{"id":3615,"date":"2026-09-29T09:17:14","date_gmt":"2026-09-29T02:17:14","guid":{"rendered":"https:\/\/cpc1.vn\/octyl-gallat\/"},"modified":"2026-09-29T12:09:56","modified_gmt":"2026-09-29T05:09:56","slug":"octyl-gallat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/octyl-gallat\/","title":{"rendered":"Octyl gallat (E311) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho d\u1ea7u m\u1ee1"},"content":{"rendered":"

Octyl gallat (E311) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho d\u1ea7u m\u1ee1<\/h1>\n

Octyl gallat<\/strong> (E311) l\u00e0 ester c\u1ee7a acid gallic v\u1edbi octanol, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng. Nh\u01b0 c\u00e1c alkyl gallat kh\u00e1c, octyl gallat l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/strong> d\u00f9ng \u0111\u1ec3 ch\u1ed1ng \u00f4i h\u00f3a d\u1ea7u m\u1ee1 trong m\u1ef9 ph\u1ea9m, n\u01b0\u1edbc hoa, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nOctyl 3,4,5-trihydroxybenzoat, ester octyl c\u1ee7a acid gallic, octylis gallas, E311<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n1034-01-1<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC15<\/sub>H22<\/sub>O5<\/sub> \u2013 282,3<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t ch\u1ed1ng oxy h\u00f3a b\u1ea3o qu\u1ea3n trong m\u1ef9 ph\u1ea9m, n\u01b0\u1edbc hoa, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m; n\u1ed3ng \u0111\u1ed9 0,001\u20130,1% (kl\/tt) \u0111\u1ec3 ch\u1ed1ng h\u01b0, \u00f4i d\u1ea7u m\u1ee1.<\/li>\n
  • Th\u01b0\u1eddng ph\u1ed1i h\u1ee3p v\u1edbi BHA, BHT v\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c v\u1edbi ion kim lo\u1ea1i (acid citric, mu\u1ed1i k\u1ebdm) \u0111\u1ec3 t\u0103ng hi\u1ec7u qu\u1ea3.<\/li>\n
  • \u0110\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u0111\u1ec3 t\u0103ng sinh kh\u1ea3 d\u1ee5ng thu\u1ed1c th\u00fa y \u0111\u01b0\u1eddng u\u1ed1ng.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, kh\u00f4ng m\u00f9i ho\u1eb7c g\u1ea7n nh\u01b0 kh\u00f4ng m\u00f9i.<\/li>\n
    • \u0110i\u1ec3m ch\u1ea3y 94\u201395 \u00b0C (100\u2013102 \u00b0C sau s\u1ea5y 6 gi\u1edd \u1edf 90 \u00b0C). D\u01b0\u1ee3c \u0111i\u1ec3n: m\u1ea5t kh\u1ed1i l\u01b0\u1ee3ng khi l\u00e0m kh\u00f4 \u2264 0,5%; tro sulfat \u2264 0,1%; h\u00e0m l\u01b0\u1ee3ng 97,0\u2013103,0%.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n\n\n\n
      Dung m\u00f4i<\/th>\n\u0110\u1ed9 tan<\/th>\n<\/tr>\n<\/thead>\n
      Methanol<\/td>\n1 trong 0,7<\/td>\n<\/tr>\n
      Aceton<\/td>\n1 trong 1<\/td>\n<\/tr>\n
      Ethanol 95%<\/td>\n1 trong 2,5<\/td>\n<\/tr>\n
      Ether<\/td>\n1 trong 3<\/td>\n<\/tr>\n
      Propylen glycol<\/td>\n1 trong 7<\/td>\n<\/tr>\n
      Cloroform<\/td>\n1 trong 30<\/td>\n<\/tr>\n
      D\u1ea7u l\u1ea1c<\/td>\n1 trong 33<\/td>\n<\/tr>\n
      N\u01b0\u1edbc<\/td>\nH\u1ea7u nh\u01b0 kh\u00f4ng tan<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed kh\u00f4ng b\u1eb1ng kim lo\u1ea1i, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      C\u00e1c alkyl gallat t\u1ea1o ph\u1ee9c m\u00e0u \u0111\u1eadm v\u1edbi kim lo\u1ea1i (natri, kali, s\u1eaft) \u2013 c\u00f3 th\u1ec3 ng\u0103n b\u1eb1ng ch\u1ea5t t\u1ea1o ph\u1ee9c nh\u01b0 acid citric. Ph\u1ea3n \u1ee9ng v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u00e0 base m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Ester h\u00f3a acid gallic v\u1edbi octanol.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • D\u00f9ng r\u1ed9ng r\u00e3i trong th\u1ef1c ph\u1ea9m, nh\u00ecn chung \u0111\u01b0\u1ee3c coi l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng; c\u00f3 th\u1ec3 g\u00e2y m\u1eabn c\u1ea3m v\u00e0 ph\u1ea3n \u1ee9ng da.<\/li>\n
      • WHO \u0111\u1eb7t ADI t\u1ea1m th\u1eddi t\u1edbi 0,1 mg\/kg th\u1ec3 tr\u1ecdng.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t c\u1ed1ng, ph\u00fac m\u1ea1c): 0,06 g\/kg; (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 1,96 g\/kg.<\/li>\n
      • \u0110un t\u1edbi ph\u00e2n h\u1ee7y sinh kh\u00f3i cay, k\u00edch \u1ee9ng. N\u00ean \u0111eo k\u00ednh v\u00e0 g\u0103ng.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E311).<\/li>\n
        • C\u00f3 trong Canadian Natural Health Products Ingredients Database (gi\u1edbi h\u1ea1n t\u1edbi 0,1 mg\/kg th\u1ec3 tr\u1ecdng\/ng\u00e0y).<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Dodecyl gallat, propyl gallat.<\/p>\n

          Ghi ch\u00fa:<\/strong> octyl gallat \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u1ec1 ho\u1ea1t t\u00ednh kh\u00e1ng n\u1ea5m v\u00e0 kh\u00e1ng virus. S\u1ed1 EINECS 213-853-0; PubChem CID 61253.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Octyl Gallate<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Octyl gallat (E311) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho d\u1ea7u m\u1ee1 Octyl gallat (E311) l\u00e0 ester c\u1ee7a acid gallic v\u1edbi octanol, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng. Nh\u01b0 c\u00e1c alkyl gallat kh\u00e1c, octyl gallat l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a d\u00f9ng \u0111\u1ec3 ch\u1ed1ng \u00f4i h\u00f3a d\u1ea7u m\u1ee1 trong m\u1ef9 ph\u1ea9m, n\u01b0\u1edbc hoa, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m. […]<\/p>\n","protected":false},"author":1,"featured_media":3614,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3615","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/octyl-gallat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/octyl-gallat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/octyl-gallat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/octyl-gallat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/octyl-gallat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/octyl-gallat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/octyl-gallat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/octyl-gallat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Octyl gallat (E311) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho d\u1ea7u m\u1ee1 Octyl gallat (E311) l\u00e0 ester c\u1ee7a acid gallic v\u1edbi octanol, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng. Nh\u01b0 c\u00e1c alkyl gallat kh\u00e1c, octyl gallat l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a d\u00f9ng \u0111\u1ec3 ch\u1ed1ng \u00f4i h\u00f3a d\u1ea7u m\u1ee1 trong m\u1ef9 ph\u1ea9m, n\u01b0\u1edbc hoa, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m.…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3615"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3615\/revisions"}],"predecessor-version":[{"id":3910,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3615\/revisions\/3910"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3614"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}