{"id":3623,"date":"2026-09-29T09:20:23","date_gmt":"2026-09-29T02:20:23","guid":{"rendered":"https:\/\/cpc1.vn\/poly-dl-lactic-acid\/"},"modified":"2026-09-29T12:11:03","modified_gmt":"2026-09-29T05:11:03","slug":"poly-dl-lactic-acid","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/poly-dl-lactic-acid\/","title":{"rendered":"Poly(acid DL-lactic) (PDLLA) \u2013 polymer ph\u00e2n h\u1ee7y sinh h\u1ecdc cho c\u1ea5y gh\u00e9p, ti\u00eam gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i"},"content":{"rendered":"

Poly(acid DL-lactic) (PDLLA) \u2013 polymer ph\u00e2n h\u1ee7y sinh h\u1ecdc cho c\u1ea5y gh\u00e9p, ti\u00eam gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/h1>\n

Poly(acid DL-lactic)<\/strong> (PDLLA, DL-PLA, poly-DL-lactid) l\u00e0 polyester m\u1ea1ch th\u1eb3ng t\u1ea1o t\u1eeb h\u1ed7n h\u1ee3p racemic acid lactic, d\u1ea1ng h\u1ea1t th\u1ee7y tinh m\u00e0u tr\u1eafng t\u1edbi v\u00e0ng \u00f3ng. \u0110\u00e2y l\u00e0 polymer ph\u00e2n h\u1ee7y sinh h\u1ecdc<\/strong> d\u00f9ng cho h\u1ec7 cung c\u1ea5p thu\u1ed1c c\u1ea5y gh\u00e9p<\/strong>, thu\u1ed1c ti\u00eam gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/strong>, ph\u00e2n t\u00e1n r\u1eafn \u0111\u01b0\u1eddng u\u1ed1ng v\u00e0 l\u00e0m t\u00e1 d\u01b0\u1ee3c bao<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nPDLLA, DL-PLA, poly-DL-lactid, poly(D,L-lactic acid), homopolymer DL-lactid<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n26023-30-3; 26680-10-4; 202832-99-3<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c<\/td>\n(C3<\/sub>H4<\/sub>O2<\/sub>)n<\/sub>; ph\u00e2n t\u1eed l\u01b0\u1ee3ng t\u00f9y \u1ee9ng d\u1ee5ng; nh\u00f3m \u0111\u1ea7u m\u1ea1ch c\u00f3 th\u1ec3 l\u00e0 ester, hydroxyl ho\u1eb7c acid carboxylic<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nV\u1eadt li\u1ec7u ph\u00e2n h\u1ee7y sinh h\u1ecdc, t\u00e1 d\u01b0\u1ee3c bao, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • H\u1ec7 cung c\u1ea5p thu\u1ed1c d\u1ea1ng c\u1ea5y gh\u00e9p, thu\u1ed1c ti\u00eam (b\u1ed9t pha h\u1ed7n d\u1ecbch ti\u00eam b\u1eafp, d\u01b0\u1edbi da gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i), h\u1ec7 cung c\u1ea5p thu\u1ed1c nha chu; ph\u00e2n t\u00e1n r\u1eafn \u0111\u01b0\u1eddng u\u1ed1ng; t\u00e1 d\u01b0\u1ee3c bao.<\/li>\n
  • Do gi\u00f2n, \u00edt d\u00f9ng \u0111\u01a1n \u0111\u1ed9c \u2013 th\u01b0\u1eddng ph\u1ed1i tr\u1ed9n ho\u1eb7c \u0111\u1ed3ng tr\u00f9ng h\u1ee3p v\u1edbi polymer kh\u00e1c (PLGA, PEO, PEG, PVP, PVA). Ph\u01b0\u01a1ng ph\u00e1p ti\u1ec7t khu\u1ea9n c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng t\u00ednh ch\u1ea5t c\u01a1 h\u1ecdc.<\/li>\n
  • Thi\u1ebft b\u1ecb y t\u1ebf: b\u0103ng g\u1ea1c ph\u1eabu thu\u1eadt, ch\u1ec9 kh\u00e2u, stent, khung m\u00f4 k\u1ef9 thu\u1eadt, c\u1ed1 \u0111\u1ecbnh r\u0103ng v\u00e0 x\u01b0\u01a1ng.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • V\u1eadt li\u1ec7u th\u1ee7y tinh d\u1ea1ng vi\u00ean ho\u1eb7c h\u1ea1t, tr\u1eafng t\u1edbi v\u00e0ng \u00f3ng; v\u1ec1 c\u01a1 b\u1ea3n v\u00f4 \u0111\u1ecbnh h\u00ecnh.<\/li>\n
    • T\u00ednh ch\u1ea5t nhi\u1ec7t v\u00e0 c\u01a1 h\u1ecdc ph\u1ee5 thu\u1ed9c tr\u1ef1c ti\u1ebfp ph\u00e2n t\u1eed l\u01b0\u1ee3ng v\u00e0 th\u00e0nh ph\u1ea7n: t\u1ef7 tr\u1ecdng 1,21\u20131,28 g\/cm\u00b3; \u0111\u1ed9 b\u1ec1n k\u00e9o 35\u201385 MPa; \u0111\u1ed9 gi\u00e3n d\u00e0i 2,5\u20137,0%; \u0111\u1ed9 nh\u1edbt n\u1ed9i t\u1ea1i \u0111i\u1ec3n h\u00ecnh 0,55\u20130,75 dL\/g.<\/li>\n
