{"id":3577,"date":"2026-09-29T09:06:48","date_gmt":"2026-09-29T02:06:48","guid":{"rendered":"https:\/\/cpc1.vn\/silica-keo-ky-nuoc\/"},"modified":"2026-09-29T09:06:48","modified_gmt":"2026-09-29T02:06:48","slug":"silica-keo-ky-nuoc","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/silica-keo-ky-nuoc\/","title":{"rendered":"Silica keo k\u1ef5 n\u01b0\u1edbc (Aerosil R972) \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n ch\u1ea3y, ch\u1ed1ng v\u00f3n cho c\u00f4ng th\u1ee9c nh\u1ea1y \u1ea9m"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Silica keo k\u1ef5 n\u01b0\u1edbc (Aerosil R972) \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n ch\u1ea3y, ch\u1ed1ng v\u00f3n cho c\u00f4ng th\u1ee9c nh\u1ea1y \u1ea9m<\/h1>\n<p><strong>Silica keo k\u1ef5 n\u01b0\u1edbc<\/strong> l\u00e0 silic dioxyd keo (t\u1ea1o b\u1eb1ng th\u1ee7y ph\u00e2n trong ng\u1ecdn l\u1eeda) \u0111\u01b0\u1ee3c x\u1eed l\u00fd b\u1ec1 m\u1eb7t b\u1eb1ng dimethyldiclorosilan, n\u00ean b\u1ec1 m\u1eb7t ph\u1ee7 nh\u00f3m dimethylsilyl v\u00e0 kh\u00f4ng th\u1ea5m n\u01b0\u1edbc. C\u00f4ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9 d\u00f9ng nh\u00ecn chung nh\u01b0 silic dioxyd keo th\u00e2n n\u01b0\u1edbc: <strong>t\u00e1 d\u01b0\u1ee3c \u0111i\u1ec1u h\u00f2a ch\u1ea3y<\/strong>, <strong>ch\u1ed1ng v\u00f3n<\/strong>, <strong>t\u0103ng \u0111\u1ed9 nh\u1edbt<\/strong>, <strong>\u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng<\/strong> \u2013 nh\u01b0ng h\u00fat \u1ea9m r\u1ea5t \u00edt, c\u00f3 l\u1ee3i cho c\u00f4ng th\u1ee9c nh\u1ea1y \u1ea9m.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Silica dimethyl silylat, silic dioxyd silan h\u00f3a, acid silicic silyl h\u00f3a; t\u00ean th\u01b0\u01a1ng m\u1ea1i Aerosil R972, HDK H13L, HDK H2000<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>68611-44-9<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>SiO<sub>2<\/sub> (m\u1ed9t ph\u1ea7n \u0111\u01b0\u1ee3c alkyl h\u00f3a \u0111\u1ec3 k\u1ef5 n\u01b0\u1edbc) \u2013 60,08<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ed1ng v\u00f3n, \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, \u0111i\u1ec1u h\u00f2a ch\u1ea3y, t\u1ea1o h\u1ed7n d\u1ecbch, t\u0103ng \u0111\u1ed9 nh\u1edbt<\/td>\n<\/tr>\n<tr>\n<td>D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<td>BP (Hydrophobic Colloidal Anhydrous Silica), Ph.Eur. (Silica, Hydrophobic Colloidal), USP-NF (Hydrophobic Colloidal Silica)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li>H\u1ea1t s\u01a1 c\u1ea5p c\u1ee1 nano, di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t l\u1edbn \u2013 c\u1ea3i thi\u1ec7n \u0111\u1ed9 tr\u01a1n ch\u1ea3y c\u1ee7a b\u1ed9t khi d\u1eadp vi\u00ean v\u00e0 \u0111\u00f3ng nang.<\/li>\n<li>H\u00fat \u1ea9m r\u1ea5t \u00edt, c\u00f3 l\u1ee3i cho c\u00f4ng th\u1ee9c nh\u1ea1y \u1ea9m.<\/li>\n<li>Ki\u1ec3m so\u00e1t \u0111\u1ed9 nh\u1edbt ki\u1ec3u x\u00fac bi\u1ebfn, l\u00e0m \u0111\u1eb7c v\u00e0 \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, t\u1ea1o h\u1ed7n d\u1ecbch trong gel v\u00e0 ch\u1ebf ph\u1ea9m n\u1eeda r\u1eafn. \u00cdt \u1ea3nh h\u01b0\u1edfng \u0111\u1ed9 nh\u1edbt pha n\u01b0\u1edbc nh\u01b0ng l\u00e0m \u0111\u1eb7c, \u1ed5n \u0111\u1ecbnh pha d\u1ea7u c\u1ee7a nh\u0169 t\u01b0\u01a1ng n\u01b0\u1edbc trong d\u1ea7u; ph\u1ed1i h\u1ee3p th\u00e0nh ph\u1ea7n c\u00f3 chi\u1ebft su\u1ea5t t\u01b0\u01a1ng \u0111\u01b0\u01a1ng c\u00f3 th\u1ec3 t\u1ea1o gel trong.