{"id":3682,"date":"2026-09-29T09:37:21","date_gmt":"2026-09-29T02:37:21","guid":{"rendered":"https:\/\/cpc1.vn\/triolein\/"},"modified":"2026-09-29T12:16:23","modified_gmt":"2026-09-29T05:16:23","slug":"triolein","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/triolein\/","title":{"rendered":"Triolein (glyceryl trioleat) \u2013 dung m\u00f4i thu\u1ed1c ti\u00eam, lipid cho liposome \u0111a t\u00fai"},"content":{"rendered":"

Triolein (glyceryl trioleat) \u2013 dung m\u00f4i thu\u1ed1c ti\u00eam, lipid cho liposome \u0111a t\u00fai<\/h1>\n

Triolein<\/strong> (glyceryl trioleat) l\u00e0 triglycerid c\u1ee7a acid oleic, ch\u1ea5t l\u1ecfng d\u1ea7u trong, kh\u00f4ng m\u00e0u t\u1edbi v\u00e0ng nh\u1ea1t, kh\u00f4ng v\u1ecb, kh\u00f4ng m\u00f9i. Trong b\u00e0o ch\u1ebf, triolein l\u00e0 ch\u1ea5t tr\u1ee3 tan<\/strong> v\u00e0 dung m\u00f4i cho thu\u1ed1c ti\u00eam<\/strong>, \u0111\u00e1ng ch\u00fa \u00fd l\u00e0 th\u00e0nh ph\u1ea7n lipid c\u1ee7a liposome \u0111a t\u00fai gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/strong>; ngo\u00e0i ra l\u00e0 ch\u1ea5t l\u00e0m m\u1ec1m v\u00e0 t\u0103ng th\u1ea5m.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nGlyceryl trioleat, olein, 1,2,3-tri(cis-9-octadecenoyl)glycerol; t\u00ean th\u01b0\u01a1ng m\u1ea1i Captex GTO<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n122-32-7<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC57<\/sub>H104<\/sub>O6<\/sub> \u2013 885,43<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m, t\u0103ng tan, dung m\u00f4i<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t tr\u1ee3 tan, dung m\u00f4i trong thu\u1ed1c ti\u00eam; c\u00f3 trong ch\u1ebf ph\u1ea9m liposome \u0111a t\u00fai gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i ch\u1ee9a cytarabin v\u00e0 morphin sulfat \u0111\u00e3 l\u01b0u h\u00e0nh.<\/li>\n
  • Nghi\u00ean c\u1ee9u: h\u1ea1t nano lipid hai th\u00e0nh ph\u1ea7n gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t itraconazol; liposome gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i breviscapin, thymopentin; th\u00eam \u00edt triolein l\u00e0m t\u0103ng m\u1ea1nh \u0111\u1ed9 b\u1ec1n ch\u1ed1ng k\u1ebft t\u1ee5 c\u1ee7a NLC tristearin; t\u0103ng hi\u1ec7u qu\u1ea3 chuy\u1ec3n gen c\u1ee7a NLC polycation v\u00e0 h\u1ea1t lai polymer \u2013 lipid; nano nh\u0169 t\u01b0\u01a1ng lipoprotein; SLN g\u1eafn transferrin d\u1eabn thu\u1ed1c l\u00ean n\u00e3o; nh\u0169 t\u01b0\u01a1ng lipid ch\u1ee9a gadolini.<\/li>\n
  • L\u00e0 ch\u1ea5t thay th\u1ebf lipid ng\u01b0\u1eddi t\u1ed1t h\u01a1n octanol hay liposome khi nghi\u00ean c\u1ee9u t\u00edch l\u0169y sinh h\u1ecdc ch\u1ea5t \u00f4 nhi\u1ec5m k\u1ef5 n\u01b0\u1edbc.<\/li>\n
  • M\u1ef9 ph\u1ea9m: d\u01b0\u1ee1ng da, \u0111i\u1ec1u ch\u1ec9nh \u0111\u1ed9 nh\u1edbt.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t l\u1ecfng d\u1ea7u trong, kh\u00f4ng m\u00e0u t\u1edbi v\u00e0ng nh\u1ea1t, kh\u00f4ng v\u1ecb, kh\u00f4ng m\u00f9i.<\/li>\n
    • T\u1ef7 tr\u1ecdng 0,915 g\/cm\u00b3; chi\u1ebft su\u1ea5t 1,4561; ch\u1ec9 s\u1ed1 iod 80\u2013100; \u0111\u1ed9 nh\u1edbt \u0111\u1ed9ng h\u1ecdc 74 mm\u00b2\/s (25 \u00b0C); \u0111i\u1ec3m ch\u1edbp ch\u00e1y 330 \u00b0C.<\/li>\n
    • \u0110\u1ed9 tan: tan trong cloroform, ether, carbon tetraclorid; h\u01a1i tan trong ethanol 95%; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n nh\u01b0ng nh\u1ea1y v\u1edbi kh\u00f4ng kh\u00ed v\u00e0 \u00e1nh s\u00e1ng. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i kh\u00f4, 2\u20138 \u00b0C; tr\u00e1nh ti\u1ebfp x\u00fac l\u00e2u v\u1edbi kh\u00f4ng kh\u00ed v\u00e0 \u1ea9m. Ph\u00e2n h\u1ee7y nhi\u1ec7t c\u00f3 th\u1ec3 sinh kh\u00ed k\u00edch \u1ee9ng (oxyd carbon).<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u00e0 ch\u1ea5t t\u1ef1 b\u1ed1c ch\u00e1y. L\u00e0 triglycerid n\u00ean b\u1ecb acid m\u1ea1nh, nh\u1ea5t l\u00e0 base m\u1ea1nh th\u1ee7y ph\u00e2n. Amin b\u1eadc m\u1ed9t c\u00f3 th\u1ec3 c\u1ed9ng v\u00e0o n\u1ed1i \u0111\u00f4i (t\u01b0\u01a1ng t\u1ef1 c\u1ed9ng Michael).<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Ester h\u00f3a acid b\u00e9o ph\u00e2n \u0111o\u1ea1n (ch\u1ee7 y\u1ebfu acid oleic) v\u1edbi glycerin.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • D\u00f9ng trong thu\u1ed1c ti\u00eam, l\u1edbp bao tan trong ru\u1ed9t v\u00e0 s\u1ea3n ph\u1ea9m ch\u0103m s\u00f3c c\u00e1 nh\u00e2n. Ph\u01a1i nhi\u1ec5m m\u1ea1n c\u00f3 th\u1ec3 g\u00e2y bu\u1ed3n n\u00f4n, n\u00f4n; ph\u01a1i nhi\u1ec5m cao c\u00f3 th\u1ec3 g\u00e2y b\u1ea5t t\u1ec9nh.<\/li>\n
      • H\u1ed9i \u0111\u1ed3ng CIR: b\u00f4i da kh\u00f4ng g\u00e2y k\u00edch \u1ee9ng \u0111\u00e1ng k\u1ec3, kh\u00f4ng g\u00e2y m\u1eabn c\u1ea3m hay nh\u1ea1y c\u1ea3m \u00e1nh s\u00e1ng; k\u00edch \u1ee9ng m\u1eaft nh\u1eb9; kh\u00f4ng g\u00e2y \u0111\u1ed9c t\u00ednh di truy\u1ec1n; ti\u00eam d\u01b0\u1edbi da kh\u00f4ng g\u00e2y u. Triglycerid \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a nh\u01b0 ch\u1ea5t b\u00e9o th\u1ef1c ph\u1ea9m (th\u00e0nh monoglycerid, acid b\u00e9o t\u1ef1 do, glycerol) n\u00ean ph\u01a1i nhi\u1ec5m \u0111\u01b0\u1eddng u\u1ed1ng kh\u00f4ng \u0111\u00e1ng lo ng\u1ea1i.<\/li>\n
      • Nh\u0169 t\u01b0\u01a1ng amphotericin n\u1ec1n triolein an to\u00e0n h\u01a1n (LD50<\/sub> cao h\u01a1n) so v\u1edbi amphotericin deoxycholat quy \u01b0\u1edbc tr\u00ean chu\u1ed9t c\u1ed1ng.<\/li>\n
      • D\u00f9ng kh\u1ea9u trang khi c\u00f3 s\u01b0\u01a1ng\/b\u1ee5i; th\u00f4ng gi\u00f3; k\u00ednh c\u00f3 t\u1ea5m ch\u1eafn b\u00ean; g\u0103ng PVC ho\u1eb7c nh\u1ef1a.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (h\u1ed7n d\u1ecbch liposome ti\u00eam ngo\u00e0i m\u00e0ng c\u1ee9ng); c\u00f3 trong h\u1ed7n d\u1ecbch ti\u00eam n\u1ed9i t\u1ee7y l\u01b0u h\u00e0nh t\u1ea1i Anh.<\/li>\n
        • CIR x\u1ebfp an to\u00e0n trong m\u1ef9 ph\u1ea9m; FDA ch\u1ea5p thu\u1eadn l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m gi\u00e1n ti\u1ebfp.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Xem th\u00eam acid oleic, tricaprylin, triglycerid m\u1ea1ch trung b\u00ecnh.<\/p>\n

          Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 204-534-7; PubChem CID 5497163.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Triolein<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Triolein (glyceryl trioleat) \u2013 dung m\u00f4i thu\u1ed1c ti\u00eam, lipid cho liposome \u0111a t\u00fai Triolein (glyceryl trioleat) l\u00e0 triglycerid c\u1ee7a acid oleic, ch\u1ea5t l\u1ecfng d\u1ea7u trong, kh\u00f4ng m\u00e0u t\u1edbi v\u00e0ng nh\u1ea1t, kh\u00f4ng v\u1ecb, kh\u00f4ng m\u00f9i. Trong b\u00e0o ch\u1ebf, triolein l\u00e0 ch\u1ea5t tr\u1ee3 tan v\u00e0 dung m\u00f4i cho thu\u1ed1c ti\u00eam, \u0111\u00e1ng ch\u00fa \u00fd l\u00e0 th\u00e0nh ph\u1ea7n lipid […]<\/p>\n","protected":false},"author":1,"featured_media":3681,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3682","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triolein.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triolein-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triolein-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triolein-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triolein-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triolein.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triolein.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triolein-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Triolein (glyceryl trioleat) \u2013 dung m\u00f4i thu\u1ed1c ti\u00eam, lipid cho liposome \u0111a t\u00fai Triolein (glyceryl trioleat) l\u00e0 triglycerid c\u1ee7a acid oleic, ch\u1ea5t l\u1ecfng d\u1ea7u trong, kh\u00f4ng m\u00e0u t\u1edbi v\u00e0ng nh\u1ea1t, kh\u00f4ng v\u1ecb, kh\u00f4ng m\u00f9i. Trong b\u00e0o ch\u1ebf, triolein l\u00e0 ch\u1ea5t tr\u1ee3 tan v\u00e0 dung m\u00f4i cho thu\u1ed1c ti\u00eam, \u0111\u00e1ng ch\u00fa \u00fd l\u00e0 th\u00e0nh ph\u1ea7n lipid…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3682"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3682\/revisions"}],"predecessor-version":[{"id":3979,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3682\/revisions\/3979"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3681"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3682"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}