{"id":3647,"date":"2026-09-29T09:27:26","date_gmt":"2026-09-29T02:27:26","guid":{"rendered":"https:\/\/cpc1.vn\/pullulan\/"},"modified":"2026-09-29T09:27:26","modified_gmt":"2026-09-29T02:27:26","slug":"pullulan","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/pullulan\/","title":{"rendered":"Pullulan (E1204) \u2013 v\u1ecf nang, m\u00e0ng tan nhanh, t\u1ea1o m\u00e0ng bao"},"content":{"rendered":"

Pullulan (E1204) \u2013 v\u1ecf nang, m\u00e0ng tan nhanh, t\u1ea1o m\u00e0ng bao<\/h1>\n

Pullulan<\/strong> (E1204) l\u00e0 polysaccharid trung t\u00ednh do n\u1ea5m men \u0111en Aureobasidium pullulans<\/em> t\u1ea1o ra, g\u1ed3m c\u00e1c \u0111\u01a1n v\u1ecb maltotriose n\u1ed1i v\u1edbi nhau b\u1eb1ng li\u00ean k\u1ebft \u03b1-1,6. D\u1ea1ng b\u1ed9t tr\u1eafng, tan t\u1ed1t trong n\u01b0\u1edbc l\u1ea1nh v\u00e0 n\u00f3ng, t\u1ea1o m\u00e0ng r\u1ea5t \u00edt th\u1ea5m oxy v\u00e0 b\u1ec1n c\u01a1 h\u1ecdc. Trong b\u00e0o ch\u1ebf, pullulan l\u00e0 v\u1eadt li\u1ec7u v\u1ecf nang<\/strong>, t\u00e1c nh\u00e2n t\u1ea1o m\u00e0ng<\/strong> (m\u00e0ng tan nhanh, bao vi\u00ean), t\u00e1 d\u01b0\u1ee3c d\u00ednh, \u0111\u1ed9n<\/strong> v\u00e0 t\u0103ng \u0111\u1ed9 nh\u1edbt<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\n1,4-1,6-\u03b1-D-glucan, maltotriose n\u1ed1i \u03b1-1,6, E1204; t\u00ean th\u01b0\u01a1ng m\u1ea1i Pullulan PI-10, PI-20<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n9057-02-7<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c<\/td>\n(C36<\/sub>H60<\/sub>O30<\/sub>)n<\/sub>; ph\u00e2n t\u1eed l\u01b0\u1ee3ng t\u1eeb kho\u1ea3ng 8000 t\u1edbi tr\u00ean 2 000 000 Da t\u00f9y \u0111i\u1ec1u ki\u1ec7n nu\u00f4i c\u1ea5y (PI-20: kho\u1ea3ng 200 000 Da)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nV\u1eadt li\u1ec7u v\u1ecf nang, t\u00e1 d\u01b0\u1ee3c bao, t\u1ea1o m\u00e0ng, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n v\u00e0 d\u00ednh vi\u00ean n\u00e9n\/vi\u00ean nang, t\u0103ng \u0111\u1ed9 nh\u1edbt<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, JP, Ph.Eur., USP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong JPE v\u00e0 Food Chemicals Codex<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t mang polymer t\u1ea1o m\u00e0ng \u0103n \u0111\u01b0\u1ee3c tan nhanh b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ed5 khu\u00f4n dung m\u00f4i.<\/li>\n
  • V\u1ecf nang tan trong n\u01b0\u1edbc, th\u1ea5m oxy th\u1ea5p \u2013 c\u00f3 \u00edch cho th\u00e0nh ph\u1ea7n nh\u1ea1y oxy h\u00f3a.<\/li>\n
  • Pullulan d\u1ea1ng h\u1ea1t c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng d\u1eadp vi\u00ean c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t v\u00e0 t\u00e1 d\u01b0\u1ee3c kh\u00e1c.<\/li>\n
  • Bao vi\u00ean: l\u00e0m l\u1edbp l\u00f3t t\u0103ng \u0111\u1ed9 b\u00e1m d\u00ednh; l\u00e0m l\u1edbp ph\u1ee7 ngo\u00e0i t\u0103ng \u0111\u1ed9 b\u1ec1n v\u00e0 \u0111\u00e0n h\u1ed3i c\u1ee7a m\u00e0ng bao.<\/li>\n
  • \u1ed4n \u0111\u1ecbnh d\u01b0\u1ee3c ch\u1ea5t nh\u1ea1y \u1ea9m trong ch\u1ebf ph\u1ea9m \u0111\u00f4ng kh\u00f4 (h\u1ea1n ch\u1ebf linh \u0111\u1ed9ng c\u1ee7a n\u01b0\u1edbc). Nghi\u00ean c\u1ee9u: ti\u1ec3u ph\u00e2n nano pullulan d\u1eabn gen, nucleotid; hydrogel pullulan th\u1ebf; li\u00ean h\u1ee3p pullulan \u2013 acid stearic; pullulan acetat phthalat t\u0103ng h\u00f2a tan diazepam.<\/li>\n
