{"id":3621,"date":"2026-09-29T09:19:16","date_gmt":"2026-09-29T02:19:16","guid":{"rendered":"https:\/\/cpc1.vn\/phospholipid\/"},"modified":"2026-09-29T09:19:16","modified_gmt":"2026-09-29T02:19:16","slug":"phospholipid","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/phospholipid\/","title":{"rendered":"Phospholipid \u2013 v\u1eadt li\u1ec7u t\u1ea1o liposome, ch\u1ea5t nh\u0169 h\u00f3a, \u1ed5n \u0111\u1ecbnh h\u1ed7n d\u1ecbch"},"content":{"rendered":"

Phospholipid \u2013 v\u1eadt li\u1ec7u t\u1ea1o liposome, ch\u1ea5t nh\u0169 h\u00f3a, \u1ed5n \u0111\u1ecbnh h\u1ed7n d\u1ecbch<\/h1>\n

Phospholipid<\/strong> l\u00e0 c\u00e1c ph\u00e2n t\u1eed l\u01b0\u1ee1ng th\u00e2n \u2013 th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a h\u1ea7u h\u1ebft m\u00e0ng t\u1ebf b\u00e0o \u2013 g\u1ed3m khung glycerol (ho\u1eb7c polyol) g\u1eafn m\u1ed9t hai chu\u1ed7i acyl\/alkyl v\u00e0 nh\u00f3m \u0111\u1ea7u phosphat, ho\u1eb7c g\u1ed3m ceramid (sphingolipid). Phospholipid t\u1ef1 t\u1eadp h\u1ee3p th\u00e0nh micell, liposome; trong b\u00e0o ch\u1ebf ch\u00fang l\u00e0 v\u1eadt li\u1ec7u t\u1ea1o m\u00e0ng liposome<\/strong>, ch\u1ea5t nh\u0169 h\u00f3a<\/strong>, \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng v\u00e0 h\u1ed7n d\u1ecbch<\/strong>, ch\u1ea5t t\u0103ng tan<\/strong> v\u00e0 v\u1eadt li\u1ec7u ph\u00e2n h\u1ee7y sinh h\u1ecdc<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
C\u00e1c nh\u00f3m ch\u00ednh<\/td>\nPhosphatidylcholin (PC), phosphatidylglycerol (PG), phosphatidylethanolamin (PE), acid phosphatidic (PA), phosphatidylserin (PS), phosphatidylinositol (PI), sphingomyelin<\/td>\n<\/tr>\n
KLPT<\/td>\nKho\u1ea3ng 600\u20135000 (v\u00ed d\u1ee5 DPPC C40<\/sub>H80<\/sub>NO8<\/sub>P \u2013 734,0; DSPC \u2013 790,2)<\/td>\n<\/tr>\n
V\u00ed d\u1ee5 CAS<\/td>\nDPPC 63-89-8; DSPC 816-94-4; DOPC 4235-95-4; DMPC 18194-24-6<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nDi\u1ec7n ho\u1ea1t anion, cation, kh\u00f4ng ion; v\u1eadt li\u1ec7u ph\u00e2n h\u1ee7y sinh h\u1ecdc; ch\u1ea5t ph\u00e2n t\u00e1n, nh\u0169 h\u00f3a, \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, t\u1ea1o m\u00e0ng, t\u0103ng tan, t\u1ea1o h\u1ed7n d\u1ecbch<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nUSP-NF (Egg Phospholipids \u2013 phospholipid l\u00f2ng \u0111\u1ecf tr\u1ee9ng d\u00f9ng l\u00e0m ch\u1ea5t nh\u0169 h\u00f3a nh\u0169 t\u01b0\u01a1ng ti\u00eam)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Liposome:<\/strong> m\u1ed9t l\u1edbp (m\u1ed9t m\u00e0ng k\u00e9p bao khoang n\u01b0\u1edbc), nhi\u1ec1u l\u1edbp (nhi\u1ec1u m\u00e0ng \u0111\u1ed3ng t\u00e2m) v\u00e0 \u0111a t\u00fai (nhi\u1ec1u khoang n\u01b0\u1edbc d\u1ea1ng t\u1ed5 ong).<\/li>\n
