{"id":3585,"date":"2026-09-29T09:10:58","date_gmt":"2026-09-29T02:10:58","guid":{"rendered":"https:\/\/cpc1.vn\/lactose-dung-cho-thuoc-hit\/"},"modified":"2026-09-29T09:10:58","modified_gmt":"2026-09-29T02:10:58","slug":"lactose-dung-cho-thuoc-hit","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/lactose-dung-cho-thuoc-hit\/","title":{"rendered":"Lactose d\u00f9ng cho thu\u1ed1c h\u00edt \u2013 ch\u1ea5t mang trong b\u1ed9t h\u00edt kh\u00f4 (DPI)"},"content":{"rendered":"

Lactose d\u00f9ng cho thu\u1ed1c h\u00edt \u2013 ch\u1ea5t mang trong b\u1ed9t h\u00edt kh\u00f4 (DPI)<\/h1>\n

Lactose d\u00f9ng cho thu\u1ed1c h\u00edt<\/strong> l\u00e0 lactose monohydrat ho\u1eb7c lactose khan d\u01b0\u1ee3c d\u1ee5ng \u0111\u01b0\u1ee3c nghi\u1ec1n, r\u00e2y, ph\u00e2n lo\u1ea1i b\u1eb1ng kh\u00ed, vi h\u00f3a v\u00e0\/ho\u1eb7c ph\u1ed1i tr\u1ed9n \u0111\u1ec3 c\u00f3 ph\u00e2n b\u1ed1 c\u1ee1 h\u1ea1t v\u00e0 b\u1ec1 m\u1eb7t ph\u00f9 h\u1ee3p. \u0110\u00e2y l\u00e0 ch\u1ea5t mang<\/strong>, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n<\/strong> v\u00e0 ch\u1ea5t \u0111i\u1ec1u h\u00f2a ch\u1ea3y<\/strong> \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i nh\u1ea5t trong b\u1ed9t h\u00edt kh\u00f4 (DPI)<\/strong> \u2013 m\u1ed9t trong r\u1ea5t \u00edt t\u00e1 d\u01b0\u1ee3c c\u00f3 m\u1eb7t trong thu\u1ed1c h\u00edt b\u1ed9t kh\u00f4 l\u01b0u h\u00e0nh.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n\n
T\u00ean th\u01b0\u01a1ng m\u1ea1i<\/td>\nLactohale, Respitose (DFE Pharma), InhaLac (Meggle)<\/td>\n<\/tr>\n
B\u1ea3n ch\u1ea5t<\/td>\nLactose monohydrat, lactose khan, ho\u1eb7c h\u1ed7n h\u1ee3p \u0111\u1ed3ng ph\u00e2n \u03b1\/\u03b2<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n5989-81-1, 10039-26-6, 64044-51-5 (monohydrat); 63-42-3 (khan)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC12<\/sub>H22<\/sub>O11<\/sub> \u2013 342,30 (khan); C12<\/sub>H22<\/sub>O11<\/sub>\u00b7H2<\/sub>O \u2013 360,31 (monohydrat)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t mang b\u1ed9t h\u00edt kh\u00f4<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nTheo chuy\u00ean lu\u1eadn lactose monohydrat\/lactose khan; kh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn ri\u00eang cho lo\u1ea1i d\u00f9ng h\u00edt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t mang, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n v\u00e0 \u0111i\u1ec1u h\u00f2a ch\u1ea3y trong b\u1ed9t h\u00edt kh\u00f4 \u2013 \u0111\u00f3ng trong nang, v\u1ec9 ho\u1eb7c thi\u1ebft b\u1ecb b\u00ecnh ch\u1ee9a. H\u1ea1t mang l\u1edbn gi\u00fap ph\u00e2n li\u1ec1u v\u00e0 ch\u1ea3y t\u1ed1t; khi h\u00edt, ho\u1ea1t ch\u1ea5t vi h\u00f3a t\u00e1ch kh\u1ecfi h\u1ea1t mang \u0111\u1ec3 \u0111i v\u00e0o ph\u1ed5i.<\/li>\n
  • Lo\u1ea1i lactose c\u00f3 c\u1ee1 h\u1ea1t ph\u00f9 h\u1ee3p c\u00f2n d\u00f9ng t\u1ea1o “vi\u00ean m\u1ec1m” (soft pellet) cho b\u1ed9t h\u00edt kh\u00f4.<\/li>\n
