{"id":3555,"date":"2026-09-29T08:41:24","date_gmt":"2026-09-29T01:41:24","guid":{"rendered":"https:\/\/cpc1.vn\/natri-calci-edetat\/"},"modified":"2026-09-29T12:08:08","modified_gmt":"2026-09-29T05:08:08","slug":"natri-calci-edetat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/natri-calci-edetat\/","title":{"rendered":"Natri calci edetat (calci dinatri EDTA, E385) \u2013 ch\u1ea5t t\u1ea1o ph\u1ee9c ion kim lo\u1ea1i"},"content":{"rendered":"

Natri calci edetat (calci dinatri EDTA, E385) \u2013 ch\u1ea5t t\u1ea1o ph\u1ee9c ion kim lo\u1ea1i<\/h1>\n

Natri calci edetat<\/strong> (edetate calcium disodium, calci dinatri EDTA, E385) l\u00e0 mu\u1ed1i calci \u2013 dinatri c\u1ee7a acid edetic. Ph\u1ee9c calci n\u00e0y t\u01b0\u01a1ng \u0111\u1ed1i y\u1ebfu n\u00ean s\u1ebd nh\u01b0\u1eddng ion calci \u0111\u1ec3 b\u1eaft c\u00e1c kim lo\u1ea1i n\u1eb7ng<\/strong> nh\u01b0 s\u1eaft, \u0111\u1ed3ng, ch\u00ec. Trong b\u00e0o ch\u1ebf, natri calci edetat l\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c<\/strong> \u1ed5n \u0111\u1ecbnh c\u00f4ng th\u1ee9c \u2013 \u0111\u1eb7c bi\u1ec7t l\u00e0 thu\u1ed1c sinh h\u1ecdc ti\u00eam \u2013 b\u1eb1ng c\u00e1ch b\u1eaft ion kim lo\u1ea1i v\u1ebft x\u00fac t\u00e1c ph\u00e2n h\u1ee7y.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nCalci dinatri edetat, EDTA calci, sodium calcium edetate, natrii calcii edetas, E385<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n62-33-9 (khan); 23411-34-9 (hydrat); 6766-87-6 (dihydrat)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC10<\/sub>H12<\/sub>CaN2<\/sub>Na2<\/sub>O8<\/sub> \u2013 374,27 (khan); 410,30 (dihydrat); 428,32 (trihydrat)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u1ea1o ph\u1ee9c<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur. (Sodium Calcium Edetate \u2013 d\u1ea1ng khan), JP (Calcium Sodium Edetate Hydrate), USP-NF (Edetate Calcium Disodium \u2013 h\u1ed7n h\u1ee3p d\u1ea1ng khan v\u00e0 hydrat)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t t\u1ea1o ph\u1ee9c trong d\u01b0\u1ee3c ph\u1ea9m, th\u01b0\u1eddng \u1edf n\u1ed3ng \u0111\u1ed9 0,01\u20130,1% (kl\/tt).<\/li>\n
  • Trong thu\u1ed1c sinh h\u1ecdc ti\u00eam: b\u1eaft ion kim lo\u1ea1i v\u1ebft \u0111\u1ec3 tr\u00e1nh ph\u00e2n h\u1ee7y protein, t\u0103ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u00f4ng th\u1ee9c.<\/li>\n
  • \u0110\u01b0\u1ee3c \u01b0u ti\u00ean h\u01a1n dinatri edetat ho\u1eb7c natri edetat khi c\u1ea7n tr\u00e1nh l\u00e0m gi\u1ea3m calci trong c\u01a1 th\u1ec3, v\u00ec b\u1ea3n th\u00e2n n\u00f3 \u0111\u00e3 b\u00e3o h\u00f2a calci.<\/li>\n
  • Th\u1ef1c ph\u1ea9m v\u00e0 m\u1ef9 ph\u1ea9m: ch\u1ea5t b\u1ea3o qu\u1ea3n, gi\u1eef m\u00e0u v\u00e0 h\u01b0\u01a1ng v\u1ecb. Kh\u00f4ng d\u00f9ng l\u00e0m ch\u1ea5t l\u00e0m m\u1ec1m n\u01b0\u1edbc v\u00ec kh\u00f4ng b\u1eaft ion calci, magnesi.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh ho\u1eb7c h\u1ea1t tr\u1eafng ho\u1eb7c tr\u1eafng ng\u00e0, h\u00fat \u1ea9m; kh\u00f4ng m\u00f9i ho\u1eb7c m\u00f9i nh\u1eb9, kh\u00f4ng v\u1ecb ho\u1eb7c h\u01a1i m\u1eb7n.<\/li>\n
    • Ti\u00eau chu\u1ea9n \u0111\u00e3 h\u00e0i h\u00f2a gi\u1eefa JP, Ph.Eur., USP-NF: pH 6,5\u20138,0; n\u01b0\u1edbc 5,0\u201313,0%; acid nitrilotriacetic \u2264 0,1%; h\u00e0m l\u01b0\u1ee3ng (ch\u1ebf ph\u1ea9m khan) 98,0\u2013102,0%.<\/li>\n