    • \u0110\u1ed9 tan: tan trong dicloromethan, tetrahydrofuran, ethyl acetat, cloroform, hexafluoroisopropanol, aceton; kh\u00f4ng tan trong n\u01b0\u1edbc.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 ph\u00e2n h\u1ee7y<\/h2>\n
        \n
      • B\u1ec1n khi kh\u00f4; ph\u00e2n h\u1ee7y sinh h\u1ecdc trong kho\u1ea3ng 10\u201315 th\u00e1ng t\u00f9y ph\u00e2n t\u1eed l\u01b0\u1ee3ng. \u1ea8m v\u00e0 nhi\u1ec7t l\u00e0m ph\u00e2n h\u1ee7y nhanh h\u01a1n; trong n\u01b0\u1edbc \u1edf 25 \u00b0C b\u1eaft \u0111\u1ea7u ph\u00e2n h\u1ee7y sau kho\u1ea3ng 6 th\u00e1ng.<\/li>\n
      • C\u01a1 ch\u1ebf hai b\u01b0\u1edbc:<\/strong> tr\u01b0\u1edbc h\u1ebft li\u00ean k\u1ebft ester b\u1ecb th\u1ee7y ph\u00e2n (kh\u00f4ng c\u1ea7n vi sinh v\u1eadt) th\u00e0nh polymer ph\u00e2n t\u1eed l\u01b0\u1ee3ng th\u1ea5p; khi ph\u00e2n t\u1eed l\u01b0\u1ee3ng xu\u1ed1ng d\u01b0\u1edbi kho\u1ea3ng 10 000, vi sinh v\u1eadt ti\u00eau h\u00f3a polymer th\u00e0nh CO2<\/sub> v\u00e0 n\u01b0\u1edbc.<\/li>\n
      • Nh\u00f3m \u0111\u1ea7u m\u1ea1ch carboxylic th\u00e2n n\u01b0\u1edbc h\u01a1n n\u00ean th\u1ee7y ph\u00e2n v\u00e0 gi\u1ea3i ph\u00f3ng thu\u1ed1c nhanh h\u01a1n nh\u00f3m \u0111\u1ea7u hydroxyl ho\u1eb7c ester. PDLLA nh\u00ecn chung b\u1ec1n h\u01a1n poly(L-lactic) ho\u1eb7c poly(D-lactic) \u0111\u01a1n \u0111\u1ed9c.<\/li>\n
      • B\u1ea3o qu\u1ea3n trong m\u00f4i tr\u01b0\u1eddng kh\u00f4, tr\u01a1, \u1edf \u221215 t\u1edbi \u221220 \u00b0C.<\/li>\n<\/ul>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        T\u01b0\u01a1ng k\u1ef5 v\u1edbi acid m\u1ea1nh v\u00e0 ch\u1ea5t ki\u1ec1m.<\/p>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        T\u1eeb h\u1ed7n h\u1ee3p racemic acid lactic. Acid lactic \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t t\u1eeb ethylen (con \u0111\u01b0\u1eddng h\u00f3a d\u1ea7u, ch\u1ec9 cho d\u1ea1ng racemic) ho\u1eb7c l\u00ean men vi khu\u1ea9n D-glucose (ch\u1ee7 y\u1ebfu cho d\u1ea1ng L). Polymer ph\u00e2n t\u1eed l\u01b0\u1ee3ng th\u1ea5p (500\u201310 000 Da) t\u1ea1o tr\u1ef1c ti\u1ebfp b\u1eb1ng tr\u00f9ng ng\u01b0ng; ph\u00e2n t\u1eed l\u01b0\u1ee3ng cao h\u01a1n t\u1ea1o b\u1eb1ng c\u00e1ch kh\u1eed tr\u00f9ng h\u1ee3p th\u00e0nh dimer v\u00f2ng (lactid) r\u1ed3i tr\u00f9ng h\u1ee3p m\u1edf v\u00f2ng, ho\u1eb7c tr\u00f9ng ng\u01b0ng tr\u1ef1c ti\u1ebfp c\u00f3 c\u1ea5t \u0111\u1eb3ng ph\u00ed.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
          \n
        • Ph\u00e2n h\u1ee7y th\u00e0nh acid lactic \u2013 ch\u1ea5t dung n\u1ea1p t\u1ed1t, kh\u00f4ng \u0111\u1ed9c. Nhi\u1ec1u nghi\u00ean c\u1ee9u in vitro, in vivo cho th\u1ea5y PLA dung n\u1ea1p t\u1ed1t, kh\u00f4ng g\u00e2y \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u00e1ng k\u1ec3; m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u ghi nh\u1eadn \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch nh\u1eb9. FDA ghi nh\u1eadn v\u00e0i ca hi\u1ebfm ph\u1ea3n \u1ee9ng vi\u00eam khi ti\u00eam PDLLA th\u1ea9m m\u1ef9.<\/li>\n
        • N\u00ean b\u1ea3o v\u1ec7 m\u1eaft v\u00e0 da; thao t\u00e1c trong \u0111i\u1ec1u ki\u1ec7n kh\u00f4, tr\u01a1.<\/li>\n<\/ul>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • C\u00f3 trong FDA Inactive Ingredients Database (ti\u00eam b\u1eafp: b\u1ed9t pha ti\u00eam, h\u1ed7n d\u1ecbch \u0111\u00f4ng kh\u00f4; h\u1ec7 cung c\u1ea5p thu\u1ed1c nha chu).<\/li>\n
          • \u0110\u01b0\u1ee3c x\u1ebfp “kh\u00f4ng nguy h\u1ea1i” theo Ch\u1ec9 th\u1ecb ch\u00e2u \u00c2u 67\/548\/EEC; c\u00f3 trong b\u1ed9t pha h\u1ed7n d\u1ecbch ti\u00eam d\u01b0\u1edbi da\/b\u1eafp gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i l\u01b0u h\u00e0nh t\u1ea1i Anh.<\/li>\n<\/ul>\n

