{"id":3631,"date":"2026-09-29T09:22:07","date_gmt":"2026-09-29T02:22:07","guid":{"rendered":"https:\/\/cpc1.vn\/phen-chua-kali-alum\/"},"modified":"2026-09-29T09:22:07","modified_gmt":"2026-09-29T02:22:07","slug":"phen-chua-kali-alum","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/phen-chua-kali-alum\/","title":{"rendered":"Ph\u00e8n chua (kali alum) \u2013 ch\u1ea5t b\u1ed5 tr\u1ee3 vaccin, ch\u1ea5t l\u00e0m se"},"content":{"rendered":"

Ph\u00e8n chua (kali alum) \u2013 ch\u1ea5t b\u1ed5 tr\u1ee3 vaccin, ch\u1ea5t l\u00e0m se<\/h1>\n

Ph\u00e8n chua<\/strong> (kali alum, nh\u00f4m kali sulfat) th\u01b0\u1eddng \u1edf d\u1ea1ng dodecahydrat, tinh th\u1ec3 kh\u00f4ng m\u00e0u, v\u1ecb h\u01a1i ng\u1ecdt v\u00e0 r\u1ea5t ch\u00e1t. Trong b\u00e0o ch\u1ebf, ph\u00e8n chua \u0111\u01b0\u1ee3c x\u1ebfp l\u00e0 ch\u1ea5t b\u1ed5 tr\u1ee3 vaccin<\/strong>: n\u00f3 t\u1ee7a protein, v\u00e0 protein tinh khi\u1ebft \u0111\u01b0\u1ee3c \u0111\u1ed3ng t\u1ee7a, h\u1ea5p ph\u1ee5 l\u00ean ph\u00e8n khi s\u1ea3n xu\u1ea5t vaccin. Ph\u00e8n chua c\u00f2n c\u00f3 trong n\u01b0\u1edbc s\u00fac mi\u1ec7ng, thu\u1ed1c s\u00fac h\u1ecdng v\u00e0 ch\u1ebf ph\u1ea9m da li\u1ec5u.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nAlum, kali alum, nh\u00f4m kali sulfat, ph\u00e8n kali, alumen, kalinit<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n10043-67-1 (khan); 7784-24-9 (dodecahydrat)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nAlK(SO4<\/sub>)2<\/sub> \u2013 258,21 (khan); AlK(SO4<\/sub>)2<\/sub>\u00b712H2<\/sub>O \u2013 474,39 (dodecahydrat)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ed5 tr\u1ee3 vaccin<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur. (Alum), JP (Aluminum Potassium Sulfate Hydrate; c\u00f3 th\u00eam chuy\u00ean lu\u1eadn d\u1ea1ng kh\u00f4), USP-NF (Potassium Alum)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • S\u1ea3n xu\u1ea5t vaccin: protein tinh khi\u1ebft \u0111\u01b0\u1ee3c \u0111\u1ed3ng t\u1ee7a v\u00e0 h\u1ea5p ph\u1ee5 l\u00ean ph\u00e8n chua.<\/li>\n
  • Nghi\u00ean c\u1ee9u: \u0111\u00f4ng kh\u00f4 m\u00e0ng m\u1ecfng t\u1ea1o b\u1ed9t kh\u00f4 vaccin ch\u1ee9a mu\u1ed1i nh\u00f4m, h\u01b0\u1edbng t\u1edbi gi\u1ea3m ph\u1ee5 thu\u1ed9c chu\u1ed7i l\u1ea1nh.<\/li>\n
  • N\u01b0\u1edbc s\u00fac mi\u1ec7ng, thu\u1ed1c s\u00fac h\u1ecdng, ch\u1ebf ph\u1ea9m da li\u1ec5u (t\u00e1c d\u1ee5ng l\u00e0m se m\u1ea1nh).<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t h\u1ea1t ho\u1eb7c kh\u1ed1i k\u1ebft tinh trong su\u1ed1t, kh\u00f4ng m\u00e0u (Ph.Eur.); tinh th\u1ec3 ho\u1eb7c b\u1ed9t kh\u00f4ng m\u00e0u hay tr\u1eafng (JP). Kh\u00f4ng m\u00f9i, v\u1ecb h\u01a1i ng\u1ecdt, r\u1ea5t ch\u00e1t.<\/li>\n
    • pH dung d\u1ecbch 10%: 3,0\u20133,5 (20 \u00b0C); t\u1ef7 tr\u1ecdng th\u1ef1c 1,725 g\/cm\u00b3; d\u1ea1ng dodecahydrat n\u00f3ng ch\u1ea3y kho\u1ea3ng 92,5 \u00b0C.<\/li>\n
    • \u0110\u1ed9 tan: d\u1ec5 tan trong n\u01b0\u1edbc, r\u1ea5t d\u1ec5 tan trong n\u01b0\u1edbc s\u00f4i; tan trong glycerol; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ethanol 96%.<\/li>\n
    • D\u01b0\u1ee3c \u0111i\u1ec3n: h\u00e0m l\u01b0\u1ee3ng 99,0\u2013100,5%.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n \u1edf nhi\u1ec7t \u0111\u1ed9, \u00e1p su\u1ea5t th\u01b0\u1eddng. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t. \u0110\u1ec3 l\u00e2u \u1edf 60\u201365 \u00b0C (ho\u1eb7c tr\u00ean acid sulfuric) d\u1ea1ng dodecahydrat m\u1ea5t n\u01b0\u1edbc, h\u00fat l\u1ea1i khi ra kh\u00f4ng kh\u00ed; tr\u1edf th\u00e0nh d\u1ea1ng khan \u1edf kho\u1ea3ng 200 \u00b0C.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh, nh\u00f4m, \u0111\u1ed3ng, th\u00e9p v\u00e0 k\u1ebdm. Ph\u1ed1i h\u1ee3p trong b\u1ed9t v\u1edbi phenol, salicylat ho\u1eb7c acid tannic c\u00f3 th\u1ec3 l\u00ean m\u00e0u x\u00e1m ho\u1eb7c xanh do v\u1ebft s\u1eaft trong ph\u00e8n.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      X\u1eed l\u00fd bauxit b\u1eb1ng acid sulfuric r\u1ed3i kali sulfat; ho\u1eb7c cho nh\u00f4m sulfat ph\u1ea3n \u1ee9ng v\u1edbi kali sulfat.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • Li\u1ec1u l\u1edbn g\u00e2y k\u00edch \u1ee9ng, c\u00f3 th\u1ec3 \u0103n m\u00f2n; \u0111\u00e3 ghi nh\u1eadn ho\u1ea1i t\u1eed l\u1ee3i v\u00e0 xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a. \u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o b\u1ec7nh n\u00e3o c\u1ea5p sau khi r\u1eeda b\u00e0ng quang b\u1eb1ng dung d\u1ecbch ph\u00e8n; n\u00ean tr\u00e1nh \u1edf ng\u01b0\u1eddi suy th\u1eadn.<\/li>\n
      • Nghi\u00ean c\u1ee9u tr\u00ean chu\u1ed9t cho th\u1ea5y ph\u00e8n g\u00e2y r\u1ed1i lo\u1ea1n gi\u1ed1ng h\u1ed9i ch\u1ee9ng Sj\u00f6gren \u2013 kh\u1ea3 n\u0103ng g\u00e2y t\u1ef1 mi\u1ec5n c\u1ee7a ch\u1ea5t b\u1ed5 tr\u1ee3 g\u1ed1c nh\u00f4m c\u1ea7n theo d\u00f5i \u1edf ng\u01b0\u1eddi c\u00f3 c\u01a1 \u0111\u1ecba d\u1ec5 m\u1eafc b\u1ec7nh t\u1ef1 mi\u1ec5n.<\/li>\n
      • K\u00edch \u1ee9ng m\u1eaft, da v\u00e0 c\u00f3 th\u1ec3 k\u00edch \u1ee9ng h\u00f4 h\u1ea5p. Khi ch\u00e1y c\u00f3 th\u1ec3 sinh kh\u00ed r\u1ea5t \u0111\u1ed9c: oxyd l\u01b0u hu\u1ef3nh, nh\u00f4m oxyd, oxyd kali. ACGIH: 2 mg\/m\u00b3 TWA (t\u00ednh theo nh\u00f4m).<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (thu\u1ed1c \u0111\u1ea1n \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c l\u01b0u h\u00e0nh t\u1ea1i Anh; c\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP, Ph.Eur., USP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Xem th\u00eam nh\u00f4m hydroxyd v\u00e0 nh\u00f4m phosphat d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c b\u1ed5 tr\u1ee3 vaccin.<\/p>\n

