{"id":3619,"date":"2026-09-29T09:19:09","date_gmt":"2026-09-29T02:19:09","guid":{"rendered":"https:\/\/cpc1.vn\/nhua-polacrilex\/"},"modified":"2026-09-29T12:09:40","modified_gmt":"2026-09-29T05:09:40","slug":"nhua-polacrilex","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/nhua-polacrilex\/","title":{"rendered":"Nh\u1ef1a polacrilex \u2013 nh\u1ef1a trao \u0111\u1ed5i cation t\u1ea1o resinat: che v\u1ecb, k\u00e9o d\u00e0i gi\u1ea3i ph\u00f3ng"},"content":{"rendered":"

Nh\u1ef1a polacrilex \u2013 nh\u1ef1a trao \u0111\u1ed5i cation t\u1ea1o resinat: che v\u1ecb, k\u00e9o d\u00e0i gi\u1ea3i ph\u00f3ng<\/h1>\n

Nh\u1ef1a polacrilex<\/strong> l\u00e0 nh\u1ef1a trao \u0111\u1ed5i cation y\u1ebfu (nh\u00f3m carboxylic), \u0111\u1ed3ng tr\u00f9ng h\u1ee3p acid methacrylic v\u1edbi divinylbenzen. Nh\u1ef1a t\u1ea1o ph\u1ee9c “resinat” v\u1edbi d\u01b0\u1ee3c ch\u1ea5t mang \u0111i\u1ec7n d\u01b0\u01a1ng qua trao \u0111\u1ed5i ion hydro, d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng<\/strong>, t\u0103ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh<\/strong>, c\u1ea3i thi\u1ec7n \u0111\u1ed9 tan<\/strong> v\u00e0 che v\u1ecb<\/strong>. V\u00ed d\u1ee5 \u0111i\u1ec3n h\u00ecnh l\u00e0 nicotin polacrilex trong k\u1eb9o cao su.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nPolacrilex, nh\u1ef1a polacrilin, \u0111\u1ed3ng tr\u00f9ng h\u1ee3p acid 2-methyl-2-propenoic \u2013 divinylbenzen; t\u00ean th\u01b0\u01a1ng m\u1ea1i Amberlite IRP-64<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n50602-21-6; 80892-32-6<\/td>\n<\/tr>\n
C\u1ea5u t\u1ea1o<\/td>\nNh\u1ef1a trao \u0111\u1ed5i cation carboxylic y\u1ebfu t\u1eeb acid methacrylic v\u00e0 divinylbenzen; m\u1ea1ng li\u00ean k\u1ebft ch\u00e9o ba chi\u1ec1u n\u00ean kh\u00f4ng x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c KLPT trung b\u00ecnh<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u1ea1o ph\u1ee9c, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, t\u0103ng tan, che v\u1ecb<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn USP-NF (c\u00f3 ch\u1ea5t chu\u1ea9n USP \u0111\u1ec3 \u0111\u1ecbnh t\u00ednh IR); nicotin polacrilex c\u00f3 chuy\u00ean lu\u1eadn (USP; Ph.Eur. \u2013 Nicotine Resinate)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • T\u1ea1o resinat \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, t\u0103ng \u1ed5n \u0111\u1ecbnh, t\u0103ng tan v\u00e0 che v\u1ecb; v\u00ed d\u1ee5 t\u1ea1o ph\u1ee9c b\u1ec1n v\u1edbi cyanocobalamin (vitamin B12).<\/li>\n
  • Nicotin n\u1ea1p l\u00ean nh\u1ef1a (nicotin polacrilex) d\u00f9ng trong k\u1eb9o cao su cai thu\u1ed1c l\u00e1; ph\u1ee9c resinat th\u01b0\u1eddng \u0111\u01b0\u1ee3c coi l\u00e0 ho\u1ea1t ch\u1ea5t c\u1ee7a th\u00e0nh ph\u1ea9m. D\u1ea1ng b\u00e0o ch\u1ebf: vi\u00ean ng\u1eadm, vi\u00ean n\u00e9n, k\u1eb9o cao su, nang, kem, mi\u1ebfng d\u00e1n qua da.<\/li>\n
  • Che v\u1ecb trong s\u1ea3n ph\u1ea9m th\u00fa y; d\u00f9ng trong ph\u00e2n t\u00edch v\u00e0 s\u1ea3n xu\u1ea5t d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m.<\/li>\n<\/ul>\n