<\/li>\n<li>&#8220;N\u01b0\u1edbc kh\u00f4&#8221; (dry water, nh\u0169 t\u01b0\u01a1ng kh\u00f4, liquid marbles): h\u1ea1t r\u1ea5t k\u1ef5 n\u01b0\u1edbc bao l\u1ea5y gi\u1ecdt n\u01b0\u1edbc t\u1ea1o b\u1ed9t; khi xoa l\u00ean da, b\u1ed9t v\u1ee1 ra gi\u1ea3i ph\u00f3ng ho\u1ea1t ch\u1ea5t tan trong n\u01b0\u1edbc.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t v\u00f4 \u0111\u1ecbnh h\u00ecnh nh\u1eb9, m\u1ecbn, tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, kh\u00f4ng th\u1ea5m n\u01b0\u1edbc.<\/li>\n<li>D\u01b0\u1ee3c \u0111i\u1ec3n: ph\u1ea7n ph\u00e2n t\u00e1n \u0111\u01b0\u1ee3c trong n\u01b0\u1edbc \u2264 3,0%; h\u00e0m l\u01b0\u1ee3ng SiO<sub>2<\/sub> (m\u1eabu \u0111\u00e3 nung) 99,0\u2013101,0%.<\/li>\n<li>\u0110\u1ed9 \u1ea9m d\u01b0\u1edbi 0,5% \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng trong c\u1ea3 d\u1ea3i \u0111\u1ed9 \u1ea9m t\u01b0\u01a1ng \u0111\u1ed1i 0\u2013100%.<\/li>\n<li>Aerosil R972: h\u1ea1t s\u01a1 c\u1ea5p 16 nm, k\u1ebft t\u1ee5 l\u1ecfng 10\u2013200 \u00b5m; kh\u1ed1i l\u01b0\u1ee3ng ri\u00eang bi\u1ec3u ki\u1ebfn kho\u1ea3ng 0,05\u20130,09 g\/cm\u00b3; di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t ri\u00eang 110 \u00b1 20 m\u00b2\/g. HDK H13L: 125 \u00b1 15 m\u00b2\/g; HDK H2000: 200 \u00b1 30 m\u00b2\/g.<\/li>\n<li>pH (ph\u00e2n t\u00e1n 4% trong n\u01b0\u1edbc \u2013 methanol 1:1): 3,8\u20134,8 ho\u1eb7c 6,5\u20138,0 t\u00f9y lo\u1ea1i; chi\u1ebft su\u1ea5t 1,46; t\u1ef7 tr\u1ecdng ri\u00eang 2,0\u20132,2.<\/li>\n<li>H\u1ea7u nh\u01b0 kh\u00f4ng tan trong dung m\u00f4i h\u1eefu c\u01a1 v\u00e0 acid (tr\u1eeb acid hydrofluoric); tan trong dung d\u1ecbch hydroxyd ki\u1ec1m n\u00f3ng.<\/li>\n<li>Aerosil R972 \u0111\u01b0\u1ee3c t\u1ea1o b\u1eb1ng c\u00e1ch bi\u1ebfn t\u00ednh b\u1ec1 m\u1eb7t Aerosil 130: c\u00f9ng c\u1ee1 h\u1ea1t, di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t, nh\u01b0ng m\u1eadt \u0111\u1ed9 nh\u00f3m silanol gi\u1ea3m t\u1eeb kho\u1ea3ng 2,0 xu\u1ed1ng 0,75 SiOH\/nm\u00b2.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn. Kh\u00f4ng h\u00fat \u1ea9m nh\u01b0ng v\u1eabn c\u00f3 th\u1ec3 h\u1ea5p ph\u1ee5 ch\u1ea5t bay h\u01a1i do di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t l\u1edbn.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>\u0110\u00e3 ghi nh\u1eadn l\u00e0m gi\u1ea3m \u0111\u1ed9 c\u1ee9ng c\u1ee7a vi\u00ean n\u00e9n n\u1ec1n tinh b\u1ed9t.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Th\u1ee7y ph\u00e2n clorosilan (nh\u01b0 silic tetraclorid) trong ng\u1ecdn l\u1eeda hydro \u2013 oxy \u1edf kho\u1ea3ng 1800 \u00b0C, l\u00e0m ngu\u1ed9i nhanh \u0111\u1ec3 thu s\u1ea3n ph\u1ea9m v\u00f4 \u0111\u1ecbnh h\u00ecnh, r\u1ed3i x\u1eed l\u00fd ngay b\u1eb1ng dimethyldiclorosilan trong thi\u1ebft b\u1ecb t\u1ea7ng s\u00f4i \u2013 b\u1ec1 m\u1eb7t \u0111\u01b0\u1ee3c ph\u1ee7 nh\u00f3m dimethylsilyl.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<ul>\n<li>H\u1ed3 s\u01a1 an to\u00e0n nh\u01b0 c\u00e1c lo\u1ea1i silica th\u00e2n n\u01b0\u1edbc \u2013 b\u1ec1 m\u1eb7t bi\u1ebfn t\u00ednh kh\u00f4ng l\u00e0m thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 \u0111\u1ed9c t\u00ednh. LD<sub>50<\/sub> (chu\u1ed9t c\u1ed1ng, t\u0129nh m\u1ea1ch): 0,015 g\/kg.<\/li>\n<li>L\u00e0 b\u1ee5i g\u00e2y phi\u1ec1n to\u00e1i; h\u00edt b\u1ee5i silica v\u00f4 \u0111\u1ecbnh h\u00ecnh c\u00f3 th\u1ec3 k\u00edch \u1ee9ng h\u00f4 h\u1ea5p nh\u01b0ng kh\u00f4ng g\u00e2y x\u01a1 ph\u1ed5i (b\u1ec7nh b\u1ee5i ph\u1ed5i silic) nh\u01b0 silica tinh th\u1ec3.