{"id":3575,"date":"2026-09-29T09:06:41","date_gmt":"2026-09-29T02:06:41","guid":{"rendered":"https:\/\/cpc1.vn\/n-hexan\/"},"modified":"2026-09-29T09:06:41","modified_gmt":"2026-09-29T02:06:41","slug":"n-hexan","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/n-hexan\/","title":{"rendered":"n-Hexan \u2013 dung m\u00f4i chi\u1ebft xu\u1ea5t, dung m\u00f4i nh\u00f3m 2 theo ICH"},"content":{"rendered":"

n-Hexan \u2013 dung m\u00f4i chi\u1ebft xu\u1ea5t, dung m\u00f4i nh\u00f3m 2 theo ICH<\/h1>\n

n-Hexan<\/strong> l\u00e0 hydrocarbon no m\u1ea1ch th\u1eb3ng 6 carbon, ch\u1ea5t l\u1ecfng kh\u00f4ng m\u00e0u, r\u1ea5t d\u1ec5 bay h\u01a1i v\u00e0 d\u1ec5 ch\u00e1y, m\u00f9i nh\u1eb9 nh\u01b0 x\u0103ng. Trong ng\u00e0nh d\u01b0\u1ee3c, n-hexan ch\u1ee7 y\u1ebfu l\u00e0 dung m\u00f4i<\/strong> \u2013 chi\u1ebft xu\u1ea5t v\u00e0 s\u1ea3n xu\u1ea5t ho\u1ea1t ch\u1ea5t (v\u00ed d\u1ee5 chi\u1ebft artemisinin t\u1eeb d\u01b0\u1ee3c li\u1ec7u), s\u1ea3n xu\u1ea5t vi\u00ean u\u1ed1ng \u2013 v\u00e0 thu\u1ed9c dung m\u00f4i t\u1ed3n d\u01b0 nh\u00f3m 2<\/strong> c\u1ea7n gi\u1edbi h\u1ea1n.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nHexan, hexan th\u01b0\u1eddng, dipropyl, hexyl hydrid<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n110-54-3<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC6<\/sub>H14<\/sub> \u2013 86,18<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nDung m\u00f4i<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn d\u01b0\u1ee3c \u0111i\u1ec3n; c\u00f3 ti\u00eau chu\u1ea9n “hexanes” trong Food Chemicals Codex<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Dung m\u00f4i trong s\u1ea3n xu\u1ea5t ho\u1ea1t ch\u1ea5t (chi\u1ebft xu\u1ea5t d\u01b0\u1ee3c li\u1ec7u) v\u00e0 s\u1ea3n xu\u1ea5t vi\u00ean n\u00e9n, nang u\u1ed1ng.<\/li>\n
  • \u0110\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong ch\u1ebf ph\u1ea9m qua da v\u00e0 trong b\u00e0o ch\u1ebf ti\u1ec3u ph\u00e2n nano, vi c\u1ea7u gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t.<\/li>\n
  • C\u00f4ng nghi\u1ec7p th\u1ef1c ph\u1ea9m: dung m\u00f4i chi\u1ebft d\u1ea7u m\u1ee1 (\u0111\u01a1n thu\u1ea7n ho\u1eb7c h\u1ed7n h\u1ee3p hexan \u2013 aceton, hexan \u2013 isopropanol). Ph\u00f2ng th\u00ed nghi\u1ec7m: dung m\u00f4i chi\u1ebft c\u00e1c ch\u1ea5t kh\u00f4ng ph\u00e2n c\u1ef1c.<\/li>\n
  • Hexan th\u01b0\u01a1ng m\u1ea1i (ch\u1ee9a 20\u201385% n-hexan c\u00f9ng c\u00e1c \u0111\u1ed3ng ph\u00e2n, cyclohexan\u2026) d\u00f9ng l\u00e0m dung m\u00f4i keo d\u00e1n, vecni, m\u1ef1c in, ch\u1ea5t t\u1ea9y d\u1ea7u m\u1ee1.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t l\u1ecfng kh\u00f4ng m\u00e0u, d\u1ec5 ch\u00e1y, d\u1ec5 bay h\u01a1i. Lo\u1ea1i tinh khi\u1ebft ch\u1ee9a 95\u201399,5% n-hexan, c\u00f2n l\u1ea1i l\u00e0 \u0111\u1ed3ng ph\u00e2n hexan kh\u00e1c.<\/li>\n
    • \u0110i\u1ec3m s\u00f4i 68\u201369 \u00b0C; t\u1ef7 tr\u1ecdng 0,66 g\/mL (20 \u00b0C); chi\u1ebft su\u1ea5t 1,373\u20131,377; nhi\u1ec7t \u0111\u1ed9 t\u1ef1 b\u1ed1c ch\u00e1y kho\u1ea3ng 225\u2013234 \u00b0C.<\/li>\n
