{"id":3672,"date":"2026-09-29T09:34:11","date_gmt":"2026-09-29T02:34:11","guid":{"rendered":"https:\/\/cpc1.vn\/saccarose-stearat\/"},"modified":"2026-09-29T12:13:06","modified_gmt":"2026-09-29T05:13:06","slug":"saccarose-stearat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/saccarose-stearat\/","title":{"rendered":"Saccarose stearat (E473) \u2013 ch\u1ea5t nh\u0169 h\u00f3a, t\u00e1 d\u01b0\u1ee3c tr\u01a1n, k\u00e9o d\u00e0i gi\u1ea3i ph\u00f3ng"},"content":{"rendered":"

Saccarose stearat (E473) \u2013 ch\u1ea5t nh\u0169 h\u00f3a, t\u00e1 d\u01b0\u1ee3c tr\u01a1n, k\u00e9o d\u00e0i gi\u1ea3i ph\u00f3ng<\/h1>\n

Saccarose stearat<\/strong> (sucrose stearat, ester \u0111\u01b0\u1eddng E473) l\u00e0 h\u1ed7n h\u1ee3p ester c\u1ee7a saccarose v\u1edbi acid b\u00e9o ngu\u1ed3n th\u1ef1c v\u1eadt, ch\u1ee7 y\u1ebfu acid stearic, g\u1ed3m mono-, di-, tri- v\u00e0 polyester. Nh\u1edd \u0111\u1ea7u ph\u00e2n c\u1ef1c saccarose v\u00e0 \u0111u\u00f4i acid b\u00e9o, \u0111\u00e2y l\u00e0 ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion<\/strong> c\u00f3 HLB tr\u1ea3i r\u1ed9ng 1\u201316 t\u00f9y t\u1ef7 l\u1ec7 monoester. Trong b\u00e0o ch\u1ebf, saccarose stearat l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a, ph\u00e2n t\u00e1n, t\u0103ng tan<\/strong>, t\u00e1 d\u01b0\u1ee3c tr\u01a1n<\/strong> v\u00e0 t\u00e1c nh\u00e2n \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nSaccarose monostearat, sucrose octadecanoat, sacchari stearas, E473; t\u00ean th\u01b0\u01a1ng m\u1ea1i Surfhope SE, Sisterna SP, Crodesta F, Tegosoft PSE<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n25168-73-4 (monostearat); 27195-16-0 (distearat); 27923-63-3 (tristearat)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC30<\/sub>H56<\/sub>O12<\/sub> \u2013 608,72 (monostearat); distearat 875,22; tristearat 1141,68<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ph\u00e2n t\u00e1n, nh\u0169 h\u00f3a, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, di\u1ec7n ho\u1ea1t kh\u00f4ng ion, t\u0103ng tan, t\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n\/vi\u00ean nang<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur. (lo\u1ea1i I, II, III), USP-NF (lo\u1ea1i I, II)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t nh\u0169 h\u00f3a, ph\u00e2n t\u00e1n v\u00e0 h\u1ed7 tr\u1ee3 t\u0103ng tan trong ch\u1ebf ph\u1ea9m b\u00f4i da; ph\u1ee7 b\u1ec1 m\u1eb7t ph\u00e2n c\u00e1ch r\u1ea5t hi\u1ec7u qu\u1ea3, cho nh\u0169 t\u01b0\u01a1ng \u0111\u1eb7c bi\u1ec7t b\u1ec1n nhi\u1ec7t. \u0110\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m ch\u1ea5t t\u0103ng th\u1ea5m qua da.<\/li>\n
  • \u0110\u01b0\u1eddng u\u1ed1ng: t\u00e1 d\u01b0\u1ee3c tr\u01a1n, t\u00e1 d\u01b0\u1ee3c r\u00e3 v\u00e0 t\u00e1c nh\u00e2n ki\u1ec3m so\u00e1t gi\u1ea3i ph\u00f3ng \u2013 k\u00e9o d\u00e0i gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t c\u00f3 \u0111\u1ed9 tan kh\u00e1c nhau t\u1eeb vi\u00ean c\u1ed1t (nh\u1edd kh\u1ea3 n\u0103ng tr\u01b0\u01a1ng n\u1edf), c\u1ea3i thi\u1ec7n \u0111\u1ed9 d\u1ebbo v\u00e0 kh\u1ea3 n\u0103ng ch\u1ecbu n\u00e9n c\u1ee7a h\u1ed7n h\u1ee3p b\u1ed9t.<\/li>\n
  • Lo\u1ea1i HLB th\u1ea5p gi\u1ea3m l\u1ef1c \u0111\u1ea9y vi\u00ean khi d\u1eadp, c\u00f3 th\u1ec3 thay magnesi stearat; lo\u1ea1i HLB cao gi\u00fap vi\u00ean r\u00e3 nhanh (h\u1ed7n h\u1ee3p d\u01b0\u1ee3c ch\u1ea5t\/saccarose stearat\/MCC d\u1eadp th\u1eb3ng c\u00f9ng croscarmellose natri v\u00e0 xylitol).<\/li>\n