            Ch\u1ea5t li\u00ean quan<\/h2>\n

            Polyester aliphatic (PLA, PGA, PLGA, PCL), acid lactic.<\/p>\n

            Ghi ch\u00fa:<\/strong> PDLLA c\u00f3 nhi\u1ec1u t\u00ean IUPAC, s\u1ed1 CAS v\u00e0 c\u00f4ng th\u1ee9c kh\u00e1c nhau do t\u00e0i li\u1ec7u l\u1ea5y ch\u1ea5t ph\u1ea3n \u1ee9ng (acid lactic hay lactid) l\u00e0m \u0111\u01a1n v\u1ecb l\u1eb7p.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Poly(DL-Lactic Acid)<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Poly(acid DL-lactic) (PDLLA) \u2013 polymer ph\u00e2n h\u1ee7y sinh h\u1ecdc cho c\u1ea5y gh\u00e9p, ti\u00eam gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i Poly(acid DL-lactic) (PDLLA, DL-PLA, poly-DL-lactid) l\u00e0 polyester m\u1ea1ch th\u1eb3ng t\u1ea1o t\u1eeb h\u1ed7n h\u1ee3p racemic acid lactic, d\u1ea1ng h\u1ea1t th\u1ee7y tinh m\u00e0u tr\u1eafng t\u1edbi v\u00e0ng \u00f3ng. \u0110\u00e2y l\u00e0 polymer ph\u00e2n h\u1ee7y sinh h\u1ecdc d\u00f9ng cho h\u1ec7 cung c\u1ea5p thu\u1ed1c […]<\/p>\n","protected":false},"author":1,"featured_media":3622,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3623","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/poly-dl-lactic-acid.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/poly-dl-lactic-acid-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/poly-dl-lactic-acid-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/poly-dl-lactic-acid-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/poly-dl-lactic-acid-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/poly-dl-lactic-acid.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/poly-dl-lactic-acid.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/poly-dl-lactic-acid-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Poly(acid DL-lactic) (PDLLA) \u2013 polymer ph\u00e2n h\u1ee7y sinh h\u1ecdc cho c\u1ea5y gh\u00e9p, ti\u00eam gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i Poly(acid DL-lactic) (PDLLA, DL-PLA, poly-DL-lactid) l\u00e0 polyester m\u1ea1ch th\u1eb3ng t\u1ea1o t\u1eeb h\u1ed7n h\u1ee3p racemic acid lactic, d\u1ea1ng h\u1ea1t th\u1ee7y tinh m\u00e0u tr\u1eafng t\u1edbi v\u00e0ng \u00f3ng. \u0110\u00e2y l\u00e0 polymer ph\u00e2n h\u1ee7y sinh h\u1ecdc d\u00f9ng cho h\u1ec7 cung c\u1ea5p thu\u1ed1c…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3623"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3623\/revisions"}],"predecessor-version":[{"id":3922,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3623\/revisions\/3922"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3622"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3623"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3623"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}