  • Do kh\u1ed1i l\u01b0\u1ee3ng lactose m\u1ed7i li\u1ec1u h\u00edt nh\u1ecf, l\u01b0\u1ee3ng lactose ng\u01b0\u1eddi b\u1ec7nh nu\u1ed1t v\u00e0o th\u1ea5p h\u01a1n nhi\u1ec1u so v\u1edbi vi\u00ean u\u1ed1ng.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • H\u1ea1t k\u1ebft tinh ho\u1eb7c b\u1ed9t tr\u1eafng t\u1edbi g\u1ea7n tr\u1eafng, kh\u00f4ng m\u00f9i, h\u01a1i ng\u1ecdt.<\/li>\n
    • C\u00e1c lo\u1ea1i th\u01b0\u01a1ng m\u1ea1i kh\u00e1c nhau r\u1ea5t nhi\u1ec1u v\u1ec1 c\u1ee1 h\u1ea1t \u2013 t\u1eeb lo\u1ea1i th\u00f4 (d50<\/sub> kho\u1ea3ng 130\u2013210 \u00b5m, v\u00ed d\u1ee5 InhaLac 70\/120, Lactohale 100) t\u1edbi lo\u1ea1i vi h\u00f3a (d50<\/sub> d\u01b0\u1edbi 5\u201310 \u00b5m, v\u00ed d\u1ee5 Lactohale 300, InhaLac 400). Di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t ri\u00eang kho\u1ea3ng 0,1\u20131,9 m\u00b2\/g; kh\u1ed1i l\u01b0\u1ee3ng ri\u00eang bi\u1ec3u ki\u1ebfn 0,33\u20130,69 g\/cm\u00b3.<\/li>\n
    • T\u00ednh ch\u1ea5t ti\u1ec3u ph\u00e2n (c\u1ee1 h\u1ea1t, t\u1ef7 l\u1ec7 h\u1ea1t m\u1ecbn, b\u1ec1 m\u1eb7t, h\u00e0m l\u01b0\u1ee3ng v\u00f4 \u0111\u1ecbnh h\u00ecnh) quy\u1ebft \u0111\u1ecbnh ch\u1ebf bi\u1ebfn, tr\u1ed9n b\u1ed9t v\u00e0 hi\u1ec7u n\u0103ng thu\u1ed1c. Ti\u00eau chu\u1ea9n d\u01b0\u1ee3c \u0111i\u1ec3n \u0111\u01b0\u1ee3c cho l\u00e0 ch\u01b0a \u0111\u1ee7 \u0111\u1ec3 ki\u1ec3m so\u00e1t c\u00e1c \u0111\u1eb7c t\u00ednh n\u00e0y \u2013 th\u01b0\u1eddng ph\u1ea3i c\u00f3 th\u00eam ch\u1ec9 ti\u00eau ri\u00eang, v\u00ed d\u1ee5 v\u1ec1 t\u00ednh ch\u1ea5t b\u1ec1 m\u1eb7t.<\/li>\n
    • \u0110\u00e3 c\u00f3 nghi\u00ean c\u1ee9u l\u00e0m nh\u1eb5n b\u1ec1 m\u1eb7t, k\u1ebft tinh l\u1ea1i ho\u1eb7c \u0111\u1ed3ng x\u1eed l\u00fd v\u1edbi t\u00e1 d\u01b0\u1ee3c kh\u00e1c \u0111\u1ec3 c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng t\u1ea1o kh\u00ed dung.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t, kh\u00f4ng c\u00f3 m\u00f9i l\u1ea1.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      Lactose l\u00e0 \u0111\u01b0\u1eddng kh\u1eed \u2013 c\u00f3 th\u1ec3 ph\u1ea3n \u1ee9ng Maillard v\u1edbi amin b\u1eadc m\u1ed9t ho\u1eb7c b\u1eadc hai. Xem th\u00eam lactose monohydrat, lactose khan.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Nghi\u1ec1n, r\u00e2y, ph\u00e2n lo\u1ea1i b\u1eb1ng d\u00f2ng kh\u00ed, vi h\u00f3a v\u00e0\/ho\u1eb7c ph\u1ed1i tr\u1ed9n lactose d\u01b0\u1ee3c d\u1ee5ng, th\u01b0\u1eddng trong d\u00e2y chuy\u1ec1n ri\u00eang c\u00f3 thi\u1ebft b\u1ecb b\u1ea3o \u0111\u1ea3m n\u1ed9i \u0111\u1ed9c t\u1ed1 th\u1ea5p. Ngo\u00e0i c\u00e1c lo\u1ea1i c\u00f3 s\u1eb5n, quy tr\u00ecnh c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh \u0111\u1ec3 \u0111\u1ea1t t\u00ednh ch\u1ea5t theo \u1ee9ng d\u1ee5ng c\u1ee5 th\u1ec3.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • Xem an to\u00e0n c\u1ee7a lactose monohydrat. Do d\u00f9ng \u0111\u01b0\u1eddng h\u00edt, c\u01a1 quan qu\u1ea3n l\u00fd th\u01b0\u1eddng y\u00eau c\u1ea7u th\u00eam ch\u1ec9 ti\u00eau vi sinh (v\u00ed d\u1ee5 n\u1ed9i \u0111\u1ed9c t\u1ed1); lactose d\u00f9ng cho thu\u1ed1c h\u00edt th\u01b0\u1eddng \u0111\u01b0\u1ee3c cung c\u1ea5p k\u00e8m ki\u1ec3m nghi\u1ec7m vi sinh m\u1edf r\u1ed9ng.<\/li>\n
