{"id":3551,"date":"2026-09-29T08:41:09","date_gmt":"2026-09-29T01:41:09","guid":{"rendered":"https:\/\/cpc1.vn\/dodecyl-gallat\/"},"modified":"2026-09-29T12:00:37","modified_gmt":"2026-09-29T05:00:37","slug":"dodecyl-gallat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/dodecyl-gallat\/","title":{"rendered":"Dodecyl gallat (lauryl gallat, E312) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho d\u1ea7u m\u1ee1"},"content":{"rendered":"

Dodecyl gallat (lauryl gallat, E312) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho d\u1ea7u m\u1ee1<\/h1>\n

Dodecyl gallat<\/strong> (lauryl gallat, E312) l\u00e0 ester c\u1ee7a acid gallic v\u1edbi dodecanol, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng. Nh\u01b0 c\u00e1c alkyl gallat kh\u00e1c, dodecyl gallat l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/strong> d\u00f9ng \u0111\u1ec3 ch\u1ed1ng \u00f4i h\u00f3a v\u00e0 h\u01b0 h\u1ecfng d\u1ea7u m\u1ee1 trong d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 m\u1ef9 ph\u1ea9m.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nLauryl gallat, dodecyl 3,4,5-trihydroxybenzoat, ester dodecyl c\u1ee7a acid gallic, E312<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n1166-52-5<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC19<\/sub>H30<\/sub>O5<\/sub> \u2013 338,4<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • C\u00e1c alkyl gallat \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m ch\u1ea5t ch\u1ed1ng oxy h\u00f3a b\u1ea3o qu\u1ea3n trong d\u01b0\u1ee3c ph\u1ea9m (t\u1eeb khi propyl gallat \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 n\u0103m 1943), hi\u1ec7u qu\u1ea3 \u1edf n\u1ed3ng \u0111\u1ed9 0,001\u20130,1% (kl\/tt), ng\u0103n d\u1ea7u m\u1ee1 b\u1ecb h\u01b0 v\u00e0 \u00f4i.<\/li>\n
  • \u0110\u00e3 nghi\u00ean c\u1ee9u \u0111\u1ec3 \u1ed5n \u0111\u1ecbnh ergocalciferol trong thu\u1ed1c m\u1ee1; l\u00e0m ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho ch\u1ebf ph\u1ea9m hormon b\u00f4i da, cho \u1ed1ng th\u00f4ng b\u00f3ng ph\u1ee7 thu\u1ed1c v\u00e0 cho c\u1ed1t polymer\/kh\u00f4ng polymer c\u1ee7a h\u1ec7 gi\u1ea3i ph\u00f3ng c\u00f3 \u0111i\u1ec1u ch\u1ec9nh.<\/li>\n
  • Th\u01b0\u1eddng ph\u1ed1i h\u1ee3p v\u1edbi BHA, BHT v\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c v\u1edbi ion kim lo\u1ea1i nh\u01b0 acid citric \u0111\u1ec3 t\u0103ng hi\u1ec7u qu\u1ea3.<\/li>\n
  • Trong th\u1ef1c ph\u1ea9m (EU): t\u1edbi 1 g\/kg trong tinh d\u1ea7u v\u00e0 0,1 g\/kg trong h\u01b0\u01a1ng li\u1ec7u kh\u00e1c, \u0111\u01a1n l\u1ebb ho\u1eb7c ph\u1ed1i h\u1ee3p gallat kh\u00e1c. \u0110\u01b0\u1ee3c ph\u00e9p trong m\u1ef9 ph\u1ea9m v\u00e0 v\u1eadt li\u1ec7u nh\u1ef1a.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, kh\u00f4ng m\u00f9i ho\u1eb7c g\u1ea7n nh\u01b0 kh\u00f4ng m\u00f9i.<\/li>\n
    • \u0110i\u1ec3m ch\u1ea3y 96\u201397,5 \u00b0C (sau s\u1ea5y 4 gi\u1edd \u1edf 60 \u00b0C); t\u1ef7 tr\u1ecdng 1,112 g\/cm\u00b3; \u0111i\u1ec3m ch\u1edbp ch\u00e1y kho\u1ea3ng 180 \u00b0C. D\u01b0\u1ee3c \u0111i\u1ec3n y\u00eau c\u1ea7u h\u00e0m l\u01b0\u1ee3ng 97,0\u2013103,0% (ch\u1ebf ph\u1ea9m kh\u00f4).<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n\n\n
      Dung m\u00f4i<\/th>\n\u0110\u1ed9 tan \u1edf 20 \u00b0C<\/th>\n<\/tr>\n<\/thead>\n
      Methanol<\/td>\n1 trong 1,5<\/td>\n<\/tr>\n
      Aceton<\/td>\n1 trong 2<\/td>\n<\/tr>\n
      Ethanol 95%<\/td>\n1 trong 3,5<\/td>\n<\/tr>\n
      Ether<\/td>\n1 trong 4<\/td>\n<\/tr>\n
      D\u1ea7u l\u1ea1c<\/td>\n1 trong 30<\/td>\n<\/tr>\n
      Cloroform<\/td>\n1 trong 60<\/td>\n<\/tr>\n
      N\u01b0\u1edbc<\/td>\nH\u1ea7u nh\u01b0 kh\u00f4ng tan<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n trong bao b\u00ec kh\u00f4ng b\u1eb1ng kim lo\u1ea1i, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      C\u00e1c alkyl gallat t\u1ea1o ph\u1ee9c m\u00e0u \u0111\u1eadm v\u1edbi kim lo\u1ea1i (natri, kali, s\u1eaft); trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p c\u00f3 th\u1ec3 ng\u0103n b\u1eb1ng ch\u1ea5t t\u1ea1o ph\u1ee9c nh\u01b0 acid citric. Ph\u1ea3n \u1ee9ng v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u00e0 base m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Ester h\u00f3a acid gallic v\u1edbi dodecanol, x\u00fac t\u00e1c acid m\u1ea1nh khan; t\u00e1ch v\u00e0 tinh ch\u1ebf b\u1eb1ng k\u1ebft tinh t\u1eeb dung m\u00f4i h\u1eefu c\u01a1 nh\u01b0 diethyl ether.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • D\u00f9ng r\u1ed9ng r\u00e3i trong th\u1ef1c ph\u1ea9m, nh\u00ecn chung \u0111\u01b0\u1ee3c coi l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng; tuy nhi\u00ean c\u00f3 th\u1ec3 g\u00e2y m\u1eabn c\u1ea3m ti\u1ebfp x\u00fac v\u00e0 ph\u1ea3n \u1ee9ng da. Th\u1eed nghi\u1ec7m tr\u00ean chu\u1ed9t lang cho th\u1ea5y dodecyl gallat l\u00e0 ch\u1ea5t g\u00e2y m\u1eabn c\u1ea3m m\u1ea1nh nh\u1ea5t trong c\u00e1c alkyl gallat \u0111\u00e3 th\u1eed.<\/li>\n
      • WHO kh\u00f4ng x\u00e1c \u0111\u1ecbnh ADI; ADI t\u1ea1m th\u1eddi tr\u01b0\u1edbc \u0111\u00e2y kh\u00f4ng \u0111\u01b0\u1ee3c gia h\u1ea1n do thi\u1ebfu nghi\u00ean c\u1ee9u b\u1ed5 sung.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t c\u1ed1ng, ph\u00fac m\u1ea1c): 0,1 g\/kg; (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 5 g\/kg; (chu\u1ed9t nh\u1eaft, u\u1ed1ng): 1,6 g\/kg.<\/li>\n
      • K\u00edch \u1ee9ng da; khi \u0111un t\u1edbi ph\u00e2n h\u1ee7y sinh kh\u00f3i cay. N\u00ean \u0111eo k\u00ednh v\u00e0 g\u0103ng.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh; c\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n
        • C\u00f3 trong danh m\u1ee5c ph\u1ee5 gia th\u1ef1c ph\u1ea9m EAFUS c\u1ee7a FDA; \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E312).<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Octyl gallat, propyl gallat.<\/p>\n