          Ghi ch\u00fa:<\/strong> ph\u00e8n chua c\u00f2n c\u00f3 c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c (l\u00e0m se, c\u1ea7m m\u00e1u t\u1ea1i ch\u1ed7) \u2013 n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. S\u1ed1 EINECS 233-141-3 (khan); PubChem CID 62667 (dodecahydrat).<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Potassium Alum<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Ph\u00e8n chua (kali alum) \u2013 ch\u1ea5t b\u1ed5 tr\u1ee3 vaccin, ch\u1ea5t l\u00e0m se Ph\u00e8n chua (kali alum, nh\u00f4m kali sulfat) th\u01b0\u1eddng \u1edf d\u1ea1ng dodecahydrat, tinh th\u1ec3 kh\u00f4ng m\u00e0u, v\u1ecb h\u01a1i ng\u1ecdt v\u00e0 r\u1ea5t ch\u00e1t. Trong b\u00e0o ch\u1ebf, ph\u00e8n chua \u0111\u01b0\u1ee3c x\u1ebfp l\u00e0 ch\u1ea5t b\u1ed5 tr\u1ee3 vaccin: n\u00f3 t\u1ee7a protein, v\u00e0 protein tinh khi\u1ebft \u0111\u01b0\u1ee3c \u0111\u1ed3ng t\u1ee7a, […]<\/p>\n","protected":false},"author":1,"featured_media":3630,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3631","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phen-chua-kali-alum.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phen-chua-kali-alum-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phen-chua-kali-alum-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phen-chua-kali-alum-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phen-chua-kali-alum-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phen-chua-kali-alum.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phen-chua-kali-alum.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phen-chua-kali-alum-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Ph\u00e8n chua (kali alum) \u2013 ch\u1ea5t b\u1ed5 tr\u1ee3 vaccin, ch\u1ea5t l\u00e0m se Ph\u00e8n chua (kali alum, nh\u00f4m kali sulfat) th\u01b0\u1eddng \u1edf d\u1ea1ng dodecahydrat, tinh th\u1ec3 kh\u00f4ng m\u00e0u, v\u1ecb h\u01a1i ng\u1ecdt v\u00e0 r\u1ea5t ch\u00e1t. Trong b\u00e0o ch\u1ebf, ph\u00e8n chua \u0111\u01b0\u1ee3c x\u1ebfp l\u00e0 ch\u1ea5t b\u1ed5 tr\u1ee3 vaccin: n\u00f3 t\u1ee7a protein, v\u00e0 protein tinh khi\u1ebft \u0111\u01b0\u1ee3c \u0111\u1ed3ng t\u1ee7a,…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3631","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3631"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3631\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3630"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3631"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3631"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3631"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}