{"id":3670,"date":"2026-09-29T09:34:04","date_gmt":"2026-09-29T02:34:04","guid":{"rendered":"https:\/\/cpc1.vn\/saccarose-palmitat\/"},"modified":"2026-09-29T12:12:59","modified_gmt":"2026-09-29T05:12:59","slug":"saccarose-palmitat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/saccarose-palmitat\/","title":{"rendered":"Saccarose palmitat (E473) \u2013 ch\u1ea5t nh\u0169 h\u00f3a kh\u00f4ng ion, t\u0103ng tan, t\u0103ng h\u1ea5p thu"},"content":{"rendered":"

Saccarose palmitat (E473) \u2013 ch\u1ea5t nh\u0169 h\u00f3a kh\u00f4ng ion, t\u0103ng tan, t\u0103ng h\u1ea5p thu<\/h1>\n

Saccarose palmitat<\/strong> (sucrose palmitat, ester \u0111\u01b0\u1eddng E473) l\u00e0 h\u1ed7n h\u1ee3p ester c\u1ee7a saccarose v\u1edbi acid b\u00e9o, ch\u1ee7 y\u1ebfu saccarose monopalmitat, k\u00e8m l\u01b0\u1ee3ng thay \u0111\u1ed5i di-, tri- v\u00e0 polyester. \u0110\u00e2y l\u00e0 ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion<\/strong> ngu\u1ed3n carbohydrat, d\u00f9ng l\u00e0m ch\u1ea5t nh\u0169 h\u00f3a<\/strong>, ch\u1ea5t ph\u00e2n t\u00e1n<\/strong>, ch\u1ea5t tr\u1ee3 tan<\/strong> v\u00e0 ch\u1ea5t t\u0103ng h\u1ea5p thu, t\u0103ng th\u1ea5m<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nSaccarose monopalmitat, sucrose hexadecanoat, sacchari monopalmitas, E473; t\u00ean th\u01b0\u01a1ng m\u1ea1i Surfhope SE Pharma, Ryoto, Sisterna PS750-C<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n26446-38-8<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC28<\/sub>H52<\/sub>O12<\/sub> \u2013 580,7 (monoester)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ph\u00e2n t\u00e1n, nh\u0169 h\u00f3a, di\u1ec7n ho\u1ea1t kh\u00f4ng ion, t\u0103ng tan<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur. (Sucrose Monopalmitate), USP-NF (Sucrose Palmitate)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t di\u1ec7n ho\u1ea1t ho\u1eb7c \u0111\u1ed3ng di\u1ec7n ho\u1ea1t \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng; \u1ed5n \u0111\u1ecbnh k\u00edch th\u01b0\u1edbc gi\u1ecdt nano nh\u0169 t\u01b0\u01a1ng d\u1ea7u \u0111\u1eadu n\u00e0nh (ph\u1ed1i h\u1ee3p phosphatidylcholin v\u00e0 natri palmitat).<\/li>\n
  • Ch\u1ea5t tr\u1ee3 tan \u2013 v\u00ed d\u1ee5 c\u1ea3i thi\u1ec7n \u0111\u1ed9 tan felodipin trong ch\u1ebf ph\u1ea9m gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t.<\/li>\n
  • T\u0103ng h\u1ea5p thu qua ni\u00eam m\u1ea1c ru\u1ed9t cho d\u01b0\u1ee3c ch\u1ea5t h\u1ea5p thu k\u00e9m; t\u01b0\u01a1ng h\u1ee3p da t\u1ed1t, t\u0103ng th\u1ea5m aciclovir t\u1eeb kem d\u1ea7u\/n\u01b0\u1edbc.<\/li>\n
  • T\u1ea1o gel nh\u1edbt \u0111\u00e0n h\u1ed3i ph\u1ee5 thu\u1ed9c nhi\u1ec7t \u0111\u1ed9 \u2013 \u1ee9ng d\u1ee5ng cho h\u1ec7 gi\u1ea3i ph\u00f3ng nh\u1ea1y nhi\u1ec7t; t\u1ea1o c\u1ed1t vi\u00ean c\u00f9ng cellulose vi tinh th\u1ec3 (l\u00e0m ch\u1eadm nh\u1eb9 gi\u1ea3i ph\u00f3ng theophylin, ibuprofen); niosome d\u00f9ng cho vaccin \u0111\u01b0\u1eddng u\u1ed1ng (nghi\u00ean c\u1ee9u).<\/li>\n
  • M\u1ef9 ph\u1ea9m (kem, lotion, son m\u00f4i, ch\u1ed1ng m\u1ed3 h\u00f4i, s\u1ea3n ph\u1ea9m t\u1eafm) \u1edf 0,5\u20135%: b\u1ecdt t\u1ed1t, r\u1ea5t d\u1ecbu da, l\u00e0m m\u1ec1m, gi\u1eef \u1ea9m. Th\u1ef1c ph\u1ea9m: b\u1ed9t m\u00ec, s\u1eefa, b\u00e1nh, k\u1eb9o, \u0111\u1ed3 u\u1ed1ng \u0111\u00f3ng g\u00f3i.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u01a1n nh\u1eddn, tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, kh\u00f4ng v\u1ecb, kh\u00f4ng m\u00f9i.<\/li>\n
    • D\u01b0\u1ee3c \u0111i\u1ec3n: monoester \u2265 55%; acid palmitic 70\u201385%, acid stearic 10\u201325% (t\u1ed5ng \u2265 90%); ch\u1ec9 s\u1ed1 acid \u2264 6,0.<\/li>\n
    • HLB kho\u1ea3ng 15\u201316 (monoester 70\u201380%); n\u00f3ng ch\u1ea3y kho\u1ea3ng 60 \u00b0C; b\u1eaft \u0111\u1ea7u ph\u00e2n h\u1ee7y \u1edf 130 \u00b0C, ho\u00e0n to\u00e0n \u1edf 240 \u00b0C.<\/li>\n
    • \u0110\u1ed9 tan: r\u1ea5t kh\u00f3 tan trong n\u01b0\u1edbc; h\u01a1i tan trong ethanol 96% v\u00e0 glycerin; kh\u00f4ng tan trong d\u1ea7u. \u1ede 75 \u00b0C tan trong n\u01b0\u1edbc v\u00e0 ethanol; \u1edf 25 \u00b0C ph\u00e2n t\u00e1n \u0111\u01b0\u1ee3c trong n\u01b0\u1edbc v\u00e0 glycerin.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n \u1edf 15\u201325 \u00b0C, tr\u00e1nh \u1ea9m.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u00e0i li\u1ec7u g\u1ed1c kh\u00f4ng ghi nh\u1eadn t\u01b0\u01a1ng k\u1ef5 c\u1ee5 th\u1ec3.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Chuy\u1ec3n ester h\u00f3a methyl ester acid palmitic (t\u1eeb m\u1ee1 \u0111\u1ed9ng v\u1eadt \u0103n \u0111\u01b0\u1ee3c, m\u1ee1 hydro h\u00f3a ho\u1eb7c d\u1ea7u th\u1ef1c v\u1eadt \u0103n \u0111\u01b0\u1ee3c, c\u00f3 b\u01b0\u1edbc c\u1ea5t) v\u1edbi saccarose. C\u00f3 th\u1ec3 d\u00f9ng ethyl acetat, methyl ethyl ceton ho\u1eb7c dimethyl sulfoxid v\u00e0 isobutanol trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u ch\u1ebf.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • JECFA \u0111\u1eb7t ADI cho ester saccarose c\u1ee7a acid b\u00e9o t\u1edbi 30 mg\/kg; li\u1ec1u cao c\u00f3 th\u1ec3 nhu\u1eadn tr\u00e0ng.<\/li>\n
      • Kh\u00f4ng k\u00edch \u1ee9ng da v\u00e0 m\u1eaft. Chu\u1ed9t c\u1ed1ng, chu\u1ed9t nh\u1eaft u\u1ed1ng t\u1ed5ng 20 g\/kg chia 10 l\u1ea7n c\u00e1ch 30\u201360 ph\u00fat kh\u00f4ng c\u00f3 t\u1eed vong. LD50<\/sub> (chu\u1ed9t nh\u1eaft, u\u1ed1ng): tr\u00ean 2 g\/kg.<\/li>\n
      • Tr\u00e1nh t\u1ea1o b\u1ee5i; n\u00ean \u0111eo k\u00ednh v\u00e0 g\u0103ng.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i M\u1ef9, ch\u00e2u \u00c2u (E473) v\u00e0 Nh\u1eadt B\u1ea3n.<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Database (u\u1ed1ng; b\u1ed9t pha h\u1ed7n d\u1ecbch); c\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh; c\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur., USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n
            \n
          • Saccarose stearat.<\/li>\n
          • Saccarose monolaurat<\/strong> (C24<\/sub>H44<\/sub>O12<\/sub>, KLPT 524,6; CAS 25339-99-5): b\u1ed9t tr\u1eafng tan trong n\u01b0\u1edbc; ch\u1ea5t nh\u0169 h\u00f3a, h\u1ed7 tr\u1ee3 t\u0103ng tan.<\/li>\n<\/ul>\n

            Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 247-706-7; PubChem CID 518683.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Sucrose Palmitate<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Saccarose palmitat (E473) \u2013 ch\u1ea5t nh\u0169 h\u00f3a kh\u00f4ng ion, t\u0103ng tan, t\u0103ng h\u1ea5p thu Saccarose palmitat (sucrose palmitat, ester \u0111\u01b0\u1eddng E473) l\u00e0 h\u1ed7n h\u1ee3p ester c\u1ee7a saccarose v\u1edbi acid b\u00e9o, ch\u1ee7 y\u1ebfu saccarose monopalmitat, k\u00e8m l\u01b0\u1ee3ng thay \u0111\u1ed5i di-, tri- v\u00e0 polyester. \u0110\u00e2y l\u00e0 ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion ngu\u1ed3n carbohydrat, d\u00f9ng l\u00e0m ch\u1ea5t nh\u0169 […]<\/p>\n","protected":false},"author":1,"featured_media":3669,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3670","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-palmitat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-palmitat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-palmitat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-palmitat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-palmitat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-palmitat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-palmitat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/saccarose-palmitat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Saccarose palmitat (E473) \u2013 ch\u1ea5t nh\u0169 h\u00f3a kh\u00f4ng ion, t\u0103ng tan, t\u0103ng h\u1ea5p thu Saccarose palmitat (sucrose palmitat, ester \u0111\u01b0\u1eddng E473) l\u00e0 h\u1ed7n h\u1ee3p ester c\u1ee7a saccarose v\u1edbi acid b\u00e9o, ch\u1ee7 y\u1ebfu saccarose monopalmitat, k\u00e8m l\u01b0\u1ee3ng thay \u0111\u1ed5i di-, tri- v\u00e0 polyester. \u0110\u00e2y l\u00e0 ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion ngu\u1ed3n carbohydrat, d\u00f9ng l\u00e0m ch\u1ea5t nh\u0169…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3670","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3670"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3670\/revisions"}],"predecessor-version":[{"id":3942,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3670\/revisions\/3942"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3669"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3670"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3670"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3670"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}