{"id":3581,"date":"2026-09-29T09:08:37","date_gmt":"2026-09-29T02:08:37","guid":{"rendered":"https:\/\/cpc1.vn\/hydroxypropyl-betadex\/"},"modified":"2026-09-29T12:03:34","modified_gmt":"2026-09-29T05:03:34","slug":"hydroxypropyl-betadex","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/hydroxypropyl-betadex\/","title":{"rendered":"Hydroxypropyl betadex (HP-\u03b2-CD) \u2013 t\u0103ng \u0111\u1ed9 tan, t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng th\u1ea5m"},"content":{"rendered":"

Hydroxypropyl betadex (HP-\u03b2-CD) \u2013 t\u0103ng \u0111\u1ed9 tan, t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng th\u1ea5m<\/h1>\n

Hydroxypropyl betadex<\/strong> (2-hydroxypropyl-\u03b2-cyclodextrin, HP-\u03b2-CD) l\u00e0 ether hydroxypropyl th\u1ebf m\u1ed9t ph\u1ea7n c\u1ee7a \u03b2-cyclodextrin. \u0110\u00e2y l\u00e0 d\u1eabn ch\u1ea5t cyclodextrin \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t \u0111\u1ec3 t\u0103ng \u0111\u1ed9 tan<\/strong> c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t s\u01a1 n\u01b0\u1edbc nh\u1edd t\u1ea1o ph\u1ee9c l\u1ed3ng<\/strong>; ngo\u00e0i ra c\u00f2n l\u00e0 ch\u1ea5t t\u0103ng th\u1ea5m<\/strong> v\u00e0 stabilizer<\/strong>. \u01afu \u0111i\u1ec3m ch\u00ednh so v\u1edbi \u03b2-cyclodextrin l\u00e0 tan trong n\u01b0\u1edbc r\u1ea5t nhi\u1ec1u.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nHP-\u03b2-CD, 2-hydroxypropyl-\u03b2-cyclodextrin, hydroxypropylbetadexum; t\u00ean th\u01b0\u01a1ng m\u1ea1i Cavasol W7 HP Pharma, Kleptose HPB<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n94035-02-6; 128446-35-5<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c<\/td>\nC42<\/sub>H70<\/sub>O35<\/sub>(C3<\/sub>H6<\/sub>O)x<\/sub>; KLPT ph\u1ee5 thu\u1ed9c m\u1ee9c th\u1ebf (\u03b2-cyclodextrin kh\u00f4ng th\u1ebf: 1134,98). USP-NF y\u00eau c\u1ea7u m\u1ee9c th\u1ebf mol 0,4\u20131,5 nh\u00f3m hydroxypropyl m\u1ed7i \u0111\u01a1n v\u1ecb anhydroglucose<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u1ea1o ph\u1ee9c, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, t\u0103ng th\u1ea5m, t\u0103ng tan, \u0111i\u1ec1u ch\u1ec9nh \u0111\u1eb3ng tr\u01b0\u01a1ng<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur. (Hydroxypropylbetadex), USP-NF (Hydroxypropyl Betadex)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t tr\u1ee3 tan cho ph\u00e2n t\u1eed s\u01a1 n\u01b0\u1edbc trong thu\u1ed1c u\u1ed1ng d\u1ea1ng l\u1ecfng v\u00e0 r\u1eafn, thu\u1ed1c ti\u00eam, thu\u1ed1c phun m\u00f9 \u0111\u1ecbnh li\u1ec1u, b\u1ed9t h\u00edt kh\u00f4, ch\u1ebf ph\u1ea9m b\u00f4i v\u00e0 nh\u1ecf m\u1eaft.<\/li>\n
  • Ch\u1ea5t t\u0103ng h\u1ea5p thu\/th\u1ea5m trong h\u1ec7 u\u1ed1ng, qua da v\u00e0 qua m\u0169i \u2013 hi\u1ec7u qu\u1ea3 t\u00f9y t\u1eebng d\u01b0\u1ee3c ch\u1ea5t.<\/li>\n
  • Ch\u1ea5t \u1ed5n \u0111\u1ecbnh trong qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t v\u00e0 b\u1ea3o qu\u1ea3n. Ph\u1ee9c l\u1ed3ng c\u00f3 t\u00ednh ch\u1ea5t c\u01a1 h\u1ecdc kh\u00e1c nguy\u00ean li\u1ec7u ri\u00eang l\u1ebb v\u00e0 c\u00f3 th\u1ec3 ph\u1ee5 thu\u1ed9c nhi\u1ec7t \u0111\u1ed9.<\/li>\n