  • M\u1ef9 ph\u1ea9m (d\u1ea7u g\u1ed9i, ch\u0103m s\u00f3c da, r\u1eeda m\u1eb7t); t\u1ea1i Nh\u1eadt B\u1ea3n d\u00f9ng l\u00e2u n\u0103m l\u00e0m ph\u1ee5 gia v\u00e0 m\u00e0ng bao th\u1ef1c ph\u1ea9m.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u1eafng t\u1edbi tr\u1eafng ng\u00e0, kh\u00f4ng m\u00f9i.<\/li>\n
    • D\u01b0\u1ee3c \u0111i\u1ec3n: pH 4,5\u20136,5; \u0111\u1ed9 nh\u1edbt \u0111\u1ed9ng h\u1ecdc 100\u2013180 mm\u00b2\/s; c\u1eafn sau nung \u2264 0,3%; gi\u1edbi h\u1ea1n mono-, di- v\u00e0 oligosaccharid.<\/li>\n
    • Kh\u00f4ng h\u00fat \u1ea9m: \u0111\u1ed9 \u1ea9m 10\u201315% \u1edf \u0111\u1ed9 \u1ea9m t\u01b0\u01a1ng \u0111\u1ed1i d\u01b0\u1edbi 70%.<\/li>\n
    • Pullulan PI-20: \u0111\u1ed9 tinh khi\u1ebft 91,2\u201395,0% (kh\u00f4); t\u1ed5ng mono-, di-, oligosaccharid 5,0\u20138,7%; \u0111\u1ed9 nh\u1edbt dung d\u1ecbch 10% \u1edf 30 \u00b0C 132\u2013179 mm\u00b2\/s; pH dung d\u1ecbch 10% 5\u20137.<\/li>\n
    • \u0110\u1ed9 tan: d\u1ec5 tan trong n\u01b0\u1edbc l\u1ea1nh v\u00e0 n\u00f3ng; tan trong dimethylformamid, dimethyl sulfoxid; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ethanol; kh\u00f4ng tan trong methylen clorid.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      Kh\u00f4ng kh\u1eed, t\u01b0\u01a1ng \u0111\u1ed1i b\u1ec1n; ph\u00e2n h\u1ee7y v\u00e0 ch\u00e1y th\u00e0nh than \u1edf 250\u2013280 \u00b0C. B\u1ec1n trong dung d\u1ecbch n\u01b0\u1edbc \u1edf kho\u1ea3ng pH r\u1ed9ng, khi c\u00f3 mu\u1ed1i v\u00e0 ph\u1ea7n l\u1edbn ion kim lo\u1ea1i; ch\u1ec9 khi \u0111un l\u00e2u \u1edf pH d\u01b0\u1edbi 3 m\u1edbi gi\u1ea3m \u0111\u1ed9 nh\u1edbt (th\u1ee7y ph\u00e2n kh\u1eed tr\u00f9ng h\u1ee3p). B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u00e0i li\u1ec7u g\u1ed1c kh\u00f4ng ghi nh\u1eadn t\u01b0\u01a1ng k\u1ef5 c\u1ee5 th\u1ec3.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      L\u00ean men siro tinh b\u1ed9t b\u1eb1ng Aureobasidium pullulans<\/em> \u1edf nhi\u1ec7t \u0111\u1ed9 \u01b0a \u1ea5m (22\u201330 \u00b0C). D\u1ecbch nu\u00f4i c\u1ea5y \u0111\u01b0\u1ee3c l\u1ecdc, ti\u1ec7t khu\u1ea9n, t\u1ea9y m\u00e0u, l\u1ecdc ti\u1ebfp; lo\u1ea1i mu\u1ed1i v\u00e0 protein b\u1eb1ng nh\u1ef1a trao \u0111\u1ed5i ion; c\u00f4 \u0111\u1eb7c, t\u1ea9y m\u00e0u, l\u1ecdc, s\u1ea5y kh\u00f4 r\u1ed3i nghi\u1ec1n.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • Enzym ti\u00eau h\u00f3a th\u1ee7y ph\u00e2n pullulan r\u1ea5t ch\u1eadm; vi khu\u1ea9n ru\u1ed9t l\u00ean men th\u00e0nh acid b\u00e9o chu\u1ed7i ng\u1eafn. Chu\u1ed9t c\u1ed1ng dung n\u1ea1p kh\u1ea9u ph\u1ea7n 10% pullulan (kho\u1ea3ng 7,9 g\/kg\/ng\u00e0y) kh\u00f4ng c\u00f3 \u0111\u1ed9c t\u00ednh. L\u01b0\u1ee3ng ch\u1ea5p nh\u1eadn h\u1eb1ng ng\u00e0y \u1edf ng\u01b0\u1eddi d\u01b0\u1edbi 10 g.<\/li>\n
      • Kh\u00f4ng c\u00f3 d\u1ea5u hi\u1ec7u \u0111\u1ed9c t\u00ednh di truy\u1ec1n (th\u1eed nghi\u1ec7m tr\u00ean Salmonella typhimurium<\/em>).<\/li>\n