    N\u1ea1p d\u01b0\u1ee3c ch\u1ea5t l\u00ean nh\u1ef1a<\/h2>\n
      \n
    • L\u01b0\u1ee3ng n\u1ea1p ph\u1ee5 thu\u1ed9c \u0111\u1ed9 ch\u1ecdn l\u1ecdc c\u1ee7a nh\u1ef1a v\u1edbi d\u01b0\u1ee3c ch\u1ea5t, n\u1ed3ng \u0111\u1ed9 d\u01b0\u1ee3c ch\u1ea5t, cation c\u1ea1nh tranh v\u00e0 pH dung d\u1ecbch trao \u0111\u1ed5i; th\u01b0\u1eddng n\u1ea1p \u1edf pH tr\u00ean 6. T\u1ed1c \u0111\u1ed9 n\u1ea1p ph\u1ee5 thu\u1ed9c k\u00edch th\u01b0\u1edbc ph\u00e2n t\u1eed v\u00e0 m\u1ee9c tr\u01b0\u01a1ng n\u1edf c\u1ee7a nh\u1ef1a.<\/li>\n
    • Do nh\u1ef1a l\u00e0 b\u1ed9t m\u1ecbn, n\u00ean n\u1ea1p theo m\u1ebb c\u00e2n b\u1eb1ng; c\u00f3 th\u1ec3 ph\u1ea3i l\u1eb7p l\u1ea1i 2 l\u1ea7n tr\u1edf l\u00ean \u0111\u1ec3 \u0111\u1ea1t m\u1ee9c n\u1ea1p t\u1ed1i \u0111a. Thu\u1eadn l\u1ee3i cho n\u1ea1p cao: m\u1eadt \u0111\u1ed9 \u0111i\u1ec7n t\u00edch d\u01b0\u1ee3c ch\u1ea5t cao, ph\u00e2n t\u1eed l\u01b0\u1ee3ng nh\u1ecf, n\u1ed3ng \u0111\u1ed9 cao, \u00edt ion c\u1ea1nh tranh.<\/li>\n
    • Gi\u1ea3i ph\u00f3ng in vivo \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1edfi khu\u1ebfch t\u00e1n d\u01b0\u1ee3c ch\u1ea5t kh\u1ecfi h\u1ea1t nh\u1ef1a, \u0111\u1ed9 ch\u1ecdn l\u1ecdc v\u00e0 n\u1ed3ng \u0111\u1ed9 ch\u1ea5t \u0111i\u1ec7n ly. Nh\u1ef1a d\u1ec5 nh\u1ea3 ch\u1ea5t \u0111\u00e3 h\u1ea5p ph\u1ee5 trong m\u00f4i tr\u01b0\u1eddng acid do \u00e1i l\u1ef1c r\u1ea5t cao v\u1edbi ion hydro.<\/li>\n<\/ul>\n

      M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
        \n
      • B\u1ed9t tr\u1eafng t\u1edbi tr\u1eafng ng\u00e0.<\/li>\n
      • Kh\u1ed1i l\u01b0\u1ee3ng ri\u00eang sau g\u00f5 kho\u1ea3ng 700 g\/L; dung l\u01b0\u1ee3ng trao \u0111\u1ed5i tr\u00ean 10 mEq\/g.<\/li>\n
      • Kh\u00f4ng tan trong n\u01b0\u1edbc v\u00e0 ph\u1ea7n l\u1edbn dung m\u00f4i.<\/li>\n<\/ul>\n

