d\u1eabn thu\u1ed1c n\u1ec1n lipid v\u00e0 c\u00e1c h\u1ec7 cung c\u1ea5p thu\u1ed1c kh\u00e1c.<\/li>\n
  • \u0110\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u1ec1 c\u01a1 ch\u1ebf v\u00e0 vai tr\u00f2 \u1ee9c ch\u1ebf P-glycoprotein; c\u0169ng l\u00e0 ngu\u1ed3n vitamin E.<\/li>\n
  • M\u1ee9c d\u00f9ng th\u1ef1c t\u1ebf: \u0111\u00e3 c\u00f3 thu\u1ed1c nang ch\u1ee9a 280 mg TPGS\/nang, u\u1ed1ng 8 nang\/ng\u00e0y (2240 mg TPGS\/ng\u00e0y); thu\u1ed1c n\u00e0y \u0111\u00e3 ng\u1eebng l\u01b0u h\u00e0nh v\u00ec l\u00fd do th\u01b0\u01a1ng m\u1ea1i.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • S\u1ea3n ph\u1ea9m t\u1ed5ng h\u1ee3p, ch\u1ea5t r\u1eafn d\u1ea1ng s\u00e1p tr\u1eafng t\u1edbi n\u00e2u nh\u1ea1t, g\u1ea7n nh\u01b0 kh\u00f4ng v\u1ecb. L\u00e0 h\u1ed7n h\u1ee3p ch\u1ee7 y\u1ebfu g\u1ed3m PEG 1000 ester h\u00f3a \u0111\u01a1n, PEG 1000 ester h\u00f3a k\u00e9p, PEG 1000 t\u1ef1 do v\u00e0 tocopherol t\u1ef1 do.<\/li>\n
    • N\u1ed3ng \u0111\u1ed9 micell t\u1edbi h\u1ea1n 0,02% (kl\/kl, 37 \u00b0C); HLB kho\u1ea3ng 13,2; n\u00f3ng ch\u1ea3y 37\u201341 \u00b0C; t\u1ef7 tr\u1ecdng ri\u00eang 1,06 (45 \u00b0C).<\/li>\n
    • Tr\u1ed9n l\u1eabn v\u1edbi n\u01b0\u1edbc \u1edf m\u1ecdi t\u1ef7 l\u1ec7.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng t\u1edbi 4 n\u0103m. Ph\u1ea3n \u1ee9ng v\u1edbi ki\u1ec1m v\u00e0 acid. Dung d\u1ecbch n\u01b0\u1edbc b\u1ec1n trong kho\u1ea3ng pH 4,5\u20137,5, c\u00f3 th\u1ec3 \u1ed5n \u0111\u1ecbnh th\u00eam b\u1eb1ng propylen glycol.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi acid m\u1ea1nh v\u00e0 ki\u1ec1m m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Ester h\u00f3a nh\u00f3m acid c\u1ee7a D-\u03b1-tocopheryl acid succinat k\u1ebft tinh b\u1eb1ng polyethylen glycol 1000.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • \u0110\u00e3 d\u00f9ng \u1edf li\u1ec1u t\u1edbi 2240 mg\/ng\u00e0y trong m\u1ed9t thu\u1ed1c u\u1ed1ng. \u0110\u00e1nh gi\u00e1 an to\u00e0n ghi nh\u1eadn NOAEL tr\u00ean chu\u1ed9t c\u1ed1ng 1000 mg\/kg\/ng\u00e0y.<\/li>\n
      • N\u00ean \u0111eo g\u0103ng v\u00e0 k\u00ednh b\u1ea3o h\u1ed9 khi thao t\u00e1c.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS.<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Database (dung d\u1ecbch\/thu\u1ed1c nh\u1ecf m\u1eaft; nang, dung d\u1ecbch, vi\u00ean u\u1ed1ng; dung d\u1ecbch\/gi\u1ecdt b\u00f4i ngo\u00e0i) v\u00e0 Canadian Natural Health Products Ingredients Database.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Alpha tocopherol; xem th\u00eam polyethylen glycol, polysorbat, macrogol 15 hydroxystearat.<\/p>\n

          Ghi ch\u00fa:<\/strong> PubChem CID 71406.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Vitamin E Polyethylene Glycol Succinate<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Vitamin E TPGS (tocofersolan) \u2013 ch\u1ea5t tr\u1ee3 tan, nh\u0169 h\u00f3a, d\u1eabn thu\u1ed1c n\u1ec1n lipid Vitamin E TPGS (D-\u03b1-tocopheryl polyethylen glycol 1000 succinat, tocofersolan) l\u00e0 d\u1eabn ch\u1ea5t ester h\u00f3a c\u1ee7a vitamin E: acid succinic n\u1ed1i \u03b1-tocopherol v\u1edbi PEG 1000. Kh\u00e1c v\u1edbi tocopherol, TPGS l\u01b0\u1ee1ng th\u00e2n v\u00e0 th\u00e2n n\u01b0\u1edbc, tan \u0111\u01b0\u1ee3c trong n\u01b0\u1edbc. Trong b\u00e0o ch\u1ebf, TPGS […]<\/p>\n","protected":false},"author":1,"featured_media":3687,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3688","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-e-tpgs.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-e-tpgs-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-e-tpgs-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-e-tpgs-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-e-tpgs-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-e-tpgs.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-e-tpgs.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vitamin-e-tpgs-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Vitamin E TPGS (tocofersolan) \u2013 ch\u1ea5t tr\u1ee3 tan, nh\u0169 h\u00f3a, d\u1eabn thu\u1ed1c n\u1ec1n lipid Vitamin E TPGS (D-\u03b1-tocopheryl polyethylen glycol 1000 succinat, tocofersolan) l\u00e0 d\u1eabn ch\u1ea5t ester h\u00f3a c\u1ee7a vitamin E: acid succinic n\u1ed1i \u03b1-tocopherol v\u1edbi PEG 1000. Kh\u00e1c v\u1edbi tocopherol, TPGS l\u01b0\u1ee1ng th\u00e2n v\u00e0 th\u00e2n n\u01b0\u1edbc, tan \u0111\u01b0\u1ee3c trong n\u01b0\u1edbc. Trong b\u00e0o ch\u1ebf, TPGS…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3688"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3688\/revisions"}],"predecessor-version":[{"id":3983,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3688\/revisions\/3983"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3687"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3688"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3688"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}