  • Liposome PEG h\u00f3a (“stealth”):<\/strong> g\u1eafn PEG l\u00ean phospholipid t\u1ea1o c\u1ea3n tr\u1edf kh\u00f4ng gian, gi\u1ea3m b\u1eaft gi\u1eef b\u1edfi h\u1ec7 th\u1ef1c b\u00e0o \u0111\u01a1n nh\u00e2n, k\u00e9o d\u00e0i th\u1eddi gian tu\u1ea7n ho\u00e0n sau ti\u00eam t\u0129nh m\u1ea1ch. G\u1eafn kh\u00e1ng th\u1ec3 t\u1ea1o liposome mi\u1ec5n d\u1ecbch h\u01b0\u1edbng \u0111\u00edch t\u1ebf b\u00e0o.<\/li>\n
  • Phospholipid t\u00edch \u0111i\u1ec7n t\u1ea1o l\u1ef1c \u0111\u1ea9y t\u0129nh \u0111i\u1ec7n, \u1ed5n \u0111\u1ecbnh v\u1eadt l\u00fd nh\u0169 t\u01b0\u01a1ng v\u00e0 h\u1ed7n d\u1ecbch.<\/li>\n
  • C\u00f3 trong ch\u1ea5t di\u1ec7n ho\u1ea1t ph\u1ed5i, nh\u0169 t\u01b0\u01a1ng lipid ti\u00eam t\u0129nh m\u1ea1ch, ch\u1ebf ph\u1ea9m b\u00f4i v\u00e0 qua da, dung d\u1ecbch u\u1ed1ng.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u1eafng; \u0111\u00f4i khi cung c\u1ea5p d\u1ea1ng dung d\u1ecbch g\u1ea7n nh\u01b0 kh\u00f4ng m\u00e0u trong cloroform ho\u1eb7c methylen clorid. PG, PA, PS th\u01b0\u1eddng \u1edf d\u1ea1ng mu\u1ed1i natri ho\u1eb7c amoni.<\/li>\n
    • T\u1ea1o pha t\u1eadp h\u1ee3p c\u1ea3 khi kh\u00f4 l\u1eabn khi hydrat h\u00f3a; nhi\u1ec7t \u0111\u1ed9 chuy\u1ec3n t\u1eeb tinh th\u1ec3 sang tinh th\u1ec3 l\u1ecfng (Tm<\/sub>) quy\u1ebft \u0111\u1ecbnh \u0111\u1ed9 “c\u1ee9ng” c\u1ee7a m\u00e0ng liposome. Ph\u1ea7n l\u1edbn d\u1ec5 tan trong dung m\u00f4i h\u1eefu c\u01a1.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
      Phospholipid<\/th>\nTm<\/sub> (\u00b0C)<\/th>\n\u0110i\u1ec7n t\u00edch \u1edf pH 7,4<\/th>\n<\/tr>\n<\/thead>\n
      Dimyristoyl PC (DMPC)<\/td>\n23<\/td>\n0<\/td>\n<\/tr>\n
      Distearoyl PC (DSPC)<\/td>\n55<\/td>\n0<\/td>\n<\/tr>\n
      Dimyristoyl PE (DMPE)<\/td>\n50<\/td>\n0<\/td>\n<\/tr>\n
      Dipalmitoyl PE (DPPE)<\/td>\n63<\/td>\n0<\/td>\n<\/tr>\n
      Dimyristoyl PG natri (DMPG)<\/td>\n23<\/td>\n\u22121<\/td>\n<\/tr>\n
      Dipalmitoyl PG natri (DPPG)<\/td>\n41<\/td>\n\u22121<\/td>\n<\/tr>\n
      Dioleoyl PG natri (DOPG)<\/td>\n\u221218<\/td>\n\u22121<\/td>\n<\/tr>\n
      Dipalmitoyl PA natri (DPPA)<\/td>\n67<\/td>\n\u22121,3<\/td>\n<\/tr>\n
      Dipalmitoyl PS natri (DPPS)<\/td>\n54<\/td>\n\u22121<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n
        \n
      • B\u1ec1n \u1edf tr\u1ea1ng th\u00e1i r\u1eafn n\u1ebfu tr\u00e1nh oxy, nhi\u1ec7t v\u00e0 \u00e1nh s\u00e1ng; dung d\u1ecbch trong cloroform ho\u1eb7c dicloromethan c\u0169ng b\u1ec1n. C\u1ea3 hai d\u1ea1ng n\u00ean b\u1ea3o qu\u1ea3n \u1edf \u221220 \u00b0C.<\/li>\n