    • \u00c1p su\u1ea5t h\u01a1i 20 kPa (25 \u00b0C); t\u1ef7 tr\u1ecdng h\u01a1i 2,97 (kh\u00f4ng kh\u00ed = 1); \u0111\u1ed9 nh\u1edbt kho\u1ea3ng 0,3 mPa\u00b7s; s\u1ee9c c\u0103ng b\u1ec1 m\u1eb7t 18,41 mN\/m; log P 3,29.<\/li>\n
    • Kh\u00f4ng tan trong n\u01b0\u1edbc; tr\u1ed9n l\u1eabn v\u1edbi aceton, ethanol, cloroform, ether.<\/li>\n
    • FCC: kho\u1ea3ng c\u1ea5t 56\u201371 \u00b0C; t\u1ef7 tr\u1ecdng 0,655\u20130,675.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n \u1edf nhi\u1ec7t \u0111\u1ed9, \u00e1p su\u1ea5t th\u01b0\u1eddng. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i m\u00e1t, th\u00f4ng tho\u00e1ng, xa ngu\u1ed3n nhi\u1ec7t v\u00e0 l\u1eeda.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh; l\u00e0m h\u1ecfng m\u1ed9t s\u1ed1 lo\u1ea1i nh\u1ef1a, cao su v\u00e0 l\u1edbp ph\u1ee7.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      n-Hexan l\u00e0 th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a ether d\u1ea7u h\u1ecfa v\u00e0 hexan th\u01b0\u01a1ng m\u1ea1i, c\u00f3 s\u1eb5n v\u1edbi l\u01b0\u1ee3ng nh\u1ecf trong d\u1ea7u th\u00f4 v\u00e0 kh\u00ed thi\u00ean nhi\u00ean. Thu ch\u1ee7 y\u1ebfu t\u1eeb c\u00e1c ph\u00e2n \u0111o\u1ea1n d\u1ea7u m\u1ecf b\u1eb1ng ch\u01b0ng c\u1ea5t ph\u00e2n \u0111o\u1ea1n c\u00f3 ki\u1ec3m so\u00e1t, t\u00e1ch b\u1eb1ng r\u00e2y ph\u00e2n t\u1eed ho\u1eb7c c\u00e1c quy tr\u00ecnh l\u1ecdc d\u1ea7u kh\u00e1c.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • Ph\u01a1i nhi\u1ec5m c\u1ea5p g\u00e2y ch\u00f3ng m\u1eb7t, bu\u1ed3n ng\u1ee7, bu\u1ed3n n\u00f4n, \u0111au \u0111\u1ea7u, n\u1eb7ng c\u00f3 th\u1ec3 b\u1ea5t t\u1ec9nh; nu\u1ed1t g\u00e2y bu\u1ed3n n\u00f4n, n\u00f4n; k\u00edch \u1ee9ng da, m\u1eaft.<\/li>\n
      • \u0110\u1ed9c t\u00ednh m\u1ea1n:<\/strong> ph\u01a1i nhi\u1ec5m ngh\u1ec1 nghi\u1ec7p k\u00e9o d\u00e0i ho\u1eb7c l\u1ea1m d\u1ee5ng g\u00e2y b\u1ec7nh th\u1ea7n kinh ngo\u1ea1i bi\u00ean (t\u00ea \u0111\u1ea7u chi, y\u1ebfu c\u01a1, nh\u00ecn m\u1edd, \u0111au \u0111\u1ea7u, m\u1ec7t) do ch\u1ea5t chuy\u1ec3n h\u00f3a hexan-2,5-dion; methyl ethyl ceton c\u00f3 th\u1ec3 l\u00e0m n\u1eb7ng th\u00eam. V\u00ec v\u1eady n-hexan th\u01b0\u1eddng \u0111\u01b0\u1ee3c thay b\u1eb1ng n-heptan.<\/li>\n
      • Gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m: OSHA (M\u1ef9) 500 ppm (1800 mg\/m\u00b3, TWA 8 gi\u1edd); Anh 20 ppm (72 mg\/m\u00b3).<\/li>\n
      • LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 28,71 g\/kg; (chu\u1ed9t nh\u1eaft, u\u1ed1ng): 5 g\/kg; (th\u1ecf, qua da): 3 g\/kg. LC50<\/sub> (chu\u1ed9t c\u1ed1ng, chu\u1ed9t nh\u1eaft, h\u00edt): 48 000 ppm.<\/li>\n
      • Ch\u1ea5t l\u1ecfng v\u00e0 h\u01a1i r\u1ea5t d\u1ec5 ch\u00e1y; tr\u00e1nh nu\u1ed1t, h\u00edt, ti\u1ebfp x\u00fac da, m\u1eaft; d\u00f9ng \u0111\u1ed3 b\u1ea3o h\u1ed9 ph\u00f9 h\u1ee3p.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (nang v\u00e0 vi\u00ean n\u00e9n u\u1ed1ng).<\/li>\n
        • Dung m\u00f4i t\u1ed3n d\u01b0 nh\u00f3m 2 khi d\u00f9ng trong s\u1ea3n xu\u1ea5t ho\u1ea1t ch\u1ea5t: PDE 2,9 mg\/ng\u00e0y, gi\u1edbi h\u1ea1n n\u1ed3ng \u0111\u1ed9 290 ppm.<\/li>\n
