{"id":3547,"date":"2026-09-29T08:40:55","date_gmt":"2026-09-29T01:40:55","guid":{"rendered":"https:\/\/cpc1.vn\/copolymer-ghep-macrogol-polyvinyl-alcol\/"},"modified":"2026-09-29T11:57:01","modified_gmt":"2026-09-29T04:57:01","slug":"copolymer-ghep-macrogol-polyvinyl-alcol","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/copolymer-ghep-macrogol-polyvinyl-alcol\/","title":{"rendered":"Copolymer gh\u00e9p macrogol \u2013 polyvinyl alcol (Kollicoat IR) \u2013 t\u1ea1o m\u00e0ng bao phim tan nhanh"},"content":{"rendered":"

Copolymer gh\u00e9p macrogol \u2013 polyvinyl alcol (Kollicoat IR) \u2013 t\u1ea1o m\u00e0ng bao phim tan nhanh<\/h1>\n

Copolymer gh\u00e9p ethylen glycol \u2013 vinyl alcol<\/strong> (macrogol poly(vinyl alcol) grafted copolymer, PVA\u2013PEG; t\u00ean th\u01b0\u01a1ng m\u1ea1i Kollicoat IR) l\u00e0 polymer t\u1ed5ng h\u1ee3p ph\u00e2n nh\u00e1nh g\u1ed3m m\u1ea1ch ch\u00ednh polyethylen glycol gh\u00e9p c\u00e1c nh\u00e1nh polyvinyl alcol. \u0110\u01b0\u1ee3c \u0111\u01b0a ra th\u1ecb tr\u01b0\u1eddng n\u0103m 2002, polymer n\u00e0y ch\u1ee7 y\u1ebfu d\u00f9ng l\u00e0m t\u00e1c nh\u00e2n t\u1ea1o m\u00e0ng cho vi\u00ean bao phim gi\u1ea3i ph\u00f3ng t\u1ee9c th\u00ec<\/strong>, ngo\u00e0i ra l\u00e0 t\u00e1 d\u01b0\u1ee3c d\u00ednh<\/strong> v\u00e0 ch\u1ea5t t\u1ea1o l\u1ed7<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nPVA\u2013PEG graft copolymer, polyvinyl alcol \u2013 polyethylen glycol graft copolymer, Kollicoat IR<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n96734-39-3<\/td>\n<\/tr>\n
C\u1ea5u t\u1ea1o<\/td>\nTrung b\u00ecnh 2\u20134 nh\u00e1nh polyvinyl alcol gh\u00e9p tr\u00ean m\u1ea1ch ch\u00ednh polyethylen glycol; kho\u1ea3ng 25% PEG v\u00e0 75% PVA (kl\/kl); KLPT trung b\u00ecnh 40 000\u201350 000. C\u00f3 th\u1ec3 ch\u1ee9a ch\u1ea5t \u0111i\u1ec1u h\u00f2a ch\u1ea3y nh\u01b0 silic dioxyd keo.<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nT\u00e1 d\u01b0\u1ee3c bao, t\u1ea1o m\u00e0ng, t\u00e1 d\u01b0\u1ee3c d\u00ednh vi\u00ean n\u00e9n\/vi\u00ean nang<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nPh.Eur. (Macrogol Poly(Vinyl Alcohol) Grafted Copolymer), USP-NF (Ethylene Glycol and Vinyl Alcohol Grafted Copolymer)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Bao phim gi\u1ea3i ph\u00f3ng t\u1ee9c th\u00ec:<\/strong> polymer th\u00e2n n\u01b0\u1edbc tan nhanh trong n\u01b0\u1edbc, kh\u00f4ng ph\u1ee5 thu\u1ed9c pH. Ph\u1ea7n PVA cho kh\u1ea3 n\u0103ng t\u1ea1o m\u00e0ng t\u1ed1t, ph\u1ea7n PEG \u0111\u00f3ng vai tr\u00f2 ch\u1ea5t h\u00f3a d\u1ebbo n\u1ed9i \u2013 n\u00ean m\u00e0ng r\u1ea5t d\u1ebbo m\u00e0 kh\u00f4ng c\u1ea7n th\u00eam ch\u1ea5t h\u00f3a d\u1ebbo.<\/li>\n
  • Dung d\u1ecbch n\u01b0\u1edbc c\u00f3 \u0111\u1ed9 nh\u1edbt th\u1ea5p, cho ph\u00e9p d\u00f9ng h\u1ed7n d\u1ecbch bao n\u1ed3ng \u0111\u1ed9 ch\u1ea5t r\u1eafn cao (r\u00fat ng\u1eafn th\u1eddi gian bao).<\/li>\n
