{"id":3567,"date":"2026-09-29T09:03:50","date_gmt":"2026-09-29T02:03:50","guid":{"rendered":"https:\/\/cpc1.vn\/glycyrrhizin\/"},"modified":"2026-09-29T09:03:50","modified_gmt":"2026-09-29T02:03:50","slug":"glycyrrhizin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/glycyrrhizin\/","title":{"rendered":"Glycyrrhizin (acid glycyrrhizic) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt, che v\u1ecb, t\u1ea1o h\u01b0\u01a1ng"},"content":{"rendered":"

Glycyrrhizin (acid glycyrrhizic) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt, che v\u1ecb, t\u1ea1o h\u01b0\u01a1ng<\/h1>\n

Glycyrrhizin<\/strong> (acid glycyrrhizic) l\u00e0 saponin triterpenoid t\u1ef1 nhi\u00ean trong r\u1ec5 v\u00e0 th\u00e2n r\u1ec5 cam th\u1ea3o (Glycyrrhiza glabra<\/em>), ng\u1ecdt g\u1ea5p kho\u1ea3ng 50 l\u1ea7n saccarose<\/strong>. Trong b\u00e0o ch\u1ebf, glycyrrhizin l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt<\/strong>, ch\u1ea5t che v\u1ecb<\/strong> v\u00e0 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng<\/strong> cho thu\u1ed1c u\u1ed1ng.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nAcid glycyrrhizic, acid glycyrrhizinic, glycosid c\u1ee7a acid glycyrrhetinic, GA<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n1405-86-3<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC42<\/sub>H62<\/sub>O16<\/sub> \u2013 822,93<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u1ea1o h\u01b0\u01a1ng, t\u1ea1o ng\u1ecdt, che v\u1ecb<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t t\u1ea1o ng\u1ecdt v\u00e0 che v\u1ecb trong thu\u1ed1c u\u1ed1ng (siro\u2026).<\/li>\n
  • T\u1ea1o gel b\u1ec1n \u2013 \u0111\u00e3 nghi\u00ean c\u1ee9u cho ch\u1ebf ph\u1ea9m b\u00f4i; nh\u1edd t\u00ednh di\u1ec7n ho\u1ea1t c\u1ee7a saponin, \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m ch\u1ea5t t\u0103ng th\u1ea5m.<\/li>\n
  • Nghi\u00ean c\u1ee9u: ti\u1ec3u ph\u00e2n nano chitosan ph\u00e2n t\u1eed l\u01b0\u1ee3ng th\u1ea5p li\u00ean h\u1ee3p glycyrrhizin \u0111\u1ec3 d\u1eabn thu\u1ed1c t\u1edbi t\u1ebf b\u00e0o gan; ph\u1ee9c glycyrrhizin \u2013 nifedipin t\u0103ng \u0111\u1ed9 tan c\u1ee7a nifedipin.<\/li>\n
  • T\u1ea1o ng\u1ecdt trong th\u1ef1c ph\u1ea9m, thu\u1ed1c l\u00e1 nhai; d\u00f9ng trong m\u1ef9 ph\u1ea9m.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh ho\u1eb7c tinh th\u1ec3 tr\u1eafng, h\u00fat \u1ea9m, v\u1ecb r\u1ea5t ng\u1ecdt.<\/li>\n
    • pKa1<\/sub> 3,98; pKa2<\/sub> 4,62; pKa3<\/sub> 5,17. N\u00f3ng ch\u1ea3y kho\u1ea3ng 200 \u00b0C, ph\u00e2n h\u1ee7y \u1edf 220 \u00b0C; n\u0103ng su\u1ea5t quay c\u1ef1c +46,2\u00b0 (dung d\u1ecbch 1,5% trong ethanol).<\/li>\n
    • \u0110\u1ed9 tan: d\u1ec5 tan trong n\u01b0\u1edbc n\u00f3ng v\u00e0 ethanol; tan trong dimethyl sulfoxid; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ether.<\/li>\n
    • C\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n v\u00e0 kh\u00e1ng virus trong nghi\u00ean c\u1ee9u.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n trong \u0111i\u1ec1u ki\u1ec7n th\u01b0\u1eddng. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i m\u00e1t, th\u00f4ng tho\u00e1ng.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      T\u00e1ch t\u1eeb d\u1ecbch chi\u1ebft n\u01b0\u1edbc c\u1ee7a r\u1ec5 v\u00e0 th\u00e2n r\u1ec5 cam th\u1ea3o; k\u1ebft tinh t\u1eeb acid acetic b\u0103ng. Nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o G. inflata<\/em> c\u0169ng t\u1ea1o \u0111\u01b0\u1ee3c glycyrrhizin \u2013 h\u01b0\u1edbng ti\u1ec1m n\u0103ng cho s\u1ea3n xu\u1ea5t quy m\u00f4 l\u1edbn.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • D\u00f9ng r\u1ed9ng r\u00e3i trong th\u1ef1c ph\u1ea9m, m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c u\u1ed1ng; nh\u00ecn chung \u0111\u01b0\u1ee3c coi l\u00e0 an to\u00e0n khi d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c. H\u1ed9i \u0111\u1ed3ng CIR k\u1ebft lu\u1eadn an to\u00e0n trong m\u1ef9 ph\u1ea9m.<\/li>\n
      • Ph\u01a1i nhi\u1ec5m c\u1ea5p c\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft, da, \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, ti\u00eau h\u00f3a; ph\u01a1i nhi\u1ec5m k\u00e9o d\u00e0i c\u00f3 th\u1ec3 c\u00f3 h\u1ea1i. Li\u1ec1u cao \u0111\u00e3 ghi nh\u1eadn g\u00e2y t\u0103ng huy\u1ebft \u00e1p v\u00e0 b\u1ec7nh c\u01a1 do h\u1ea1 kali m\u00e1u.<\/li>\n
      • ADI \u0111\u1ec1 xu\u1ea5t 0,015\u20130,229 mg\/kg\/ng\u00e0y; khuy\u1ebfn c\u00e1o gi\u1edbi h\u1ea1n tr\u00ean 100 mg\/ng\u00e0y.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t nh\u1eaft, u\u1ed1ng): 4,32 g\/kg.<\/li>\n
      • Tr\u00e1nh h\u00edt, tr\u00e1nh d\u00ednh m\u1eaft, da, qu\u1ea7n \u00e1o; m\u1eb7c \u0111\u1ed3 b\u1ea3o h\u1ed9, g\u0103ng, k\u00ednh v\u00e0 kh\u1ea9u trang.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS.<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Database (siro u\u1ed1ng) v\u00e0 Canadian Natural Health Products Ingredients Database.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n
            \n
          • Amoni glycyrrhizat.<\/li>\n
          • Kali glycyrrhizat<\/strong> (monokali: C42<\/sub>H61<\/sub>KO16<\/sub>, KLPT 861,02, CAS 42294-03-1; dikali: C42<\/sub>H60<\/sub>K2<\/sub>O16<\/sub>, KLPT 899,11, CAS 68797-35-3): ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng v\u00e0 nh\u0169 h\u00f3a trong d\u01b0\u1ee3c ph\u1ea9m, m\u1ef9 ph\u1ea9m; \u0111\u00e3 th\u1eed l\u00e0m ch\u1ea5t nh\u0169 h\u00f3a cho liposome benzocain d\u00f9ng ngo\u00e0i.<\/li>\n<\/ul>\n