    • Kh\u1ed1i l\u01b0\u1ee3ng ri\u00eang bi\u1ec3u ki\u1ebfn 0,67 g\/cm\u00b3; \u0111i\u1ec3m ch\u1ea3y tr\u00ean 300 \u00b0C.<\/li>\n
    • \u0110\u1ed9 tan: d\u1ec5 tan trong n\u01b0\u1edbc (1 trong 2); r\u1ea5t kh\u00f3 tan trong ethanol 96%; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong cloroform, ether v\u00e0 dung m\u00f4i h\u1eefu c\u01a1 kh\u00e1c.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      C\u00e1c mu\u1ed1i edetat b\u1ec1n h\u01a1n acid edetic. H\u01a1i h\u00fat \u1ea9m \u2013 tr\u00e1nh \u1ea9m; b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n
        \n
      • T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh; ti\u1ebfp x\u00fac kim lo\u1ea1i nh\u01b0 nh\u00f4m c\u00f3 th\u1ec3 sinh hydro.<\/li>\n
      • \u0110\u00e3 ghi nh\u1eadn t\u01b0\u01a1ng k\u1ef5 v\u1edbi amphotericin v\u00e0 hydralazin hydroclorid trong thu\u1ed1c ti\u00eam truy\u1ec1n.<\/li>\n
      • B\u1eaft k\u1ebdm n\u00ean l\u00e0m m\u1ea5t ho\u1ea1t t\u00ednh m\u1ed9t s\u1ed1 ch\u1ebf ph\u1ea9m insulin.<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Cho calci carbonat v\u00e0o dung d\u1ecbch dinatri edetat, \u0111un s\u00f4i t\u1edbi khi h\u1ebft tho\u00e1t CO2<\/sub>, l\u1ecdc v\u00e0 k\u1ebft tinh.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
          \n
        • D\u00f9ng trong thu\u1ed1c u\u1ed1ng v\u00e0 l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m. C\u00f3 th\u1ec3 g\u00e2y k\u00edch \u1ee9ng m\u1eaft nghi\u00eam tr\u1ecdng; g\u00e2y m\u1eabn c\u1ea3m y\u1ebfu. H\u1ed9i \u0111\u1ed3ng CIR k\u1ebft lu\u1eadn an to\u00e0n trong m\u1ef9 ph\u1ea9m.<\/li>\n
        • Kh\u00f4ng b\u1eaft calci n\u00ean kh\u00f4ng g\u00e2y gi\u1ea3m calci m\u00e1u nh\u01b0 dinatri edetat, nh\u01b0ng c\u00f3 th\u1ec3 b\u1eaft kim lo\u1ea1i v\u1ebft nh\u01b0 k\u1ebdm, d\u1eabn t\u1edbi thi\u1ebfu k\u1ebdm khi d\u00f9ng l\u01b0\u1ee3ng l\u1edbn.<\/li>\n
        • WHO \u0111\u1eb7t ADI 0\u20132,5 mg\/kg th\u1ec3 tr\u1ecdng.<\/li>\n
        • LD50<\/sub>: chu\u1ed9t c\u1ed1ng u\u1ed1ng 10 g\/kg, t\u0129nh m\u1ea1ch 3,0 g\/kg, ph\u00fac m\u1ea1c 3,85 g\/kg; th\u1ecf u\u1ed1ng 7 g\/kg, ph\u00fac m\u1ea1c 6 g\/kg; chu\u1ed9t nh\u1eaft ph\u00fac m\u1ea1c 4,5 g\/kg.<\/li>\n
        • \u0110eo k\u00ednh, g\u0103ng, kh\u1ea9u trang ch\u1ed1ng b\u1ee5i. \u0110un t\u1edbi ph\u00e2n h\u1ee7y sinh kh\u00f3i \u0111\u1ed9c oxyd nit\u01a1, \u0111\u1ed3ng th\u1eddi t\u1ea1o calci oxalat v\u00e0 natri oxalat.<\/li>\n<\/ul>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • C\u00f3 trong FDA Inactive Ingredients Database (thu\u1ed1c ti\u00eam; nang, dung d\u1ecbch, h\u1ed7n d\u1ecbch, siro, gi\u1ecdt v\u00e0 vi\u00ean n\u00e9n u\u1ed1ng; ch\u1ebf ph\u1ea9m tr\u1ef1c tr\u00e0ng, ni\u1ec7u \u0111\u1ea1o, b\u00f4i ngo\u00e0i); c\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh.<\/li>\n
          • C\u00f3 trong danh m\u1ee5c EAFUS; \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E385); c\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n
          • Thu\u1ed9c nh\u00f3m t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c h\u00e0i h\u00f2a ti\u00eau chu\u1ea9n gi\u1eefa JP, Ph.Eur., USP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