  • Saccarose distearat l\u00e0 ch\u1ea5t tr\u1ee3 tan l\u01b0\u1ee1ng th\u00e2n, t\u0103ng kh\u1ea3 n\u0103ng h\u00f2a tan c\u1ee7a vi nh\u0169 t\u01b0\u01a1ng d\u1ea7u\/n\u01b0\u1edbc ho\u1eb7c n\u01b0\u1edbc\/d\u1ea7u.<\/li>\n
  • Gel nh\u1edbt \u0111\u00e0n h\u1ed3i ph\u1ee5 thu\u1ed9c nhi\u1ec7t \u0111\u1ed9 v\u00e0 n\u1ed3ng \u0111\u1ed9, b\u1ec1n h\u01a1n saccarose palmitat \u2013 \u1ee9ng d\u1ee5ng h\u1ec7 nh\u1ea1y nhi\u1ec7t; ch\u1ea5t \u1ed5n \u0111\u1ecbnh gi\u1ecdt khi \u0111i\u1ec1u ch\u1ebf vi c\u1ea7u polymer (t\u0103ng \u0111\u1ed9 x\u1ed1p b\u1ec1 m\u1eb7t).<\/li>\n
  • Niosome t\u1eeb proniosome d\u00f9ng kh\u00ed dung cromolyn natri; ph\u1ee7 saccarose tristearat l\u00ean h\u1ea1t lactose mang l\u00e0m t\u0103ng ph\u00e2n \u0111o\u1ea1n h\u1ea1t m\u1ecbn c\u1ee7a b\u1ed9t h\u00edt kh\u00f4.<\/li>\n
  • M\u1ef9 ph\u1ea9m (kem, d\u1ea7u g\u1ed9i, s\u1eefa t\u1eafm, kem \u0111\u00e1nh r\u0103ng); ch\u1ea5t nh\u0169 h\u00f3a th\u1ef1c ph\u1ea9m.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u01a1n nh\u1eddn, tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, kh\u00f4ng v\u1ecb.<\/li>\n
    • D\u01b0\u1ee3c \u0111i\u1ec3n: acid stearic 55\u201375%, palmitic 25\u201340% (t\u1ed5ng \u2265 90%). Lo\u1ea1i I: monoester \u2265 50%; lo\u1ea1i II: monoester 20\u201345%, diester 30\u201340%; lo\u1ea1i III (Ph.Eur.): monoester 15\u201325%, diester 30\u201345%, tri- v\u00e0 polyester 35\u201350%.<\/li>\n
    • HLB kho\u1ea3ng 1\u201316, t\u0103ng theo t\u1ef7 l\u1ec7 monoester (v\u00ed d\u1ee5 monoester kho\u1ea3ng 20% \u2192 HLB 3; 70\u201375% \u2192 HLB 15\u201316).<\/li>\n
    • N\u00f3ng ch\u1ea3y kho\u1ea3ng 60 \u00b0C; ph\u00e2n h\u1ee7y 130\u2013240 \u00b0C.<\/li>\n
    • \u0110\u1ed9 tan: h\u01a1i tan trong ethanol 96%; r\u1ea5t kh\u00f3 tan trong n\u01b0\u1edbc; tan trong tetrahydrofuran. Lo\u1ea1i HLB cao tan trong n\u01b0\u1edbc n\u00f3ng, lo\u1ea1i HLB th\u1ea5p tan trong d\u1ea7u n\u00f3ng.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng, tr\u00e1nh \u1ea9m.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u00e0i li\u1ec7u g\u1ed1c kh\u00f4ng ghi nh\u1eadn t\u01b0\u01a1ng k\u1ef5 c\u1ee5 th\u1ec3.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Chuy\u1ec3n ester h\u00f3a methyl ester acid stearic ngu\u1ed3n th\u1ef1c v\u1eadt (c\u00f3 b\u01b0\u1edbc c\u1ea5t) v\u1edbi saccarose; c\u00f3 th\u1ec3 d\u00f9ng ethyl acetat, methyl ethyl ceton ho\u1eb7c dimethyl sulfoxid v\u00e0 isobutanol. Tr\u00ean th\u1ecb tr\u01b0\u1eddng ch\u1ec9 c\u00f3 mono-, di- v\u00e0 tristearat.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • Ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion ngu\u1ed3n carbohydrat, kh\u00f4ng \u0111\u1ed9c, d\u00f9ng r\u1ed9ng r\u00e3i trong d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m, m\u1ef9 ph\u1ea9m. JECFA \u0111\u1eb7t ADI cho ester saccarose c\u1ee7a acid b\u00e9o t\u1edbi 30 mg\/kg; li\u1ec1u cao c\u00f3 th\u1ec3 nhu\u1eadn tr\u00e0ng.<\/li>\n
      • U\u1ed1ng t\u1ed5ng 20 g\/kg chia 10 l\u1ea7n (chu\u1ed9t c\u1ed1ng, chu\u1ed9t nh\u1eaft) kh\u00f4ng c\u00f3 t\u1eed vong. Kh\u00f4ng k\u00edch \u1ee9ng da, h\u01a1i k\u00edch \u1ee9ng m\u1eaft. LD50<\/sub> (chu\u1ed9t nh\u1eaft, u\u1ed1ng): tr\u00ean 2,0 g\/kg; NOAEL (chu\u1ed9t c\u1ed1ng): kho\u1ea3ng 2,0 g\/kg\/ng\u00e0y.<\/li>\n