        \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

        B\u1ec1n \u00edt nh\u1ea5t 2 n\u0103m. B\u1ea3o qu\u1ea3n trong bao b\u00ec g\u1ed1c k\u00edn, \u0111i\u1ec1u ki\u1ec7n th\u01b0\u1eddng, tr\u00e1nh nhi\u1ec7t (d\u01b0\u1edbi 40 \u00b0C), \u00e1nh s\u00e1ng v\u00e0 \u1ea9m.<\/p>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a.<\/p>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        \u0110\u1ed3ng tr\u00f9ng h\u1ee3p huy\u1ec1n ph\u00f9 acid methacrylic v\u00e0 divinylbenzen, t\u1ea1o nh\u1ef1a trao \u0111\u1ed5i cation acid y\u1ebfu d\u1ea1ng h\u1ea1t c\u1ea7u, sau \u0111\u00f3 nghi\u1ec1n th\u00e0nh b\u1ed9t.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
          \n
        • Kh\u00f4ng g\u00e2y \u0111\u1ed9t bi\u1ebfn trong th\u1eed nghi\u1ec7m Ames (d\u1ecbch chi\u1ebft n\u01b0\u1edbc). Nghi\u00ean c\u1ee9u \u0111\u1ed9c t\u00ednh b\u00e1n tr\u01b0\u1eddng di\u1ec5n 90 ng\u00e0y \u0111\u01b0\u1eddng u\u1ed1ng: NOEL tr\u00ean chu\u1ed9t c\u1ed1ng 1000 mg\/kg (li\u1ec1u cao nh\u1ea5t \u0111\u00e3 th\u1eed).<\/li>\n
        • LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): tr\u00ean 2 g\/kg.<\/li>\n
        • Khi ch\u00e1y sinh kh\u00ed k\u00edch \u1ee9ng v\u00e0 \u0111\u1ed9c. Tr\u00e1nh t\u1ea1o b\u1ee5i, tr\u00e1nh d\u00ednh m\u1eaft; n\u00ean \u0111eo k\u00ednh v\u00e0 g\u0103ng.<\/li>\n<\/ul>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • C\u00f3 trong FDA Inactive Ingredients Database (vi\u00ean n\u00e9n u\u1ed1ng; h\u1ec7 tr\u1ecb li\u1ec7u qua da v\u00e0 \u0111i\u1ec7n di ion); c\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh v\u00e0 ch\u1ebf ph\u1ea9m th\u00fa y.<\/li>\n
          • \u0110\u01b0\u1ee3c ph\u00e9p l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i M\u1ef9; c\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n<\/ul>\n

            Ch\u1ea5t li\u00ean quan<\/h2>\n

            Polacrilin kali (d\u1ea1ng mu\u1ed1i kali, d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c r\u00e3), nh\u1ef1a colestyramin (trao \u0111\u1ed5i anion).<\/p>\n

            Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 610-547-2; UNII RCZ785HI7S.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Polacrilex Resin<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Nh\u1ef1a polacrilex \u2013 nh\u1ef1a trao \u0111\u1ed5i cation t\u1ea1o resinat: che v\u1ecb, k\u00e9o d\u00e0i gi\u1ea3i ph\u00f3ng Nh\u1ef1a polacrilex l\u00e0 nh\u1ef1a trao \u0111\u1ed5i cation y\u1ebfu (nh\u00f3m carboxylic), \u0111\u1ed3ng tr\u00f9ng h\u1ee3p acid methacrylic v\u1edbi divinylbenzen. Nh\u1ef1a t\u1ea1o ph\u1ee9c “resinat” v\u1edbi d\u01b0\u1ee3c ch\u1ea5t mang \u0111i\u1ec7n d\u01b0\u01a1ng qua trao \u0111\u1ed5i ion hydro, d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, t\u0103ng \u0111\u1ed9 […]<\/p>\n","protected":false},"author":1,"featured_media":3618,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3619","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/nhua-polacrilex.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/nhua-polacrilex-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/nhua-polacrilex-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/nhua-polacrilex-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/nhua-polacrilex-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/nhua-polacrilex.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/nhua-polacrilex.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/nhua-polacrilex-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Nh\u1ef1a polacrilex \u2013 nh\u1ef1a trao \u0111\u1ed5i cation t\u1ea1o resinat: che v\u1ecb, k\u00e9o d\u00e0i gi\u1ea3i ph\u00f3ng Nh\u1ef1a polacrilex l\u00e0 nh\u1ef1a trao \u0111\u1ed5i cation y\u1ebfu (nh\u00f3m carboxylic), \u0111\u1ed3ng tr\u00f9ng h\u1ee3p acid methacrylic v\u1edbi divinylbenzen. Nh\u1ef1a t\u1ea1o ph\u1ee9c “resinat” v\u1edbi d\u01b0\u1ee3c ch\u1ea5t mang \u0111i\u1ec7n d\u01b0\u01a1ng qua trao \u0111\u1ed5i ion hydro, d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, t\u0103ng \u0111\u1ed9…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3619","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3619"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3619\/revisions"}],"predecessor-version":[{"id":3907,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3619\/revisions\/3907"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3618"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3619"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3619"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3619"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}