  • Ch\u1ea5t t\u1ea1o l\u1ed7 th\u00e2n n\u01b0\u1edbc ph\u1ed1i h\u1ee3p v\u1edbi t\u00e1c nh\u00e2n bao gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i (ethylcellulose, polyvinyl acetat) \u2013 \u0111i\u1ec1u ch\u1ec9nh t\u1ed1c \u0111\u1ed9 gi\u1ea3i ph\u00f3ng b\u1eb1ng t\u1ef7 l\u1ec7 polymer th\u00eam v\u00e0o.<\/li>\n
  • Nh\u1edd \u0111\u1ed9 d\u1ebbo cao, ph\u00f9 h\u1ee3p l\u00e0m ch\u1ea5t mang cho phim\/mi\u1ebfng m\u1ecfng ch\u1ee9a thu\u1ed1c.<\/li>\n
  • \u0110\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh x\u00e1t h\u1ea1t \u01b0\u1edbt v\u00e0 ch\u1ea5t mang trong ph\u00e2n t\u00e1n r\u1eafn; l\u00e0 keo b\u1ea3o v\u1ec7 \u1ed5n \u0111\u1ecbnh h\u1ec7 ph\u00e2n t\u00e1n (ethylcellulose) v\u00e0 nh\u0169 t\u01b0\u01a1ng (triglycerid m\u1ea1ch trung b\u00ecnh\/n\u01b0\u1edbc).<\/li>\n
  • D\u1ea1ng th\u01b0\u01a1ng m\u1ea1i: b\u1ed9t s\u1ea5y phun (Kollicoat IR), ph\u1ed1i h\u1ee3p v\u1edbi polyvinyl alcol cho m\u00e0ng ch\u1ed1ng \u1ea9m (Kollicoat IR Protect), ho\u1eb7c h\u1ec7 bao m\u00e0u pha s\u1eb5n.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u01a1n ch\u1ea3y, tr\u1eafng t\u1edbi h\u01a1i v\u00e0ng; polymer v\u00f4 \u0111\u1ecbnh h\u00ecnh c\u00f3 v\u00f9ng k\u1ebft tinh m\u1ed9t ph\u1ea7n.<\/li>\n
    • D\u01b0\u1ee3c \u0111i\u1ec3n: pH 5,0\u20138,0; ch\u1ec9 s\u1ed1 ester 10\u201375; t\u1ea1p vinyl acetat \u2264 100 ppm; acid acetic \u2264 1,5%.<\/li>\n
    • \u0110\u1ed9 tan: tan nhanh trong n\u01b0\u1edbc v\u00e0 dung d\u1ecbch n\u01b0\u1edbc (acid, ki\u1ec1m y\u1ebfu) t\u1edbi 40% (kl\/kl); pha \u0111\u01b0\u1ee3c dung d\u1ecbch t\u1edbi 25% trong h\u1ed7n h\u1ee3p ethanol \u2013 n\u01b0\u1edbc 1:1; \u00edt tan trong dung m\u00f4i kh\u00f4ng ph\u00e2n c\u1ef1c. Lo\u1ea1i ch\u1ee9a silic dioxyd cho dung d\u1ecbch h\u01a1i \u0111\u1ee5c.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      H\u01a1i h\u00fat \u1ea9m; b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u00e0i li\u1ec7u g\u1ed1c kh\u00f4ng ghi nh\u1eadn t\u01b0\u01a1ng k\u1ef5 c\u1ee5 th\u1ec3.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      T\u1eeb polyethylen glycol v\u00e0 vinyl acetat: PEG l\u00e0m m\u1ea1ch ch\u00ednh \u0111\u1ec3 gh\u00e9p polyvinyl acetat, sau \u0111\u00f3 x\u00e0 ph\u00f2ng h\u00f3a ph\u1ea7n polyvinyl acetat th\u00e0nh c\u00e1c nh\u00e1nh polyvinyl alcol.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • D\u00f9ng trong thu\u1ed1c u\u1ed1ng, nh\u00ecn chung \u0111\u01b0\u1ee3c coi l\u00e0 an to\u00e0n; kh\u00f4ng k\u00edch \u1ee9ng m\u1eaft, da th\u1ecf; kh\u00f4ng g\u00e2y \u0111\u1ed9t bi\u1ebfn.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): tr\u00ean 2,0 g\/kg.<\/li>\n
