{"id":3662,"date":"2026-09-29T09:31:09","date_gmt":"2026-09-29T02:31:09","guid":{"rendered":"https:\/\/cpc1.vn\/squalan\/"},"modified":"2026-09-29T12:14:37","modified_gmt":"2026-09-29T05:14:37","slug":"squalan","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/squalan\/","title":{"rendered":"Squalan \u2013 ch\u1ea5t l\u00e0m m\u1ec1m, n\u1ec1n thu\u1ed1c m\u1ee1, t\u0103ng th\u1ea5m, b\u1ed5 tr\u1ee3 vaccin"},"content":{"rendered":"

Squalan \u2013 ch\u1ea5t l\u00e0m m\u1ec1m, n\u1ec1n thu\u1ed1c m\u1ee1, t\u0103ng th\u1ea5m, b\u1ed5 tr\u1ee3 vaccin<\/h1>\n

Squalan<\/strong> (perhydrosqualen) l\u00e0 hydrocarbon no C30, thu \u0111\u01b0\u1ee3c b\u1eb1ng hydro h\u00f3a ho\u00e0n to\u00e0n squalen \u2013 m\u1ed9t triterpen c\u00f3 trong b\u00e3 nh\u1eddn ng\u01b0\u1eddi, d\u1ea7u gan c\u00e1 m\u1eadp v\u00e0 ph\u1ea7n kh\u00f4ng x\u00e0 ph\u00f2ng h\u00f3a c\u1ee7a d\u1ea7u \u00f4 liu. D\u1ea1ng d\u1ea7u trong su\u1ed1t, kh\u00f4ng m\u00e0u, g\u1ea7n nh\u01b0 kh\u00f4ng m\u00f9i. Trong b\u00e0o ch\u1ebf, squalan l\u00e0 ch\u1ea5t l\u00e0m m\u1ec1m<\/strong>, n\u1ec1n thu\u1ed1c m\u1ee1<\/strong> v\u00e0 ch\u1ea5t t\u0103ng th\u1ea5m qua da<\/strong>; ngo\u00e0i ra d\u00f9ng l\u00e0m ch\u1ea5t mang trong thu\u1ed1c \u0111\u1ea1n v\u00e0 ch\u1ea5t b\u1ed5 tr\u1ee3 vaccin<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nPerhydrosqualen, dodecahydrosqualen, spinacan, squalanum<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n111-01-3<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC30<\/sub>H62<\/sub> \u2013 422,8 (2,6,10,15,19,23-hexamethyltetracosan)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t l\u00e0m m\u1ec1m, n\u1ec1n thu\u1ed1c m\u1ee1, ch\u1ea5t t\u0103ng th\u1ea5m<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur., USP-NF<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ebf ph\u1ea9m b\u00f4i: t\u0103ng t\u00ednh th\u1ea5m c\u1ee7a da nh\u1edd h\u00f2a l\u1eabn v\u1edbi b\u00e3 nh\u1eddn.<\/li>\n
  • Ch\u1ea5t mang d\u01b0\u1ee3c ch\u1ea5t tan trong d\u1ea7u trong thu\u1ed1c \u0111\u1ea1n.<\/li>\n
  • Ch\u1ea5t b\u1ed5 tr\u1ee3 vaccin; th\u00e0nh ph\u1ea7n nano nh\u0169 t\u01b0\u01a1ng, vi nh\u0169 t\u01b0\u01a1ng d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, m\u0169i, qua da.<\/li>\n
  • Nghi\u00ean c\u1ee9u: h\u1ec7 cung c\u1ea5p protein k\u00edch th\u00edch t\u1ea1o x\u01b0\u01a1ng (gi\u1ea3i ph\u00f3ng ch\u1eadm t\u1ea1i ch\u1ed7 t\u1eeb nang gelatin).<\/li>\n
  • Ch\u1ea5t l\u00e0m m\u1ec1m trong m\u1ef9 ph\u1ea9m, s\u1ea3n ph\u1ea9m t\u00f3c, s\u1ea3n ph\u1ea9m c\u1ea1o r\u00e2u.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • D\u1ea7u trong su\u1ed1t, kh\u00f4ng m\u00e0u, g\u1ea7n nh\u01b0 kh\u00f4ng m\u00f9i.<\/li>\n
