{"id":3559,"date":"2026-09-29T09:01:41","date_gmt":"2026-09-29T02:01:41","guid":{"rendered":"https:\/\/cpc1.vn\/gom-gellan\/"},"modified":"2026-09-29T09:01:41","modified_gmt":"2026-09-29T02:01:41","slug":"gom-gellan","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/gom-gellan\/","title":{"rendered":"G\u00f4m gellan (E418) \u2013 t\u1ea1o gel t\u1ea1i ch\u1ed7, b\u00e1m d\u00ednh ni\u00eam m\u1ea1c, t\u0103ng \u0111\u1ed9 nh\u1edbt"},"content":{"rendered":"

G\u00f4m gellan (E418) \u2013 t\u1ea1o gel t\u1ea1i ch\u1ed7, b\u00e1m d\u00ednh ni\u00eam m\u1ea1c, t\u0103ng \u0111\u1ed9 nh\u1edbt<\/h1>\n

G\u00f4m gellan<\/strong> (E418) l\u00e0 heteropolysaccharid anion ph\u00e2n t\u1eed l\u01b0\u1ee3ng l\u1edbn, s\u1ea3n xu\u1ea5t b\u1eb1ng l\u00ean men vi khu\u1ea9n. \u0110\u1eb7c t\u00ednh n\u1ed5i b\u1eadt l\u00e0 t\u1ea1o gel khi g\u1eb7p cation<\/strong>: dung d\u1ecbch gellan chuy\u1ec3n t\u1eeb l\u1ecfng sang gel khi ti\u1ebfp x\u00fac v\u1edbi ion trong d\u1ecbch n\u01b0\u1edbc m\u1eaft, d\u1ecbch ni\u00eam m\u1ea1c m\u0169i. Trong b\u00e0o ch\u1ebf, gellan l\u00e0 ch\u1ea5t t\u1ea1o gel<\/strong>, t\u0103ng \u0111\u1ed9 nh\u1edbt<\/strong>, b\u00e1m d\u00ednh ni\u00eam m\u1ea1c<\/strong> v\u00e0 \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nGellan acyl th\u1ea5p (deacetyl h\u00f3a), gellan acyl cao, polysaccharid S-60, Kelcogel, E418<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n71010-52-1<\/td>\n<\/tr>\n
C\u1ea5u t\u1ea1o<\/td>\n\u0110\u01a1n v\u1ecb l\u1eb7p tetrasaccharid g\u1ed3m 1 rhamnose, 1 acid glucuronic v\u00e0 2 glucose; nh\u00f3m acid glucuronic \u0111\u01b0\u1ee3c trung h\u00f2a th\u00e0nh mu\u1ed1i h\u1ed7n h\u1ee3p K, Na, Ca, Mg; c\u00f3 th\u1ec3 ch\u1ee9a nh\u00f3m acyl (glyceryl, acetyl) d\u1ea1ng ester<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u1ea1o gel, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, b\u00e1m d\u00ednh ni\u00eam m\u1ea1c, t\u0103ng \u0111\u1ed9 nh\u1edbt<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nUSP-NF<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Gel t\u1ea1i ch\u1ed7 (in situ):<\/strong> dung d\u1ecbch nh\u1edbt chuy\u1ec3n sol \u2013 gel khi thay \u0111\u1ed5i l\u1ef1c ion (li\u00ean k\u1ebft ch\u00e9o v\u1edbi cation), nhi\u1ec7t \u0111\u1ed9 ho\u1eb7c pH, gi\u00fap k\u00e9o d\u00e0i th\u1eddi gian l\u01b0u tr\u00ean b\u1ec1 m\u1eb7t m\u1eaft v\u00e0 ni\u00eam m\u1ea1c m\u0169i. \u0110\u00e3 nghi\u00ean c\u1ee9u cho thu\u1ed1c nh\u1ecf m\u1eaft, x\u1ecbt m\u0169i v\u00e0 \u0111\u01b0\u1eddng u\u1ed1ng gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t.<\/li>\n
  • Gel \u00e2m \u0111\u1ea1o: d\u00f2ng ch\u1ea3y gi\u1ea3 d\u1ebbo, x\u00fac bi\u1ebfn k\u00e8m gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i gi\u00fap l\u01b0u l\u00e2u, gi\u1ea3m s\u1ed1 l\u1ea7n d\u00f9ng.<\/li>\n
  • Hydrocolloid b\u00f4i da: t\u0103ng \u0111\u00e1ng k\u1ec3 th\u1ea5m qua da c\u1ee7a ibuprofen.<\/li>\n
  • Vi c\u1ea7u, vi h\u1ea1t gellan (\u0111\u01a1n \u0111\u1ed9c ho\u1eb7c ph\u1ed1i h\u1ee3p polymer kh\u00e1c) l\u00e0m ch\u1ea5t mang gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t v\u00e0 h\u1ec7 n\u1ed5i; h\u1ea1t hydrogel gellan \u2013 chitosan; bao g\u00f3i probiotic c\u00f9ng natri alginat\/g\u00f4m xanthan.<\/li>\n
  • Th\u1ef1c ph\u1ea9m, m\u1ef9 ph\u1ea9m: t\u1ea1o gel, bao; ti\u1ec1m n\u0103ng l\u00e0m khung m\u00f4 k\u1ef9 thu\u1eadt v\u00e0 gi\u00e1 th\u1ec3 nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u01a1n ch\u1ea3y m\u00e0u tr\u1eafng t\u1edbi n\u00e2u nh\u1ea1t.<\/li>\n
    • Dung d\u1ecbch 1% trong n\u01b0\u1edbc kh\u1eed ion c\u00f3 pH g\u1ea7n trung t\u00ednh; tan trong n\u01b0\u1edbc kh\u1eed ion n\u00f3ng ho\u1eb7c l\u1ea1nh.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n
      T\u00ednh ch\u1ea5t<\/th>\nGellan acyl th\u1ea5p<\/th>\nGellan acyl cao<\/th>\n<\/tr>\n<\/thead>\n
      Nhi\u1ec7t \u0111\u1ed9 t\u1ea1o gel<\/td>\n35\u201355 \u00b0C<\/td>\nTr\u00ean 55 \u00b0C<\/td>\n<\/tr>\n
