{"id":3603,"date":"2026-09-29T09:14:11","date_gmt":"2026-09-29T02:14:11","guid":{"rendered":"https:\/\/cpc1.vn\/n-methylpyrrolidon\/"},"modified":"2026-09-29T09:14:11","modified_gmt":"2026-09-29T02:14:11","slug":"n-methylpyrrolidon","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/n-methylpyrrolidon\/","title":{"rendered":"N-Methylpyrrolidon (NMP) \u2013 \u0111\u1ed3ng dung m\u00f4i ph\u00e2n c\u1ef1c, ch\u1ea5t t\u0103ng th\u1ea5m"},"content":{"rendered":"

N-Methylpyrrolidon (NMP) \u2013 \u0111\u1ed3ng dung m\u00f4i ph\u00e2n c\u1ef1c, ch\u1ea5t t\u0103ng th\u1ea5m<\/h1>\n

N-Methylpyrrolidon<\/strong> (NMP, methylpyrrolidon) l\u00e0 dung m\u00f4i ph\u00e2n c\u1ef1c kh\u00f4ng proton, ch\u1ea5t l\u1ecfng trong, h\u00fat \u1ea9m, m\u00f9i amin nh\u1eb9, tr\u1ed9n l\u1eabn v\u1edbi n\u01b0\u1edbc v\u00e0 ph\u1ea7n l\u1edbn dung m\u00f4i h\u1eefu c\u01a1. Trong b\u00e0o ch\u1ebf, NMP l\u00e0 \u0111\u1ed3ng dung m\u00f4i<\/strong> h\u00f2a tan d\u01b0\u1ee3c ch\u1ea5t trong thu\u1ed1c u\u1ed1ng, ti\u00eam v\u00e0 b\u00f4i, v\u00e0 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m ch\u1ea5t t\u0103ng th\u1ea5m qua da<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nNMP, 1-methyl-2-pyrrolidon, N-methyl-2-pyrrolidinon, N-methyl-\u03b3-butyrolactam; t\u00ean th\u01b0\u01a1ng m\u1ea1i Pharmasolve<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n872-50-4<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC5<\/sub>H9<\/sub>NO \u2013 99,1<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u0103ng th\u1ea5m, ch\u1ea5t t\u0103ng tan, dung m\u00f4i<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP (Methylpyrrolidone), Ph.Eur. (N-Methylpyrrolidone), USP-NF (Methylpyrrolidone)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • \u0110\u1ed3ng dung m\u00f4i kh\u00f4ng proton h\u00f2a tan d\u01b0\u1ee3c ch\u1ea5t trong ch\u1ebf ph\u1ea9m u\u1ed1ng, ti\u00eam v\u00e0 b\u00f4i.<\/li>\n
  • C\u00f3 trong h\u1ec7 d\u1eabn thu\u1ed1c nha chu v\u00e0 thu\u1ed1c ti\u00eam d\u01b0\u1edbi da (theo FDA IID).<\/li>\n
  • \u0110\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m ch\u1ea5t t\u0103ng th\u1ea5m qua da.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t l\u1ecfng trong, h\u00fat \u1ea9m, m\u00f9i amin nh\u1eb9.<\/li>\n
    • \u0110i\u1ec3m s\u00f4i 204 \u00b0C; \u0111i\u1ec3m \u0111\u00f4ng \u0111\u1eb7c \u221224,4 \u00b0C; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 93 \u00b0C (c\u1ed1c k\u00edn); t\u1ef7 tr\u1ecdng t\u01b0\u01a1ng \u0111\u1ed1i 1,034; chi\u1ebft su\u1ea5t 1,469.<\/li>\n
    • H\u1eb1ng s\u1ed1 \u0111i\u1ec7n m\u00f4i 32,2 (25 \u00b0C); \u0111\u1ed9 nh\u1edbt 1,65 mPa\u00b7s (25 \u00b0C); \u00e1p su\u1ea5t h\u01a1i 0,33 mmHg (23 \u00b0C).<\/li>\n
    • Th\u00f4ng s\u1ed1 \u0111\u1ed9 tan Hansen: t\u1ed5ng 11,2; ph\u00e2n t\u00e1n 8,8; ph\u00e2n c\u1ef1c 6,0; li\u00ean k\u1ebft hydro 3,5 (MPa\u00bd<\/sup>).<\/li>\n
    • Tr\u1ed9n l\u1eabn v\u1edbi n\u01b0\u1edbc, ethanol 95% v\u00e0 ph\u1ea7n l\u1edbn dung m\u00f4i h\u1eefu c\u01a1.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n nhi\u1ec7t khi kh\u00f4ng c\u00f3 kh\u00f4ng kh\u00ed. B\u1ea3o qu\u1ea3n tr\u00e1nh \u00e1nh s\u00e1ng v\u00e0 \u1ea9m.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      H\u1ea7u nh\u01b0 kh\u00f4ng ph\u1ea3n \u1ee9ng, tr\u1eeb khi c\u00f3 acid ho\u1eb7c base m\u1ea1nh. C\u00f3 th\u1ec3 t\u1ea1o ph\u1ee9c v\u1edbi kim lo\u1ea1i, mu\u1ed1i kim lo\u1ea1i ki\u1ec1m v\u00e0 m\u1ed9t s\u1ed1 d\u01b0\u1ee3c ch\u1ea5t nh\u01b0 benzocain, phenol, iod. Kh\u00f4ng \u0103n m\u00f2n v\u00e0 ph\u00e2n h\u1ee7y sinh h\u1ecdc \u0111\u01b0\u1ee3c.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Ng\u01b0ng t\u1ee5 butyrolacton v\u1edbi methylamin.