      • Thao t\u00e1c theo l\u01b0u \u00fd th\u00f4ng th\u01b0\u1eddng.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • \u0110\u01b0\u1ee3c ch\u1ea5p thu\u1eadn d\u00f9ng trong thu\u1ed1c t\u1ea1i ch\u00e2u \u00c2u, Nh\u1eadt B\u1ea3n v\u00e0 M\u1ef9.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Polyethylen glycol, polyvinyl alcol.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Ethylene Glycol and Vinyl Alcohol Grafted Copolymer<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Copolymer gh\u00e9p macrogol \u2013 polyvinyl alcol (Kollicoat IR) \u2013 t\u1ea1o m\u00e0ng bao phim tan nhanh Copolymer gh\u00e9p ethylen glycol \u2013 vinyl alcol (macrogol poly(vinyl alcol) grafted copolymer, PVA\u2013PEG; t\u00ean th\u01b0\u01a1ng m\u1ea1i Kollicoat IR) l\u00e0 polymer t\u1ed5ng h\u1ee3p ph\u00e2n nh\u00e1nh g\u1ed3m m\u1ea1ch ch\u00ednh polyethylen glycol gh\u00e9p c\u00e1c nh\u00e1nh polyvinyl alcol. \u0110\u01b0\u1ee3c \u0111\u01b0a ra th\u1ecb tr\u01b0\u1eddng n\u0103m […]<\/p>\n","protected":false},"author":1,"featured_media":3546,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3547","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copolymer-ghep-macrogol-polyvinyl-alcol.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copolymer-ghep-macrogol-polyvinyl-alcol-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copolymer-ghep-macrogol-polyvinyl-alcol-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copolymer-ghep-macrogol-polyvinyl-alcol-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copolymer-ghep-macrogol-polyvinyl-alcol-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copolymer-ghep-macrogol-polyvinyl-alcol.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copolymer-ghep-macrogol-polyvinyl-alcol.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/copolymer-ghep-macrogol-polyvinyl-alcol-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Copolymer gh\u00e9p macrogol \u2013 polyvinyl alcol (Kollicoat IR) \u2013 t\u1ea1o m\u00e0ng bao phim tan nhanh Copolymer gh\u00e9p ethylen glycol \u2013 vinyl alcol (macrogol poly(vinyl alcol) grafted copolymer, PVA\u2013PEG; t\u00ean th\u01b0\u01a1ng m\u1ea1i Kollicoat IR) l\u00e0 polymer t\u1ed5ng h\u1ee3p ph\u00e2n nh\u00e1nh g\u1ed3m m\u1ea1ch ch\u00ednh polyethylen glycol gh\u00e9p c\u00e1c nh\u00e1nh polyvinyl alcol. \u0110\u01b0\u1ee3c \u0111\u01b0a ra th\u1ecb tr\u01b0\u1eddng n\u0103m…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3547","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3547"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3547\/revisions"}],"predecessor-version":[{"id":3773,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3547\/revisions\/3773"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3546"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3547"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3547"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3547"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}