      \u0110\u1ed9 nh\u1edbt n\u00f3ng (1%, 80 \u00b0C)<\/td>\nD\u01b0\u1edbi 25 mPa\u00b7s<\/td>\nTr\u00ean 100 mPa\u00b7s<\/td>\n<\/tr>\n
      K\u1ebft c\u1ea5u gel<\/td>\nC\u1ee9ng, gi\u00f2n<\/td>\nM\u1ec1m, \u0111\u00e0n h\u1ed3i<\/td>\n<\/tr>\n
      Nh\u1ea1y ion<\/td>\nCao (d\u01b0\u1edbi 10 mM Ca)<\/td>\nTh\u1ea5p (tr\u00ean 20 mM Ca)<\/td>\n<\/tr>\n
      \u0110\u1ed9 d\u1ebbo m\u00e0ng<\/td>\nTh\u1ea5p<\/td>\nTrung b\u00ecnh<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n trong bao g\u1ed1c ch\u01b0a m\u1edf, n\u01a1i c\u00f3 m\u00e1i che, th\u00f4ng tho\u00e1ng. B\u1ec1n trong kho\u1ea3ng pH r\u1ed9ng (kho\u1ea3ng 3\u201313); \u1edf pH r\u1ea5t th\u1ea5p, nh\u1ea5t l\u00e0 khi n\u00f3ng, c\u00f3 th\u1ec3 b\u1ecb th\u1ee7y ph\u00e2n acid, gi\u1ea3m tr\u00f9ng h\u1ee3p. \u0110\u1ed9 b\u1ec1n gel ph\u1ee5 thu\u1ed9c lo\u1ea1i v\u00e0 n\u1ed3ng \u0111\u1ed9 ion n\u00ean c\u00f3 th\u1ec3 thay \u0111\u1ed5i theo pH, nh\u01b0ng ph\u00e2n t\u1eed gellan kh\u00f4ng bi\u1ebfn \u0111\u1ed5i h\u00f3a h\u1ecdc.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n
        \n
      • B\u1ecb ph\u00e2n h\u1ee7y b\u1edfi ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u00e0 h\u1ed7n h\u1ee3p ch\u1ea5t oxy h\u00f3a \u2013 ch\u1ea5t kh\u1eed.<\/li>\n
      • Dung m\u00f4i h\u1eefu c\u01a1 tr\u1ed9n l\u1eabn v\u1edbi n\u01b0\u1edbc (alcol) c\u00f3 th\u1ec3 t\u1ee7a gellan t\u00f9y l\u01b0\u1ee3ng th\u00eam; n\u1ed3ng \u0111\u1ed9 v\u1eeba ph\u1ea3i (t\u1edbi 10%) th\u01b0\u1eddng ch\u01b0a g\u00e2y t\u1ee7a.<\/li>\n
      • Th\u1ee7y ph\u00e2n \u1edf nhi\u1ec7t \u0111\u1ed9 cao, nh\u1ea5t l\u00e0 m\u00f4i tr\u01b0\u1eddng acid; lo\u1ea1i acyl cao d\u1ec5 b\u1ecb h\u01a1n n\u00ean tr\u00e1nh gi\u1eef l\u00e2u \u1edf m\u00f4i tr\u01b0\u1eddng acid. \u1ede pH 3,5, dung d\u1ecbch gellan acyl th\u1ea5p gi\u1eef \u1edf 80 \u00b0C t\u1edbi 1 gi\u1edd g\u1ea7n nh\u01b0 kh\u00f4ng gi\u1ea3m ch\u1ea5t l\u01b0\u1ee3ng gel.<\/li>\n
      • T\u01b0\u01a1ng h\u1ee3p v\u1edbi nhi\u1ec1u ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion; t\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t di\u1ec7n ho\u1ea1t cation (t\u1ee7a). Ch\u1ea5t di\u1ec7n ho\u1ea1t anion v\u00e0 l\u01b0\u1ee1ng t\u00ednh tr\u00ean 15% c\u00f3 th\u1ec3 l\u00e0m “mu\u1ed1i k\u1ebft” gellan \u2013 c\u00f3 th\u1ec3 h\u1ea1n ch\u1ebf b\u1eb1ng th\u00eam ch\u1ea5t \u0111i\u1ec7n ly; th\u1ee9 t\u1ef1 th\u00eam ch\u1ea5t di\u1ec7n ho\u1ea1t \u1ea3nh h\u01b0\u1edfng t\u1edbi s\u1ef1 hydrat h\u00f3a c\u1ee7a gellan.<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        L\u00ean men thu\u1ea7n ch\u1ee7ng vi khu\u1ea9n Sphingomonas elodea<\/em> (tr\u01b0\u1edbc \u0111\u00e2y g\u1ecdi l\u00e0 Pseudomonas elodea<\/em>) tr\u00ean ngu\u1ed3n carbohydrat; thu h\u1ed3i b\u1eb1ng isopropanol, s\u1ea5y v\u00e0 nghi\u1ec1n.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
          \n
        • Nh\u00ecn chung kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng khi d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c. JECFA x\u1ebfp ADI “kh\u00f4ng x\u00e1c \u0111\u1ecbnh”. D\u00f9ng l\u01b0\u1ee3ng l\u1edbn trong th\u1ef1c ph\u1ea9m c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng nhu\u1eadn tr\u00e0ng.<\/li>\n
        • LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): tr\u00ean 5 g\/kg; LC50<\/sub> (chu\u1ed9t c\u1ed1ng, h\u00edt): tr\u00ean 6 mg\/L. Kh\u00f4ng k\u00edch \u1ee9ng m\u1eaft, da th\u1ecf.<\/li>\n
        • Tr\u00e1nh t\u1ea1o b\u1ee5i; n\u00ean \u0111eo g\u0103ng.<\/li>\n<\/ul>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • C\u00f3 trong FDA Inactive Ingredients Database (dung d\u1ecbch nh\u00e3n khoa) v\u00e0 Canadian Natural Health Products Ingredients Database.<\/li>\n
          • \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E418).<\/li>\n
          • C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

