{"id":3561,"date":"2026-09-29T09:03:28","date_gmt":"2026-09-29T02:03:28","guid":{"rendered":"https:\/\/cpc1.vn\/gluconolacton\/"},"modified":"2026-09-29T12:01:57","modified_gmt":"2026-09-29T05:01:57","slug":"gluconolacton","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/gluconolacton\/","title":{"rendered":"Gluconolacton (GDL, E575) \u2013 ch\u1ea5t acid h\u00f3a, ch\u1ea5t t\u1ea1o ph\u1ee9c"},"content":{"rendered":"

Gluconolacton (GDL, E575) \u2013 ch\u1ea5t acid h\u00f3a, ch\u1ea5t t\u1ea1o ph\u1ee9c<\/h1>\n

Gluconolacton<\/strong> (glucono delta lacton, GDL, E575) l\u00e0 lacton v\u00f2ng 6 c\u1ee7a acid D-gluconic, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng, v\u1ecb ng\u1ecdt. Khi h\u00f2a v\u00e0o n\u01b0\u1edbc, GDL th\u1ee7y ph\u00e2n d\u1ea7n th\u00e0nh acid gluconic n\u00ean pH gi\u1ea3m t\u1eeb t\u1eeb. Trong b\u00e0o ch\u1ebf, gluconolacton l\u00e0 ch\u1ea5t acid h\u00f3a<\/strong> cho ch\u1ebf ph\u1ea9m u\u1ed1ng, b\u00f4i v\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c<\/strong> trong thu\u1ed1c ti\u00eam.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nGlucono delta lacton (GDL), \u03b4-gluconolacton, D-glucono-1,5-lacton, lacton c\u1ee7a acid D-gluconic, E575<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n90-80-2<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC6<\/sub>H10<\/sub>O6<\/sub> \u2013 178,14<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t acid h\u00f3a, ch\u1ea5t t\u1ea1o ph\u1ee9c<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nUSP-NF<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t acid h\u00f3a trong ch\u1ebf ph\u1ea9m u\u1ed1ng v\u00e0 b\u00f4i ngo\u00e0i; ch\u1ea5t t\u1ea1o ph\u1ee9c trong thu\u1ed1c ti\u00eam.<\/li>\n
  • \u0110\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u1eadp th\u1eb3ng, cho vi\u00ean \u0111\u1ea1t y\u00eau c\u1ea7u t\u01b0\u01a1ng \u0111\u01b0\u01a1ng lactose khan.<\/li>\n
  • Nghi\u00ean c\u1ee9u l\u00e0m ch\u1ea5t mang trong ph\u00e2n t\u00e1n r\u1eafn \u0111\u1ec3 t\u0103ng t\u1ed1c \u0111\u1ed9 h\u00f2a tan piroxicam.<\/li>\n
  • D\u00f9ng ph\u1ed5 bi\u1ebfn h\u01a1n trong th\u1ef1c ph\u1ea9m (E575).<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng, kh\u00f4ng m\u00f9i, v\u1ecb ng\u1ecdt. Trong n\u01b0\u1edbc th\u1ee7y ph\u00e2n m\u1ed9t ph\u1ea7n th\u00e0nh acid gluconic; nhi\u1ec7t \u0111\u1ed9 v\u00e0 pH c\u00e0ng cao ph\u1ea3n \u1ee9ng c\u00e0ng nhanh.<\/li>\n
    • Dung d\u1ecbch 1% m\u1edbi pha c\u00f3 pH 3,6, gi\u1ea3m xu\u1ed1ng 2,5 trong v\u00f2ng 2 gi\u1edd.<\/li>\n
    • \u0110i\u1ec3m ch\u1ea3y 153 \u00b0C, ph\u00e2n h\u1ee7y \u1edf 160 \u00b0C. USP-NF y\u00eau c\u1ea7u h\u00e0m l\u01b0\u1ee3ng 99,0\u2013101,0%.<\/li>\n
    • \u0110\u1ed9 tan: d\u1ec5 tan trong n\u01b0\u1edbc l\u1ea1nh (59 g\/100 mL); kh\u00f3 tan trong ethanol (1 g\/100 mL); kh\u00f4ng tan trong ether.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u00e0 base m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n
        \n
      • Oxy h\u00f3a glucose b\u1eb1ng n\u01b0\u1edbc brom; ho\u1eb7c<\/li>\n
      • K\u1ebft tinh D-glucono-1,5-lacton t\u1eeb dung d\u1ecbch acid gluconic qu\u00e1 b\u00e3o h\u00f2a \u1edf kho\u1ea3ng 36\u201357 \u00b0C. Quy tr\u00ecnh k\u1ebft tinh li\u00ean t\u1ee5c hai b\u01b0\u1edbc (t\u1ea1o h\u1ed7n d\u1ecbch tinh th\u1ec3 \u1edf 65\u201375 \u00b0C, r\u1ed3i l\u00e0m l\u1ea1nh c\u00f3 ki\u1ec3m so\u00e1t xu\u1ed1ng 40\u201345 \u00b0C v\u00e0 \u1ee7 tinh th\u1ec3) cho n\u0103ng su\u1ea5t cao, ti\u1ebft ki\u1ec7m n\u0103ng l\u01b0\u1ee3ng. C\u0169ng c\u00f3 th\u1ec3 lo\u1ea1i n\u01b0\u1edbc b\u1eb1ng c\u1ea5t \u0111\u1eb3ng ph\u00ed v\u1edbi alcol r\u1ed3i k\u1ebft tinh. K\u1ebft tinh tr\u00ean 70 \u00b0C t\u1ea1o 1,4-lacton.<\/li>\n<\/ul>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
          \n
        • LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 7,93 g\/kg.<\/li>\n
        • M\u1eb7c \u0111\u1ed3 b\u1ea3o h\u1ed9, \u0111eo k\u00ednh; thao t\u00e1c n\u01a1i th\u00f4ng tho\u00e1ng, tr\u00e1nh h\u00edt b\u1ee5i.<\/li>\n<\/ul>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • C\u00f3 trong FDA Inactive Ingredients Database (ti\u00eam t\u0129nh m\u1ea1ch, ti\u00eam b\u1eafp; dung d\u1ecbch d\u00f9ng ngo\u00e0i, thu\u1ed1c phun m\u00f9 \u0111\u1ecbnh li\u1ec1u, mi\u1ebfng x\u1ed1p) v\u00e0 Canadian Natural Health Products Ingredients Database.<\/li>\n
          • C\u00f3 trong thu\u1ed1c l\u01b0u h\u00e0nh t\u1ea1i Anh (vi\u00ean s\u1ee7i, ch\u1ebf ph\u1ea9m b\u00f4i).<\/li>\n
          • Ph\u1ee5 gia th\u1ef1c ph\u1ea9m E575; c\u00f3 chuy\u00ean lu\u1eadn trong USP-NF v\u00e0 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

