{"id":3676,"date":"2026-09-29T09:35:44","date_gmt":"2026-09-29T02:35:44","guid":{"rendered":"https:\/\/cpc1.vn\/tetranatri-edetat\/"},"modified":"2026-09-29T12:15:01","modified_gmt":"2026-09-29T05:15:01","slug":"tetranatri-edetat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/tetranatri-edetat\/","title":{"rendered":"Tetranatri edetat (EDTA tetranatri) \u2013 ch\u1ea5t t\u1ea1o ph\u1ee9c, hi\u1ec7p \u0111\u1ed3ng ch\u1ed1ng oxy h\u00f3a"},"content":{"rendered":"

Tetranatri edetat (EDTA tetranatri) \u2013 ch\u1ea5t t\u1ea1o ph\u1ee9c, hi\u1ec7p \u0111\u1ed3ng ch\u1ed1ng oxy h\u00f3a<\/h1>\n

Tetranatri edetat<\/strong> (EDTA tetranatri) l\u00e0 mu\u1ed1i natri ho\u00e0n to\u00e0n c\u1ee7a acid edetic, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng, dung d\u1ecbch ki\u1ec1m m\u1ea1nh. Trong b\u00e0o ch\u1ebf, tetranatri edetat l\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c<\/strong>: ph\u1ea3n \u1ee9ng v\u1edbi ph\u1ea7n l\u1edbn ion kim lo\u1ea1i h\u00f3a tr\u1ecb hai v\u00e0 ba t\u1ea1o chelat tan, d\u00f9ng l\u00e0m ch\u1ea5t hi\u1ec7p \u0111\u1ed3ng ch\u1ed1ng oxy h\u00f3a<\/strong> v\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nEDTA tetranatri, mu\u1ed1i tetranatri c\u1ee7a acid edetic, natri edetat, tetracemat tetranatri; t\u00ean th\u01b0\u01a1ng m\u1ea1i Trilon B, Versene 100, Sequestrene NA4<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n64-02-8 (khan); 194491-31-1 (hydrat); 10378-23-1 (dihydrat); 13235-36-4 (tetrahydrat)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC10<\/sub>H12<\/sub>N2<\/sub>Na4<\/sub>O8<\/sub> \u2013 380,17 (khan); 416,20 (dihydrat); 452,23 (tetrahydrat)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t t\u1ea1o ph\u1ee9c<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t t\u1ea1o ph\u1ee9c trong d\u01b0\u1ee3c ph\u1ea9m, n\u1ed3ng \u0111\u1ed9 0,01\u20130,2% (kl\/tt); hi\u1ec7p \u0111\u1ed3ng v\u1edbi ch\u1ea5t ch\u1ed1ng oxy h\u00f3a.<\/li>\n
  • \u0110\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m ch\u1ea5t kh\u00e1ng khu\u1ea9n ng\u0103n t\u1ea1o m\u00e0ng sinh h\u1ecdc (biofilm).<\/li>\n
  • Ch\u1ea5t t\u1ea1o ph\u1ee9c trong m\u1ef9 ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng.<\/li>\n
    • pH dung d\u1ecbch 1%: 11,3; kh\u1ed1i l\u01b0\u1ee3ng ri\u00eang bi\u1ec3u ki\u1ebfn 1,27 g\/cm\u00b3; n\u00f3ng ch\u1ea3y tr\u00ean 300 \u00b0C k\u00e8m ph\u00e2n h\u1ee7y; t\u1ef1 b\u1ed1c ch\u00e1y tr\u00ean 200 \u00b0C.<\/li>\n
    • D\u1ec5 tan trong n\u01b0\u1edbc (1 trong 1).<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      C\u00e1c mu\u1ed1i edetat b\u1ec1n h\u01a1n acid edetic. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t, th\u00f4ng tho\u00e1ng.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u00e0 base m\u1ea1nh. Xem th\u00eam acid edetic, dinatri edetat.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Cho dung d\u1ecbch ki\u1ec1m c\u1ee7a ethylendiamin ph\u1ea3n \u1ee9ng v\u1edbi formaldehyd v\u00e0 natri cyanid ho\u1eb7c hydro cyanid, sau \u0111\u00f3 th\u1ee7y ph\u00e2n t\u1ea1o mu\u1ed1i; ho\u1eb7c d\u00f9ng natri hydroxyd d\u01b0.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • D\u00f9ng trong thu\u1ed1c u\u1ed1ng v\u00e0 l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m. \u0110\u00e3 ghi nh\u1eadn ph\u1ea3n \u1ee9ng da b\u1ea5t l\u1ee3i do ti\u1ebfp x\u00fac tetranatri edetat trong m\u1ef9 ph\u1ea9m; h\u1ed9i \u0111\u1ed3ng CIR k\u1ebft lu\u1eadn an to\u00e0n trong m\u1ef9 ph\u1ea9m.<\/li>\n
      • Chu\u1ed9t nh\u1eaft u\u1ed1ng tetranatri edetat gi\u1ea3m r\u00f5 calci trong x\u01b0\u01a1ng, gan, c\u01a1; gi\u1ea3m magnesi trong x\u01b0\u01a1ng, gan v\u00e0 k\u1ebdm trong th\u1eadn, gan, c\u01a1.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t c\u1ed1ng, ph\u00fac m\u1ea1c): tr\u00ean 2,0 g\/kg; (chu\u1ed9t nh\u1eaft, ph\u00fac m\u1ea1c): 0,33 g\/kg.<\/li>\n
      • C\u00f3 th\u1ec3 g\u00e2y k\u00edch \u1ee9ng m\u1eaft nghi\u00eam tr\u1ecdng, k\u00edch \u1ee9ng nh\u1eb9 da. Tr\u00e1nh t\u1ea1o b\u1ee5i; \u0111eo k\u00ednh, g\u0103ng, kh\u1ea9u trang. \u0110un t\u1edbi ph\u00e2n h\u1ee7y sinh kh\u00f3i \u0111\u1ed9c (amoniac, oxyd nit\u01a1).<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (h\u00edt; ti\u00eam; nh\u00e3n khoa; nang, vi\u00ean u\u1ed1ng; b\u00f4i ngo\u00e0i); c\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh.<\/li>\n
        • C\u00f3 trong danh m\u1ee5c EAFUS v\u00e0 Canadian Natural Health Products Ingredients Database.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Natri calci edetat, dinatri edetat, acid edetic (EDTA). T\u00ean “natri edetat” trong t\u00e0i li\u1ec7u \u0111\u01b0\u1ee3c d\u00f9ng cho nhi\u1ec1u mu\u1ed1i natri kh\u00e1c nhau c\u1ee7a acid edetic.<\/p>\n

