{"id":3680,"date":"2026-09-29T09:37:13","date_gmt":"2026-09-29T02:37:13","guid":{"rendered":"https:\/\/cpc1.vn\/trimethyl-beta-cyclodextrin\/"},"modified":"2026-09-29T09:37:13","modified_gmt":"2026-09-29T02:37:13","slug":"trimethyl-beta-cyclodextrin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/trimethyl-beta-cyclodextrin\/","title":{"rendered":"Trimethyl-\u03b2-cyclodextrin (TRIMEB) \u2013 t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng \u0111\u1ed9 tan"},"content":{"rendered":"

Trimethyl-\u03b2-cyclodextrin (TRIMEB) \u2013 t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng \u0111\u1ed9 tan<\/h1>\n

Trimethyl-\u03b2-cyclodextrin<\/strong> (TRIMEB, permethyl-\u03b2-cyclodextrin) l\u00e0 d\u1eabn ch\u1ea5t methyl h\u00f3a ho\u00e0n to\u00e0n, kh\u00f4ng ion c\u1ee7a \u03b2-cyclodextrin \u2013 m\u1ecdi nh\u00f3m hydroxyl \u1edf C2, C3 v\u00e0 C6 \u0111\u1ec1u \u0111\u01b0\u1ee3c methyl h\u00f3a. Nh\u01b0 c\u00e1c cyclodextrin kh\u00e1c, TRIMEB t\u1ea1o ph\u1ee9c l\u1ed3ng<\/strong> \u0111\u1ec3 t\u0103ng \u0111\u1ed9 tan, t\u1ed1c \u0111\u1ed9 h\u00f2a tan, sinh kh\u1ea3 d\u1ee5ng v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh<\/strong> c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t k\u00e9m tan, v\u00e0 tan trong n\u01b0\u1edbc t\u1ed1t h\u01a1n \u03b2-cyclodextrin.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nTRIMEB, TM-\u03b2-CD, heptakis(2,3,6-tri-O-methyl)-\u03b2-cyclodextrin, permethyl-\u03b2-cyclodextrin<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n55216-11-0<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC63<\/sub>H112<\/sub>O35<\/sub> \u2013 1429,54<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u1ea1o ph\u1ee9c, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, t\u1ea1o vi nang, t\u0103ng tan, \u0111i\u1ec1u ch\u1ec9nh \u0111\u1eb3ng tr\u01b0\u01a1ng<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • T\u1ea1o ph\u1ee9c l\u1ed3ng c\u1ea3i thi\u1ec7n h\u00f2a tan, \u0111\u1ed9 tan, sinh kh\u1ea3 d\u1ee5ng v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t k\u00e9m tan trong ch\u1ebf ph\u1ea9m u\u1ed1ng, x\u1ecbt m\u0169i, nh\u1ecf m\u1eaft v\u00e0 \u0111\u1eb7t tr\u1ef1c tr\u00e0ng; \u1ee9ng d\u1ee5ng t\u01b0\u01a1ng t\u1ef1 \u03b2-cyclodextrin.<\/li>\n
  • Ch\u1ea5t ph\u1ee5 gia b\u1ea5t \u0111\u1ed1i trong s\u1eafc k\u00fd l\u1ecfng \u0111\u1ec3 t\u00e1ch \u0111\u1ed3ng ph\u00e2n \u0111\u1ed1i quang; t\u00e1ch b\u1ea5t \u0111\u1ed1i c\u00e1c d\u01b0\u1ee3c ch\u1ea5t base b\u1eb1ng \u0111i\u1ec7n di mao qu\u1ea3n.<\/li>\n
  • L\u00e0 ch\u1ea5t t\u00e1ch cholesterol.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng.<\/li>\n
    • \u0110i\u1ec3m ch\u1ea3y 157 \u00b0C (c\u00f3 t\u00e0i li\u1ec7u ghi 170\u2013178 \u00b0C); s\u1ee9c c\u0103ng b\u1ec1 m\u1eb7t 56 mN\/m (25 \u00b0C).<\/li>\n
    • Tan 1 trong 3,2 ph\u1ea7n n\u01b0\u1edbc \u1edf 25 \u00b0C, \u0111\u1ed9 tan gi\u1ea3m khi nhi\u1ec7t \u0111\u1ed9 t\u0103ng; tan trong dung m\u00f4i h\u1eefu c\u01a1.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n \u1edf tr\u1ea1ng th\u00e1i r\u1eafn n\u1ebfu tr\u00e1nh \u0111\u1ed9 \u1ea9m cao. T\u01b0\u01a1ng \u0111\u1ed1i b\u1ec1n trong m\u00f4i tr\u01b0\u1eddng ki\u1ec1m nh\u01b0ng r\u1ea5t d\u1ec5 b\u1ecb th\u1ee7y ph\u00e2n acid do v\u00f2ng cyclodextrin b\u1ecb bi\u1ebfn d\u1ea1ng m\u1ea1nh. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t, th\u00f4ng tho\u00e1ng.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Methyl h\u00f3a ho\u00e0n to\u00e0n \u03b2-cyclodextrin \u1edf m\u1ecdi nh\u00f3m hydroxyl b\u1eadc hai (C2, C3) v\u00e0 b\u1eadc m\u1ed9t (C6).<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • \u0110\u01b0\u1ee3c coi l\u00e0 \u0111\u1ed9c t\u00ednh th\u1ea5p khi d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c. D\u1ea1ng tinh khi\u1ebft kh\u00f4ng \u0111\u01b0\u1ee3c coi l\u00e0 c\u00f3 h\u1ea1i qua h\u00edt, nu\u1ed1t, d\u00ednh m\u1eaft ho\u1eb7c da; ch\u01b0a c\u00f3 d\u1eef li\u1ec7u \u0111\u1ed9c t\u00ednh c\u1ea5p \u0111\u00e1ng k\u1ec3. Ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp c\u00f3 th\u1ec3 g\u00e2y k\u00edch \u1ee9ng.<\/li>\n
      • Kh\u00f4ng c\u00f3 th\u00e0nh ph\u1ea7n \u2265 0,1% \u0111\u01b0\u1ee3c IARC x\u1ebfp l\u00e0 ch\u1ea5t g\u00e2y ung th\u01b0. OSHA (M\u1ef9): gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m 5 mg\/m\u00b3 b\u1ee5i h\u00f4 h\u1ea5p.<\/li>\n
      • Tr\u00e1nh d\u00ednh da, m\u1eaft, tr\u00e1nh h\u00edt; \u0111eo g\u0103ng, k\u00ednh; thao t\u00e1c n\u01a1i th\u00f4ng tho\u00e1ng.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n

