{"id":3617,"date":"2026-09-29T09:19:02","date_gmt":"2026-09-29T02:19:02","guid":{"rendered":"https:\/\/cpc1.vn\/acid-pentetic\/"},"modified":"2026-09-29T09:19:02","modified_gmt":"2026-09-29T02:19:02","slug":"acid-pentetic","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/acid-pentetic\/","title":{"rendered":"Acid pentetic (DTPA) \u2013 ch\u1ea5t t\u1ea1o ph\u1ee9c ion kim lo\u1ea1i, ch\u1ed1ng oxy h\u00f3a"},"content":{"rendered":"

Acid pentetic (DTPA) \u2013 ch\u1ea5t t\u1ea1o ph\u1ee9c ion kim lo\u1ea1i, ch\u1ed1ng oxy h\u00f3a<\/h1>\n

Acid pentetic<\/strong> (DTPA, acid diethylentriamin pentaacetic) l\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c m\u1ea1nh h\u1ecd aminopolycarboxylic, t\u01b0\u01a1ng t\u1ef1 EDTA nh\u01b0ng c\u00f3 5 nh\u00f3m carboxyl. Trong ng\u00e0nh d\u01b0\u1ee3c, DTPA ch\u1ee7 y\u1ebfu l\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c<\/strong> trong ch\u1ebf ph\u1ea9m t\u1ea1o \u1ea3nh ph\u00f3ng x\u1ea1 v\u00e0 c\u1ed9ng h\u01b0\u1edfng t\u1eeb; ngo\u00e0i ra l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/strong> (b\u1eaft ion kim lo\u1ea1i x\u00fac t\u00e1c) v\u00e0 ch\u1ea5t \u0111\u1ed3ng b\u1ea3o qu\u1ea3n<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nDTPA, acid diethylentriamin-N,N,N’,N”,N”-pentaacetic, pentacarboxymethyl diethylentriamin, acidum penteticum<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n67-43-6<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC14<\/sub>H23<\/sub>N3<\/sub>O10<\/sub> \u2013 393,35<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t t\u1ea1o ph\u1ee9c<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nUSP-NF<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t t\u1ea1o ph\u1ee9c \u0111\u1ec3 \u0111i\u1ec1u ch\u1ebf ch\u1ea5t t\u1ea1o \u1ea3nh d\u01b0\u1ee3c ch\u1ea5t ph\u00f3ng x\u1ea1 v\u00e0 ch\u1ea5t t\u01b0\u01a1ng ph\u1ea3n c\u1ed9ng h\u01b0\u1edfng t\u1eeb (MRI); ch\u1ea5t mang cho \u0111\u1ed3ng v\u1ecb b\u1eaft neutron trong x\u1ea1 tr\u1ecb.<\/li>\n
  • Ph\u1ee9c DTPA \u2013 \u0111\u1ed3ng v\u1ecb \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t thay th\u1ebf ho\u1ea1t ch\u1ea5t trong nghi\u00ean c\u1ee9u x\u1ea1 h\u00ecnh.<\/li>\n
  • Ch\u1ed1ng oxy h\u00f3a: t\u1ea1o ph\u1ee9c v\u1edbi ion kim lo\u1ea1i, gi\u1ea3m h\u00ecnh th\u00e0nh g\u1ed1c oxy ho\u1ea1t \u0111\u1ed9ng khi \u0111\u00f4ng kh\u00f4.<\/li>\n<\/ul>\n\n\n\n\n\n\n
    C\u00f4ng d\u1ee5ng<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
    Ch\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/td>\n0,1\u20130,3<\/td>\n<\/tr>\n
    Ch\u1ea5t \u0111\u1ed3ng b\u1ea3o qu\u1ea3n<\/td>\n0,05<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t r\u1eafn k\u1ebft tinh tr\u1eafng, g\u1ea7n nh\u01b0 kh\u00f4ng m\u00f9i.<\/li>\n
    • pH dung d\u1ecbch 1%: 2,1\u20132,5; \u0111i\u1ec3m ch\u1ea3y 220\u2013222 \u00b0C; tan 1 trong 200 ph\u1ea7n n\u01b0\u1edbc (25 \u00b0C).<\/li>\n
    • USP-NF: h\u00e0m l\u01b0\u1ee3ng 98,0\u2013100,5%.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      Ho\u1ea1t t\u00ednh t\u1ea1o ph\u1ee9c c\u00f3 th\u1ec3 g\u00e2y t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n trong c\u00f4ng th\u1ee9c ch\u1ee9a ion kim lo\u1ea1i; ph\u1ee9c chelat mong mu\u1ed1n c\u00f3 th\u1ec3 b\u1ecb c\u00e1c ion kh\u00e1c trong c\u00f4ng th\u1ee9c thay th\u1ebf.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      H\u00ecnh th\u00e0nh trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u ch\u1ebf acid aminocarboxylic v\u00e0 mu\u1ed1i c\u1ee7a n\u00f3.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • D\u00f9ng trong thu\u1ed1c ti\u00eam t\u1ee7y s\u1ed1ng v\u00e0 t\u0129nh m\u1ea1ch. D\u1ea1ng tinh khi\u1ebft \u0111\u1ed9c v\u1eeba qua \u0111\u01b0\u1eddng ph\u00fac m\u1ea1c.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t nh\u1eaft, ph\u00fac m\u1ea1c): 0,54 g\/kg; (chu\u1ed9t nh\u1eaft, u\u1ed1ng): 4,84 g\/kg.<\/li>\n
      • \u0110un t\u1edbi ph\u00e2n h\u1ee7y sinh kh\u00f3i cay, k\u00edch \u1ee9ng. Thao t\u00e1c theo l\u01b0u \u00fd th\u00f4ng th\u01b0\u1eddng.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (ti\u00eam t\u1ee7y s\u1ed1ng, t\u0129nh m\u1ea1ch); c\u00f3 trong thu\u1ed1c ti\u00eam t\u0129nh m\u1ea1ch v\u00e0 ti\u00eam kh\u1edbp l\u01b0u h\u00e0nh t\u1ea1i Anh.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n
            \n
          • Calci trinatri pentetat<\/strong> (CaNa3<\/sub>-DTPA; CAS 12111-24-9): tan trong n\u01b0\u1edbc, h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ethanol; c\u00f3 trong FDA IID (ti\u00eam t\u1ee7y s\u1ed1ng, t\u0129nh m\u1ea1ch); \u0111\u1ed9c v\u1eeba qua \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch, ph\u00fac m\u1ea1c.<\/li>\n
          • Pentanatri pentetat<\/strong> (C14<\/sub>H18<\/sub>N3<\/sub>Na5<\/sub>O10<\/sub>, KLPT 503,25; CAS 140-01-2): c\u00f3 trong FDA IID (ti\u00eam t\u0129nh m\u1ea1ch); k\u00edch \u1ee9ng v\u1eeba da v\u00e0 ni\u00eam m\u1ea1c.<\/li>\n
          • K\u1ebdm trinatri pentetat<\/strong> (C14<\/sub>H18<\/sub>N3<\/sub>Na3<\/sub>O10<\/sub>Zn, KLPT 522,7).<\/li>\n<\/ul>\n