      • LD50<\/sub> (chu\u1ed9t nh\u1eaft, u\u1ed1ng): tr\u00ean 14 g\/kg; (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): tr\u00ean 24 g\/kg.<\/li>\n
      • Thao t\u00e1c theo l\u01b0u \u00fd th\u00f4ng th\u01b0\u1eddng.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS; \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E1204); \u0111\u01b0\u1ee3c ph\u00e9p l\u00e0m th\u00e0nh ph\u1ea7n th\u1ef1c ph\u1ea9m t\u1ea1i Nh\u1eadt B\u1ea3n.<\/li>\n
        • C\u00f3 trong Canadian Natural Health Products Ingredients Database v\u00e0 thu\u1ed1c kh\u00f4ng ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Dextran, dextrin (\u0111\u1ec1u l\u00e0 polysaccharid t\u1eeb l\u00ean men vi sinh ho\u1eb7c tinh b\u1ed9t).<\/p>\n

          Ghi ch\u00fa:<\/strong> trong t\u00ean Pullulan PI-20: P l\u00e0 pullulan, I l\u00e0 \u0111\u00e3 kh\u1eed ion, 20 ch\u1ec9 ph\u00e2n t\u1eed l\u01b0\u1ee3ng trung b\u00ecnh kho\u1ea3ng 200 000 Da. S\u1ed1 EINECS 232-945-1.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Pullulan<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Pullulan (E1204) \u2013 v\u1ecf nang, m\u00e0ng tan nhanh, t\u1ea1o m\u00e0ng bao Pullulan (E1204) l\u00e0 polysaccharid trung t\u00ednh do n\u1ea5m men \u0111en Aureobasidium pullulans t\u1ea1o ra, g\u1ed3m c\u00e1c \u0111\u01a1n v\u1ecb maltotriose n\u1ed1i v\u1edbi nhau b\u1eb1ng li\u00ean k\u1ebft \u03b1-1,6. D\u1ea1ng b\u1ed9t tr\u1eafng, tan t\u1ed1t trong n\u01b0\u1edbc l\u1ea1nh v\u00e0 n\u00f3ng, t\u1ea1o m\u00e0ng r\u1ea5t \u00edt th\u1ea5m oxy v\u00e0 b\u1ec1n […]<\/p>\n","protected":false},"author":1,"featured_media":3646,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3647","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/pullulan.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/pullulan-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/pullulan-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/pullulan-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/pullulan-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/pullulan.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/pullulan.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/pullulan-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Pullulan (E1204) \u2013 v\u1ecf nang, m\u00e0ng tan nhanh, t\u1ea1o m\u00e0ng bao Pullulan (E1204) l\u00e0 polysaccharid trung t\u00ednh do n\u1ea5m men \u0111en Aureobasidium pullulans t\u1ea1o ra, g\u1ed3m c\u00e1c \u0111\u01a1n v\u1ecb maltotriose n\u1ed1i v\u1edbi nhau b\u1eb1ng li\u00ean k\u1ebft \u03b1-1,6. D\u1ea1ng b\u1ed9t tr\u1eafng, tan t\u1ed1t trong n\u01b0\u1edbc l\u1ea1nh v\u00e0 n\u00f3ng, t\u1ea1o m\u00e0ng r\u1ea5t \u00edt th\u1ea5m oxy v\u00e0 b\u1ec1n…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3647","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3647"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3647\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3646"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3647"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3647"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3647"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}