{"id":3678,"date":"2026-09-29T09:35:51","date_gmt":"2026-09-29T02:35:51","guid":{"rendered":"https:\/\/cpc1.vn\/tricaprylin\/"},"modified":"2026-09-29T12:16:06","modified_gmt":"2026-09-29T05:16:06","slug":"tricaprylin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/tricaprylin\/","title":{"rendered":"Tricaprylin (glyceryl tricaprylat) \u2013 dung m\u00f4i d\u1ea7u, ch\u1ea5t l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Tricaprylin (glyceryl tricaprylat) \u2013 dung m\u00f4i d\u1ea7u, ch\u1ea5t l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m<\/h1>\n<p><strong>Tricaprylin<\/strong> (glyceryl tricaprylat, trioctanoin) l\u00e0 triglycerid c\u1ee7a acid caprylic (C8), ch\u1ea5t l\u1ecfng trong, kh\u00f4ng m\u00e0u t\u1edbi v\u00e0ng nh\u1ea1t, kh\u00f4ng m\u00f9i, \u0111\u1ed9 nh\u1edbt th\u1ea5p. Trong b\u00e0o ch\u1ebf, tricaprylin l\u00e0 <strong>ch\u1ea5t mang trung t\u00ednh<\/strong>, <strong>dung m\u00f4i, ch\u1ea5t tr\u1ee3 tan<\/strong>, <strong>ch\u1ea5t t\u0103ng h\u1ea5p thu\/t\u0103ng th\u1ea5m<\/strong>, <strong>ch\u1ea5t l\u00e0m m\u1ec1m<\/strong> v\u00e0 <strong>ch\u1ea5t ph\u00e2n t\u00e1n<\/strong>.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Glyceryl tricaprylat, glycerol trioctanoat, trioctanoin, triglycerid acid caprylic; t\u00ean th\u01b0\u01a1ng m\u1ea1i Captex 8000, Miglyol 808, Rofetan GTC, Trivent OC-G, Hest TC<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>538-23-8<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>C<sub>27<\/sub>H<sub>50<\/sub>O<sub>6<\/sub> \u2013 470,70<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t ph\u00e2n t\u00e1n, l\u00e0m m\u1ec1m, b\u00f4i tr\u01a1n, di\u1ec7n ho\u1ea1t kh\u00f4ng ion, t\u0103ng th\u1ea5m, h\u00f3a d\u1ebbo, t\u0103ng tan, dung m\u00f4i<\/td>\n<\/tr>\n<tr>\n<td>D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<td>Kh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn d\u01b0\u1ee3c \u0111i\u1ec3n; c\u00f3 ti\u00eau chu\u1ea9n trong JPED (h\u00e0m l\u01b0\u1ee3ng \u2265 98,0%)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li>Ch\u1ea5t mang trung t\u00ednh, t\u0103ng h\u1ea5p thu, t\u0103ng tan cho d\u01b0\u1ee3c ch\u1ea5t.<\/li>\n<li>Pha d\u1ea7u cho nh\u0169 t\u01b0\u01a1ng k\u00e9p n\u01b0\u1edbc\/d\u1ea7u\/n\u01b0\u1edbc ch\u1ee9a d\u01b0\u1ee3c ch\u1ea5t tan trong n\u01b0\u1edbc; vi nang \u1ed5n \u0111\u1ecbnh; vi nh\u0169 t\u01b0\u01a1ng u\u1ed1ng; colloidosome; h\u1ec7 tinh th\u1ec3 l\u1ecfng l\u1ee5c gi\u00e1c \u0111\u1ea3o (monoolein\/tricaprylin\/n\u01b0\u1edbc) h\u00f2a tan l\u01b0\u1ee3ng l\u1edbn ciclosporin A, gabapentin.<\/li>\n<li>Liposome \u0111a t\u00fai triolein\/tricaprylin ti\u00eam b\u1eafp gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i (nghi\u00ean c\u1ee9u); ti\u1ec3u ph\u00e2n lipid r\u1eafn (SLN) v\u00e0 ch\u1ea5t mang lipid c\u1ea5u tr\u00fac nano (NLC) \u2013 tricaprylin l\u00e0m \u1ed5n \u0111\u1ecbnh h\u1ec7 ph\u00e2n t\u00e1n NLC.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c cho kem, lotion b\u00f4i da; n\u1ec1n lipid t\u0103ng th\u1ea5m, ch\u1ea5t l\u00e0m m\u1ec1m: kh\u00f4ng nh\u1eddn, \u0111\u1ed9 nh\u1edbt th\u1ea5p, d\u1ec5 t\u00e1n, cho c\u1ea3m gi\u00e1c &#8220;m\u01b0\u1ee3t&#8221;; kh\u00f4ng c\u1ea3n tr\u1edf h\u00f4 h\u1ea5p da n\u00ean d\u00f9ng trong d\u1ea7u em b\u00e9, d\u1ea7u massage, m\u1eb7t n\u1ea1.