        T\u00e0i li\u1ec7u g\u1ed1c kh\u00f4ng n\u00eau t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u1ee5 th\u1ec3.<\/p>\n

        Ch\u1ea5t li\u00ean quan<\/h2>\n

        Cyclodextrin (\u03b1, \u03b2, \u03b3), dimethyl-\u03b2-cyclodextrin, hydroxyethyl-\u03b2-cyclodextrin, hydroxypropyl betadex, sulfobutylether-\u03b2-cyclodextrin natri.<\/p>\n

        Ghi ch\u00fa:<\/strong> PubChem CID 162771.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Trimethyl-beta-cyclodextrin<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Trimethyl-\u03b2-cyclodextrin (TRIMEB) \u2013 t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng \u0111\u1ed9 tan Trimethyl-\u03b2-cyclodextrin (TRIMEB, permethyl-\u03b2-cyclodextrin) l\u00e0 d\u1eabn ch\u1ea5t methyl h\u00f3a ho\u00e0n to\u00e0n, kh\u00f4ng ion c\u1ee7a \u03b2-cyclodextrin \u2013 m\u1ecdi nh\u00f3m hydroxyl \u1edf C2, C3 v\u00e0 C6 \u0111\u1ec1u \u0111\u01b0\u1ee3c methyl h\u00f3a. Nh\u01b0 c\u00e1c cyclodextrin kh\u00e1c, TRIMEB t\u1ea1o ph\u1ee9c l\u1ed3ng \u0111\u1ec3 t\u0103ng \u0111\u1ed9 tan, t\u1ed1c \u0111\u1ed9 h\u00f2a tan, sinh kh\u1ea3 d\u1ee5ng […]<\/p>\n","protected":false},"author":1,"featured_media":3679,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3680","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trimethyl-beta-cyclodextrin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trimethyl-beta-cyclodextrin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trimethyl-beta-cyclodextrin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trimethyl-beta-cyclodextrin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trimethyl-beta-cyclodextrin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trimethyl-beta-cyclodextrin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trimethyl-beta-cyclodextrin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trimethyl-beta-cyclodextrin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Trimethyl-\u03b2-cyclodextrin (TRIMEB) \u2013 t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng \u0111\u1ed9 tan Trimethyl-\u03b2-cyclodextrin (TRIMEB, permethyl-\u03b2-cyclodextrin) l\u00e0 d\u1eabn ch\u1ea5t methyl h\u00f3a ho\u00e0n to\u00e0n, kh\u00f4ng ion c\u1ee7a \u03b2-cyclodextrin \u2013 m\u1ecdi nh\u00f3m hydroxyl \u1edf C2, C3 v\u00e0 C6 \u0111\u1ec1u \u0111\u01b0\u1ee3c methyl h\u00f3a. Nh\u01b0 c\u00e1c cyclodextrin kh\u00e1c, TRIMEB t\u1ea1o ph\u1ee9c l\u1ed3ng \u0111\u1ec3 t\u0103ng \u0111\u1ed9 tan, t\u1ed1c \u0111\u1ed9 h\u00f2a tan, sinh kh\u1ea3 d\u1ee5ng…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3680","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3680"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3680\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3679"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}