            Ghi ch\u00fa:<\/strong> c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c c\u1ee7a glycyrrhizin n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. S\u1ed1 EINECS 215-785-7; PubChem CID 14982.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Glycyrrhizin<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Glycyrrhizin (acid glycyrrhizic) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt, che v\u1ecb, t\u1ea1o h\u01b0\u01a1ng Glycyrrhizin (acid glycyrrhizic) l\u00e0 saponin triterpenoid t\u1ef1 nhi\u00ean trong r\u1ec5 v\u00e0 th\u00e2n r\u1ec5 cam th\u1ea3o (Glycyrrhiza glabra), ng\u1ecdt g\u1ea5p kho\u1ea3ng 50 l\u1ea7n saccarose. Trong b\u00e0o ch\u1ebf, glycyrrhizin l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt, ch\u1ea5t che v\u1ecb v\u00e0 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng cho thu\u1ed1c u\u1ed1ng. Th\u00f4ng tin nhanh […]<\/p>\n","protected":false},"author":1,"featured_media":3566,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3567","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycyrrhizin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycyrrhizin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycyrrhizin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycyrrhizin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycyrrhizin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycyrrhizin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycyrrhizin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glycyrrhizin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Glycyrrhizin (acid glycyrrhizic) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt, che v\u1ecb, t\u1ea1o h\u01b0\u01a1ng Glycyrrhizin (acid glycyrrhizic) l\u00e0 saponin triterpenoid t\u1ef1 nhi\u00ean trong r\u1ec5 v\u00e0 th\u00e2n r\u1ec5 cam th\u1ea3o (Glycyrrhiza glabra), ng\u1ecdt g\u1ea5p kho\u1ea3ng 50 l\u1ea7n saccarose. Trong b\u00e0o ch\u1ebf, glycyrrhizin l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt, ch\u1ea5t che v\u1ecb v\u00e0 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng cho thu\u1ed1c u\u1ed1ng. Th\u00f4ng tin nhanh…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3567"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3567\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3566"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}