    • USP-NF: squalan t\u1eeb hydro h\u00f3a squalen (c\u00f3 trong m\u1ed9t s\u1ed1 d\u1ea7u c\u00e1). Ph.Eur.: c\u00f3 th\u1ec3 ngu\u1ed3n th\u1ef1c v\u1eadt (ph\u1ea7n kh\u00f4ng x\u00e0 ph\u00f2ng h\u00f3a c\u1ee7a d\u1ea7u \u00f4 liu) ho\u1eb7c \u0111\u1ed9ng v\u1eadt (d\u1ea7u gan c\u00e1 m\u1eadp); h\u00e0m l\u01b0\u1ee3ng 90,0\u2013103,0%.<\/li>\n
    • T\u1ef7 tr\u1ecdng ri\u00eang kho\u1ea3ng 0,807\u20130,815; chi\u1ebft su\u1ea5t 1,450\u20131,454; \u0111\u1ed9 nh\u1edbt 34 mPa\u00b7s (20 \u00b0C); \u0111i\u1ec3m ch\u1edbp ch\u00e1y 218\u2013230 \u00b0C; s\u00f4i kho\u1ea3ng 350 \u00b0C (760 mmHg).<\/li>\n
    • \u0110\u1ed9 tan: h\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc v\u00e0 ethanol 96%; r\u1ea5t kh\u00f3 tan trong ethanol khan; tr\u1ed9n l\u1eabn v\u1edbi cloroform, ether v\u00e0 ph\u1ea7n l\u1edbn d\u1ea7u m\u1ee1; d\u1ec5 tan trong aceton, cyclohexan.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n \u1edf nhi\u1ec7t \u0111\u1ed9, \u00e1p su\u1ea5t th\u01b0\u1eddng. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i kh\u00f4 m\u00e1t, th\u00f4ng tho\u00e1ng, xa ch\u1ea5t t\u01b0\u01a1ng k\u1ef5.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Hydro h\u00f3a ho\u00e0n to\u00e0n squalen. Lo\u1ea1i th\u01b0\u01a1ng m\u1ea1i th\u01b0\u1eddng hydro h\u00f3a tr\u1ef1c ti\u1ebfp d\u1ea7u gan c\u00e1 m\u1eadp (c\u00f3 th\u1ec3 c\u00f2n \u00edt batyl alcol); ho\u1eb7c chi\u1ebft t\u1eeb ph\u1ea7n kh\u00f4ng x\u00e0 ph\u00f2ng h\u00f3a c\u1ee7a d\u1ea7u \u00f4 liu r\u1ed3i hydro h\u00f3a. Squalan ngu\u1ed3n c\u00e1 m\u1eadp ng\u00e0y c\u00e0ng k\u00e9m h\u1ea5p d\u1eabn v\u1edbi th\u1ecb tr\u01b0\u1eddng m\u1ef9 ph\u1ea9m, nh\u01b0ng v\u1eabn chi\u1ebfm \u01b0u th\u1ebf \u1edf ch\u00e2u \u00c1 do n\u0103ng su\u1ea5t cao, gi\u00e1 th\u1ea5p h\u01a1n ngu\u1ed3n \u00f4 liu; c\u00e1c ngu\u1ed3n t\u00e1i t\u1ea1o kh\u00e1c \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 \u0111\u00e3 c\u00f3 ph\u01b0\u01a1ng ph\u00e1p ph\u00e2n bi\u1ec7t ngu\u1ed3n th\u1ef1c v\u1eadt\/\u0111\u1ed9ng v\u1eadt.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • Nh\u00ecn chung \u0111\u01b0\u1ee3c coi l\u00e0 an to\u00e0n; h\u1ed9i \u0111\u1ed3ng CIR k\u1ebft lu\u1eadn an to\u00e0n trong m\u1ef9 ph\u1ea9m.<\/li>\n
      • C\u00f3 th\u1ec3 k\u00edch \u1ee9ng da, m\u1eaft, h\u00f4 h\u1ea5p, ti\u00eau h\u00f3a. Nh\u0169 t\u01b0\u01a1ng d\u1ea7u\/n\u01b0\u1edbc squalan c\u00f3 th\u1ec3 g\u00e2y \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch d\u1ecbch th\u1ec3 v\u00e0 t\u1ebf b\u00e0o (c\u01a1 s\u1edf c\u1ee7a vai tr\u00f2 b\u1ed5 tr\u1ee3 vaccin).<\/li>\n
      • LD50<\/sub> (chu\u1ed9t nh\u1eaft, t\u0129nh m\u1ea1ch): 1,8 g\/kg; (chu\u1ed9t nh\u1eaft, u\u1ed1ng): 5,0 g\/kg.<\/li>\n