            Ch\u1ea5t li\u00ean quan<\/h2>\n

            Agar; xem th\u00eam carrageenan, g\u00f4m xanthan, natri alginat.<\/p>\n

            Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 275-117-5.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Gellan Gum<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            G\u00f4m gellan (E418) \u2013 t\u1ea1o gel t\u1ea1i ch\u1ed7, b\u00e1m d\u00ednh ni\u00eam m\u1ea1c, t\u0103ng \u0111\u1ed9 nh\u1edbt G\u00f4m gellan (E418) l\u00e0 heteropolysaccharid anion ph\u00e2n t\u1eed l\u01b0\u1ee3ng l\u1edbn, s\u1ea3n xu\u1ea5t b\u1eb1ng l\u00ean men vi khu\u1ea9n. \u0110\u1eb7c t\u00ednh n\u1ed5i b\u1eadt l\u00e0 t\u1ea1o gel khi g\u1eb7p cation: dung d\u1ecbch gellan chuy\u1ec3n t\u1eeb l\u1ecfng sang gel khi ti\u1ebfp x\u00fac v\u1edbi ion […]<\/p>\n","protected":false},"author":1,"featured_media":3558,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3559","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gom-gellan.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gom-gellan-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gom-gellan-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gom-gellan-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gom-gellan-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gom-gellan.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gom-gellan.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/gom-gellan-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"G\u00f4m gellan (E418) \u2013 t\u1ea1o gel t\u1ea1i ch\u1ed7, b\u00e1m d\u00ednh ni\u00eam m\u1ea1c, t\u0103ng \u0111\u1ed9 nh\u1edbt G\u00f4m gellan (E418) l\u00e0 heteropolysaccharid anion ph\u00e2n t\u1eed l\u01b0\u1ee3ng l\u1edbn, s\u1ea3n xu\u1ea5t b\u1eb1ng l\u00ean men vi khu\u1ea9n. \u0110\u1eb7c t\u00ednh n\u1ed5i b\u1eadt l\u00e0 t\u1ea1o gel khi g\u1eb7p cation: dung d\u1ecbch gellan chuy\u1ec3n t\u1eeb l\u1ecfng sang gel khi ti\u1ebfp x\u00fac v\u1edbi ion…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3559","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3559"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3559\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3558"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3559"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3559"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3559"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}