{"id":3573,"date":"2026-09-29T09:06:34","date_gmt":"2026-09-29T02:06:34","guid":{"rendered":"https:\/\/cpc1.vn\/hydroxyethyl-beta-cyclodextrin\/"},"modified":"2026-09-29T09:06:34","modified_gmt":"2026-09-29T02:06:34","slug":"hydroxyethyl-beta-cyclodextrin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/hydroxyethyl-beta-cyclodextrin\/","title":{"rendered":"Hydroxyethyl-\u03b2-cyclodextrin (HE-\u03b2-CD) \u2013 t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng \u0111\u1ed9 tan"},"content":{"rendered":"

Hydroxyethyl-\u03b2-cyclodextrin (HE-\u03b2-CD) \u2013 t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng \u0111\u1ed9 tan<\/h1>\n

Hydroxyethyl-\u03b2-cyclodextrin<\/strong> (HE-\u03b2-CD) l\u00e0 d\u1eabn ch\u1ea5t hydroxyalkyl kh\u00f4ng ion c\u1ee7a \u03b2-cyclodextrin, t\u1ea1o b\u1eb1ng c\u00e1ch g\u1eafn nh\u00f3m 2-hydroxyethyl l\u00ean c\u00e1c nh\u00f3m hydroxyl. Nh\u01b0 \u03b2-cyclodextrin, HE-\u03b2-CD t\u1ea1o ph\u1ee9c l\u1ed3ng<\/strong> \u0111\u1ec3 t\u0103ng \u0111\u1ed9 tan, t\u1ed1c \u0111\u1ed9 h\u00f2a tan, sinh kh\u1ea3 d\u1ee5ng v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh<\/strong> c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t k\u00e9m tan, nh\u01b0ng tan trong n\u01b0\u1edbc t\u1ed1t h\u01a1n nhi\u1ec1u.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nHE-\u03b2-CD, HEBCD, 2-hydroxyethyl-\u03b2-cyclodextrin, ether 2-hydroxyethyl c\u1ee7a \u03b2-cyclodextrin<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n128446-32-2; 98513-20-3<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c<\/td>\nC42<\/sub>H70<\/sub>O35<\/sub>(C2<\/sub>H4<\/sub>O)x<\/sub> (x = m\u1ee9c th\u1ebf mol); KLPT ph\u1ee5 thu\u1ed9c m\u1ee9c th\u1ebf (\u03b2-cyclodextrin kh\u00f4ng th\u1ebf: 1134,98)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u1ea1o ph\u1ee9c, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, t\u1ea1o vi nang, t\u0103ng tan, \u0111i\u1ec1u ch\u1ec9nh \u0111\u1eb3ng tr\u01b0\u01a1ng<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • T\u1ea1o ph\u1ee9c l\u1ed3ng \u0111\u1ec3 c\u1ea3i thi\u1ec7n h\u00f2a tan, \u0111\u1ed9 tan, sinh kh\u1ea3 d\u1ee5ng v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t k\u00e9m tan trong ch\u1ebf ph\u1ea9m u\u1ed1ng, b\u00f4i v\u00e0 nh\u1ecf m\u1eaft; \u1ee9ng d\u1ee5ng t\u01b0\u01a1ng t\u1ef1 \u03b2-cyclodextrin.<\/li>\n
  • Th\u1ef1c ph\u1ea9m: k\u00e9o d\u00e0i h\u1ea1n d\u00f9ng, che v\u1ecb; d\u00f9ng trong m\u1ef9 ph\u1ea9m.<\/li>\n
  • H\u00f3a ph\u00e2n t\u00edch: t\u00e1ch \u0111\u1ed3ng ph\u00e2n \u0111\u1ed1i quang v\u00e0 \u0111\u1ed3ng ph\u00e2n l\u1eadp th\u1ec3 tr\u00ean s\u1eafc k\u00fd l\u1edbp m\u1ecfng.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng.<\/li>\n
    • Kh\u1ed1i l\u01b0\u1ee3ng ri\u00eang bi\u1ec3u ki\u1ebfn 0,681 g\/cm\u00b3, sau g\u00f5 0,916 g\/cm\u00b3, th\u1ef1c 1,378 g\/cm\u00b3; \u0111i\u1ec3m ch\u1ea3y 260 \u00b0C; s\u1ee9c c\u0103ng b\u1ec1 m\u1eb7t 68\u201371 mN\/m (25 \u00b0C).<\/li>\n
    • C\u00e1c d\u1eabn ch\u1ea5t hydroxyalkyl \u00edt h\u00fat \u1ea9m h\u01a1n \u03b2-cyclodextrin g\u1ed1c, nh\u01b0ng tan ch\u1ea3y khi \u0111\u1ed9 \u1ea9m r\u1ea5t cao (tr\u00ean 90%).<\/li>\n
    • \u0110\u1ed9 tan: h\u01a1n 1 trong 2 ph\u1ea7n n\u01b0\u1edbc (25 \u00b0C).<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n \u1edf tr\u1ea1ng th\u00e1i r\u1eafn n\u1ebfu tr\u00e1nh \u0111\u1ed9 \u1ea9m cao. B\u1ea3o qu\u1ea3n d\u01b0\u1edbi kh\u00ed tr\u01a1, n\u01a1i kh\u00f4 m\u00e1t, th\u00f4ng tho\u00e1ng.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Ng\u01b0ng t\u1ee5 \u03b2-cyclodextrin v\u1edbi t\u00e1c nh\u00e2n hydroxyalkyl h\u00f3a nh\u01b0 2-cloroethanol trong m\u00f4i tr\u01b0\u1eddng ki\u1ec1m; m\u1ee9c th\u1ebf nh\u00f3m hydroxyethyl c\u00f3 th\u1ec3 kh\u00e1c nhau.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • \u0110\u01b0\u1ee3c coi l\u00e0 \u0111\u1ed9c t\u00ednh th\u1ea5p khi d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c; ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp c\u00f3 th\u1ec3 g\u00e2y k\u00edch \u1ee9ng.<\/li>\n
      • Tr\u00ean chu\u1ed9t nh\u1eaft, HE-\u03b2-CD \u0111\u1ed9c h\u01a1n hydroxypropyl-\u03b2-cyclodextrin, nh\u01b0ng g\u00e2y tan m\u00e1u y\u1ebfu nh\u1ea5t trong c\u00e1c d\u1eabn ch\u1ea5t cyclodextrin \u0111\u00e3 th\u1eed.<\/li>\n
      • Kh\u00f4ng c\u00f3 th\u00e0nh ph\u1ea7n n\u00e0o \u2265 0,1% \u0111\u01b0\u1ee3c IARC x\u1ebfp l\u00e0 ch\u1ea5t g\u00e2y ung th\u01b0.<\/li>\n
      • Tr\u00e1nh d\u00ednh da, m\u1eaft, tr\u00e1nh h\u00edt; \u0111eo g\u0103ng, k\u00ednh; thao t\u00e1c n\u01a1i th\u00f4ng tho\u00e1ng.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n

