{"id":3684,"date":"2026-09-29T09:37:28","date_gmt":"2026-09-29T02:37:28","guid":{"rendered":"https:\/\/cpc1.vn\/tromethamin\/"},"modified":"2026-09-29T12:16:28","modified_gmt":"2026-09-29T05:16:28","slug":"tromethamin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/tromethamin\/","title":{"rendered":"Tromethamin (trometamol, TRIS) \u2013 ch\u1ea5t \u0111\u1ec7m, ch\u1ea5t ki\u1ec1m h\u00f3a, t\u1ea1o mu\u1ed1i tan"},"content":{"rendered":"

Tromethamin (trometamol, TRIS) \u2013 ch\u1ea5t \u0111\u1ec7m, ch\u1ea5t ki\u1ec1m h\u00f3a, t\u1ea1o mu\u1ed1i tan<\/h1>\n

Tromethamin<\/strong> (trometamol, TRIS, tris(hydroxymethyl)aminomethan) l\u00e0 amin b\u1eadc m\u1ed9t c\u00f3 ba nh\u00f3m hydroxymethyl, d\u1ea1ng b\u1ed9t k\u1ebft tinh ho\u1eb7c tinh th\u1ec3 tr\u1eafng. V\u1edbi pKa kho\u1ea3ng 8,1\u20138,3, tromethamin l\u00e0 ch\u1ea5t \u0111\u1ec7m<\/strong> \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong thu\u1ed1c ti\u00eam, u\u1ed1ng, b\u00f4i v\u00e0 nh\u1ecf m\u1eaft; ngo\u00e0i ra l\u00e0 ch\u1ea5t ki\u1ec1m h\u00f3a<\/strong>, d\u00f9ng t\u1ea1o mu\u1ed1i tan trong n\u01b0\u1edbc<\/strong> c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t acid v\u00e0 l\u00e0m ch\u1ea5t nh\u0169 h\u00f3a<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nTrometamol, TRIS, tris(hydroxymethyl)aminomethan, aminotrimethylolmethan, THAM, trometamolum<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n77-86-1<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC4<\/sub>H11<\/sub>NO3<\/sub> \u2013 121,14<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ki\u1ec1m h\u00f3a, ch\u1ea5t \u0111\u1ec7m, ch\u1ea5t nh\u0169 h\u00f3a<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur. (Trometamol), USP-NF (Tromethamine)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t \u0111\u1ec7m trong thu\u1ed1c ti\u00eam, u\u1ed1ng, b\u00f4i v\u00e0 nh\u1ecf m\u1eaft.<\/li>\n
  • T\u1ea1o mu\u1ed1i tan trong n\u01b0\u1edbc c\u1ee7a thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (ketorolac, ibuprofen), c\u00f3 th\u1ec3 \u0111\u01b0a v\u00e0o ch\u1ea5t mang polymer \u0111\u1ec3 gi\u1ea3i ph\u00f3ng li\u00ean t\u1ee5c.<\/li>\n
  • Ch\u1ea5t nh\u0169 h\u00f3a cho kem, lotion m\u1ef9 ph\u1ea9m v\u00e0 nh\u0169 t\u01b0\u01a1ng d\u1ea7u kho\u00e1ng, s\u00e1p parafin.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh ho\u1eb7c tinh th\u1ec3 tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, kh\u00f4ng m\u00e0u.<\/li>\n
    • pKa 8,3 (20 \u00b0C), 7,82 (37 \u00b0C). D\u01b0\u1ee3c \u0111i\u1ec3n: kho\u1ea3ng n\u00f3ng ch\u1ea3y 168\u2013174 \u00b0C; pH 10,0\u201311,5; h\u00e0m l\u01b0\u1ee3ng 99,0\u2013101,0%.<\/li>\n
    • T\u1ef7 tr\u1ecdng 1,353 g\/cm\u00b3; s\u00f4i 219\u2013220 \u00b0C \u1edf 10 mmHg.<\/li>\n
    • \u0110\u1ed9 tan: d\u1ec5 tan trong n\u01b0\u1edbc; tan trong methanol, ethylen glycol, aceton; h\u01a1i tan trong ethanol 90%; r\u1ea5t kh\u00f3 tan trong cyclohexan, ethyl acetat, d\u1ea7u \u00f4 liu; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong cloroform, carbon tetraclorid.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      H\u00fat \u1ea9m. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh, base, \u0111\u1ed3ng, \u0111\u1ed3ng thau v\u00e0 nh\u00f4m.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Kh\u1eed ho\u1eb7c hydro h\u00f3a x\u00fac t\u00e1c h\u1ee3p ch\u1ea5t nitro t\u01b0\u01a1ng \u1ee9ng.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • D\u1ea1ng tinh khi\u1ebft \u0111\u1ed9c v\u1eeba khi nu\u1ed1t v\u00e0 ti\u00eam t\u0129nh m\u1ea1ch; k\u00edch \u1ee9ng m\u1eaft, da, \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t nh\u1eaft): ph\u00fac m\u1ea1c 3,3 g\/kg; t\u0129nh m\u1ea1ch 3,5 g\/kg; u\u1ed1ng 5,5 g\/kg. (Chu\u1ed9t c\u1ed1ng): t\u0129nh m\u1ea1ch 1,8 g\/kg; u\u1ed1ng 5,9 g\/kg.<\/li>\n
      • Ch\u00e1y \u0111\u01b0\u1ee3c; \u0111un t\u1edbi ph\u00e2n h\u1ee7y sinh oxyd nit\u01a1, CO, CO2<\/sub>. N\u00ean b\u1ea3o v\u1ec7 m\u1eaft, da v\u00e0 h\u00f4 h\u1ea5p.<\/li>\n
      • L\u01b0u \u00fd th\u1ec3 thao: tromethamin c\u00f3 th\u1ec3 b\u1ecb h\u1ea1n ch\u1ebf v\u00ec thu\u1ed9c nh\u00f3m ch\u1ea5t c\u1ea5m (l\u1ee3i ti\u1ec3u).<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (ti\u00eam t\u0129nh m\u1ea1ch, b\u1eafp, d\u01b0\u1edbi da, n\u1ed9i t\u1ee7y, \u0111\u1ed9ng m\u1ea1ch v\u00e0 thu\u1ed1c ti\u00eam truy\u1ec1n; dung d\u1ecbch, h\u1ed7n d\u1ecbch nh\u1ecf m\u1eaft; vi\u00ean, nang u\u1ed1ng; gel, dung d\u1ecbch d\u00f9ng ngo\u00e0i; dung d\u1ecbch h\u00edt, tr\u1ef1c tr\u00e0ng, ni\u1ec7u \u0111\u1ea1o).<\/li>\n
        • C\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh; c\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur., USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Xem th\u00eam meglumin, HEPES, diethanolamin.<\/p>\n