          Ghi ch\u00fa:<\/strong> dodecyl gallat c\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng virus v\u00e0 kh\u00e1ng vi khu\u1ea9n Gram d\u01b0\u01a1ng (k\u1ec3 c\u1ea3 MRSA) trong nghi\u00ean c\u1ee9u; \u0111\u01b0\u1ee3c th\u1eed gh\u00e9p l\u00ean chitosan, cellulose s\u1ee3i nano \u0111\u1ec3 t\u0103ng t\u00ednh k\u1ef5 n\u01b0\u1edbc v\u00e0 kh\u1ea3 n\u0103ng ch\u1eafn oxy cho bao b\u00ec, t\u0103ng \u0111\u1ed9 b\u1ec1n oxy h\u00f3a c\u1ee7a UHMWPE d\u00f9ng trong c\u1ea5y gh\u00e9p ch\u1ec9nh h\u00ecnh. S\u1ed1 EINECS 214-620-6; PubChem CID 14425.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Dodecyl Gallate<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Dodecyl gallat (lauryl gallat, E312) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho d\u1ea7u m\u1ee1 Dodecyl gallat (lauryl gallat, E312) l\u00e0 ester c\u1ee7a acid gallic v\u1edbi dodecanol, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng. Nh\u01b0 c\u00e1c alkyl gallat kh\u00e1c, dodecyl gallat l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a d\u00f9ng \u0111\u1ec3 ch\u1ed1ng \u00f4i h\u00f3a v\u00e0 h\u01b0 h\u1ecfng d\u1ea7u m\u1ee1 trong d\u01b0\u1ee3c ph\u1ea9m, […]<\/p>\n","protected":false},"author":1,"featured_media":3550,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3551","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dodecyl-gallat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dodecyl-gallat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dodecyl-gallat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dodecyl-gallat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dodecyl-gallat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dodecyl-gallat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dodecyl-gallat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dodecyl-gallat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Dodecyl gallat (lauryl gallat, E312) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho d\u1ea7u m\u1ee1 Dodecyl gallat (lauryl gallat, E312) l\u00e0 ester c\u1ee7a acid gallic v\u1edbi dodecanol, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng. Nh\u01b0 c\u00e1c alkyl gallat kh\u00e1c, dodecyl gallat l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a d\u00f9ng \u0111\u1ec3 ch\u1ed1ng \u00f4i h\u00f3a v\u00e0 h\u01b0 h\u1ecfng d\u1ea7u m\u1ee1 trong d\u01b0\u1ee3c ph\u1ea9m,…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3551"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3551\/revisions"}],"predecessor-version":[{"id":3811,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3551\/revisions\/3811"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3550"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}