            Ch\u1ea5t li\u00ean quan<\/h2>\n

            Acid edetic (EDTA), dinatri edetat, tetranatri edetat.<\/p>\n

            Ghi ch\u00fa:<\/strong> natri calci edetat c\u00f2n l\u00e0 ho\u1ea1t ch\u1ea5t t\u1ea1o chelat kim lo\u1ea1i n\u1eb7ng \u2013 c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. S\u1ed1 EINECS 200-529-9; PubChem CID 6093170.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Edetate Calcium Disodium<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Natri calci edetat (calci dinatri EDTA, E385) \u2013 ch\u1ea5t t\u1ea1o ph\u1ee9c ion kim lo\u1ea1i Natri calci edetat (edetate calcium disodium, calci dinatri EDTA, E385) l\u00e0 mu\u1ed1i calci \u2013 dinatri c\u1ee7a acid edetic. Ph\u1ee9c calci n\u00e0y t\u01b0\u01a1ng \u0111\u1ed1i y\u1ebfu n\u00ean s\u1ebd nh\u01b0\u1eddng ion calci \u0111\u1ec3 b\u1eaft c\u00e1c kim lo\u1ea1i n\u1eb7ng nh\u01b0 s\u1eaft, \u0111\u1ed3ng, ch\u00ec. Trong b\u00e0o […]<\/p>\n","protected":false},"author":1,"featured_media":3554,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3555","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-calci-edetat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-calci-edetat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-calci-edetat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-calci-edetat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-calci-edetat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-calci-edetat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-calci-edetat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-calci-edetat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Natri calci edetat (calci dinatri EDTA, E385) \u2013 ch\u1ea5t t\u1ea1o ph\u1ee9c ion kim lo\u1ea1i Natri calci edetat (edetate calcium disodium, calci dinatri EDTA, E385) l\u00e0 mu\u1ed1i calci \u2013 dinatri c\u1ee7a acid edetic. Ph\u1ee9c calci n\u00e0y t\u01b0\u01a1ng \u0111\u1ed1i y\u1ebfu n\u00ean s\u1ebd nh\u01b0\u1eddng ion calci \u0111\u1ec3 b\u1eaft c\u00e1c kim lo\u1ea1i n\u1eb7ng nh\u01b0 s\u1eaft, \u0111\u1ed3ng, ch\u00ec. Trong b\u00e0o…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3555","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3555"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3555\/revisions"}],"predecessor-version":[{"id":3891,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3555\/revisions\/3891"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3554"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3555"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3555"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}