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • \u0110\u01b0\u1ee3c coi l\u00e0 ch\u1ea5t \u0111\u1ed9c qua \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch; \u0111\u1ed9c v\u1eeba khi nu\u1ed1t, qua da v\u00e0 ti\u00eam ph\u00fac m\u1ea1c. L\u00e0 ch\u1ea5t g\u00e2y qu\u00e1i thai tr\u00ean th\u1ef1c nghi\u1ec7m; c\u00f3 d\u1eef li\u1ec7u v\u1ec1 g\u00e2y \u0111\u1ed9t bi\u1ebfn.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t nh\u1eaft): ph\u00fac m\u1ea1c 3,05 g\/kg; t\u0129nh m\u1ea1ch 0,0545 g\/kg; u\u1ed1ng 5,13 g\/kg. (Chu\u1ed9t c\u1ed1ng): ph\u00fac m\u1ea1c 2,472 g\/kg; t\u0129nh m\u1ea1ch 0,0805 g\/kg; u\u1ed1ng 3,914 g\/kg. (Th\u1ecf, d\u01b0\u1edbi da): 8,0 g\/kg.<\/li>\n
      • Gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m ngh\u1ec1 nghi\u1ec7p t\u1ea1i Anh: 40 mg\/m\u00b3 (10 ppm) TWA 8 gi\u1edd; 80 mg\/m\u00b3 (20 ppm) 15 ph\u00fat.<\/li>\n
      • \u0110un t\u1edbi ph\u00e2n h\u1ee7y sinh kh\u00f3i \u0111\u1ed9c NOx<\/sub>.<\/li>\n
      • NMP thu\u1ed9c dung m\u00f4i t\u1ed3n d\u01b0 nh\u00f3m 2 theo ICH Q3C, gi\u1edbi h\u1ea1n 530 ppm (ngo\u00e0i s\u00e1ch).<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (h\u1ec7 d\u1eabn thu\u1ed1c nha chu; ti\u00eam d\u01b0\u1edbi da).<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur., USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          2-Pyrrolidon; xem th\u00eam dimethylacetamid, dimethyl sulfoxyd.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Methylpyrrolidone<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          N-Methylpyrrolidon (NMP) \u2013 \u0111\u1ed3ng dung m\u00f4i ph\u00e2n c\u1ef1c, ch\u1ea5t t\u0103ng th\u1ea5m N-Methylpyrrolidon (NMP, methylpyrrolidon) l\u00e0 dung m\u00f4i ph\u00e2n c\u1ef1c kh\u00f4ng proton, ch\u1ea5t l\u1ecfng trong, h\u00fat \u1ea9m, m\u00f9i amin nh\u1eb9, tr\u1ed9n l\u1eabn v\u1edbi n\u01b0\u1edbc v\u00e0 ph\u1ea7n l\u1edbn dung m\u00f4i h\u1eefu c\u01a1. Trong b\u00e0o ch\u1ebf, NMP l\u00e0 \u0111\u1ed3ng dung m\u00f4i h\u00f2a tan d\u01b0\u1ee3c ch\u1ea5t trong thu\u1ed1c u\u1ed1ng, […]<\/p>\n","protected":false},"author":1,"featured_media":3602,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3603","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-methylpyrrolidon.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-methylpyrrolidon-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-methylpyrrolidon-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-methylpyrrolidon-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-methylpyrrolidon-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-methylpyrrolidon.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-methylpyrrolidon.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-methylpyrrolidon-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"N-Methylpyrrolidon (NMP) \u2013 \u0111\u1ed3ng dung m\u00f4i ph\u00e2n c\u1ef1c, ch\u1ea5t t\u0103ng th\u1ea5m N-Methylpyrrolidon (NMP, methylpyrrolidon) l\u00e0 dung m\u00f4i ph\u00e2n c\u1ef1c kh\u00f4ng proton, ch\u1ea5t l\u1ecfng trong, h\u00fat \u1ea9m, m\u00f9i amin nh\u1eb9, tr\u1ed9n l\u1eabn v\u1edbi n\u01b0\u1edbc v\u00e0 ph\u1ea7n l\u1edbn dung m\u00f4i h\u1eefu c\u01a1. Trong b\u00e0o ch\u1ebf, NMP l\u00e0 \u0111\u1ed3ng dung m\u00f4i h\u00f2a tan d\u01b0\u1ee3c ch\u1ea5t trong thu\u1ed1c u\u1ed1ng,…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3603","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3603"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3603\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3602"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3603"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}