        T\u00e0i li\u1ec7u g\u1ed1c kh\u00f4ng n\u00eau t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u1ee5 th\u1ec3.<\/p>\n

        Ch\u1ea5t li\u00ean quan<\/h2>\n

        Sulfobutylether-\u03b2-cyclodextrin natri, cyclodextrin (\u03b1, \u03b2, \u03b3), dimethyl-\u03b2-cyclodextrin, hydroxypropyl betadex, trimethyl-\u03b2-cyclodextrin.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Hydroxyethyl-beta-cyclodextrin<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Hydroxyethyl-\u03b2-cyclodextrin (HE-\u03b2-CD) \u2013 t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng \u0111\u1ed9 tan Hydroxyethyl-\u03b2-cyclodextrin (HE-\u03b2-CD) l\u00e0 d\u1eabn ch\u1ea5t hydroxyalkyl kh\u00f4ng ion c\u1ee7a \u03b2-cyclodextrin, t\u1ea1o b\u1eb1ng c\u00e1ch g\u1eafn nh\u00f3m 2-hydroxyethyl l\u00ean c\u00e1c nh\u00f3m hydroxyl. Nh\u01b0 \u03b2-cyclodextrin, HE-\u03b2-CD t\u1ea1o ph\u1ee9c l\u1ed3ng \u0111\u1ec3 t\u0103ng \u0111\u1ed9 tan, t\u1ed1c \u0111\u1ed9 h\u00f2a tan, sinh kh\u1ea3 d\u1ee5ng v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t k\u00e9m tan, […]<\/p>\n","protected":false},"author":1,"featured_media":3572,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3573","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxyethyl-beta-cyclodextrin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxyethyl-beta-cyclodextrin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxyethyl-beta-cyclodextrin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxyethyl-beta-cyclodextrin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxyethyl-beta-cyclodextrin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxyethyl-beta-cyclodextrin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxyethyl-beta-cyclodextrin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/hydroxyethyl-beta-cyclodextrin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Hydroxyethyl-\u03b2-cyclodextrin (HE-\u03b2-CD) \u2013 t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng \u0111\u1ed9 tan Hydroxyethyl-\u03b2-cyclodextrin (HE-\u03b2-CD) l\u00e0 d\u1eabn ch\u1ea5t hydroxyalkyl kh\u00f4ng ion c\u1ee7a \u03b2-cyclodextrin, t\u1ea1o b\u1eb1ng c\u00e1ch g\u1eafn nh\u00f3m 2-hydroxyethyl l\u00ean c\u00e1c nh\u00f3m hydroxyl. Nh\u01b0 \u03b2-cyclodextrin, HE-\u03b2-CD t\u1ea1o ph\u1ee9c l\u1ed3ng \u0111\u1ec3 t\u0103ng \u0111\u1ed9 tan, t\u1ed1c \u0111\u1ed9 h\u00f2a tan, sinh kh\u1ea3 d\u1ee5ng v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t k\u00e9m tan,…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3573","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3573"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3573\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3572"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3573"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3573"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}