<\/li>\n<li>M\u1ef9 ph\u1ea9m m\u00e0u (ph\u00e2n t\u00e1n, t\u0103ng tan, th\u1ea5m \u01b0\u1edbt, k\u1ebft d\u00ednh); s\u1eefa t\u1eafm hai pha; kem, d\u1ea7u ch\u1ed1ng n\u1eafng; ch\u1ea5t \u0111\u1ecbnh h\u01b0\u01a1ng n\u01b0\u1edbc hoa.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Ch\u1ea5t l\u1ecfng trong, kh\u00f4ng m\u00e0u t\u1edbi v\u00e0ng nh\u1ea1t, kh\u00f4ng m\u00f9i; k\u1ebft tinh t\u1eeb aceton\/ethanol 95%.<\/li>\n<li>\u0110i\u1ec3m ch\u1ea3y 9\u201310 \u00b0C; t\u1ef7 tr\u1ecdng kho\u1ea3ng 0,94\u20130,96 g\/cm\u00b3; chi\u1ebft su\u1ea5t kho\u1ea3ng 1,443\u20131,448; s\u00f4i 233 \u00b0C \u1edf 1 mmHg; \u0111i\u1ec3m ch\u1edbp ch\u00e1y kho\u1ea3ng 209\u2013246 \u00b0C.<\/li>\n<li>\u0110\u1ed9 nh\u1edbt 23\u201329 mPa\u00b7s (20 \u00b0C); s\u1ee9c c\u0103ng b\u1ec1 m\u1eb7t 0,030 N\/m; log K<sub>ow<\/sub> 9,20; HLB kho\u1ea3ng 7.<\/li>\n<li>Lo\u1ea1i th\u01b0\u01a1ng m\u1ea1i: acid caprylic \u2265 90\u201395%; ch\u1ec9 s\u1ed1 acid \u2264 0,1\u20130,5; ch\u1ec9 s\u1ed1 iod \u2264 0,3; ch\u1ec9 s\u1ed1 x\u00e0 ph\u00f2ng h\u00f3a 335\u2013370; n\u01b0\u1edbc \u2264 0,1%.<\/li>\n<li>Tr\u1ed9n l\u1eabn v\u1edbi ph\u1ea7n l\u1edbn dung m\u00f4i h\u1eefu c\u01a1 k\u1ec3 c\u1ea3 ethanol 95%; kh\u00f4ng tan trong n\u01b0\u1edbc v\u00e0 c\u00e1c diol, triol ph\u00e2n t\u1eed l\u01b0\u1ee3ng th\u1ea5p.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<ul>\n<li>B\u1ec1n; r\u1ea5t b\u1ec1n v\u1edbi oxy h\u00f3a, kh\u00f4ng nh\u1ea1y nhi\u1ec7t \u2013 k\u1ec3 c\u1ea3 kh\u00ed h\u1eadu n\u00f3ng c\u0169ng kh\u00f4ng c\u1ea7n l\u00e0m l\u1ea1nh, nh\u01b0ng tr\u00e1nh nhi\u1ec7t \u0111\u1ed9 g\u1ea7n \u0111i\u1ec3m ch\u1edbp ch\u00e1y. Do r\u1ea5t \u00edt n\u01b0\u1edbc n\u00ean kh\u00f4ng nh\u1ea1y v\u1edbi th\u1ee7y ph\u00e2n v\u00e0 ph\u00e2n h\u1ee7y vi sinh.<\/li>\n<li>B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4, nhi\u1ec7t \u0111\u1ed9 th\u01b0\u1eddng. Bao b\u00ec ph\u00f9 h\u1ee3p: HDPE, polypropylen, nh\u00f4m, th\u1ee7y tinh. M\u1ed9t s\u1ed1 nh\u1ef1a (nh\u1ea5t l\u00e0 ch\u1ee9a ch\u1ea5t h\u00f3a d\u1ebbo) c\u00f3 th\u1ec3 gi\u00f2n ho\u1eb7c tr\u01b0\u01a1ng; kh\u00f4ng d\u00f9ng polystyren v\u00e0 PVC. Tricaprylin d\u1ec5 di chuy\u1ec3n n\u00ean c\u1ea7n ch\u1ecdn k\u1ef9 v\u1eadt li\u1ec7u gio\u0103ng.<\/li>\n<\/ul>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Ester h\u00f3a acid caprylic v\u1edbi glycerin.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<ul>\n<li>H\u1ed9i \u0111\u1ed3ng CIR: b\u00f4i da kh\u00f4ng g\u00e2y k\u00edch \u1ee9ng \u0111\u00e1ng k\u1ec3 tr\u00ean th\u1ecf; d\u00ednh m\u1eaft k\u00edch \u1ee9ng nh\u1eb9. L\u00e0 ch\u1ea5t t\u0103ng th\u1ea5m n\u00ean c\u00f3 th\u1ec3 l\u00e0m c\u00e1c ch\u1ea5t kh\u00e1c th\u1ea5m s\u00e2u h\u01a1n v\u00e0o da.<\/li>\n<li>\u0110\u1ed9c t\u00ednh u\u1ed1ng c\u1ea5p, b\u00e1n tr\u01b0\u1eddng di\u1ec5n, m\u1ea1n r\u1ea5t th\u1ea5p tr\u1eeb khi chi\u1ebfm t\u1ef7 l\u1ec7 l\u1edbn n\u0103ng l\u01b0\u1ee3ng kh\u1ea9u ph\u1ea7n. Ti\u00eam d\u01b0\u1edbi da nhi\u1ec1u tu\u1ea7n g\u00e2y ph\u1ea3n \u1ee9ng u h\u1ea1t tr\u00ean chu\u1ed9t. Kh\u00f4ng g\u00e2y qu\u00e1i thai \u1edf chu\u1ed9t c\u1ed1ng, chu\u1ed9t nh\u1eaft, chu\u1ed9t hamster; c\u00f3 \u1ea3nh h\u01b0\u1edfng sinh s\u1ea3n tr\u00ean th\u1ecf; \u0111\u1ed9c th\u1ea7n kinh trung \u01b0\u01a1ng ph\u1ee5 thu\u1ed9c li\u1ec1u tr\u00ean ch\u00f3.<\/li>\n<li>LD<sub>50<\/sub> (\u0111\u01b0\u1eddng u\u1ed1ng): chu\u1ed9t nh\u1eaft 29,6 g\/kg; chu\u1ed9t c\u1ed1ng 33,3 g\/kg. Chu\u1ed9t nh\u1eaft t\u0129nh m\u1ea1ch 3,7 g\/kg; ph\u00fac m\u1ea1c v\u00e0 d\u01b0\u1edbi da tr\u00ean 27,8 g\/kg.