{"id":3579,"date":"2026-09-29T09:08:30","date_gmt":"2026-09-29T02:08:30","guid":{"rendered":"https:\/\/cpc1.vn\/hepes\/"},"modified":"2026-09-29T09:08:30","modified_gmt":"2026-09-29T02:08:30","slug":"hepes","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/hepes\/","title":{"rendered":"HEPES (hydroxyethylpiperazin ethan sulfonic acid) \u2013 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c ti\u00eam"},"content":{"rendered":"

HEPES (hydroxyethylpiperazin ethan sulfonic acid) \u2013 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c ti\u00eam<\/h1>\n

HEPES<\/strong> (acid 4-(2-hydroxyethyl)-1-piperazinethanesulfonic) l\u00e0 ch\u1ea5t \u0111\u1ec7m zwitterion c\u00f3 pKa kho\u1ea3ng 7,5, gi\u1eef pH quanh m\u1ee9c sinh l\u00fd r\u1ea5t t\u1ed1t. Trong b\u00e0o ch\u1ebf, HEPES l\u00e0 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c ti\u00eam<\/strong>; n\u00f3 c\u0169ng l\u00e0 ch\u1ea5t \u0111\u1ec7m quen thu\u1ed9c trong m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nHEPES, acid N-(2-hydroxyethyl)piperazin-N’-2-ethansulfonic, acid 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethansulfonic<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n7365-45-9<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC8<\/sub>H18<\/sub>N2<\/sub>O4<\/sub>S \u2013 238,30<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t \u0111\u1ec7m<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn; c\u00f3 trong BP d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c th\u1eed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u1ee8ng d\u1ee5ng<\/h2>\n
    \n
  • Ch\u1ea5t \u0111\u1ec7m trong thu\u1ed1c ti\u00eam.<\/li>\n
  • D\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m ch\u1ea5t \u0111\u1ec7m trong nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o khi c\u1ea7n gi\u1eef pH \u1edf m\u1ee9c ho\u1eb7c g\u1ea7n m\u1ee9c sinh l\u00fd.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng, kh\u00f4ng m\u00f9i.<\/li>\n
    • pKa1<\/sub> kho\u1ea3ng 3; pKa2<\/sub> 7,55 (20 \u00b0C), gi\u1ea3m kho\u1ea3ng 0,014 \u0111\u01a1n v\u1ecb m\u1ed7i \u00b0C khi nhi\u1ec7t \u0111\u1ed9 t\u0103ng.<\/li>\n
    • Dung d\u1ecbch 1 M c\u00f3 pH 5,0\u20136,5; n\u00f3ng ch\u1ea3y kho\u1ea3ng 236 \u00b0C k\u00e8m ph\u00e2n h\u1ee7y.<\/li>\n
    • Tan trong n\u01b0\u1edbc; dung d\u1ecbch b\u00e3o h\u00f2a \u1edf 0 \u00b0C c\u00f3 n\u1ed3ng \u0111\u1ed9 2,25 M.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      H\u00fat \u1ea9m. B\u1ea3o qu\u1ea3n trong bao b\u00ec g\u1ed1c \u0111\u1eady k\u00edn t\u1edbi khi d\u00f9ng, n\u01a1i kh\u00f4 m\u00e1t, tr\u00e1nh \u00e1nh n\u1eafng tr\u1ef1c ti\u1ebfp.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      T\u1ed5ng h\u1ee3p qua ph\u1ea3n \u1ee9ng sulfon h\u00f3a t\u1eeb natri bromoethansulfonat v\u00e0 N-2-hydroxyethylpiperazin.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • C\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft, h\u00f4 h\u1ea5p, da n\u1ebfu thao t\u00e1c kh\u00f4ng \u0111\u00fang; c\u00f3 th\u1ec3 c\u00f3 h\u1ea1i khi nu\u1ed1t (k\u00edch \u1ee9ng ti\u00eau h\u00f3a, bu\u1ed3n n\u00f4n, n\u00f4n, ti\u00eau ch\u1ea3y). \u0110\u1ed9c t\u00ednh ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7.<\/li>\n
      • Nghi\u00ean c\u1ee9u in vitro: HEPES c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc (\u1ee9c ch\u1ebf t\u1ebf b\u00e0o nu\u00f4i c\u1ea5y h\u1ea5p thu taurin); khi c\u00f3 HEPES, t\u1ebf b\u00e0o ch\u1ebft nhanh h\u01a1n d\u01b0\u1edbi \u00e1nh s\u00e1ng; \u1ea3nh h\u01b0\u1edfng b\u1ea5t l\u1ee3i t\u1edbi t\u1ef7 l\u1ec7 th\u1ee5 thai trong \u1ed1ng nghi\u1ec7m.<\/li>\n
      • LD50<\/sub> (chim c\u00fat, u\u1ed1ng): tr\u00ean 0,316 g\/kg.<\/li>\n
      • Ph\u00e2n h\u1ee7y nhi\u1ec7t c\u00f3 th\u1ec3 sinh CO2<\/sub>, CO, oxyd nit\u01a1, oxyd l\u01b0u hu\u1ef3nh. Tr\u00e1nh d\u00ednh da, m\u1eaft; \u0111eo k\u00ednh b\u1ea3o h\u1ed9 ho\u1eb7c t\u1ea5m che m\u1eb7t khi c\u00f3 nguy c\u01a1 b\u1eafn t\u00f3e. Kh\u00f4ng c\u00f3 nguy c\u01a1 ch\u00e1y n\u1ed5 \u0111\u1eb7c bi\u1ec7t.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (ti\u00eam t\u0129nh m\u1ea1ch, thu\u1ed1c ti\u00eam).<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Xem th\u00eam tromethamin v\u00e0 c\u00e1c ch\u1ea5t \u0111\u1ec7m phosphat, citrat.<\/p>\n

          Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 230-907-9; PubChem CID 23830.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Hydroxyethylpiperazine Ethane Sulfonic Acid<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

          HEPES (hydroxyethylpiperazin ethan sulfonic acid) \u2013 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c ti\u00eam HEPES (acid 4-(2-hydroxyethyl)-1-piperazinethanesulfonic) l\u00e0 ch\u1ea5t \u0111\u1ec7m zwitterion c\u00f3 pKa kho\u1ea3ng 7,5, gi\u1eef pH quanh m\u1ee9c sinh l\u00fd r\u1ea5t t\u1ed1t. Trong b\u00e0o ch\u1ebf, HEPES l\u00e0 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c ti\u00eam; n\u00f3 c\u0169ng l\u00e0 ch\u1ea5t \u0111\u1ec7m quen thu\u1ed9c trong m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o. Th\u00f4ng […]<\/p>\n","protected":false},"author":1,"featured_media":3578,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3579","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hepes.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hepes-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hepes-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hepes-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hepes-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hepes.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hepes.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hepes-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"HEPES (hydroxyethylpiperazin ethan sulfonic acid) \u2013 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c ti\u00eam HEPES (acid 4-(2-hydroxyethyl)-1-piperazinethanesulfonic) l\u00e0 ch\u1ea5t \u0111\u1ec7m zwitterion c\u00f3 pKa kho\u1ea3ng 7,5, gi\u1eef pH quanh m\u1ee9c sinh l\u00fd r\u1ea5t t\u1ed1t. Trong b\u00e0o ch\u1ebf, HEPES l\u00e0 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c ti\u00eam; n\u00f3 c\u0169ng l\u00e0 ch\u1ea5t \u0111\u1ec7m quen thu\u1ed9c trong m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o. Th\u00f4ng…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3579","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3579"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3579\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3578"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3579"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}