{"id":3595,"date":"2026-09-29T09:13:42","date_gmt":"2026-09-29T02:13:42","guid":{"rendered":"https:\/\/cpc1.vn\/acid-maleic\/"},"modified":"2026-09-29T11:51:21","modified_gmt":"2026-09-29T04:51:21","slug":"acid-maleic","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/acid-maleic\/","title":{"rendered":"Acid maleic \u2013 ch\u1ea5t acid h\u00f3a, ch\u1ea5t \u0111\u1ec7m, ch\u1ed1ng \u00f4i d\u1ea7u m\u1ee1"},"content":{"rendered":"

Acid maleic \u2013 ch\u1ea5t acid h\u00f3a, ch\u1ea5t \u0111\u1ec7m, ch\u1ed1ng \u00f4i d\u1ea7u m\u1ee1<\/h1>\n

Acid maleic<\/strong> (acid cis-butenedioic) l\u00e0 acid dicarboxylic kh\u00f4ng no \u0111\u01a1n gi\u1ea3n nh\u1ea5t, \u0111\u1ed3ng ph\u00e2n cis c\u1ee7a acid fumaric. Trong b\u00e0o ch\u1ebf, acid maleic \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t \u0111i\u1ec1u ch\u1ec9nh pH, ch\u1ea5t acid h\u00f3a<\/strong> v\u00e0 ch\u1ea5t \u0111\u1ec7m<\/strong> cho thu\u1ed1c u\u1ed1ng, b\u00f4i v\u00e0 ti\u00eam; n\u00f3 c\u00f2n gi\u00fap ch\u1ed1ng \u00f4i d\u1ea7u m\u1ee1<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nAcid cis-butenedioic, acid (Z)-2-butenedioic, acid cis-ethylen-1,2-dicarboxylic, acidum maleicum, acid toxilic<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n110-16-7<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC4<\/sub>H4<\/sub>O4<\/sub> \u2013 116,07<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t acid h\u00f3a, ch\u1ea5t \u0111\u1ec7m<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur., USP-NF<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t \u0111i\u1ec1u ch\u1ec9nh pH v\u00e0 ch\u1ea5t \u0111\u1ec7m trong ch\u1ebf ph\u1ea9m u\u1ed1ng, b\u00f4i, ti\u00eam v\u00e0 th\u1ef1c ph\u1ea9m.<\/li>\n
  • Ch\u1ed1ng \u00f4i d\u1ea7u m\u1ee1: t\u1ef7 l\u1ec7 1:10 000 th\u01b0\u1eddng \u0111\u1ee7 \u0111\u1ec3 l\u00e0m ch\u1eadm \u00f4i h\u00f3a.<\/li>\n
  • L\u00e0 trung gian t\u1ea1o mu\u1ed1i maleat c\u1ee7a nhi\u1ec1u d\u01b0\u1ee3c ch\u1ea5t (v\u00ed d\u1ee5 c\u00e1c thu\u1ed1c kh\u00e1ng histamin).<\/li>\n
  • Nghi\u00ean c\u1ee9u: dung d\u1ecbch r\u1eeda nha khoa kh\u00e1ng khu\u1ea9n, h\u1ec7 cung c\u1ea5p thu\u1ed1c qua m\u0169i, micell copolymer styren \u2013 acid maleic. Copolymer c\u1ee7a acid maleic (ester butyl c\u1ee7a poly(methyl vinyl ether\/acid maleic)) d\u00f9ng l\u00e0m t\u00e1c nh\u00e2n t\u1ea1o m\u00e0ng trong s\u01a1n m\u00f3ng c\u00f3 thu\u1ed1c, thu\u1ed1c ch\u1ed1ng mu\u1ed7i, vi kim h\u00f2a tan qua da, v\u00e0 ch\u1ebf ph\u1ea9m ch\u1ed1ng b\u00e1m m\u1ea3ng b\u00e1m r\u0103ng.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng (h\u1ec7 \u0111\u01a1n t\u00e0), m\u00f9i chua nh\u1eb9, v\u1ecb se.<\/li>\n
    • pKa1<\/sub> 1,91; pKa2<\/sub> 6,33; dung d\u1ecbch 5% c\u00f3 pH kho\u1ea3ng 2 (25 \u00b0C).<\/li>\n
    • \u0110i\u1ec3m ch\u1ea3y 130\u2013134 \u00b0C; s\u00f4i 135 \u00b0C k\u00e8m ph\u00e2n h\u1ee7y; t\u1ef7 tr\u1ecdng ri\u00eang 1,590; log Kow<\/sub> \u22120,48; nhi\u1ec7t \u0111\u1ed1t ch\u00e1y 1356,3 kJ\/mol.<\/li>\n
    • D\u01b0\u1ee3c \u0111i\u1ec3n y\u00eau c\u1ea7u h\u00e0m l\u01b0\u1ee3ng 99,0\u2013101,0% (ch\u1ebf ph\u1ea9m khan).<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n
      Dung m\u00f4i<\/th>\n\u0110\u1ed9 tan \u1edf 20 \u00b0C<\/th>\n<\/tr>\n<\/thead>\n
      N\u01b0\u1edbc<\/td>\n1 trong 2,05<\/td>\n<\/tr>\n
      Diethyl ether<\/td>\n1 trong 13,2<\/td>\n<\/tr>\n
      Cloroform<\/td>\n1 trong 909<\/td>\n<\/tr>\n
      Benzen<\/td>\n1 trong 4167<\/td>\n<\/tr>\n
      Carbon tetraclorid<\/td>\n1 trong 50 000<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      \u0110un h\u01a1i tr\u00ean \u0111i\u1ec3m ch\u1ea3y, acid maleic chuy\u1ec3n th\u00e0nh acid fumaric c\u00f3 \u0111i\u1ec3m ch\u1ea3y cao h\u01a1n nhi\u1ec1u (287 \u00b0C). Ch\u00e1y \u0111\u01b0\u1ee3c khi g\u1eb7p nhi\u1ec7t ho\u1eb7c l\u1eeda. B\u1ea3o qu\u1ea3n nguy\u00ean li\u1ec7u trong l\u1ecd th\u1ee7y tinh k\u00edn kh\u00ed, tr\u00e1nh \u00e1nh s\u00e1ng, kh\u00f4ng qu\u00e1 25 \u00b0C.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      C\u00f3 th\u1ec3 ph\u1ea3n \u1ee9ng v\u1edbi ch\u1ea5t oxy h\u00f3a. Dung d\u1ecbch n\u01b0\u1edbc \u0103n m\u00f2n th\u00e9p carbon.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Ch\u1ee7 y\u1ebfu hydrat h\u00f3a anhydrid maleic; anhydrid maleic \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t th\u01b0\u01a1ng m\u1ea1i b\u1eb1ng oxy h\u00f3a benzen ho\u1eb7c cho butan ph\u1ea3n \u1ee9ng v\u1edbi oxy c\u00f3 x\u00fac t\u00e1c vanadi.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • \u1ede m\u1ee9c th\u1ea5p l\u00e0m t\u00e1 d\u01b0\u1ee3c, nh\u00ecn chung \u0111\u01b0\u1ee3c coi l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng.<\/li>\n
      • D\u1ea1ng nguy\u00ean ch\u1ea5t r\u1ea5t nguy hi\u1ec3m khi d\u00ednh m\u1eaft (c\u00f3 th\u1ec3 t\u1ed5n th\u01b0\u01a1ng gi\u00e1c m\u1ea1c); nguy h\u1ea1i khi ti\u1ebfp x\u00fac da (vi\u00eam, ph\u1ed3ng r\u1ed9p t\u00f9y th\u1eddi gian ti\u1ebfp x\u00fac) v\u00e0 khi h\u00edt.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t nh\u1eaft, u\u1ed1ng): 2,40 g\/kg; (th\u1ecf, qua da): 1,56 g\/kg; (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 0,708 g\/kg.<\/li>\n
      • D\u00f9ng g\u0103ng, k\u00ednh v\u00e0 m\u1eb7t n\u1ea1 ph\u00f2ng \u0111\u1ed9c \u0111\u1ea1t chu\u1ea9n.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch; siro, vi\u00ean n\u00e9n, nang u\u1ed1ng; b\u00f4i ngo\u00e0i); c\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur., USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Acid fumaric (\u0111\u1ed3ng ph\u00e2n trans, b\u1ec1n h\u01a1n; acid maleic \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u ch\u1ebf acid fumaric b\u1eb1ng \u0111\u1ed3ng ph\u00e2n h\u00f3a x\u00fac t\u00e1c).<\/p>\n

          Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 203-742-5; PubChem CID 444266.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Maleic Acid<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Acid maleic \u2013 ch\u1ea5t acid h\u00f3a, ch\u1ea5t \u0111\u1ec7m, ch\u1ed1ng \u00f4i d\u1ea7u m\u1ee1 Acid maleic (acid cis-butenedioic) l\u00e0 acid dicarboxylic kh\u00f4ng no \u0111\u01a1n gi\u1ea3n nh\u1ea5t, \u0111\u1ed3ng ph\u00e2n cis c\u1ee7a acid fumaric. Trong b\u00e0o ch\u1ebf, acid maleic \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t \u0111i\u1ec1u ch\u1ec9nh pH, ch\u1ea5t acid h\u00f3a v\u00e0 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c u\u1ed1ng, b\u00f4i v\u00e0 ti\u00eam; n\u00f3 […]<\/p>\n","protected":false},"author":1,"featured_media":3594,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3595","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-maleic.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-maleic-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-maleic-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-maleic-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-maleic-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-maleic.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-maleic.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-maleic-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Acid maleic \u2013 ch\u1ea5t acid h\u00f3a, ch\u1ea5t \u0111\u1ec7m, ch\u1ed1ng \u00f4i d\u1ea7u m\u1ee1 Acid maleic (acid cis-butenedioic) l\u00e0 acid dicarboxylic kh\u00f4ng no \u0111\u01a1n gi\u1ea3n nh\u1ea5t, \u0111\u1ed3ng ph\u00e2n cis c\u1ee7a acid fumaric. Trong b\u00e0o ch\u1ebf, acid maleic \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t \u0111i\u1ec1u ch\u1ec9nh pH, ch\u1ea5t acid h\u00f3a v\u00e0 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c u\u1ed1ng, b\u00f4i v\u00e0 ti\u00eam; n\u00f3…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3595"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3595\/revisions"}],"predecessor-version":[{"id":3716,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3595\/revisions\/3716"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3594"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}