<\/li>\n<li>D\u00f9ng kh\u1ea9u trang\/m\u1eb7t n\u1ea1, k\u00ednh ch\u1ed1ng b\u1eafn, g\u0103ng neopren; th\u00f4ng gi\u00f3. \u0110un t\u1edbi ph\u00e2n h\u1ee7y sinh kh\u00f3i cay, k\u00edch \u1ee9ng.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>C\u00f3 trong FDA Inactive Ingredients Database (thu\u1ed1c ti\u00eam, vi\u00ean u\u1ed1ng) v\u00e0 Canadian Natural Health Products Ingredients Database.<\/li>\n<li>CIR x\u1ebfp an to\u00e0n trong m\u1ef9 ph\u1ea9m.<\/li>\n<\/ul>\n<h2>Ch\u1ea5t li\u00ean quan<\/h2>\n<p>Triglycerid m\u1ea1ch trung b\u00ecnh; <strong>glyceryl triisooctanoat<\/strong> (glyceryl tris-2-ethylhexanoat; CAS 7360-38-5): ch\u1ea5t l\u1ecfng d\u1ea7u trong, kh\u00f4ng m\u00f9i, t\u1ef7 tr\u1ecdng 0,945\u20130,950, c\u00f3 trong JPE.<\/p>\n<p><strong>Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 208-686-5; PubChem CID 10850.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Tricaprylin<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Tricaprylin (glyceryl tricaprylat) \u2013 dung m\u00f4i d\u1ea7u, ch\u1ea5t l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m Tricaprylin (glyceryl tricaprylat, trioctanoin) l\u00e0 triglycerid c\u1ee7a acid caprylic (C8), ch\u1ea5t l\u1ecfng trong, kh\u00f4ng m\u00e0u t\u1edbi v\u00e0ng nh\u1ea1t, kh\u00f4ng m\u00f9i, \u0111\u1ed9 nh\u1edbt th\u1ea5p. Trong b\u00e0o ch\u1ebf, tricaprylin l\u00e0 ch\u1ea5t mang trung t\u00ednh, dung m\u00f4i, ch\u1ea5t tr\u1ee3 tan, ch\u1ea5t t\u0103ng h\u1ea5p thu\/t\u0103ng th\u1ea5m, ch\u1ea5t [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3677,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3678","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricaprylin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricaprylin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricaprylin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricaprylin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricaprylin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricaprylin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricaprylin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tricaprylin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Tricaprylin (glyceryl tricaprylat) \u2013 dung m\u00f4i d\u1ea7u, ch\u1ea5t l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m Tricaprylin (glyceryl tricaprylat, trioctanoin) l\u00e0 triglycerid c\u1ee7a acid caprylic (C8), ch\u1ea5t l\u1ecfng trong, kh\u00f4ng m\u00e0u t\u1edbi v\u00e0ng nh\u1ea1t, kh\u00f4ng m\u00f9i, \u0111\u1ed9 nh\u1edbt th\u1ea5p. Trong b\u00e0o ch\u1ebf, tricaprylin l\u00e0 ch\u1ea5t mang trung t\u00ednh, dung m\u00f4i, ch\u1ea5t tr\u1ee3 tan, ch\u1ea5t t\u0103ng h\u1ea5p thu\/t\u0103ng th\u1ea5m, ch\u1ea5t&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3678","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3678"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3678\/revisions"}],"predecessor-version":[{"id":3976,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3678\/revisions\/3976"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3677"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3678"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3678"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3678"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}