      • Phospholipid trong liposome b\u1ecb ph\u00e2n h\u1ee7y do oxy h\u00f3a v\u00e0 th\u1ee7y ph\u00e2n: h\u1ea1n ch\u1ebf oxy h\u00f3a b\u1eb1ng m\u00f4i tr\u01b0\u1eddng kh\u00f4ng oxy v\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a (BHT); h\u1ea1n ch\u1ebf th\u1ee7y ph\u00e2n b\u1eb1ng \u0111\u00f4ng kh\u00f4, n\u1ebfu liposome kh\u00f4ng ch\u1ecbu \u0111\u01b0\u1ee3c \u0111\u00f4ng kh\u00f4 th\u00ec b\u1ea3o qu\u1ea3n 2\u20138 \u00b0C. Th\u1ee7y ph\u00e2n ester theo \u0111\u01b0\u1eddng cong h\u00ecnh ch\u1eef V, ch\u1eadm nh\u1ea5t quanh pH 6,5.<\/li>\n<\/ul>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        T\u00e0i li\u1ec7u g\u1ed1c kh\u00f4ng ghi nh\u1eadn t\u01b0\u01a1ng k\u1ef5 c\u1ee5 th\u1ec3.<\/p>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Chi\u1ebft, ph\u00e2n \u0111o\u1ea1n v\u00e0 tinh ch\u1ebf t\u1eeb ngu\u1ed3n t\u1ef1 nhi\u00ean (ch\u1ee7 y\u1ebfu \u0111\u1eadu n\u00e0nh, tr\u1ee9ng); ho\u1eb7c t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc b\u1eb1ng c\u00e1ch cho glycerol phosphocholin, phosphoglycerol, phosphoserin, phosphoethanolamin hay phosphoinositol ph\u1ea3n \u1ee9ng v\u1edbi acid b\u00e9o tinh khi\u1ebft. Th\u00e0nh ph\u1ea7n phospholipid tr\u1ee9ng, \u0111\u1eadu n\u00e0nh thay \u0111\u1ed5i theo ngu\u1ed3n (kh\u1ea9u ph\u1ea7n, gi\u1ed1ng g\u00e0\u2026), n\u00ean phospholipid t\u1ed5ng h\u1ee3p th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 b\u1ea3o \u0111\u1ea3m \u0111\u1ed3ng nh\u1ea5t gi\u1eefa c\u00e1c l\u00f4.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
          \n
        • Nh\u00ecn chung \u0111\u1ed9c t\u00ednh c\u1ea5p r\u1ea5t th\u1ea5p, dung n\u1ea1p t\u1ed1t c\u1ea3 \u1edf li\u1ec1u m\u1ee9c g\/kg; \u0111\u00e0o th\u1ea3i qua c\u00e1c \u0111\u01b0\u1eddng chuy\u1ec3n h\u00f3a \u0111\u00e3 bi\u1ebft. Kh\u00e1ng th\u1ec3 t\u1ef1 nhi\u00ean kh\u00e1ng phospholipid kh\u00f4ng \u0111\u01b0\u1ee3c coi l\u00e0 c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng.<\/li>\n
        • Lipid t\u00edch \u0111i\u1ec7n d\u01b0\u01a1ng (nh\u01b0 stearylamin) l\u00e0m t\u0103ng \u0111\u1ed9c t\u00ednh c\u1ee7a liposome: LD50<\/sub> (t\u0129nh m\u1ea1ch) 1,1 g\/kg khi c\u00f3 stearylamin so v\u1edbi 7,5 g\/kg khi kh\u00f4ng c\u00f3.<\/li>\n
        • \u0110\u01b0\u1eddng t\u0129nh m\u1ea1ch: phospholipid t\u1ea1o ti\u1ec3u ph\u00e2n b\u1ecb \u0111\u1ea1i th\u1ef1c b\u00e0o c\u1ee7a h\u1ec7 th\u1ef1c b\u00e0o \u0111\u01a1n nh\u00e2n nh\u1eadn di\u1ec7n, t\u00f9y k\u00edch th\u01b0\u1edbc v\u00e0 th\u00e0nh ph\u1ea7n.<\/li>\n
        • N\u00ean \u0111eo k\u00ednh v\u00e0 g\u0103ng khi thao t\u00e1c.<\/li>\n<\/ul>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • C\u00f3 trong FDA Inactive Ingredients Database (u\u1ed1ng, nh\u1ecf tai, ng\u1eadm m\u00e1, \u00e2m \u0111\u1ea1o, b\u00f4i, ngo\u00e0i m\u00e0ng c\u1ee9ng, t\u0129nh m\u1ea1ch, ti\u00eam b\u1eafp, kh\u00ed dung h\u00edt). Nhi\u1ec1u phospholipid nh\u01b0 DPPG, DOPC c\u00f3 trong thu\u1ed1c \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t t\u1ea1i ch\u00e2u \u00c2u v\u00e0 M\u1ef9.<\/li>\n
