{"id":3569,"date":"2026-09-29T09:06:19","date_gmt":"2026-09-29T02:06:19","guid":{"rendered":"https:\/\/cpc1.vn\/histidin\/"},"modified":"2026-09-29T09:06:19","modified_gmt":"2026-09-29T02:06:19","slug":"histidin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/histidin\/","title":{"rendered":"Histidin \u2013 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c kh\u00e1ng th\u1ec3, ch\u1ea5t ch\u1ed1ng oxy h\u00f3a"},"content":{"rendered":"

Histidin \u2013 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c kh\u00e1ng th\u1ec3, ch\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/h1>\n

Histidin<\/strong> (L-histidin) l\u00e0 acid amin c\u00f3 nh\u00f3m imidazol v\u1edbi pKa kho\u1ea3ng 6, n\u00ean cho kh\u1ea3 n\u0103ng \u0111\u1ec7m t\u1ed1t quanh pH 5,5\u20136,5. Trong b\u00e0o ch\u1ebf, histidin \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t \u0111\u1ec7m cho c\u00f4ng th\u1ee9c kh\u00e1ng th\u1ec3<\/strong> v\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/strong> b\u1eaft g\u1ed1c hydroxyl trong dung d\u1ecbch.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nL-Histidin, His, H, acid (S)-2-amino-3-(imidazol-4-yl)propanoic, histidinum<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n71-00-1<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC6<\/sub>H9<\/sub>N3<\/sub>O2<\/sub> \u2013 155,15<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ch\u1ed1ng oxy h\u00f3a, ch\u1ea5t \u0111\u1ec7m<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, JP, Ph.Eur., USP-NF<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t \u0111\u1ec7m cho c\u00f4ng th\u1ee9c kh\u00e1ng th\u1ec3 (thu\u1ed1c ti\u00eam sinh h\u1ecdc).<\/li>\n
  • Ch\u1ea5t ch\u1ed1ng oxy h\u00f3a, b\u1eaft g\u1ed1c hydroxyl trong dung d\u1ecbch.<\/li>\n
  • Th\u1ef1c ph\u1ea9m b\u1ed5 sung (acid amin thi\u1ebft y\u1ebfu cho tr\u1ebb nh\u1ecf).<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh ho\u1eb7c tinh th\u1ec3 tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, kh\u00f4ng m\u00e0u.<\/li>\n
    • pKa1<\/sub> 1,82; pKa2<\/sub> 6,00 (nh\u00f3m imidazol); pKa3<\/sub> 9,17.<\/li>\n
    • N\u00f3ng ch\u1ea3y 282 \u00b0C (m\u1ec1m \u1edf 277 \u00b0C, ph\u00e2n h\u1ee7y \u1edf 287 \u00b0C); t\u1ef7 tr\u1ecdng ri\u00eang 1,44.<\/li>\n
    • D\u01b0\u1ee3c \u0111i\u1ec3n: pH 7,0\u20138,5; h\u00e0m l\u01b0\u1ee3ng (ch\u1ebf ph\u1ea9m kh\u00f4) 98,5\u2013101,5% t\u00f9y chuy\u00ean lu\u1eadn.<\/li>\n
    • \u0110\u1ed9 tan: d\u1ec5 tan trong acid formic; tan trong n\u01b0\u1edbc; r\u1ea5t kh\u00f3 tan trong ethanol; kh\u00f4ng tan trong ether.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Histidin l\u00e0 acid amin c\u00f3 s\u1eb5n trong t\u1ef1 nhi\u00ean.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • Chu\u1ed9t c\u1ed1ng nh\u1eadn 400 mg\/kg\/ng\u00e0y gi\u1ea3m t\u1ed1c \u0111\u1ed9 t\u0103ng tr\u01b0\u1edfng v\u00e0 t\u0103ng ure huy\u1ebft; li\u1ec1u an to\u00e0n t\u1ed1i \u0111a trong nghi\u00ean c\u1ee9u n\u00e0y kho\u1ea3ng 200 mg\/kg. C\u00f3 b\u00e1o c\u00e1o t\u00e1c d\u1ee5ng g\u00e2y \u0111\u1ed9t bi\u1ebfn tr\u00ean ng\u01b0\u1eddi.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): tr\u00ean 5,11 g\/kg; (chu\u1ed9t nh\u1eaft, u\u1ed1ng): 15 g\/kg.<\/li>\n
      • Tr\u00e1nh nhi\u1ec7t v\u00e0 ngu\u1ed3n l\u1eeda; bay h\u01a1i c\u1eb7n trong bao b\u00ec r\u1ed7ng d\u01b0\u1edbi t\u1ee7 h\u00fat. M\u1eb7c \u0111\u1ed3 b\u1ea3o h\u1ed9 tr\u00e1nh h\u00edt b\u1ee5i v\u00e0 d\u00ednh m\u1eaft. \u0110un t\u1edbi ph\u00e2n h\u1ee7y sinh kh\u00f3i \u0111\u1ed9c oxyd nit\u01a1.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (ti\u00eam t\u0129nh m\u1ea1ch, ti\u00eam d\u01b0\u1edbi da; h\u1ed7n d\u1ecbch u\u1ed1ng) v\u00e0 Canadian Natural Health Products Ingredients Database.<\/li>\n
        • C\u00f3 trong thu\u1ed1c ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n
            \n
          • D-Histidin (CAS 351-50-8); DL-histidin (CAS 4998-57-6, tan trong n\u01b0\u1edbc).<\/li>\n
          • Histidin hydroclorid monohydrat<\/strong> (C6<\/sub>H9<\/sub>N3<\/sub>O2<\/sub>\u00b7HCl\u00b7H2<\/sub>O, KLPT 209,63; CAS 5934-29-2; d\u1ea1ng khan 645-35-2): b\u1ed9t k\u1ebft tinh tr\u1eafng, tan trong n\u01b0\u1edbc, h\u01a1i tan trong ethanol; c\u00f3 chuy\u00ean lu\u1eadn trong JP v\u00e0 Ph.Eur.; d\u00f9ng l\u00e0m th\u1ef1c ph\u1ea9m b\u1ed5 sung.<\/li>\n
          • D-Histidin monohydroclorid (monohydrat) (CAS 6341-24-8).<\/li>\n<\/ul>\n