      • Tr\u00e1nh t\u1ea1o v\u00e0 h\u00edt nhi\u1ec1u b\u1ee5i.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS. Lactose monohydrat v\u00e0 lactose khan c\u00f3 trong FDA Inactive Ingredients Database (b\u1ed9t h\u00edt) v\u00e0 trong thu\u1ed1c h\u00edt l\u01b0u h\u00e0nh t\u1ea1i Anh.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Lactose khan, lactose monohydrat, lactose s\u1ea5y phun.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Lactose, Inhalation<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Lactose d\u00f9ng cho thu\u1ed1c h\u00edt \u2013 ch\u1ea5t mang trong b\u1ed9t h\u00edt kh\u00f4 (DPI) Lactose d\u00f9ng cho thu\u1ed1c h\u00edt l\u00e0 lactose monohydrat ho\u1eb7c lactose khan d\u01b0\u1ee3c d\u1ee5ng \u0111\u01b0\u1ee3c nghi\u1ec1n, r\u00e2y, ph\u00e2n lo\u1ea1i b\u1eb1ng kh\u00ed, vi h\u00f3a v\u00e0\/ho\u1eb7c ph\u1ed1i tr\u1ed9n \u0111\u1ec3 c\u00f3 ph\u00e2n b\u1ed1 c\u1ee1 h\u1ea1t v\u00e0 b\u1ec1 m\u1eb7t ph\u00f9 h\u1ee3p. \u0110\u00e2y l\u00e0 ch\u1ea5t mang, t\u00e1 d\u01b0\u1ee3c […]<\/p>\n","protected":false},"author":1,"featured_media":3584,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3585","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactose-dung-cho-thuoc-hit.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactose-dung-cho-thuoc-hit-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactose-dung-cho-thuoc-hit-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactose-dung-cho-thuoc-hit-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactose-dung-cho-thuoc-hit-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactose-dung-cho-thuoc-hit.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactose-dung-cho-thuoc-hit.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactose-dung-cho-thuoc-hit-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Lactose d\u00f9ng cho thu\u1ed1c h\u00edt \u2013 ch\u1ea5t mang trong b\u1ed9t h\u00edt kh\u00f4 (DPI) Lactose d\u00f9ng cho thu\u1ed1c h\u00edt l\u00e0 lactose monohydrat ho\u1eb7c lactose khan d\u01b0\u1ee3c d\u1ee5ng \u0111\u01b0\u1ee3c nghi\u1ec1n, r\u00e2y, ph\u00e2n lo\u1ea1i b\u1eb1ng kh\u00ed, vi h\u00f3a v\u00e0\/ho\u1eb7c ph\u1ed1i tr\u1ed9n \u0111\u1ec3 c\u00f3 ph\u00e2n b\u1ed1 c\u1ee1 h\u1ea1t v\u00e0 b\u1ec1 m\u1eb7t ph\u00f9 h\u1ee3p. \u0110\u00e2y l\u00e0 ch\u1ea5t mang, t\u00e1 d\u01b0\u1ee3c…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3585","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3585"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3585\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3584"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3585"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3585"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3585"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}