            Ch\u1ea5t li\u00ean quan<\/h2>\n

            Xem th\u00eam acid lactic, acid citric.<\/p>\n

            Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 202-016-5; PubChem CID 7027.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Gluconolactone<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Gluconolacton (GDL, E575) \u2013 ch\u1ea5t acid h\u00f3a, ch\u1ea5t t\u1ea1o ph\u1ee9c Gluconolacton (glucono delta lacton, GDL, E575) l\u00e0 lacton v\u00f2ng 6 c\u1ee7a acid D-gluconic, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng, v\u1ecb ng\u1ecdt. Khi h\u00f2a v\u00e0o n\u01b0\u1edbc, GDL th\u1ee7y ph\u00e2n d\u1ea7n th\u00e0nh acid gluconic n\u00ean pH gi\u1ea3m t\u1eeb t\u1eeb. Trong b\u00e0o ch\u1ebf, gluconolacton l\u00e0 ch\u1ea5t acid h\u00f3a cho […]<\/p>\n","protected":false},"author":1,"featured_media":3560,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3561","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gluconolacton.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gluconolacton-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gluconolacton-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gluconolacton-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gluconolacton-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gluconolacton.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gluconolacton.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gluconolacton-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Gluconolacton (GDL, E575) \u2013 ch\u1ea5t acid h\u00f3a, ch\u1ea5t t\u1ea1o ph\u1ee9c Gluconolacton (glucono delta lacton, GDL, E575) l\u00e0 lacton v\u00f2ng 6 c\u1ee7a acid D-gluconic, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng, v\u1ecb ng\u1ecdt. Khi h\u00f2a v\u00e0o n\u01b0\u1edbc, GDL th\u1ee7y ph\u00e2n d\u1ea7n th\u00e0nh acid gluconic n\u00ean pH gi\u1ea3m t\u1eeb t\u1eeb. Trong b\u00e0o ch\u1ebf, gluconolacton l\u00e0 ch\u1ea5t acid h\u00f3a cho…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3561"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3561\/revisions"}],"predecessor-version":[{"id":3825,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3561\/revisions\/3825"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3560"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}