          Ghi ch\u00fa:<\/strong> PubChem CID 6144.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Tetrasodium Edetate<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Tetranatri edetat (EDTA tetranatri) \u2013 ch\u1ea5t t\u1ea1o ph\u1ee9c, hi\u1ec7p \u0111\u1ed3ng ch\u1ed1ng oxy h\u00f3a Tetranatri edetat (EDTA tetranatri) l\u00e0 mu\u1ed1i natri ho\u00e0n to\u00e0n c\u1ee7a acid edetic, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng, dung d\u1ecbch ki\u1ec1m m\u1ea1nh. Trong b\u00e0o ch\u1ebf, tetranatri edetat l\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c: ph\u1ea3n \u1ee9ng v\u1edbi ph\u1ea7n l\u1edbn ion kim lo\u1ea1i h\u00f3a tr\u1ecb hai v\u00e0 […]<\/p>\n","protected":false},"author":1,"featured_media":3675,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3676","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tetranatri-edetat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tetranatri-edetat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tetranatri-edetat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tetranatri-edetat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tetranatri-edetat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tetranatri-edetat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tetranatri-edetat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tetranatri-edetat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Tetranatri edetat (EDTA tetranatri) \u2013 ch\u1ea5t t\u1ea1o ph\u1ee9c, hi\u1ec7p \u0111\u1ed3ng ch\u1ed1ng oxy h\u00f3a Tetranatri edetat (EDTA tetranatri) l\u00e0 mu\u1ed1i natri ho\u00e0n to\u00e0n c\u1ee7a acid edetic, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng, dung d\u1ecbch ki\u1ec1m m\u1ea1nh. Trong b\u00e0o ch\u1ebf, tetranatri edetat l\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c: ph\u1ea3n \u1ee9ng v\u1edbi ph\u1ea7n l\u1edbn ion kim lo\u1ea1i h\u00f3a tr\u1ecb hai v\u00e0…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3676","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3676"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3676\/revisions"}],"predecessor-version":[{"id":3964,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3676\/revisions\/3964"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3675"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3676"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3676"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3676"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}