            Ghi ch\u00fa:<\/strong> histidin l\u00e0 ti\u1ec1n ch\u1ea5t c\u1ee7a histamin v\u00e0 l\u00e0 th\u00e0nh ph\u1ea7n c\u1ee7a carnosin. S\u1ed1 EINECS 200-745-3; PubChem CID 6274.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Histidine<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Histidin \u2013 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c kh\u00e1ng th\u1ec3, ch\u1ea5t ch\u1ed1ng oxy h\u00f3a Histidin (L-histidin) l\u00e0 acid amin c\u00f3 nh\u00f3m imidazol v\u1edbi pKa kho\u1ea3ng 6, n\u00ean cho kh\u1ea3 n\u0103ng \u0111\u1ec7m t\u1ed1t quanh pH 5,5\u20136,5. Trong b\u00e0o ch\u1ebf, histidin \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t \u0111\u1ec7m cho c\u00f4ng th\u1ee9c kh\u00e1ng th\u1ec3 v\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a b\u1eaft g\u1ed1c hydroxyl […]<\/p>\n","protected":false},"author":1,"featured_media":3568,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3569","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/histidin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/histidin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/histidin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/histidin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/histidin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/histidin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/histidin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/histidin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Histidin \u2013 ch\u1ea5t \u0111\u1ec7m cho thu\u1ed1c kh\u00e1ng th\u1ec3, ch\u1ea5t ch\u1ed1ng oxy h\u00f3a Histidin (L-histidin) l\u00e0 acid amin c\u00f3 nh\u00f3m imidazol v\u1edbi pKa kho\u1ea3ng 6, n\u00ean cho kh\u1ea3 n\u0103ng \u0111\u1ec7m t\u1ed1t quanh pH 5,5\u20136,5. Trong b\u00e0o ch\u1ebf, histidin \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t \u0111\u1ec7m cho c\u00f4ng th\u1ee9c kh\u00e1ng th\u1ec3 v\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a b\u1eaft g\u1ed1c hydroxyl…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3569","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3569"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3569\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3568"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3569"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3569"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}