<\/li>\n<li>\u0110eo k\u00ednh, g\u0103ng; khi kh\u00f4ng c\u00f3 thi\u1ebft b\u1ecb bao k\u00edn c\u1ea7n \u0111eo kh\u1ea9u trang ch\u1ed1ng b\u1ee5i (l\u01b0\u1ee3ng nh\u1ecf) ho\u1eb7c m\u1eb7t n\u1ea1 l\u1ecdc b\u1ee5i (l\u01b0\u1ee3ng l\u1edbn). C\u00f3 th\u1ec3 t\u00edch \u0111i\u1ec7n t\u0129nh khi v\u1eadn chuy\u1ec3n kh\u00ed n\u00e9n \u2013 c\u1ea7n bi\u1ec7n ph\u00e1p k\u1ef9 thu\u1eadt ph\u00f9 h\u1ee3p.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>\u0110\u01b0\u1ee3c ph\u00e9p d\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u; c\u00f3 trong vi\u00ean n\u00e9n u\u1ed1ng v\u00e0 thu\u1ed1c \u0111\u1ea1n l\u01b0u h\u00e0nh t\u1ea1i Anh.<\/li>\n<li>FDA v\u00e0 ch\u00e2u \u00c2u cho ph\u00e9p trong v\u1eadt li\u1ec7u ti\u1ebfp x\u00fac th\u1ef1c ph\u1ea9m; kh\u00f4ng d\u00f9ng l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m cho ng\u01b0\u1eddi; \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t ch\u1ed1ng v\u00f3n trong premix kho\u00e1ng th\u1ee9c \u0103n ch\u0103n nu\u00f4i t\u1ea1i ch\u00e2u \u00c2u v\u00e0 M\u1ef9.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur., USP-NF.<\/li>\n<\/ul>\n<h2>Ch\u1ea5t li\u00ean quan<\/h2>\n<p>Silic dioxyd keo (Aerosil \u2013 lo\u1ea1i th\u00e2n n\u01b0\u1edbc).<\/p>\n<p><strong>Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 271-893-4.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Hydrophobic Colloidal Silica<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Silica keo k\u1ef5 n\u01b0\u1edbc (Aerosil R972) \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n ch\u1ea3y, ch\u1ed1ng v\u00f3n cho c\u00f4ng th\u1ee9c nh\u1ea1y \u1ea9m Silica keo k\u1ef5 n\u01b0\u1edbc l\u00e0 silic dioxyd keo (t\u1ea1o b\u1eb1ng th\u1ee7y ph\u00e2n trong ng\u1ecdn l\u1eeda) \u0111\u01b0\u1ee3c x\u1eed l\u00fd b\u1ec1 m\u1eb7t b\u1eb1ng dimethyldiclorosilan, n\u00ean b\u1ec1 m\u1eb7t ph\u1ee7 nh\u00f3m dimethylsilyl v\u00e0 kh\u00f4ng th\u1ea5m n\u01b0\u1edbc. C\u00f4ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3576,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3577","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silica-keo-ky-nuoc.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silica-keo-ky-nuoc-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silica-keo-ky-nuoc-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silica-keo-ky-nuoc-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silica-keo-ky-nuoc-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silica-keo-ky-nuoc.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silica-keo-ky-nuoc.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/silica-keo-ky-nuoc-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Silica keo k\u1ef5 n\u01b0\u1edbc (Aerosil R972) \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n ch\u1ea3y, ch\u1ed1ng v\u00f3n cho c\u00f4ng th\u1ee9c nh\u1ea1y \u1ea9m Silica keo k\u1ef5 n\u01b0\u1edbc l\u00e0 silic dioxyd keo (t\u1ea1o b\u1eb1ng th\u1ee7y ph\u00e2n trong ng\u1ecdn l\u1eeda) \u0111\u01b0\u1ee3c x\u1eed l\u00fd b\u1ec1 m\u1eb7t b\u1eb1ng dimethyldiclorosilan, n\u00ean b\u1ec1 m\u1eb7t ph\u1ee7 nh\u00f3m dimethylsilyl v\u00e0 kh\u00f4ng th\u1ea5m n\u01b0\u1edbc. C\u00f4ng d\u1ee5ng v\u00e0 n\u1ed3ng \u0111\u1ed9&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3577","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3577"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3577\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3576"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}