        • FAO\/WHO kh\u00f4ng \u0111\u1eb7t ADI, ch\u1ec9 khuy\u1ebfn c\u00e1o d\u00f9ng theo GMP \u0111\u1ec3 t\u1ed3n d\u01b0 t\u1ed1i thi\u1ec3u. M\u1ef9 gi\u1edbi h\u1ea1n n-hexan t\u1ed3n d\u01b0: 60 mg\/kg trong s\u1ea3n ph\u1ea9m h\u1ea1t b\u00f4ng, 25 mg\/kg trong chi\u1ebft xu\u1ea5t hoa bia v\u00e0 m\u1ed9t s\u1ed1 ch\u1ea5t m\u00e0u th\u1ef1c ph\u1ea9m.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          n-Heptan<\/strong> (C7<\/sub>H16<\/sub>, KLPT 100,2; CAS 142-82-5): s\u00f4i 98,38 \u00b0C, t\u1ef7 tr\u1ecdng 0,6795 g\/cm\u00b3; kh\u00f4ng t\u1ea1o ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u1ed9c hexan-2,5-dion n\u00ean \u0111\u01b0\u1ee3c d\u00f9ng thay n-hexan; gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m t\u1ea1i Anh 500 ppm.<\/p>\n

          Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 203-777-6; PubChem CID 8058.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Hexane<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          n-Hexan \u2013 dung m\u00f4i chi\u1ebft xu\u1ea5t, dung m\u00f4i nh\u00f3m 2 theo ICH n-Hexan l\u00e0 hydrocarbon no m\u1ea1ch th\u1eb3ng 6 carbon, ch\u1ea5t l\u1ecfng kh\u00f4ng m\u00e0u, r\u1ea5t d\u1ec5 bay h\u01a1i v\u00e0 d\u1ec5 ch\u00e1y, m\u00f9i nh\u1eb9 nh\u01b0 x\u0103ng. Trong ng\u00e0nh d\u01b0\u1ee3c, n-hexan ch\u1ee7 y\u1ebfu l\u00e0 dung m\u00f4i \u2013 chi\u1ebft xu\u1ea5t v\u00e0 s\u1ea3n xu\u1ea5t ho\u1ea1t ch\u1ea5t (v\u00ed d\u1ee5 chi\u1ebft […]<\/p>\n","protected":false},"author":1,"featured_media":3574,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3575","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-hexan.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-hexan-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-hexan-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-hexan-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-hexan-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-hexan.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-hexan.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/n-hexan-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"n-Hexan \u2013 dung m\u00f4i chi\u1ebft xu\u1ea5t, dung m\u00f4i nh\u00f3m 2 theo ICH n-Hexan l\u00e0 hydrocarbon no m\u1ea1ch th\u1eb3ng 6 carbon, ch\u1ea5t l\u1ecfng kh\u00f4ng m\u00e0u, r\u1ea5t d\u1ec5 bay h\u01a1i v\u00e0 d\u1ec5 ch\u00e1y, m\u00f9i nh\u1eb9 nh\u01b0 x\u0103ng. Trong ng\u00e0nh d\u01b0\u1ee3c, n-hexan ch\u1ee7 y\u1ebfu l\u00e0 dung m\u00f4i \u2013 chi\u1ebft xu\u1ea5t v\u00e0 s\u1ea3n xu\u1ea5t ho\u1ea1t ch\u1ea5t (v\u00ed d\u1ee5 chi\u1ebft…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3575","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3575"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3575\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3574"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3575"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3575"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}