{"id":3563,"date":"2026-09-29T09:03:36","date_gmt":"2026-09-29T02:03:36","guid":{"rendered":"https:\/\/cpc1.vn\/glyceryl-laurat\/"},"modified":"2026-09-29T12:02:08","modified_gmt":"2026-09-29T05:02:08","slug":"glyceryl-laurat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/glyceryl-laurat\/","title":{"rendered":"Glyceryl laurat (monolaurin) \u2013 ch\u1ea5t nh\u0169 h\u00f3a kh\u00f4ng ion, l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m"},"content":{"rendered":"

Glyceryl laurat (monolaurin) \u2013 ch\u1ea5t nh\u0169 h\u00f3a kh\u00f4ng ion, l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m<\/h1>\n

Glyceryl laurat<\/strong> (glyceryl monolaurat, GML, monolaurin) l\u00e0 monoester c\u1ee7a glycerin v\u1edbi acid lauric. Trong ch\u1ebf ph\u1ea9m b\u00f4i ngo\u00e0i, glyceryl laurat l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a kh\u00f4ng ion<\/strong>, ch\u1ea5t \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng<\/strong>, ch\u1ea5t l\u00e0m m\u1ec1m<\/strong> v\u00e0 l\u00e0m \u0111\u1eb7c<\/strong>; ngo\u00e0i ra c\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n v\u00e0 t\u00e1c d\u1ee5ng t\u0103ng th\u1ea5m.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nGlyceryl monolaurat, glycerol monolaurat, GML, monolaurin, 1-monolaurin, 2,3-dihydroxypropyl dodecanoat<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n142-18-7<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC15<\/sub>H30<\/sub>O4<\/sub> \u2013 274,40<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t l\u00e0m m\u1ec1m, nh\u0169 h\u00f3a, \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, t\u0103ng tan, di\u1ec7n ho\u1ea1t kh\u00f4ng ion, t\u0103ng \u0111\u1ed9 nh\u1edbt<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t nh\u0169 h\u00f3a kh\u00f4ng ion, \u1ed5n \u0111\u1ecbnh, l\u00e0m m\u1ec1m v\u00e0 l\u00e0m \u0111\u1eb7c trong ch\u1ebf ph\u1ea9m b\u00f4i.<\/li>\n
  • C\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n v\u00e0 t\u00e1c d\u1ee5ng t\u0103ng th\u1ea5m; t\u00e1c d\u1ee5ng t\u0103ng h\u1ea5p thu (c\u1ee7a glyceryl laurat v\u00e0 copolymer v\u1edbi chitosan) \u0111\u01b0\u1ee3c cho l\u00e0 nh\u1edd l\u00e0m t\u0103ng \u0111\u1ed9 tan d\u01b0\u1ee3c ch\u1ea5t.<\/li>\n
  • C\u00f3 lo\u1ea1i kh\u00f4ng t\u1ef1 nh\u0169 h\u00f3a (n\/e) v\u00e0 lo\u1ea1i t\u1ef1 nh\u0169 h\u00f3a (s\/e) \u2013 lo\u1ea1i s\/e ch\u1ee9a th\u00eam m\u1ed9t \u00edt natri v\u00e0\/ho\u1eb7c kali laurat.<\/li>\n
  • Th\u1ef1c ph\u1ea9m v\u00e0 m\u1ef9 ph\u1ea9m: ch\u1ea5t nh\u0169 h\u00f3a, \u1ed5n \u0111\u1ecbnh, l\u00e0m m\u1ec1m, l\u00e0m \u0111\u1eb7c, b\u00f4i tr\u01a1n v\u00e0 b\u1ea3o qu\u1ea3n.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t, h\u1ea1t, vi\u00ean, h\u1ea1t s\u00e1p tr\u1eafng t\u1edbi tr\u1eafng ng\u00e0 ho\u1eb7c b\u1ed9t nh\u00e3o m\u00e0u kem, m\u00f9i b\u00e9o nh\u1eb9.<\/li>\n
    • HLB 5,2; ch\u1ec9 s\u1ed1 hydroxyl kho\u1ea3ng 395; ch\u1ec9 s\u1ed1 x\u00e0 ph\u00f2ng h\u00f3a 200\u2013210; t\u1ef7 tr\u1ecdng 0,98 g\/cm\u00b3; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 182 \u00b0C.<\/li>\n
    • \u0110i\u1ec3m ch\u1ea3y th\u01b0\u1eddng 23\u201327 \u00b0C nh\u01b0ng dao \u0111\u1ed9ng r\u1ed9ng (20\u201360 \u00b0C) gi\u1eefa c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t do kh\u00e1c th\u00e0nh ph\u1ea7n.<\/li>\n
    • \u0110\u1ed9 tan: tan trong cloroform, methanol, ethanol, toluen, naphtha, d\u1ea7u kho\u00e1ng; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc nh\u01b0ng ph\u00e2n t\u00e1n \u0111\u01b0\u1ee3c \u1edf 60 \u00b0C; lo\u1ea1i t\u1ef1 nh\u0169 h\u00f3a ph\u00e2n t\u00e1n \u0111\u01b0\u1ee3c trong n\u01b0\u1edbc.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t, tr\u00e1nh nhi\u1ec7t \u0111\u1ed9 cao v\u00e0 \u00e1nh s\u00e1ng, xa ch\u1ea5t oxy h\u00f3a v\u00e0 ch\u1ea5t kh\u1eed m\u1ea1nh.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh, acid, ki\u1ec1m v\u00e0 ch\u1ea5t t\u1ef1 b\u1ed1c ch\u00e1y. T\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n b\u1ecb m\u1ea5t khi c\u00f3 ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion ethoxy h\u00f3a\/propoxy h\u00f3a (nh\u01b0 polysorbat 80) v\u00e0 natri lauryl sarcosinat.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Ester h\u00f3a tr\u1ef1c ti\u1ebfp glycerin v\u1edbi acid lauric ngu\u1ed3n th\u1ef1c v\u1eadt; trong th\u01b0\u01a1ng m\u1ea1i th\u01b0\u1eddng d\u00f9ng ph\u1ea3n \u1ee9ng glycerol ph\u00e2n (chuy\u1ec3n ester). \u0110\u00e3 nghi\u00ean c\u1ee9u c\u00e1c x\u00fac t\u00e1c d\u1ecb th\u1ec3 (nh\u1ef1a cation, r\u00e2y ph\u00e2n t\u1eed zeolit, v\u1eadt li\u1ec7u mao qu\u1ea3n trung b\u00ecnh) v\u00e0 t\u1ed5ng h\u1ee3p b\u1eb1ng enzym lipase.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • Nh\u00ecn chung \u0111\u01b0\u1ee3c coi l\u00e0 t\u01b0\u01a1ng \u0111\u1ed1i kh\u00f4ng k\u00edch \u1ee9ng, kh\u00f4ng \u0111\u1ed9c; h\u1ed9i \u0111\u1ed3ng CIR k\u1ebft lu\u1eadn an to\u00e0n trong m\u1ef9 ph\u1ea9m \u1edf m\u1ee9c d\u00f9ng hi\u1ec7n nay.<\/li>\n
      • Ph\u01a1i nhi\u1ec5m qu\u00e1 m\u1ee9c c\u00f3 th\u1ec3 g\u00e2y \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, m\u1ec7t, bu\u1ed3n n\u00f4n, n\u00f4n, ban \u0111\u1ecf v\u00e0 ph\u00f9 da.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): tr\u00ean 5 g\/kg (c\u00e1c ngu\u1ed3n kh\u00e1c ghi tr\u00ean 20 g\/kg, 53 g\/kg).<\/li>\n
      • Tr\u00e1nh d\u00ednh da, m\u1eaft; r\u1eeda k\u1ef9 sau thao t\u00e1c; \u0111eo g\u0103ng, k\u00ednh, \u0111\u1ed3 b\u1ea3o h\u1ed9 v\u00e0 b\u1ea3o v\u1ec7 h\u00f4 h\u1ea5p khi c\u00f3 s\u01b0\u01a1ng, h\u01a1i ho\u1eb7c b\u1ee5i. Ph\u00e2n h\u1ee7y nhi\u1ec7t sinh kh\u00ed k\u00edch \u1ee9ng (oxyd carbon).<\/li>\n
      • D\u00f9ng \u0111\u01b0\u1eddng \u00e2m \u0111\u1ea1o t\u1eebng ghi nh\u1eadn \u0111\u1ed9c t\u00ednh tr\u00ean bi\u1ec3u m\u00f4 t\u1ea1i ch\u1ed7.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS.<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Database (mi\u1ebfng d\u00e1n b\u00f4i, m\u00e0ng qua da); c\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh; c\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Glyceryl behenat, glyceryl monooleat, glyceryl monostearat, glyceryl palmitostearat.<\/p>\n