            Xem th\u00eam acid edetic (EDTA), dinatri edetat, natri calci edetat.<\/p>\n

            Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 200-652-8; PubChem CID 3053.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Pentetic Acid<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Acid pentetic (DTPA) \u2013 ch\u1ea5t t\u1ea1o ph\u1ee9c ion kim lo\u1ea1i, ch\u1ed1ng oxy h\u00f3a Acid pentetic (DTPA, acid diethylentriamin pentaacetic) l\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c m\u1ea1nh h\u1ecd aminopolycarboxylic, t\u01b0\u01a1ng t\u1ef1 EDTA nh\u01b0ng c\u00f3 5 nh\u00f3m carboxyl. Trong ng\u00e0nh d\u01b0\u1ee3c, DTPA ch\u1ee7 y\u1ebfu l\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c trong ch\u1ebf ph\u1ea9m t\u1ea1o \u1ea3nh ph\u00f3ng x\u1ea1 v\u00e0 c\u1ed9ng h\u01b0\u1edfng t\u1eeb; […]<\/p>\n","protected":false},"author":1,"featured_media":3616,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3617","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-pentetic.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-pentetic-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-pentetic-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-pentetic-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-pentetic-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-pentetic.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-pentetic.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-pentetic-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Acid pentetic (DTPA) \u2013 ch\u1ea5t t\u1ea1o ph\u1ee9c ion kim lo\u1ea1i, ch\u1ed1ng oxy h\u00f3a Acid pentetic (DTPA, acid diethylentriamin pentaacetic) l\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c m\u1ea1nh h\u1ecd aminopolycarboxylic, t\u01b0\u01a1ng t\u1ef1 EDTA nh\u01b0ng c\u00f3 5 nh\u00f3m carboxyl. Trong ng\u00e0nh d\u01b0\u1ee3c, DTPA ch\u1ee7 y\u1ebfu l\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c trong ch\u1ebf ph\u1ea9m t\u1ea1o \u1ea3nh ph\u00f3ng x\u1ea1 v\u00e0 c\u1ed9ng h\u01b0\u1edfng t\u1eeb;…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3617","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3617"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3617\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3616"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3617"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}