  • Kh\u00e1c: m\u00e0ng composit chitosan \u2013 acid gallic ch\u1ed1ng oxy h\u00f3a (bao b\u00ec th\u1ef1c ph\u1ea9m), v\u1eadt li\u1ec7u k\u00ednh \u00e1p tr\u00f2ng, m\u1ea1ch m\u00e1u nh\u00e2n t\u1ea1o v\u00e0 l\u01b0\u1edbi c\u1ea5y gh\u00e9p gi\u1ea3i ph\u00f3ng thu\u1ed1c c\u00f3 ki\u1ec3m so\u00e1t.<\/li>\n
  • L\u01b0u \u00fd: d\u1ecbch \u0111\u1eadm \u0111\u1eb7c itraconazol ch\u1ee9a HP-\u03b2-CD c\u00f3 nguy c\u01a1 t\u1ee7a thu\u1ed1c n\u1ebfu pha lo\u00e3ng b\u1eb1ng dung d\u1ecbch kh\u00e1c v\u1edbi dung d\u1ecbch \u0111\u01b0\u1ee3c cung c\u1ea5p k\u00e8m.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t v\u00f4 \u0111\u1ecbnh h\u00ecnh ho\u1eb7c k\u1ebft tinh, tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng.<\/li>\n
    • pH dung d\u1ecbch 20 g\/L: 5\u20138; kh\u1ed1i l\u01b0\u1ee3ng ri\u00eang bi\u1ec3u ki\u1ebfn 0,2\u20130,4 g\/cm\u00b3 t\u00f9y lo\u1ea1i; n\u0103ng su\u1ea5t quay c\u1ef1c +140\u00b0 t\u1edbi +145\u00b0; n\u01b0\u1edbc th\u01b0\u1eddng d\u01b0\u1edbi 3,0%.<\/li>\n
    • \u00cdt h\u00fat \u1ea9m h\u01a1n \u03b2-cyclodextrin g\u1ed1c, nh\u01b0ng tan v\u00e0o l\u01b0\u1ee3ng n\u01b0\u1edbc h\u1ea5p ph\u1ee5 khi \u0111\u1ed9 \u1ea9m r\u1ea5t cao (tr\u00ean 90%).<\/li>\n
    • \u0110\u1ed9 tan: d\u1ec5 tan trong n\u01b0\u1edbc (kho\u1ea3ng 2300 g\/L \u1edf 24\u201325 \u00b0C) v\u00e0 propylen glycol; tan trong ethanol, methanol, dimethyl sulfoxid, dimethylformamid.<\/li>\n
    • Gi\u1edbi h\u1ea1n vi sinh \u2264 10\u00b3 cfu\/g; lo\u1ea1i d\u00f9ng pha ti\u00eam \u2264 10\u00b2 cfu\/g.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh. Ho\u1ea1t t\u00ednh c\u1ee7a m\u1ed9t s\u1ed1 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n trong dung d\u1ecbch n\u01b0\u1edbc c\u00f3 th\u1ec3 gi\u1ea3m khi c\u00f3 HP-\u03b2-CD (do t\u1ea1o ph\u1ee9c v\u1edbi ch\u1ea5t b\u1ea3o qu\u1ea3n).<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Cho dung d\u1ecbch ki\u1ec1m c\u1ee7a \u03b2-cyclodextrin ph\u1ea3n \u1ee9ng v\u1edbi propylen oxyd. Ki\u1ec3u th\u1ebf thay \u0111\u1ed5i theo pH: ki\u1ec1m cao \u01b0u ti\u00ean th\u1ebf \u1edf C6, ki\u1ec1m th\u1ea5p \u01b0u ti\u00ean C2. H\u1ed7n h\u1ee3p s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 tinh ch\u1ebf b\u1eb1ng s\u1eafc k\u00fd \u0111i\u1ec1u ch\u1ebf.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • \u0110\u1ed9c t\u00ednh d\u01b0\u1ee3c h\u1ecdc \u0111\u00e3 \u0111\u01b0\u1ee3c t\u1ed5ng quan: nh\u00ecn chung \u0111\u1ed9c t\u00ednh th\u1ea5p; d\u1ea1ng tinh khi\u1ebft c\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft, da, \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p.<\/li>\n
      • C\u00f3 \u00fd ki\u1ebfn cho r\u1eb1ng HP-\u03b2-CD c\u00f3 th\u1ec3 l\u00e0m t\u0103ng \u0111\u1ed9c t\u00ednh c\u1ee7a ch\u1ea5t kh\u00e1c (v\u00ed d\u1ee5 ch\u1ea5t g\u00e2y ung th\u01b0) do l\u00e0m t\u0103ng \u0111\u1ed9 tan v\u00e0 sinh kh\u1ea3 d\u1ee5ng c\u1ee7a ch\u00fang.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): tr\u00ean 2 g\/kg.<\/li>\n
      • \u0110eo k\u00ednh, g\u0103ng; d\u00f9ng kh\u1ea9u trang ch\u1ed1ng b\u1ee5i. \u0110un t\u1edbi ph\u00e2n h\u1ee7y sinh kh\u00f3i \u0111\u1ed9c.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (ch\u1ebf ph\u1ea9m u\u1ed1ng v\u00e0 ti\u00eam); c\u00f3 trong thu\u1ed1c ti\u00eam b\u1eafp\/t\u0129nh m\u1ea1ch l\u01b0u h\u00e0nh t\u1ea1i Anh.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur., USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n