          Ghi ch\u00fa:<\/strong> tromethamin c\u00f2n l\u00e0 ho\u1ea1t ch\u1ea5t ki\u1ec1m h\u00f3a d\u00f9ng \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch \u2013 c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. S\u1ed1 EINECS 201-064-4; PubChem CID 6503.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Tromethamine<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Tromethamin (trometamol, TRIS) \u2013 ch\u1ea5t \u0111\u1ec7m, ch\u1ea5t ki\u1ec1m h\u00f3a, t\u1ea1o mu\u1ed1i tan Tromethamin (trometamol, TRIS, tris(hydroxymethyl)aminomethan) l\u00e0 amin b\u1eadc m\u1ed9t c\u00f3 ba nh\u00f3m hydroxymethyl, d\u1ea1ng b\u1ed9t k\u1ebft tinh ho\u1eb7c tinh th\u1ec3 tr\u1eafng. V\u1edbi pKa kho\u1ea3ng 8,1\u20138,3, tromethamin l\u00e0 ch\u1ea5t \u0111\u1ec7m \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong thu\u1ed1c ti\u00eam, u\u1ed1ng, b\u00f4i v\u00e0 nh\u1ecf m\u1eaft; ngo\u00e0i ra l\u00e0 […]<\/p>\n","protected":false},"author":1,"featured_media":3683,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3684","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tromethamin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tromethamin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tromethamin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tromethamin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tromethamin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tromethamin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tromethamin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tromethamin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Tromethamin (trometamol, TRIS) \u2013 ch\u1ea5t \u0111\u1ec7m, ch\u1ea5t ki\u1ec1m h\u00f3a, t\u1ea1o mu\u1ed1i tan Tromethamin (trometamol, TRIS, tris(hydroxymethyl)aminomethan) l\u00e0 amin b\u1eadc m\u1ed9t c\u00f3 ba nh\u00f3m hydroxymethyl, d\u1ea1ng b\u1ed9t k\u1ebft tinh ho\u1eb7c tinh th\u1ec3 tr\u1eafng. V\u1edbi pKa kho\u1ea3ng 8,1\u20138,3, tromethamin l\u00e0 ch\u1ea5t \u0111\u1ec7m \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong thu\u1ed1c ti\u00eam, u\u1ed1ng, b\u00f4i v\u00e0 nh\u1ecf m\u1eaft; ngo\u00e0i ra l\u00e0…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3684"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3684\/revisions"}],"predecessor-version":[{"id":3980,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3684\/revisions\/3980"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3683"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}