      • Tr\u00e1nh t\u1ea1o b\u1ee5i; n\u00ean \u0111eo k\u00ednh v\u00e0 g\u0103ng.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i M\u1ef9, ch\u00e2u \u00c2u (E473) v\u00e0 Nh\u1eadt B\u1ea3n.<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Database (nang, vi\u00ean gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i\/t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i; saccarose distearat: nh\u0169 t\u01b0\u01a1ng, kem); c\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh; mono-, di-, tristearat c\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur., USP-NF; JPE c\u00f3 ti\u00eau chu\u1ea9n cho ester saccarose c\u1ee7a acid b\u00e9o.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Saccarose monolaurat, saccarose palmitat.<\/p>\n

          Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 246-705-9 (monostearat), 248-317-5 (distearat), 248-731-6 (tristearat); PubChem CID 5360773 (monostearat).<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Sucrose Stearate<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Saccarose stearat (E473) \u2013 ch\u1ea5t nh\u0169 h\u00f3a, t\u00e1 d\u01b0\u1ee3c tr\u01a1n, k\u00e9o d\u00e0i gi\u1ea3i ph\u00f3ng Saccarose stearat (sucrose stearat, ester \u0111\u01b0\u1eddng E473) l\u00e0 h\u1ed7n h\u1ee3p ester c\u1ee7a saccarose v\u1edbi acid b\u00e9o ngu\u1ed3n th\u1ef1c v\u1eadt, ch\u1ee7 y\u1ebfu acid stearic, g\u1ed3m mono-, di-, tri- v\u00e0 polyester. Nh\u1edd \u0111\u1ea7u ph\u00e2n c\u1ef1c saccarose v\u00e0 \u0111u\u00f4i acid b\u00e9o, \u0111\u00e2y l\u00e0 ch\u1ea5t […]<\/p>\n","protected":false},"author":1,"featured_media":3671,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3672","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-stearat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-stearat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-stearat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-stearat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-stearat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-stearat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-stearat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-stearat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Saccarose stearat (E473) \u2013 ch\u1ea5t nh\u0169 h\u00f3a, t\u00e1 d\u01b0\u1ee3c tr\u01a1n, k\u00e9o d\u00e0i gi\u1ea3i ph\u00f3ng Saccarose stearat (sucrose stearat, ester \u0111\u01b0\u1eddng E473) l\u00e0 h\u1ed7n h\u1ee3p ester c\u1ee7a saccarose v\u1edbi acid b\u00e9o ngu\u1ed3n th\u1ef1c v\u1eadt, ch\u1ee7 y\u1ebfu acid stearic, g\u1ed3m mono-, di-, tri- v\u00e0 polyester. Nh\u1edd \u0111\u1ea7u ph\u00e2n c\u1ef1c saccarose v\u00e0 \u0111u\u00f4i acid b\u00e9o, \u0111\u00e2y l\u00e0 ch\u1ea5t…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3672","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3672"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3672\/revisions"}],"predecessor-version":[{"id":3943,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3672\/revisions\/3943"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3671"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3672"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3672"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3672"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}