            \n
          • Sulfobutylether-\u03b2-cyclodextrin natri; cyclodextrin (\u03b1, \u03b2, \u03b3).<\/li>\n
          • 3-Hydroxypropyl-\u03b2-cyclodextrin<\/strong> (3-HP-\u03b2-CD): b\u1ed9t k\u1ebft tinh tr\u1eafng, tan h\u01a1n 1 trong 2 ph\u1ea7n n\u01b0\u1edbc; kh\u00f4ng \u0111\u1ed9c th\u1eadn n\u00ean \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t cho thu\u1ed1c ti\u00eam.<\/li>\n<\/ul>\n

            Ghi ch\u00fa:<\/strong> c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c c\u1ee7a HP-\u03b2-CD n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Hydroxypropyl Betadex<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Hydroxypropyl betadex (HP-\u03b2-CD) \u2013 t\u0103ng \u0111\u1ed9 tan, t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng th\u1ea5m Hydroxypropyl betadex (2-hydroxypropyl-\u03b2-cyclodextrin, HP-\u03b2-CD) l\u00e0 ether hydroxypropyl th\u1ebf m\u1ed9t ph\u1ea7n c\u1ee7a \u03b2-cyclodextrin. \u0110\u00e2y l\u00e0 d\u1eabn ch\u1ea5t cyclodextrin \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t \u0111\u1ec3 t\u0103ng \u0111\u1ed9 tan c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t s\u01a1 n\u01b0\u1edbc nh\u1edd t\u1ea1o ph\u1ee9c l\u1ed3ng; ngo\u00e0i ra c\u00f2n l\u00e0 […]<\/p>\n","protected":false},"author":1,"featured_media":3580,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3581","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-betadex.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-betadex-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-betadex-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-betadex-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-betadex-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-betadex.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-betadex.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxypropyl-betadex-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Hydroxypropyl betadex (HP-\u03b2-CD) \u2013 t\u0103ng \u0111\u1ed9 tan, t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng th\u1ea5m Hydroxypropyl betadex (2-hydroxypropyl-\u03b2-cyclodextrin, HP-\u03b2-CD) l\u00e0 ether hydroxypropyl th\u1ebf m\u1ed9t ph\u1ea7n c\u1ee7a \u03b2-cyclodextrin. \u0110\u00e2y l\u00e0 d\u1eabn ch\u1ea5t cyclodextrin \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t \u0111\u1ec3 t\u0103ng \u0111\u1ed9 tan c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t s\u01a1 n\u01b0\u1edbc nh\u1edd t\u1ea1o ph\u1ee9c l\u1ed3ng; ngo\u00e0i ra c\u00f2n l\u00e0…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3581","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3581"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3581\/revisions"}],"predecessor-version":[{"id":3843,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3581\/revisions\/3843"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3580"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3581"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3581"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3581"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}