          Ghi ch\u00fa:<\/strong> glyceryl laurat \u1ee9c ch\u1ebf Staphylococcus aureus<\/em> trong nghi\u00ean c\u1ee9u (nh\u01b0ng b\u1ecb lipase c\u1ee7a vi khu\u1ea9n n\u00e0y ph\u00e2n h\u1ee7y). S\u1ed1 EINECS 205-526-6; PubChem CID 14871.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Glyceryl Laurate<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Glyceryl laurat (monolaurin) \u2013 ch\u1ea5t nh\u0169 h\u00f3a kh\u00f4ng ion, l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m Glyceryl laurat (glyceryl monolaurat, GML, monolaurin) l\u00e0 monoester c\u1ee7a glycerin v\u1edbi acid lauric. Trong ch\u1ebf ph\u1ea9m b\u00f4i ngo\u00e0i, glyceryl laurat l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a kh\u00f4ng ion, ch\u1ea5t \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, ch\u1ea5t l\u00e0m m\u1ec1m v\u00e0 l\u00e0m \u0111\u1eb7c; ngo\u00e0i ra c\u00f3 ho\u1ea1t t\u00ednh […]<\/p>\n","protected":false},"author":1,"featured_media":3562,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3563","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-laurat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-laurat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-laurat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-laurat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-laurat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-laurat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-laurat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/glyceryl-laurat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Glyceryl laurat (monolaurin) \u2013 ch\u1ea5t nh\u0169 h\u00f3a kh\u00f4ng ion, l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m Glyceryl laurat (glyceryl monolaurat, GML, monolaurin) l\u00e0 monoester c\u1ee7a glycerin v\u1edbi acid lauric. Trong ch\u1ebf ph\u1ea9m b\u00f4i ngo\u00e0i, glyceryl laurat l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a kh\u00f4ng ion, ch\u1ea5t \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng, ch\u1ea5t l\u00e0m m\u1ec1m v\u00e0 l\u00e0m \u0111\u1eb7c; ngo\u00e0i ra c\u00f3 ho\u1ea1t t\u00ednh…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3563","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3563"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3563\/revisions"}],"predecessor-version":[{"id":3827,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3563\/revisions\/3827"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3562"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3563"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3563"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3563"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}