          • C\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n<\/ul>\n

            Ch\u1ea5t li\u00ean quan<\/h2>\n

            Lecithin \u2013 h\u1ed7n h\u1ee3p phospholipid t\u1ef1 nhi\u00ean tinh ch\u1ebf m\u1ed9t ph\u1ea7n k\u00e8m c\u00e1c ch\u1ea5t kh\u00e1c.<\/p>\n

            Ghi ch\u00fa:<\/strong> c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Phospholipids<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Phospholipid \u2013 v\u1eadt li\u1ec7u t\u1ea1o liposome, ch\u1ea5t nh\u0169 h\u00f3a, \u1ed5n \u0111\u1ecbnh h\u1ed7n d\u1ecbch Phospholipid l\u00e0 c\u00e1c ph\u00e2n t\u1eed l\u01b0\u1ee1ng th\u00e2n \u2013 th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a h\u1ea7u h\u1ebft m\u00e0ng t\u1ebf b\u00e0o \u2013 g\u1ed3m khung glycerol (ho\u1eb7c polyol) g\u1eafn m\u1ed9t hai chu\u1ed7i acyl\/alkyl v\u00e0 nh\u00f3m \u0111\u1ea7u phosphat, ho\u1eb7c g\u1ed3m ceramid (sphingolipid). Phospholipid t\u1ef1 t\u1eadp h\u1ee3p th\u00e0nh micell, […]<\/p>\n","protected":false},"author":1,"featured_media":3620,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3621","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phospholipid.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phospholipid-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phospholipid-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phospholipid-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phospholipid-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phospholipid.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phospholipid.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phospholipid-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Phospholipid \u2013 v\u1eadt li\u1ec7u t\u1ea1o liposome, ch\u1ea5t nh\u0169 h\u00f3a, \u1ed5n \u0111\u1ecbnh h\u1ed7n d\u1ecbch Phospholipid l\u00e0 c\u00e1c ph\u00e2n t\u1eed l\u01b0\u1ee1ng th\u00e2n \u2013 th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a h\u1ea7u h\u1ebft m\u00e0ng t\u1ebf b\u00e0o \u2013 g\u1ed3m khung glycerol (ho\u1eb7c polyol) g\u1eafn m\u1ed9t hai chu\u1ed7i acyl\/alkyl v\u00e0 nh\u00f3m \u0111\u1ea7u phosphat, ho\u1eb7c g\u1ed3m ceramid (sphingolipid). Phospholipid t\u1ef1 t\u1eadp h\u1ee3p th\u00e0nh micell,…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3621","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3621"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3621\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3620"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3621"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3621"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3621"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}