      • \u0110un t\u1edbi ph\u00e2n h\u1ee7y sinh kh\u00f3i cay, k\u00edch \u1ee9ng. Tr\u00e1nh d\u00ednh m\u1eaft, da, tr\u00e1nh nu\u1ed1t, h\u00edt; m\u1eb7c \u0111\u1ed3 b\u1ea3o h\u1ed9, \u0111eo k\u00ednh.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (nh\u0169 t\u01b0\u01a1ng, kem, dung d\u1ecbch d\u00f9ng ngo\u00e0i); c\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh; c\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur., USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Xem th\u00eam d\u1ea7u kho\u00e1ng, vaselin, d\u1ea7u \u00f4 liu.<\/p>\n

          Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 203-825-6; PubChem CID 8089.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Squalane<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Squalan \u2013 ch\u1ea5t l\u00e0m m\u1ec1m, n\u1ec1n thu\u1ed1c m\u1ee1, t\u0103ng th\u1ea5m, b\u1ed5 tr\u1ee3 vaccin Squalan (perhydrosqualen) l\u00e0 hydrocarbon no C30, thu \u0111\u01b0\u1ee3c b\u1eb1ng hydro h\u00f3a ho\u00e0n to\u00e0n squalen \u2013 m\u1ed9t triterpen c\u00f3 trong b\u00e3 nh\u1eddn ng\u01b0\u1eddi, d\u1ea7u gan c\u00e1 m\u1eadp v\u00e0 ph\u1ea7n kh\u00f4ng x\u00e0 ph\u00f2ng h\u00f3a c\u1ee7a d\u1ea7u \u00f4 liu. D\u1ea1ng d\u1ea7u trong su\u1ed1t, kh\u00f4ng m\u00e0u, […]<\/p>\n","protected":false},"author":1,"featured_media":3661,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3662","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/squalan.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/squalan-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/squalan-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/squalan-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/squalan-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/squalan.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/squalan.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/squalan-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Squalan \u2013 ch\u1ea5t l\u00e0m m\u1ec1m, n\u1ec1n thu\u1ed1c m\u1ee1, t\u0103ng th\u1ea5m, b\u1ed5 tr\u1ee3 vaccin Squalan (perhydrosqualen) l\u00e0 hydrocarbon no C30, thu \u0111\u01b0\u1ee3c b\u1eb1ng hydro h\u00f3a ho\u00e0n to\u00e0n squalen \u2013 m\u1ed9t triterpen c\u00f3 trong b\u00e3 nh\u1eddn ng\u01b0\u1eddi, d\u1ea7u gan c\u00e1 m\u1eadp v\u00e0 ph\u1ea7n kh\u00f4ng x\u00e0 ph\u00f2ng h\u00f3a c\u1ee7a d\u1ea7u \u00f4 liu. D\u1ea1ng d\u1ea7u trong su\u1ed1t, kh\u00f4ng m\u00e0u,…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3662","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3662"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3662\/revisions"}],"predecessor-version":[{"id":3960,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3662\/revisions\/3960"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3661"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3662"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3662"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3662"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}